Pegorgotein (BioDeep_00000842056)

   


代谢物信息卡片


Pegorgotein

化学式: C7H13NO4 (175.0844538)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COCCOC(=O)CCC(=O)N
InChI: InChI=1S/C7H13NO4/c1-11-4-5-12-7(10)3-2-6(8)9/h2-5H2,1H3,(H2,8,9)

描述信息

D013501 - Surface-Active Agents > D011092 - Polyethylene Glycols
D000975 - Antioxidants > D016166 - Free Radical Scavengers
D020011 - Protective Agents > D000975 - Antioxidants
C26170 - Protective Agent > C275 - Antioxidant
D001697 - Biomedical and Dental Materials

同义名列表

1 个代谢物同义名

Pegorgotein



数据库引用编号

2 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Ahmed Yousef, I G Saleh, Adel R A Abd-Allah, Mohamed R Elnagar, El-Sayed Akool. PEG-SOD attenuates the mitogenic ERK1/2 signaling cascade induced by cyclosporin A in the liver and kidney of albino mice. Chemico-biological interactions. 2020 Oct; 330(?):109245. doi: 10.1016/j.cbi.2020.109245. [PMID: 32866465]
  • Xiaoyan Sun, Weiguang Wang, Jiao Chen, Xueting Cai, Jie Yang, Yang Yang, Huaijiang Yan, Xiaolan Cheng, Juan Ye, Wuguang Lu, Chunping Hu, Handong Sun, Jianxin Pu, Peng Cao. The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects. Cancer research. 2017 02; 77(4):926-936. doi: 10.1158/0008-5472.can-16-0987. [PMID: 28011619]
  • Sudip Banerjee, Nukhet Aykin-Burns, Kimberly J Krager, Sumit K Shah, Stepan B Melnyk, Martin Hauer-Jensen, Snehalata A Pawar. Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction. Free radical biology & medicine. 2016 10; 99(?):296-307. doi: 10.1016/j.freeradbiomed.2016.08.022. [PMID: 27554969]
  • Ai-Dong Chen, Xiao-Qing Xiong, Xian-Bing Gan, Feng Zhang, Ye-Bo Zhou, Xing-Ya Gao, Ying Han. Endothelin-1 in paraventricular nucleus modulates cardiac sympathetic afferent reflex and sympathetic activity in rats. PloS one. 2012; 7(7):e40748. doi: 10.1371/journal.pone.0040748. [PMID: 22815806]
  • M-K Zhong, J Gao, F Zhang, B Xu, Z-D Fan, W Wang, G-Q Zhu. Reactive oxygen species in rostral ventrolateral medulla modulate cardiac sympathetic afferent reflex in rats. Acta physiologica (Oxford, England). 2009 Dec; 197(4):297-304. doi: 10.1111/j.1748-1716.2009.02026.x. [PMID: 19645750]
  • Jianfei Jiang, Natalia A Belikova, Adam T Hoye, Qing Zhao, Michael W Epperly, Joel S Greenberger, Peter Wipf, Valerian E Kagan. A mitochondria-targeted nitroxide/hemigramicidin S conjugate protects mouse embryonic cells against gamma irradiation. International journal of radiation oncology, biology, physics. 2008 Mar; 70(3):816-25. doi: 10.1016/j.ijrobp.2007.10.047. [PMID: 18262096]
  • Giselle T Y Cheung, Yaw L Siow, Karmin O. Homocysteine stimulates monocyte chemoattractant protein-1 expression in mesangial cells via NF-kappaB activation. Canadian journal of physiology and pharmacology. 2008 Mar; 86(3):88-96. doi: 10.1139/y08-002. [PMID: 18418435]
  • Yang Yu, Ming-Kui Zhong, Jing Li, Xiu-Lan Sun, Gui-Qing Xie, Wei Wang, Guo-Qing Zhu. Endogenous hydrogen peroxide in paraventricular nucleus mediating cardiac sympathetic afferent reflex and regulating sympathetic activity. Pflugers Archiv : European journal of physiology. 2007 Jul; 454(4):551-7. doi: 10.1007/s00424-007-0256-9. [PMID: 17387509]
  • Shaohua Ye, Huiquin Zhong, Swati Yanamadala, Vito M Campese. Oxidative stress mediates the stimulation of sympathetic nerve activity in the phenol renal injury model of hypertension. Hypertension (Dallas, Tex. : 1979). 2006 Aug; 48(2):309-15. doi: 10.1161/01.hyp.0000231307.69761.2e. [PMID: 16785328]
  • Gerald S Supinski, Leigh A Callahan. Polyethylene glycol-superoxide dismutase prevents endotoxin-induced cardiac dysfunction. American journal of respiratory and critical care medicine. 2006 Jun; 173(11):1240-7. doi: 10.1164/rccm.200410-1346oc. [PMID: 16514113]
  • Vito M Campese, Ye Shaohua, Zhong Huiquin. Oxidative stress mediates angiotensin II-dependent stimulation of sympathetic nerve activity. Hypertension (Dallas, Tex. : 1979). 2005 Sep; 46(3):533-9. doi: 10.1161/01.hyp.0000179088.57586.26. [PMID: 16116043]
  • Akihisa Matsubara, Kazushi Tamai, Yoshito Matsuda, Yuji Niwa, Hiroshi Morita, Kazuyuki Tomida, Donald Armstrong, Yuichiro Ogura. Protective effect of polyethylene glycol-superoxide dismutase on leukocyte dynamics in rat retinal microcirculation under lipid hydroperoxide-induced oxidative stress. Experimental eye research. 2005 Aug; 81(2):193-9. doi: 10.1016/j.exer.2005.01.021. [PMID: 16080913]
  • Katsuo Kamata, Noriyasu Kanie, Takayuki Matsumoto, Tsuneo Kobayashi. Endothelin-1-induced impairment of endothelium-dependent relaxation in aortas isolated from controls and diabetic rats. Journal of cardiovascular pharmacology. 2004 Nov; 44 Suppl 1(?):S186-90. doi: 10.1097/01.fjc.0000166241.49453.e9. [PMID: 15838275]
  • J V Guarrera, M M R Polyak, B Arrington, B O'Mar Arrington, J Boykin, T Brown, M A Jean-Jacques, S Kapur, W T Stubenbord, M Kinkhabwala. Pushing the envelope in renal preservation; improved results with novel perfusate modifications for pulsatile machine perfusion of cadaver kidneys. Transplantation proceedings. 2004 Jun; 36(5):1257-60. doi: 10.1016/j.transproceed.2004.04.083. [PMID: 15251306]
  • Hui Xu, Gregory D Fink, James J Galligan. Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. Hypertension (Dallas, Tex. : 1979). 2004 Feb; 43(2):329-34. doi: 10.1161/01.hyp.0000112304.26158.5c. [PMID: 14707156]
  • Zhi-Zhang Yang, Andrew Y Zhang, Fu-Xian Yi, Pin-Lan Li, Ai-Ping Zou. Redox regulation of HIF-1alpha levels and HO-1 expression in renal medullary interstitial cells. American journal of physiology. Renal physiology. 2003 Jun; 284(6):F1207-15. doi: 10.1152/ajprenal.00017.2002. [PMID: 12595275]
  • Rajat S Barua, John A Ambrose, Sudhesh Srivastava, Mary C DeVoe, Lesley-Jane Eales-Reynolds. Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase: an in vitro demonstration in human coronary artery endothelial cells. Circulation. 2003 May; 107(18):2342-7. doi: 10.1161/01.cir.0000066691.52789.be. [PMID: 12707237]
  • Ken Y Lin, Akira Ito, Tomoko Asagami, Philip S Tsao, Shanthi Adimoolam, Masumi Kimoto, Hideaki Tsuji, Gerald M Reaven, John P Cooke. Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase. Circulation. 2002 Aug; 106(8):987-92. doi: 10.1161/01.cir.0000027109.14149.67. [PMID: 12186805]
  • Edgaras Stankevicius, Ana Cristina Martinez, Michael J Mulvany, Ulf Simonsen. Blunted acetylcholine relaxation and nitric oxide release in arteries from renal hypertensive rats. Journal of hypertension. 2002 Aug; 20(8):1571-9. doi: 10.1097/00004872-200208000-00020. [PMID: 12172319]
  • Francesco M Veronese, Paolo Caliceti, Oddone Schiavon, Mauro Sergi. Polyethylene glycol-superoxide dismutase, a conjugate in search of exploitation. Advanced drug delivery reviews. 2002 Jun; 54(4):587-606. doi: 10.1016/s0169-409x(02)00029-7. [PMID: 12052716]
  • M Hangaishi, H Nakajima, J Taguchi , R Igarashi, J Hoshino, K Kurokawa, S Kimura, R Nagai, M Ohno. Lecithinized Cu, Zn-superoxide dismutase limits the infarct size following ischemia-reperfusion injury in rat hearts in vivo. Biochemical and biophysical research communications. 2001 Aug; 285(5):1220-5. doi: 10.1006/bbrc.2001.5319. [PMID: 11478786]
  • C Liang, N K Rounds, E Dong, S Y Stevens, J Shite, F Qin. Alterations by norepinephrine of cardiac sympathetic nerve terminal function and myocardial beta-adrenergic receptor sensitivity in the ferret: normalization by antioxidant vitamins. Circulation. 2000 Jul; 102(1):96-103. doi: 10.1161/01.cir.102.1.96. [PMID: 10880421]
  • N Fujimura, S Sumita, E Narimatsu. Alteration in diaphragmatic contractility during septic peritonitis in rats: effect of polyethylene glycol-absorbed superoxide dismutase. Critical care medicine. 2000 Jul; 28(7):2406-14. doi: 10.1097/00003246-200007000-00036. [PMID: 10921571]
  • O Jung, W Jung, T Malinski, G Wiemer, B A Schoelkens, W Linz. Ischemic preconditioning and infarct mass: the effect of hypercholesterolemia and endothelial dysfunction. Clinical and experimental hypertension (New York, N.Y. : 1993). 2000 Feb; 22(2):165-79. doi: 10.1081/ceh-100100070. [PMID: 10744357]
  • T T Huynh, M G Davies, M J Trovato, L Barber, H J Safi, P O Hagen. Reduction of lipid peroxidation with intraoperative superoxide dismutase treatment decreases intimal hyperplasia in experimental vein grafts. The Journal of surgical research. 1999 Jun; 84(2):223-32. doi: 10.1006/jsre.1999.5647. [PMID: 10357924]
  • W D Nguyen, D H Kim, H B Alam, H S Provido, J R Kirkpatrick. Polyethylene glycol-superoxide dismutase inhibits lipid peroxidation in hepatic ischemia/reperfusion injury. Critical care (London, England). 1999; 3(5):127-30. doi: 10.1186/cc358. [PMID: 11056736]
  • S Iinuma, T Yoshikawa, N Yoshida, Y Naito, M Kondo. Role of active oxygen species and lipid peroxidation in mepirizole-induced duodenal ulcers in rats. Digestive diseases and sciences. 1998 Aug; 43(8):1657-64. doi: 10.1023/a:1018898612090. [PMID: 9724147]
  • G Supinski, D Nethery, D Stofan, A DiMarco. Effect of free radical scavengers on diaphragmatic fatigue. American journal of respiratory and critical care medicine. 1997 Feb; 155(2):622-9. doi: 10.1164/ajrccm.155.2.9032204. [PMID: 9032204]
  • C L Schleien, B Eberle, D H Shaffner, R C Koehler, R J Traystman. Reduced blood-brain barrier permeability after cardiac arrest by conjugated superoxide dismutase and catalase in piglets. Stroke. 1994 Sep; 25(9):1830-4; discussion 1834. doi: 10.1161/01.str.25.9.1830. [PMID: 8073465]
  • M G Saifer, R Somack, L D Williams. Plasma clearance and immunologic properties of long-acting superoxide dismutase prepared using 35,000 to 120,000 dalton poly-ethylene glycol. Advances in experimental medicine and biology. 1994; 366(?):377-87. doi: 10.1007/978-1-4615-1833-4_26. [PMID: 7771266]
  • S Kawasaki, S Sugiyama, N Ishiguro, T Ozawa, T Miura. Implication of superoxide radicals on ischemia-reperfusion-induced skeletal muscle injury in rats. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. 1993 May; 25(3):129-36. doi: 10.1159/000129267. [PMID: 8388794]
  • J D Lehman, C Dyke, A Abd-Elfattah, T Yeh, M Ding, A Ezrin, A S Wechsler. Polyethylene glycol-conjugated superoxide dismutase attenuates reperfusion injury when administered twenty-four hours before ischemia. The Journal of thoracic and cardiovascular surgery. 1992 Dec; 104(6):1597-601. doi: 10.1016/s0022-5223(19)33889-9. [PMID: 1453723]
  • W C Stone, D E Bjorling, J H Southard, E J Galbreath, W A Lindsay. Evaluation of intestinal villus height in rats after ischemia and reperfusion by administration of superoxide dismutase, polyethylene glycol-conjugated superoxide dismutase, and two 21-aminosteroids. American journal of veterinary research. 1992 Nov; 53(11):2153-6. doi: ". [PMID: 1466514]
  • M Galiñanes, R Ferrari, Y Qiu, A Cargnoni, A Ezrin, D J Hearse. PEG-SOD and myocardial antioxidant status during ischaemia and reperfusion: dose-response studies in the isolated blood perfused rabbit heart. Journal of molecular and cellular cardiology. 1992 Sep; 24(9):1021-30. doi: 10.1016/0022-2828(92)91868-6. [PMID: 1433318]
  • M Galiñanes, Y Qiu, A Ezrin, D J Hearse. PEG-SOD and myocardial protection. Studies in the blood- and crystalloid-perfused rabbit and rat hearts. Circulation. 1992 Aug; 86(2):672-82. doi: 10.1161/01.cir.86.2.672. [PMID: 1638731]
  • K Yoshida, G F Burton, J S McKinney, H Young, E F Ellis. Brain and tissue distribution of polyethylene glycol-conjugated superoxide dismutase in rats. Stroke. 1992 Jun; 23(6):865-9. doi: 10.1161/01.str.23.6.865. [PMID: 1595107]
  • C Shindoh, A Dimarco, D Nethery, G Supinski. Effect of PEG-superoxide dismutase on the diaphragmatic response to endotoxin. The American review of respiratory disease. 1992 Jun; 145(6):1350-4. doi: 10.1164/ajrccm/145.6.1350. [PMID: 1596002]
  • Y Suzuki, T Tanigaki, D Heimer, W Z Wang, W G Ross, H H Sussman, T A Raffin. Polyethylene glycol-conjugated superoxide dismutase attenuates septic lung injury in guinea pigs. The American review of respiratory disease. 1992 Feb; 145(2 Pt 1):388-93. doi: 10.1164/ajrccm/145.2_pt_1.388. [PMID: 1736747]
  • T Matsumoto, Y Mitzunoe, N Ogata, M Tanaka, K Takahashi, J Kumazawa. Antioxidant effect on renal scarring following infection of mannose-sensitive-piliated bacteria. Nephron. 1992; 60(2):210-5. doi: 10.1159/000186741. [PMID: 1348108]
  • M A Helfaer, J R Kirsch, S E Haun, L E Moore, R J Traystman. Polyethylene glycol-conjugated superoxide dismutase fails to blunt postischemic reactive hyperemia. The American journal of physiology. 1991 Aug; 261(2 Pt 2):H548-53. doi: 10.1152/ajpheart.1991.261.2.h548. [PMID: 1877680]
  • H Ooiwa, A Stanley, A C Felaneous-Bylund, W Wilborn, J M Downey. Superoxide dismutase conjugated to polyethylene glycol fails to limit myocardial infarct size after 30 min ischemia followed by 72 h of reperfusion in the rabbit. Journal of molecular and cellular cardiology. 1991 Feb; 23(2):119-25. doi: 10.1016/0022-2828(91)90099-8. [PMID: 2067022]
  • P D Thomson, G O Till, J O Woolliscroft, D J Smith, J K Prasad. Superoxide dismutase prevents lipid peroxidation in burned patients. Burns : journal of the International Society for Burn Injuries. 1990 Dec; 16(6):406-8. doi: 10.1016/0305-4179(90)90066-6. [PMID: 2073336]
  • M Tanaka, R C Stoler, G P FitzHarris, R B Jennings, K A Reimer. Evidence against the 'early protection-delayed death' hypothesis of superoxide dismutase therapy in experimental myocardial infarction. Polyethylene glycol-superoxide dismutase plus catalase does not limit myocardial infarct size in dogs. Circulation research. 1990 Sep; 67(3):636-44. doi: 10.1161/01.res.67.3.636. [PMID: 2397573]
  • J M Jacobson, J R Michael, M H Jafri, G H Gurtner. Antioxidants and antioxidant enzymes protect against pulmonary oxygen toxicity in the rabbit. Journal of applied physiology (Bethesda, Md. : 1985). 1990 Mar; 68(3):1252-9. doi: 10.1152/jappl.1990.68.3.1252. [PMID: 2341349]
  • S Sasaki. [Experimental study on renal protection against damage in kidneys subjected warm ischemia--protective effect of FOY, SOD, and PEG-SOD on ischemic acute renal failure]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science. 1989 Jul; 64(4):457-65. doi: NULL. [PMID: 2511130]
  • L G Chi, Y Tamura, P T Hoff, M Macha, K P Gallagher, M A Schork, B R Lucchesi. Effect of superoxide dismutase on myocardial infarct size in the canine heart after 6 hours of regional ischemia and reperfusion: a demonstration of myocardial salvage. Circulation research. 1989 Apr; 64(4):665-75. doi: 10.1161/01.res.64.4.665. [PMID: 2702730]
  • Y Tamura, S Saito, M Hatano, B R Lucchesi. [Limitation of myocardial infarct size by polyethylene glycol-conjugated superoxide dismutase in a canine model of 90 min coronary occlusion followed by 4 days of reperfusion]. Kokyu to junkan. Respiration & circulation. 1989 Feb; 37(2):201-8. doi: NULL. [PMID: 2727408]