N-(6-Aminopyridin-2-yl)-4-cyanobiphenyl-4-sulfonamide (BioDeep_00000842050)
代谢物信息卡片
化学式: C18H14N4O2S (350.0837424)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)C3=CC=C(C=C3)C#N)N
InChI: InChI=1S/C18H14N4O2S/c19-12-13-4-6-14(7-5-13)15-8-10-16(11-9-15)25(23,24)22-18-3-1-2-17(20)21-18/h1-11H,(H3,20,21,22)
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xin Yang, Wenyi Hua, Sangwoo Ryu, Phillip Yates, Cheng Chang, Hui Zhang, Li Di. 11β-Hydroxysteroid Dehydrogenase 1 Human Tissue Distribution, Selective Inhibitor, and Role in Doxorubicin Metabolism.
Drug metabolism and disposition: the biological fate of chemicals.
2018 Jul; 46(7):1023-1029. doi:
10.1124/dmd.118.081083. [PMID: 29674492] - Ling-Ling Chang, Wan-Song A Wun, Paulus S Wang. Nonylphenol-induced hyperadrenalism can be reversed/alleviated by inhibiting of 11-β hydroxysteroid dehydrogenase type 1.
Environmental toxicology and pharmacology.
2016 Jun; 44(?):1-12. doi:
10.1016/j.etap.2016.03.019. [PMID: 27060500] - Keiji Kuroda, Radha Venkatakrishnan, Madhuri S Salker, Emma S Lucas, Fozia Shaheen, Masako Kuroda, Andrew Blanks, Mark Christian, Siobhan Quenby, Jan J Brosens. Induction of 11β-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells.
Molecular endocrinology (Baltimore, Md.).
2013 Feb; 27(2):192-202. doi:
10.1210/me.2012-1247. [PMID: 23275455] - S E Lee, J-M Kim, M-K Jeong, C C Zouboulis, S H Lee. 11β-hydroxysteroid dehydrogenase type 1 is expressed in human sebaceous glands and regulates glucocorticoid-induced lipid synthesis and toll-like receptor 2 expression in SZ95 sebocytes.
The British journal of dermatology.
2013 Jan; 168(1):47-55. doi:
10.1111/bjd.12009. [PMID: 22897663] - Rachel Courtney, Paul M Stewart, Melvin Toh, Marie-Noella Ndongo, Roberto A Calle, Boaz Hirshberg. Modulation of 11beta-hydroxysteroid dehydrogenase (11betaHSD) activity biomarkers and pharmacokinetics of PF-00915275, a selective 11betaHSD1 inhibitor.
The Journal of clinical endocrinology and metabolism.
2008 Feb; 93(2):550-6. doi:
10.1210/jc.2007-1912. [PMID: 17986636]