3-(3,4-Difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2(5H)-furanone (BioDeep_00000842078)
代谢物信息卡片
化学式: C17H12F2O4S (350.04243360000004)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC(=C(C=C3)F)F
InChI: InChI=1S/C17H12F2O4S/c1-24(21,22)12-5-2-10(3-6-12)13-9-23-17(20)16(13)11-4-7-14(18)15(19)8-11/h2-8H,9H2,1H3
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Patsy Clark, Steven E Rowland, Danielle Denis, Marie-Claude Mathieu, Rino Stocco, Hugo Poirier, Jason Burch, Yongxin Han, Laurent Audoly, Alex G Therien, Daigen Xu. MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis.
The Journal of pharmacology and experimental therapeutics.
2008 May; 325(2):425-34. doi:
10.1124/jpet.107.134510. [PMID: 18287210] - Steven E Rowland, Patsy Clark, Robert Gordon, Anne K Mullen, Jocelyne Guay, Lynn Dufresne, Christine Brideau, Bernard Cote, Yves Ducharme, Joseph Mancini, Chi-chung Chan, Laurent Audoly, Daigen Xu. Pharmacological characterization of a selective COX-2 inhibitor MF-tricyclic, [3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone], in multiple preclinical species.
European journal of pharmacology.
2007 Apr; 560(2-3):216-24. doi:
10.1016/j.ejphar.2007.01.008. [PMID: 17316604] - Radko Komers, Jessie N Lindsley, Terry T Oyama, Sharon Anderson. Cyclo-oxygenase-2 inhibition attenuates the progression of nephropathy in uninephrectomized diabetic rats.
Clinical and experimental pharmacology & physiology.
2007 Jan; 34(1-2):36-41. doi:
10.1111/j.1440-1681.2007.04534.x. [PMID: 17201733] - Hadas Dvory-Sobol, Diana Kazanov, Eliezer Liberman, Shlomo Birkenfeld, Benny Bulvik, Pauline Luk, Moshe Leshno, Nadir Arber. MF tricyclic and sulindac retard tumor formation in an animal model.
International journal of cancer.
2006 Jan; 118(1):11-6. doi:
10.1002/ijc.21218. [PMID: 16003752] - Pierre-Olivier Hétu, Denis Riendeau. Cyclo-oxygenase-2 contributes to constitutive prostanoid production in rat kidney and brain.
The Biochemical journal.
2005 Nov; 391(Pt 3):561-6. doi:
10.1042/bj20050451. [PMID: 16008526] - Karine M Egan, Miao Wang, Susanne Fries, Margaret B Lucitt, Alicia M Zukas, Ellen Puré, John A Lawson, Garret A FitzGerald. Cyclooxygenases, thromboxane, and atherosclerosis: plaque destabilization by cyclooxygenase-2 inhibition combined with thromboxane receptor antagonism.
Circulation.
2005 Jan; 111(3):334-42. doi:
10.1161/01.cir.0000153386.95356.78. [PMID: 15655126] - Zhong Jian Cheng, Piet Finckenberg, Marjut Louhelainen, Saara Merasto, Ilkka Tikkanen, Heikki Vapaatalo, Eero M A Mervaala. Cardiovascular and renal effects of cyclooxygenase inhibition in transgenic rats harboring mouse renin-2 gene (TGR[mREN2]27).
European journal of pharmacology.
2003 Feb; 461(2-3):159-69. doi:
10.1016/s0014-2999(03)01307-4. [PMID: 12586211] - Mette Olesen, Elizabeth Kwong, Arguello Meztli, Frederic Kontny, Ingebjörg Seljeflot, Harald Arnesen, Line Lyngdorf, Erling Falk. No effect of cyclooxygenase inhibition on plaque size in atherosclerosis-prone mice.
Scandinavian cardiovascular journal : SCJ.
2002 Dec; 36(6):362-7. doi:
10.1080/140174302762659094. [PMID: 12626204] - Radko Komers, Wei Tian, Jessie N Lindsley, Terry T Oyama, David M Cohen, Sharon Anderson. Effects of cyclooxygenase-2 (COX-2) inhibition on plasma and renal renin in diabetes.
The Journal of laboratory and clinical medicine.
2002 Nov; 140(5):351-7. doi:
10.1067/mlc.2002.128551. [PMID: 12434137] - S C Black, C Brideau, M Cirino, M Belley, J Bosquet, C C Chan, I W Rodger. Differential effect of a selective cyclooxygenase-2 inhibitor versus indomethacin on renal blood flow in conscious volume-depleted dogs.
Journal of cardiovascular pharmacology.
1998 Nov; 32(5):686-94. doi:
10.1097/00005344-199811000-00002. [PMID: 9821840]