Propyl 6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-4-propylpyridine-3-carboxylate (BioDeep_00000842033)
代谢物信息卡片
化学式: C23H29NO3S (399.1868)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCC1=C(C(=NC(=C1C(=O)SCC)CC)C2=CC=CC=C2)C(=O)OCCC
InChI: InChI=1S/C23H29NO3S/c1-5-12-17-19(23(26)28-8-4)18(7-3)24-21(16-13-10-9-11-14-16)20(17)22(25)27-15-6-2/h9-11,13-14H,5-8,12,15H2,1-4H3
描述信息
D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058914 - Purinergic Antagonists
MRS 1523 is a potent and selective adenosine A3 receptor antagonist with Ki values of 18.9 nM and 113 nM for human and rat A3 receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs A1 and A2A receptors, respectively. MRS 1523 can exert antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons[1][2].
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Aliaa Abdelrahman, Swapnil G Yerande, Vigneshwaran Namasivayam, Tim A Klapschinski, Mohamad Wessam Alnouri, Ali El-Tayeb, Christa E Müller. Substituted 4-phenylthiazoles: Development of potent and selective A1, A3 and dual A1/A3 adenosine receptor antagonists.
European journal of medicinal chemistry.
2020 Jan; 186(?):111879. doi:
10.1016/j.ejmech.2019.111879. [PMID: 31780082] - Amanda Ford, Annie Castonguay, Martin Cottet, Joshua W Little, Zhoumou Chen, Ashley M Symons-Liguori, Timothy Doyle, Terrance M Egan, Todd W Vanderah, Yves De Koninck, Dilip K Tosh, Kenneth A Jacobson, Daniela Salvemini. Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2015 04; 35(15):6057-67. doi:
10.1523/jneurosci.4495-14.2015. [PMID: 25878279] - Joshua W Little, Amanda Ford, Ashley M Symons-Liguori, Zhoumou Chen, Kali Janes, Timothy Doyle, Jennifer Xie, Livio Luongo, Dillip K Tosh, Sabatino Maione, Kirsty Bannister, Anthony H Dickenson, Todd W Vanderah, Frank Porreca, Kenneth A Jacobson, Daniela Salvemini. Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states.
Brain : a journal of neurology.
2015 Jan; 138(Pt 1):28-35. doi:
10.1093/brain/awu330. [PMID: 25414036] - Theresa Pang, Xiaohong Tracey Gan, David J Freeman, Michael A Cook, Morris Karmazyn. Compensatory upregulation of the adenosine system following phenylephrine-induced hypertrophy in cultured rat ventricular myocytes.
American journal of physiology. Heart and circulatory physiology.
2010 Feb; 298(2):H545-53. doi:
10.1152/ajpheart.00417.2009. [PMID: 19966059] - Zhan-Guo Gao, Bao Teng, Haitao Wu, Bhalchandra V Joshi, Gary L Griffiths, Kenneth A Jacobson. Synthesis and pharmacological characterization of [(125)I]MRS1898, a high-affinity, selective radioligand for the rat A(3) adenosine receptor.
Purinergic signalling.
2009 Mar; 5(1):31-7. doi:
10.1007/s11302-008-9107-1. [PMID: 18528782] - Xiaohong Tracey Gan, Venkatesh Rajapurohitam, James V Haist, Peter Chidiac, Michael A Cook, Morris Karmazyn. Inhibition of phenylephrine-induced cardiomyocyte hypertrophy by activation of multiple adenosine receptor subtypes.
The Journal of pharmacology and experimental therapeutics.
2005 Jan; 312(1):27-34. doi:
10.1124/jpet.104.073122. [PMID: 15452191] - Zhan-Guo Gao, Soo-Kyung Kim, Thibaud Biadatti, Wangzhong Chen, Kyeong Lee, Dov Barak, Seong Gon Kim, Carl R Johnson, Kenneth A Jacobson. Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.
Journal of medicinal chemistry.
2002 Sep; 45(20):4471-84. doi:
10.1021/jm020211+. [PMID: 12238926] - Seong Gon Kim, Gnana Ravi, Carsten Hoffmann, Yun Jin Jung, Min Kim, Aishe Chen, Kenneth A Jacobson. p53-Independent induction of Fas and apoptosis in leukemic cells by an adenosine derivative, Cl-IB-MECA.
Biochemical pharmacology.
2002 Mar; 63(5):871-80. doi:
10.1016/s0006-2952(02)00839-0. [PMID: 11911839] - V Shneyvays, L Mamedova, T Zinman, K Jacobson, A Shainberg. Activation of A(3)adenosine receptor protects against doxorubicin-induced cardiotoxicity.
Journal of molecular and cellular cardiology.
2001 Jun; 33(6):1249-61. doi:
10.1006/jmcc.2001.1387. [PMID: 11444927] - S J Reshkin, L Guerra, A Bagorda, L Debellis, R Cardone, A H Li, K A Jacobson, V Casavola. Activation of A(3) adenosine receptor induces calcium entry and chloride secretion in A(6) cells.
The Journal of membrane biology.
2000 Nov; 178(2):103-13. doi:
10.1007/s002320010018. [PMID: 11083899] - A H Li, S Moro, N Forsyth, N Melman, X D Ji, K A Jacobson. Synthesis, CoMFA analysis, and receptor docking of 3,5-diacyl-2, 4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.
Journal of medicinal chemistry.
1999 Feb; 42(4):706-21. doi:
10.1021/jm980550w. [PMID: 10052977] - A H Li, S Moro, N Melman, X D Ji, K A Jacobson. Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.
Journal of medicinal chemistry.
1998 Aug; 41(17):3186-201. doi:
10.1021/jm980093j. [PMID: 9703464]
