Sample A of helenalin (BioDeep_00000842016)

   


代谢物信息卡片


Sample A of helenalin

化学式: C15H18O4 (262.1205)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CC2C(C(C3(C1C=CC3=O)C)O)C(=C)C(=O)O2
InChI: InChI=1S/C15H18O4/c1-7-6-10-12(8(2)14(18)19-10)13(17)15(3)9(7)4-5-11(15)16/h4-5,7,9-10,12-13,17H,2,6H2,1,3H3

描述信息

同义名列表

1 个代谢物同义名

Sample A of helenalin



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Chuan Bian Lim, Pan You Fu, Nung Ky, Hong Shuang Zhu, XiaoLing Feng, Jinming Li, Kandhadayar Gopalan Srinivasan, Mohamed Sabry Hamza, Yan Zhao. NF-κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death. BMC complementary and alternative medicine. 2012 Jul; 12(?):93. doi: 10.1186/1472-6882-12-93. [PMID: 22784363]
  • Peng Wu, Miao-Xian Su, Ying Wang, Guo-Cai Wang, Wen-Cai Ye, Hau-Yin Chung, Juan Li, Ren-Wang Jiang, Yao-Lan Li. Supercritical fluid extraction assisted isolation of sesquiterpene lactones with antiproliferative effects from Centipeda minima. Phytochemistry. 2012 Apr; 76(?):133-40. doi: 10.1016/j.phytochem.2012.01.003. [PMID: 22277736]
  • Muhammad Khan, Chuan Ding, Azhar Rasul, Fei Yi, Ting Li, Hongwen Gao, Rong Gao, Lili Zhong, Kun Zhang, Xuedong Fang, Tonghui Ma. Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells. International journal of biological sciences. 2012; 8(4):533-47. doi: 10.7150/ijbs.3753. [PMID: 22532787]
  • B S Geetha, Mangalam S Nair, P G Latha, P Remani. Sesquiterpene lactones isolated from Elephantopus scaber L. inhibits human lymphocyte proliferation and the growth of tumour cell lines and induces apoptosis in vitro. Journal of biomedicine & biotechnology. 2012; 2012(?):721285. doi: 10.1155/2012/721285. [PMID: 22500104]
  • Irmgard Merfort. Perspectives on sesquiterpene lactones in inflammation and cancer. Current drug targets. 2011 Oct; 12(11):1560-73. doi: 10.2174/138945011798109437. [PMID: 21561425]
  • Jordanka Staneva, Pavletta Denkova, Milka Todorova, Ljuba Evstatieva. Quantitative analysis of sesquiterpene lactones in extract of Arnica montana L. by 1H NMR spectroscopy. Journal of pharmaceutical and biomedical analysis. 2011 Jan; 54(1):94-9. doi: 10.1016/j.jpba.2010.08.018. [PMID: 20837387]
  • Qing Liu, Mohammad Majdi, Katarina Cankar, Miriam Goedbloed, Tatsiana Charnikhova, Francel W A Verstappen, Ric C H de Vos, Jules Beekwilder, Sander van der Krol, Harro J Bouwmeester. Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana. PloS one. 2011; 6(8):e23255. doi: 10.1371/journal.pone.0023255. [PMID: 21858047]
  • Wen-Wan Chao, Yueh-Hsiung Kuo, Shie-Liang Hsieh, Bi-Fong Lin. Inhibitory Effects of Ethyl Acetate Extract of Andrographis paniculata on NF-κB Trans-Activation Activity and LPS-Induced Acute Inflammation in Mice. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):254531. doi: 10.1093/ecam/nep120. [PMID: 19745004]
  • Ji Yun Lee, Bong Jae Cho, Tae Wook Park, Byoung Eun Park, Soo Jung Kim, Sang Soo Sim, Chang Jong Kim. Dibenzylbutyrolactone lignans from Forsythia koreana fruits attenuate lipopolysaccharide-induced inducible nitric oxide synthetase and cyclooxygenase-2 expressions through activation of nuclear factor-κb and mitogen-activated protein kinase in RAW264.7 cells. Biological & pharmaceutical bulletin. 2010; 33(11):1847-53. doi: 10.1248/bpb.33.1847. [PMID: 21048310]
  • Jamal Al-Saghir, Randa Al-Ashi, Ralph Salloum, Najat A Saliba, Rabih S Talhouk, Fadia R Homaidan. Anti-inflammatory properties of Salograviolide A purified from Lebanese plant Centaurea ainetensis. BMC complementary and alternative medicine. 2009 Sep; 9(?):36. doi: 10.1186/1472-6882-9-36. [PMID: 19775456]
  • Nigel B Perry, Elaine J Burgess, Manuel A Rodríguez Guitián, Rosa Romero Franco, Elvira López Mosquera, Bruce M Smallfield, Nigel I Joyce, Roger P Littlejohn. Sesquiterpene lactones in Arnica montana: helenalin and dihydrohelenalin chemotypes in Spain. Planta medica. 2009 May; 75(6):660-6. doi: 10.1055/s-0029-1185362. [PMID: 19235681]
  • Ching-Yi Cheng, Hsi-Lung Hsieh, Chi-Chin Sun, Chih-Chung Lin, Shue-Fen Luo, Chuen-Mao Yang. IL-1 beta induces urokinase-plasminogen activator expression and cell migration through PKC alpha, JNK1/2, and NF-kappaB in A549 cells. Journal of cellular physiology. 2009 Apr; 219(1):183-93. doi: 10.1002/jcp.21669. [PMID: 19097143]
  • S H Kim, M Danilenko, T S Kim. Differential enhancement of leukaemia cell differentiation without elevation of intracellular calcium by plant-derived sesquiterpene lactone compounds. British journal of pharmacology. 2008 Nov; 155(6):814-25. doi: 10.1038/bjp.2008.319. [PMID: 18724384]
  • Maria Hägg Olofsson, Aleksandra Mandic Havelka, Slavica Brnjic, Maria C Shoshan, Stig Linder. Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II. BMC chemical biology. 2008 Aug; 8(?):2. doi: 10.1186/1472-6769-8-2. [PMID: 18673549]
  • K K Dholwani, A K Saluja, A R Gupta, D R Shah. A review on plant-derived natural products and their analogs with anti-tumor activity. Indian journal of pharmacology. 2008 Mar; 40(2):49-58. doi: 10.4103/0253-7613.41038. [PMID: 21279166]
  • Valentina Bergamante, Gian Carlo Ceschel, Sergio Marazzita, Celestino Ronchi, Adamo Fini. Effect of vehicles on topical application of aloe vera and arnica montana components. Drug delivery. 2007 Oct; 14(7):427-32. doi: 10.1080/10717540701202960. [PMID: 17994359]
  • Cheryl Lans. Ethnomedicines used in Trinidad and Tobago for reproductive problems. Journal of ethnobiology and ethnomedicine. 2007 Mar; 3(?):13. doi: 10.1186/1746-4269-3-13. [PMID: 17362507]
  • Steen Lisby, Annesofie Faurschou, Robert Gniadecki. The autocrine TNFalpha signalling loop in keratinocytes requires atypical PKC species and NF-kappaB activation but is independent of cholesterol-enriched membrane microdomains. Biochemical pharmacology. 2007 Feb; 73(4):526-33. doi: 10.1016/j.bcp.2006.11.006. [PMID: 17145042]
  • Steffen Wagner, Irmgard Merfort. Skin penetration behaviour of sesquiterpene lactones from different Arnica preparations using a validated GC-MSD method. Journal of pharmaceutical and biomedical analysis. 2007 Jan; 43(1):32-8. doi: 10.1016/j.jpba.2006.06.008. [PMID: 16930911]
  • Vichit Supornsilchai, Olle Söder, Konstantin Svechnikov. Sesquiterpene lactone helenalin suppresses Leydig and adrenocortical cell steroidogenesis by inhibiting expression of the steroidogenic acute regulatory protein. Reproductive toxicology (Elmsford, N.Y.). 2006 Nov; 22(4):631-5. doi: 10.1016/j.reprotox.2006.04.011. [PMID: 16777379]
  • Juan Li, Sergey Zelenin, Anita Aperia, Oleg Aizman. Low doses of ouabain protect from serum deprivation-triggered apoptosis and stimulate kidney cell proliferation via activation of NF-kappaB. Journal of the American Society of Nephrology : JASN. 2006 Jul; 17(7):1848-57. doi: 10.1681/asn.2005080894. [PMID: 16707566]
  • Anna Rita Bilia, Maria Camilla Bergonzi, Giovanni Mazzi, Franco Francesco Vincieri. Development and stability of semisolid preparations based on a supercritical CO2 Arnica extract. Journal of pharmaceutical and biomedical analysis. 2006 May; 41(2):449-54. doi: 10.1016/j.jpba.2005.12.024. [PMID: 16457981]
  • Takeshi Nitta, Mariam Nasreen, Takafumi Seike, Atsushi Goji, Izumi Ohigashi, Tadaaki Miyazaki, Tsutomu Ohta, Masamoto Kanno, Yousuke Takahama. IAN family critically regulates survival and development of T lymphocytes. PLoS biology. 2006 Apr; 4(4):e103. doi: 10.1371/journal.pbio.0040103. [PMID: 16509771]
  • Eske Voss, Jan Wehkamp, Kai Wehkamp, Eduard F Stange, Jens M Schröder, Jürgen Harder. NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2. The Journal of biological chemistry. 2006 Jan; 281(4):2005-11. doi: 10.1074/jbc.m511044200. [PMID: 16319062]
  • Jari Huuskonen, Tiina Suuronen, Riitta Miettinen, Thomas van Groen, Antero Salminen. A refined in vitro model to study inflammatory responses in organotypic membrane culture of postnatal rat hippocampal slices. Journal of neuroinflammation. 2005 Nov; 2(?):25. doi: 10.1186/1742-2094-2-25. [PMID: 16285888]
  • Olha Kos, Maja T Lindenmeyer, Aurelia Tubaro, Silvio Sosa, Irmgard Merfort. New sesquiterpene lactones from Arnica tincture prepared from fresh flowerheads of Arnica montana. Planta medica. 2005 Nov; 71(11):1044-52. doi: 10.1055/s-2005-871284. [PMID: 16320207]
  • Verónica Jimenez-Ortiz, Silvia D Brengio, Oscar Giordano, Carlos Tonn, Matías Sánchez, Mario H Burgos, Miguel A Sosa. The trypanocidal effect of sesquiterpene lactones helenalin and mexicanin on cultured epimastigotes. The Journal of parasitology. 2005 Feb; 91(1):170-4. doi: 10.1645/ge-3373. [PMID: 15856894]
  • Steffen Wagner, Andreas Suter, Irmgard Merfort. Skin penetration studies of Arnica preparations and of their sesquiterpene lactones. Planta medica. 2004 Oct; 70(10):897-903. doi: 10.1055/s-2004-832613. [PMID: 15490315]
  • Thomas J Schmidt, Jeanette von Raison, Günter Willuhn. New triterpene esters from flowerheads of Arnica lonchophylla. Planta medica. 2004 Oct; 70(10):967-77. doi: 10.1055/s-2004-832624. [PMID: 15490326]
  • James A Douglas, Bruce M Smallfield, Elaine J Burgess, Nigel B Perry, Rosemary E Anderson, Malcolm H Douglas, V LeAnne Glennie. Sesquiterpene lactones in Arnica montana: a rapid analytical method and the effects of flower maturity and simulated mechanical harvesting on quality and yield. Planta medica. 2004 Feb; 70(2):166-70. doi: 10.1055/s-2004-815495. [PMID: 14994196]
  • S Tornhamre, T J Schmidt, B Näsman-Glaser, I Ericsson, Lindgren JA. Inhibitory effects of helenalin and related compounds on 5-lipoxygenase and leukotriene C(4) synthase in human blood cells. Biochemical pharmacology. 2001 Oct; 62(7):903-11. doi: 10.1016/s0006-2952(01)00729-8. [PMID: 11543725]