Furamidine (BioDeep_00000842026)
代谢物信息卡片
化学式: C18H16N4O (304.1324)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC=C1C2=CC=C(O2)C3=CC=C(C=C3)C(=N)N)C(=N)N
InChI: InChI=1S/C18H16N4O/c19-17(20)13-5-1-11(2-6-13)15-9-10-16(23-15)12-3-7-14(8-4-12)18(21)22/h1-10H,(H3,19,20)(H3,21,22)
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Sihyung Yang, Tanja Wenzler, Patrik N Miller, Huali Wu, David W Boykin, Reto Brun, Michael Zhuo Wang. Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis.
Antimicrobial agents and chemotherapy.
2014 Jul; 58(7):4064-74. doi:
10.1128/aac.02605-14. [PMID: 24798280] - Myaing M Nyunt, Craig W Hendrix, Rahul P Bakshi, Nirbhay Kumar, Theresa A Shapiro. Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in healthy volunteers challenged with Plasmodium falciparum sporozoites.
The American journal of tropical medicine and hygiene.
2009 Apr; 80(4):528-35. doi:
10.4269/ajtmh.2009.80.528. [PMID: 19346370] - Xin Ming, Wujian Ju, Huali Wu, Richard R Tidwell, James E Hall, Dhiren R Thakker. Transport of dicationic drugs pentamidine and furamidine by human organic cation transporters.
Drug metabolism and disposition: the biological fate of chemicals.
2009 Feb; 37(2):424-30. doi:
10.1124/dmd.108.024083. [PMID: 18971316] - Ian Midgley, Karen Fitzpatrick, Lynne M Taylor, Tara L Houchen, Simon J Henderson, Sarah J Wright, Zbigniew R Cybulski, Brian A John, Alan McBurney, David W Boykin, Kerri L Trendler. Pharmacokinetics and metabolism of the prodrug DB289 (2,5-bis[4-(N-methoxyamidino)phenyl]furan monomaleate) in rat and monkey and its conversion to the antiprotozoal/antifungal drug DB75 (2,5-bis(4-guanylphenyl)furan dihydrochloride).
Drug metabolism and disposition: the biological fate of chemicals.
2007 Jun; 35(6):955-67. doi:
10.1124/dmd.106.013391. [PMID: 17360833] - Amanda M Mathis, Jacqueline L Holman, Lisa M Sturk, Mohamed A Ismail, David W Boykin, Richard R Tidwell, James Edwin Hall. Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes.
Antimicrobial agents and chemotherapy.
2006 Jun; 50(6):2185-91. doi:
10.1128/aac.00192-06. [PMID: 16723581] - Lisa M Sturk, Jacqueline L Brock, C Robert Bagnell, James E Hall, Richard R Tidwell. Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue.
Acta tropica.
2004 Jul; 91(2):131-43. doi:
10.1016/j.actatropica.2004.03.010. [PMID: 15234662]
