Antalarmin (BioDeep_00000842023)
代谢物信息卡片
Antalarmin
化学式: C24H34N4 (378.2783)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCN(CC)C1=NC(=NC2=C1C(=C(N2C3=C(C=C(C=C3C)C)C)C)C)C
InChI: InChI=1S/C24H34N4/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5/h13-14H,9-12H2,1-8H3
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Masaya Seki, Xin-Min Zha, So Inamura, Minekatsu Taga, Yosuke Matsuta, Yoshitaka Aoki, Hideaki Ito, Osamu Yokoyama. Role of corticotropin-releasing factor on bladder function in rats with psychological stress.
Scientific reports.
2019 07; 9(1):9828. doi:
10.1038/s41598-019-46267-9. [PMID: 31285518] - Anna Skórzewska, Aleksandra Wisłowska-Stanek, Małgorzata Lehner, Danuta Turzyńska, Alicja Sobolewska, Paweł Krząścik, Janusz Szyndler, Piotr Maciejak, Adam Płaźnik. The effect of a corticotropin-releasing factor receptor 1 antagonist on the fear conditioning response in low- and high-anxiety rats after chronic corticosterone administration.
Stress (Amsterdam, Netherlands).
2019 01; 22(1):113-122. doi:
10.1080/10253890.2018.1505857. [PMID: 30345859] - Angelo Contarino, Pierre Kitchener, Monique Vallée, Francesco Papaleo, Pier-Vincenzo Piazza. CRF1 receptor-deficiency increases cocaine reward.
Neuropharmacology.
2017 05; 117(?):41-48. doi:
10.1016/j.neuropharm.2017.01.024. [PMID: 28137450] - Júlia Szakács, Krisztina Csabafi, Nándor Lipták, Gyula Szabó. The effect of obestatin on anxiety-like behaviour in mice.
Behavioural brain research.
2015 Oct; 293(?):41-5. doi:
10.1016/j.bbr.2015.06.042. [PMID: 26192908] - Hongxin Dong, Shirlene Wang, Ziling Zeng, Fei Li, Janitza Montalvo-Ortiz, Christopher Tucker, Shahzad Akhtar, Jingshan Shi, Herbert Y Meltzer, Kenner C Rice, John G Csernansky. Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice.
Psychopharmacology.
2014 Dec; 231(24):4711-22. doi:
10.1007/s00213-014-3629-8. [PMID: 24862368] - Maria M Buckley, Ken D O'Halloran, Mark G Rae, Timothy G Dinan, Dervla O'Malley. Modulation of enteric neurons by interleukin-6 and corticotropin-releasing factor contributes to visceral hypersensitivity and altered colonic motility in a rat model of irritable bowel syndrome.
The Journal of physiology.
2014 Dec; 592(23):5235-50. doi:
10.1113/jphysiol.2014.279968. [PMID: 25260633] - Patricia B de la Tremblaye, Julie Raymond, Marc R Milot, Zul Merali, Hélène Plamondon. Evidence of lasting dysregulation of neuroendocrine and HPA axis function following global cerebral ischemia in male rats and the effect of Antalarmin on plasma corticosterone level.
Hormones and behavior.
2014 Mar; 65(3):273-84. doi:
10.1016/j.yhbeh.2014.01.003. [PMID: 24444675] - Eran Gershon, Wylie W Vale. CRF type 2 receptors mediate the metabolic effects of ghrelin in C2C12 cells.
Obesity (Silver Spring, Md.).
2014 Feb; 22(2):380-9. doi:
10.1002/oby.20535. [PMID: 23804489] - Joana Pérez-Tejada, Amaia Arregi, Eneritz Gómez-Lázaro, Oscar Vegas, Arantza Azpiroz, Larraitz Garmendia. Coping with chronic social stress in mice: hypothalamic-pituitary-adrenal/ sympathetic-adrenal-medullary axis activity, behavioral changes and effects of antalarmin treatment: implications for the study of stress-related psychopathologies.
Neuroendocrinology.
2013; 98(1):73-88. doi:
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Journal of neurochemistry.
2012 Mar; 120(6):1108-16. doi:
10.1111/j.1471-4159.2011.07633.x. [PMID: 22191943] - Fátima Martín, Cristina Núñez, M Teresa Marín, M Luisa Laorden, Krisztina J Kovács, M Victoria Milanés. Involvement of noradrenergic transmission in the PVN on CREB activation, TORC1 levels, and pituitary-adrenal axis activity during morphine withdrawal.
PloS one.
2012; 7(2):e31119. doi:
10.1371/journal.pone.0031119. [PMID: 22355339] - Guillermo A Ariza Traslaviña, Celso Rodrigues Franci. The CRH-R₁ receptor mediates luteinizing hormone, prolactin, corticosterone and progesterone secretion induced by restraint stress in estrogen-primed rats.
Brain research.
2011 Nov; 1421(?):11-9. doi:
10.1016/j.brainres.2011.09.004. [PMID: 21959177] - Liansheng Liu, Qian Li, Robert Sapolsky, Min Liao, Kshama Mehta, Aditi Bhargava, Pankaj J Pasricha. Transient gastric irritation in the neonatal rats leads to changes in hypothalamic CRF expression, depression- and anxiety-like behavior as adults.
PloS one.
2011 May; 6(5):e19498. doi:
10.1371/journal.pone.0019498. [PMID: 21589865] - Tobias Backström, Andreas Pettersson, Viktoria Johansson, Svante Winberg. CRF and urotensin I effects on aggression and anxiety-like behavior in rainbow trout.
The Journal of experimental biology.
2011 Mar; 214(Pt 6):907-14. doi:
10.1242/jeb.045070. [PMID: 21346117] - Zheng Lin Zhao, Guang Wen Zhao, Hou Zhong Li, Xu Dong Yang, Yi Yan Wu, Feng Lin, Li Xin Guan, Feng Guo Zhai, Jia Qi Liu, Chae Ha Yang, Sang Chan Kim, Kee Won Kim, Rong Jie Zhao. Acupuncture Attenuates Anxiety-Like Behavior by Normalizing Amygdaloid Catecholamines during Ethanol Withdrawal in Rats.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):429843. doi:
10.1093/ecam/neq045. [PMID: 21869897] - S M Herod, C R Pohl, J L Cameron. Treatment with a CRH-R1 antagonist prevents stress-induced suppression of the central neural drive to the reproductive axis in female macaques.
American journal of physiology. Endocrinology and metabolism.
2011 Jan; 300(1):E19-27. doi:
10.1152/ajpendo.00224.2010. [PMID: 20823449] - William Boucher, Duraisamy Kempuraj, Margaret Michaelian, Theoharis C Theoharides. Corticotropin-releasing hormone-receptor 2 is required for acute stress-induced bladder vascular permeability and release of vascular endothelial growth factor.
BJU international.
2010 Nov; 106(9):1394-9. doi:
10.1111/j.1464-410x.2010.09237.x. [PMID: 20201838] - Javier Navarro-Zaragoza, Cristina Núñez, M Luisa Laorden, M Victoria Milanés. Effects of corticotropin-releasing factor receptor-1 antagonists on the brain stress system responses to morphine withdrawal.
Molecular pharmacology.
2010 May; 77(5):864-73. doi:
10.1124/mol.109.062463. [PMID: 20159948] - O Vegas, L Garmendia, A Arregi, G Beitia, A Azpiroz. Effects of antalarmin and nadolol on the relationship between social stress and pulmonary metastasis development in male OF1 mice.
Behavioural brain research.
2009 Dec; 205(1):200-6. doi:
10.1016/j.bbr.2009.06.033. [PMID: 19573565] - Miklós Jászberényi, Zsolt Bagosi, Balázs Thurzó, Imre Földesi, Gyula Szabó, Gyula Telegdy. Endocrine, behavioral and autonomic effects of neuropeptide AF.
Hormones and behavior.
2009 Jun; 56(1):24-34. doi:
10.1016/j.yhbeh.2009.02.006. [PMID: 19269292] - Ritesh Sanghvi, Erik Mogalian, Stephen G Machatha, Ryuichi Narazaki, Kelly L Karlage, Parijat Jain, S Esmail Tabibi, Elizabeth Glaze, Paul B Myrdal, Samuel H Yalkowsky. Preformulation and pharmacokinetic studies on antalarmin: a novel stress inhibitor.
Journal of pharmaceutical sciences.
2009 Jan; 98(1):205-14. doi:
10.1002/jps.21421. [PMID: 18428980] - Stine Lastein, Erik Höglund, Oyvind Overli, Kjell B Døving. Effects of antalarmin, a CRF receptor 1 antagonist, on fright reaction and endocrine stress response in crucian carp (Carassius carassius).
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology.
2008 Dec; 194(12):1007-12. doi:
10.1007/s00359-008-0372-9. [PMID: 18830607] - Thomas L Horn, J Brooks Harder, William D Johnson, Patrick T Curry, Ralph E Parchment, Robert L Morrissey, Paul W Mellick, Karim A Calis, Philip W Gold, Kenner C Rice, Carlo Contoreggi, Dennis S Charney, Giovanni Cizza, Elizabeth R Glaze, Joseph E Tomaszewski, David L McCormick. Integration of in vivo and in vitro approaches to characterize the toxicity of Antalarmin, a corticotropin-releasing hormone receptor antagonist.
Toxicology.
2008 Jun; 248(1):8-17. doi:
10.1016/j.tox.2008.03.002. [PMID: 18423834] - Beverly A S Reyes, Rita J Valentino, Elisabeth J Van Bockstaele. Stress-induced intracellular trafficking of corticotropin-releasing factor receptors in rat locus coeruleus neurons.
Endocrinology.
2008 Jan; 149(1):122-30. doi:
10.1210/en.2007-0705. [PMID: 17947354] - Miklós Jászberényi, Zsolt Bagosi, Balázs Thurzó, Imre Földesi, Gyula Telegdy. Endocrine and behavioral effects of neuromedin S.
Hormones and behavior.
2007 Dec; 52(5):631-9. doi:
10.1016/j.yhbeh.2007.08.002. [PMID: 17900576] - Peter W Marinelli, Douglas Funk, Walter Juzytsch, Stephen Harding, Kenner C Rice, Yavin Shaham, A D Lê. The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats.
Psychopharmacology.
2007 Dec; 195(3):345-55. doi:
10.1007/s00213-007-0905-x. [PMID: 17705061] - Jeffrey A French, Jeffrey E Fite, Heather Jensen, Katie Oparowski, Michael R Rukstalis, Holly Fix, Brenda Jones, Heather Maxwell, Molly Pacer, Michael L Power, Jay Schulkin. Treatment with CRH-1 antagonist antalarmin reduces behavioral and endocrine responses to social stressors in marmosets (Callithrix kuhlii).
American journal of primatology.
2007 Aug; 69(8):877-89. doi:
10.1002/ajp.20385. [PMID: 17397037] - Reiko Okada, Mark F Miller, Kazutoshi Yamamoto, Bert De Groef, Robert J Denver, Sakaé Kikuyama. Involvement of the corticotropin-releasing factor (CRF) type 2 receptor in CRF-induced thyrotropin release by the amphibian pituitary gland.
General and comparative endocrinology.
2007 Feb; 150(3):437-44. doi:
10.1016/j.ygcen.2006.11.002. [PMID: 17188689] - H Berger, N Heinrich, D Wietfeld, M Bienert, M Beyermann. Evidence that corticotropin-releasing factor receptor type 1 couples to Gs- and Gi-proteins through different conformations of its J-domain.
British journal of pharmacology.
2006 Dec; 149(7):942-7. doi:
10.1038/sj.bjp.0706926. [PMID: 17057757] - Ivana Grakalic, Charles W Schindler, Michael H Baumann, Kenner C Rice, Anthony L Riley. Effects of stress modulation on morphine-induced conditioned place preferences and plasma corticosterone levels in Fischer, Lewis, and Sprague-Dawley rat strains.
Psychopharmacology.
2006 Dec; 189(3):277-86. doi:
10.1007/s00213-006-0562-5. [PMID: 17016707] - Brian Dyck, Dimitri E Grigoriadis, Raymond S Gross, Zhiqiang Guo, Mustapha Haddach, Dragan Marinkovic, James R McCarthy, Manisha Moorjani, Collin F Regan, John Saunders, Michael K Schwaebe, Tomas Szabo, John P Williams, Xiaohu Zhang, Haig Bozigian, Ta Kung Chen. Potent, orally active corticotropin-releasing factor receptor-1 antagonists containing a tricyclic pyrrolopyridine or pyrazolopyridine core.
Journal of medicinal chemistry.
2005 Jun; 48(12):4100-10. doi:
10.1021/jm050070m. [PMID: 15943483] - Stephen D Fox, John M Roman, Giovanni Cizza, Timothy D Veenstra, Haleem J Issaq. Quantitative determination of antalarmin, a novel corticotropin-releasing hormone receptor-1 antagonist, in canine plasma by HPLC-MS.
Journal of separation science.
2005 Mar; 28(4):332-6. doi:
10.1002/jssc.200400048. [PMID: 15792247] - Alejandro R Ayala, Judy Pushkas, J Dee Higley, Donna Ronsaville, Philip W Gold, George P Chrousos, Karel Pacak, Karim A Calis, Melissa Gerald, Stephen Lindell, Kenner C Rice, Giovanni Cizza. Behavioral, adrenal, and sympathetic responses to long-term administration of an oral corticotropin-releasing hormone receptor antagonist in a primate stress paradigm.
The Journal of clinical endocrinology and metabolism.
2004 Nov; 89(11):5729-37. doi:
10.1210/jc.2003-032170. [PMID: 15531536] - George Mastorakos, Ioannis Ilias. Maternal and fetal hypothalamic-pituitary-adrenal axes during pregnancy and postpartum.
Annals of the New York Academy of Sciences.
2003 Nov; 997(?):136-49. doi:
10.1196/annals.1290.016. [PMID: 14644820] - I Ross Young, E Cheng Chan, Roger Smith, George P Chrousos, Johannes D Veldhuis, Benedict J Canny. Effect of antalarmin, a novel corticotropin-releasing hormone antagonist, on the dynamic function of the preterm ovine fetal hypothalamo-pituitary-adrenal axis.
Neuroendocrinology.
2002 Jul; 76(1):47-54. doi:
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British journal of pharmacology.
2002 Jul; 136(6):896-904. doi:
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Current pharmaceutical design.
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Journal of medicinal chemistry.
1999 Mar; 42(5):833-48. doi:
10.1021/jm980224g. [PMID: 10072681] - M L Wong, E L Webster, H Spokes, P Phu, M Ehrhart-Bornstein, S Bornstein, C S Park, K C Rice, G P Chrousos, J Licinio, P W Gold. Chronic administration of the non-peptide CRH type 1 receptor antagonist antalarmin does not blunt hypothalamic-pituitary-adrenal axis responses to acute immobilization stress.
Life sciences.
1999; 65(4):PL53-8. doi:
10.1016/s0024-3205(99)00268-4. [PMID: 10421433] - E C Chan, J Falconer, G Madsen, K C Rice, E L Webster, G P Chrousos, R Smith. A corticotropin-releasing hormone type I receptor antagonist delays parturition in sheep.
Endocrinology.
1998 Jul; 139(7):3357-60. doi:
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Endocrinology.
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