PYR-41 (BioDeep_00000842029)

   


代谢物信息卡片


PYR-41

化学式: C17H13N3O7 (371.07534680000003)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOC(=O)C1=CC=C(C=C1)N2C(=O)C(=CC3=CC=C(O3)[N+](=O)[O-])C(=O)N2
InChI: InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9-

描述信息

同义名列表

1 个代谢物同义名

PYR-41



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lian Yang, Qing Zhang, Yili Yang, Qun Wang. PYR-41, an inhibitor of ubiquitin-activating enzyme E1, attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023 10; 37(10):e23210. doi: 10.1096/fj.202200951rrr. [PMID: 37738047]
  • Jennifer L Goeckeler-Fried, Rajiah Aldrin Denny, Disha Joshi, Clare Hill, Mads B Larsen, Annette N Chiang, Raymond A Frizzell, Peter Wipf, Eric J Sorscher, Jeffrey L Brodsky. Improved correction of F508del-CFTR biogenesis with a folding facilitator and an inhibitor of protein ubiquitination. Bioorganic & medicinal chemistry letters. 2021 09; 48(?):128243. doi: 10.1016/j.bmcl.2021.128243. [PMID: 34246753]
  • Jiawei Liao, Xiaolei Yang, Qiuyue Lin, Shuang Liu, Yunpeng Xie, Yunlong Xia, Hui-Hua Li. Inhibition of the Ubiquitin-Activating Enzyme UBA1 Suppresses Diet-Induced Atherosclerosis in Apolipoprotein E-Knockout Mice. Journal of immunology research. 2020; 2020(?):7812709. doi: 10.1155/2020/7812709. [PMID: 32258175]
  • Shingo Matsuo, Andrew Chaung, Deanna Liou, Ping Wang, Weng-Lang Yang. Inhibition of ubiquitin-activating enzyme protects against organ injury after intestinal ischemia-reperfusion. American journal of physiology. Gastrointestinal and liver physiology. 2018 08; 315(2):G283-G292. doi: 10.1152/ajpgi.00024.2018. [PMID: 29771572]
  • Keiichi Yoshida, Woojin Kang, Akihiro Nakamura, Natsuko Kawano, Maito Hanai, Mami Miyado, Yoshitaka Miyamoto, Maki Iwai, Toshio Hamatani, Hidekazu Saito, Kenji Miyado, Akihiro Umezawa. Ubiquitin-activating enzyme E1 inhibitor PYR-41 retards sperm enlargement after fusion to the egg. Reproductive toxicology (Elmsford, N.Y.). 2018 03; 76(?):71-77. doi: 10.1016/j.reprotox.2018.01.001. [PMID: 29355596]
  • Chun-Tao Lei, Yan-Hong Wei, Hui Tang, Qian Wen, Chen Ye, Chun Zhang, Hua Su. PKC-α Triggers EGFR Ubiquitination, Endocytosis and ERK Activation in Podocytes Stimulated with High Glucose. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017; 42(1):281-294. doi: 10.1159/000477329. [PMID: 28535513]
  • Kathleen E Dennis, William M Valentine. Ziram and sodium N,N-dimethyldithiocarbamate inhibit ubiquitin activation through intracellular metal transport and increased oxidative stress in HEK293 cells. Chemical research in toxicology. 2015 Apr; 28(4):682-90. doi: 10.1021/tx500450x. [PMID: 25714994]
  • Megumi Ishii, Ayumi Maeda, Shuji Tani, Mitsugu Akagawa. Palmitate induces insulin resistance in human HepG2 hepatocytes by enhancing ubiquitination and proteasomal degradation of key insulin signaling molecules. Archives of biochemistry and biophysics. 2015 Jan; 566(?):26-35. doi: 10.1016/j.abb.2014.12.009. [PMID: 25527164]
  • Hua Su, Minguang Chen, Jeff M Sands, Guangping Chen. Activation of the cAMP/PKA pathway induces UT-A1 urea transporter monoubiquitination and targets it for lysosomal degradation. American journal of physiology. Renal physiology. 2013 Dec; 305(12):F1775-82. doi: 10.1152/ajprenal.00393.2013. [PMID: 24133116]
  • James D Londino, Ahmed Lazrak, Asta Jurkuvenaite, James F Collawn, James W Noah, Sadis Matalon. Influenza matrix protein 2 alters CFTR expression and function through its ion channel activity. American journal of physiology. Lung cellular and molecular physiology. 2013 May; 304(9):L582-92. doi: 10.1152/ajplung.00314.2012. [PMID: 23457187]
  • Y-J Yi, S W Zimmerman, G Manandhar, J F Odhiambo, C Kennedy, V Jonáková, P Maňásková-Postlerová, M Sutovsky, C-S Park, P Sutovsky. Ubiquitin-activating enzyme (UBA1) is required for sperm capacitation, acrosomal exocytosis and sperm-egg coat penetration during porcine fertilization. International journal of andrology. 2012 Apr; 35(2):196-210. doi: 10.1111/j.1365-2605.2011.01217.x. [PMID: 21950462]