Patamostat (BioDeep_00000842035)
代谢物信息卡片
化学式: C20H20N4O4S (412.12052000000006)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(=O)N(C1=O)CCSC2=CC=C(C=C2)OC(=O)C3=CC=C(C=C3)N=C(N)N
InChI: InChI=1S/C20H20N4O4S/c21-20(22)23-14-3-1-13(2-4-14)19(27)28-15-5-7-16(8-6-15)29-12-11-24-17(25)9-10-18(24)26/h1-8H,9-12H2,(H4,21,22,23)
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015842 - Serine Proteinase Inhibitors
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- T Hirano, H Furuyama, Y Kawakami, K Ando, T Tsuchitani. Protective effects of prophylaxis with a protease inhibitor and a free radical scavenger against a temporary ischemia model of pancreatitis.
Canadian journal of surgery. Journal canadien de chirurgie.
1995 Jun; 38(3):241-8. doi:
NULL. [PMID: 7540502] - T Hirano, T Manabe. Effect of short-term pancreatico-biliary duct obstruction with intraductal hypertension on subcellular organelle fragility and pancreatic adenylate energy metabolism in rats: protective effect of a new protease inhibitor, E-3123.
Acta chirurgica Belgica.
1994 Mar; 94(2):80-5. doi:
NULL. [PMID: 7517090] - H Sobajima, T Hayakawa, T Kondo, T Shibata, M Kitagawa, Y Sakai, H Ishiguro, M Tanikawa, Y Nakae. Monitoring serum tryptic activity and effect of trypsin inhibitor on rat acute pancreatitis.
Digestion.
1994; 55(2):90-6. doi:
10.1159/000201131. [PMID: 7514553] - K Satake, S S Ha, A Hiura, H Nishiwaki. The therapeutic effect of a new synthetic protease inhibitor (E-3123) on hemodynamic changes during experimental acute pancreatitis in dogs.
Gastroenterologia Japonica.
1993 Feb; 28(1):64-71. doi:
10.1007/bf02775005. [PMID: 8440425] - T Hirano, T Manabe, K Imanishi, T Tobe. Protective effect of a cephalosporin, Shiomarin, plus a new potent protease inhibitor, E3123, on rat taurocholate-induced pancreatitis.
Journal of gastroenterology and hepatology.
1993 Jan; 8(1):52-9. doi:
10.1111/j.1440-1746.1993.tb01175.x. [PMID: 8439663] - H Nishiwaki, I Ko, A Hiura, S S Ha, K Satake, M Sowa. Renal microcirculation in experimental acute pancreatitis of dogs.
Renal failure.
1993; 15(1):27-31. doi:
10.3109/08860229309065568. [PMID: 8441833] - T Hirano, T Manabe. Combined therapy of a cephalosporin, Shiomarin and a new potent protease inhibitor, E3123 in rat taurocholate-induced pancreatitis.
Nihon geka hokan. Archiv fur japanische Chirurgie.
1992 Nov; 61(6):423-32. doi:
NULL. [PMID: 1306980] - T Hirano, T Manabe, G Ohshio, Y Nio. Improved survival in mice with diet-induced pancreatitis treated with new potent protease inhibitor, E-3123 and a broad spectrum antibiotic, cefmetazole.
Nihon geka hokan. Archiv fur japanische Chirurgie.
1992 May; 61(3):213-23. doi:
NULL. [PMID: 1444701] - T Hirano, T Manabe, F Yotsumoto, G Ohshio, Y Nio. Effect of short-termed pancreatico-biliary duct obstruction on lysosomal enzyme in rats: protective effect of a potent new protease inhibitor, E-3123.
Nihon geka hokan. Archiv fur japanische Chirurgie.
1992 May; 61(3):234-48. doi:
NULL. [PMID: 1280076] - T Hirano, T Manabe, K Ando, T Tobe. Acute cytotoxic effect of cyclosporin A on pancreatic acinar cells in rats. Protective effect of the synthetic protease inhibitor E3123.
Scandinavian journal of gastroenterology.
1992; 27(2):103-7. doi:
10.3109/00365529209165426. [PMID: 1373246] - K Satake, A Hiura, S S Ha, H Nishiwaki, K Umeyama. Effect of a new synthetic protease inhibitor on beta-endorphin release during acute pancreatitis in dogs.
Pancreas.
1991 Jul; 6(4):441-7. doi:
10.1097/00006676-199107000-00011. [PMID: 1876600] - K Iwatsuki, A Horiuchi, H Yonekura, L M Ren, S Chiba. E-3123, a new synthetic protease inhibitor, protects against deoxycholic acid-induced acute pancreatitis in dogs.
Archives internationales de pharmacodynamie et de therapie.
1990 Nov; 308(?):168-77. doi:
. [PMID: 1711836] - K Miyamoto, I Hishinuma, J Nagakawa, N Nagaoka, T Yamanaka, T Wakabayashi. [Effects of E-3123, a new protease inhibitor, on several protease activities and on experimental acute pancreatitis].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1988 May; 91(5):285-93. doi:
10.1254/fpj.91.285. [PMID: 3410375]