Palmitoyl carnitine (BioDeep_00000841992)
代谢物信息卡片
Palmitoyl carnitine
化学式: C23H46NO4+ (400.3427)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCC(=O)OC(CC(=O)O)C[N+](C)(C)C
InChI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/p+1
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:94442
- PubChem: 462
- ChEMBL: CHEMBL1358827
- ChEMBL: CHEMBL1256761
- CAS: 7085-35-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - YueTao Liu, XinQi Li, AiPing Li, Ke Li, XueMei Qin. UHPLC Q-Exactive MS-based spleen metabolomics and lipidomics to explore the effect mechanisms of Danggui Buxue Decoction in anemia mice.
Journal of pharmaceutical and biomedical analysis.
2020 Jun; 185(?):113234. doi:
10.1016/j.jpba.2020.113234. [PMID: 32171146] - Khalil Mallah, Jusal Quanico, Antonella Raffo-Romero, Tristan Cardon, Soulaimane Aboulouard, David Devos, Firas Kobeissy, Kazem Zibara, Michel Salzet, Isabelle Fournier. Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging of Lipids in Experimental Model of Traumatic Brain Injury Detecting Acylcarnitines as Injury Related Markers.
Analytical chemistry.
2019 09; 91(18):11879-11887. doi:
10.1021/acs.analchem.9b02633. [PMID: 31412203] - Sree V Chintapalli, Andriy Anishkin, Sean H Adams. Exploring the entry route of palmitic acid and palmitoylcarnitine into myoglobin.
Archives of biochemistry and biophysics.
2018 10; 655(?):56-66. doi:
10.1016/j.abb.2018.07.024. [PMID: 30092229] - Margot Riggi, Karolina Niewola-Staszkowska, Nicolas Chiaruttini, Adai Colom, Beata Kusmider, Vincent Mercier, Saeideh Soleimanpour, Michael Stahl, Stefan Matile, Aurélien Roux, Robbie Loewith. Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2.
Nature cell biology.
2018 09; 20(9):1043-1051. doi:
10.1038/s41556-018-0150-z. [PMID: 30154550] - Fatima-Zahra Bouchouirab, Mélanie Fortin, Christophe Noll, Jean Dubé, André C Carpentier. Plasma Palmitoyl-Carnitine (AC16:0) Is a Marker of Increased Postprandial Nonesterified Incomplete Fatty Acid Oxidation Rate in Adults With Type 2 Diabetes.
Canadian journal of diabetes.
2018 Aug; 42(4):382-388.e1. doi:
10.1016/j.jcjd.2017.09.002. [PMID: 29129455] - Maria Chondronikola, Rabia Asghar, Xiaojun Zhang, Edgar L Dillon, William J Durham, Zhanpin Wu, Craig Porter, Maria Camacho-Hughes, Yingxin Zhao, Allan R Brasier, Elena Volpi, Melinda Sheffield-Moore, Nicola Abate, Labros Sidossis, Demidmaa Tuvdendorj. Palmitoyl-carnitine production by blood cells associates with the concentration of circulating acyl-carnitines in healthy overweight women.
Clinical nutrition (Edinburgh, Scotland).
2017 10; 36(5):1310-1319. doi:
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BioFactors (Oxford, England).
2017 Sep; 43(5):718-730. doi:
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The Biochemical journal.
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Brain & development.
2017 Jan; 39(1):48-57. doi:
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Obesity (Silver Spring, Md.).
2013 Mar; 21(3):516-24. doi:
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PloS one.
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Journal of lipid research.
2012 Nov; 53(11):2318-30. doi:
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2012 Jan; 53(1):119-25. doi:
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2011 Oct; 25(10):3646-60. doi:
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Genome biology.
2011 Aug; 12(8):R75. doi:
10.1186/gb-2011-12-8-r75. [PMID: 21843327] - Lena Burri, Bodil Bjørndal, Hege Wergedahl, Kjetil Berge, Pavol Bohov, Asbjørn Svardal, Rolf K Berge. Tetradecylthioacetic acid increases hepatic mitochondrial β-oxidation and alters fatty acid composition in a mouse model of chronic inflammation.
Lipids.
2011 Aug; 46(8):679-89. doi:
10.1007/s11745-011-3536-2. [PMID: 21479675] - Jolita Ciapaite, Nicole M van den Broek, Heleen Te Brinke, Klaas Nicolay, Jeroen A Jeneson, Sander M Houten, Jeanine J Prompers. Differential effects of short- and long-term high-fat diet feeding on hepatic fatty acid metabolism in rats.
Biochimica et biophysica acta.
2011 Jul; 1811(7-8):441-51. doi:
10.1016/j.bbalip.2011.05.005. [PMID: 21621638] - Xudong Wang, Gail J Mick, Edmund Maser, Kenneth McCormick. Manifold effects of palmitoylcarnitine on endoplasmic reticulum metabolism: 11β-hydroxysteroid dehydrogenase 1, flux through hexose-6-phosphate dehydrogenase and NADPH concentration.
The Biochemical journal.
2011 Jul; 437(1):109-15. doi:
10.1042/bj20102069. [PMID: 21492096] - Jurga Bernatoniene, Daiva Majiene, Rimantas Peciura, Ale Laukeviciene, Ruta Bernatoniene, Tauras Mekas, Arturas Kasauskas, Dalia Kopustinskiene. The effect of Ginkgo biloba extract on mitochondrial oxidative phosphorylation in the normal and ischemic rat heart.
Phytotherapy research : PTR.
2011 Jul; 25(7):1054-60. doi:
10.1002/ptr.3399. [PMID: 21259351] - Crystal Sloan, Joseph Tuinei, Katherine Nemetz, Jonathan Frandsen, Jamie Soto, Noah Wride, Tomoki Sempokuya, Luis Alegria, Heiko Bugger, E Dale Abel. Central leptin signaling is required to normalize myocardial fatty acid oxidation rates in caloric-restricted ob/ob mice.
Diabetes.
2011 May; 60(5):1424-34. doi:
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International journal of pharmaceutics.
2011 Feb; 404(1-2):36-41. doi:
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Diabetes.
2010 Oct; 59(10):2444-52. doi:
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Journal of inherited metabolic disease.
2010 Oct; 33(5):479-94. doi:
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PloS one.
2010 Jul; 5(7):e11519. doi:
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Diabetologia.
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American journal of physiology. Endocrinology and metabolism.
2009 Nov; 297(5):E1162-70. doi:
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Diabetes.
2009 Sep; 58(9):1986-97. doi:
10.2337/db09-0259. [PMID: 19542201] - John R Ussher, Timothy R Koves, Jagdip S Jaswal, Liyan Zhang, Olga Ilkayeva, Jason R B Dyck, Deborah M Muoio, Gary D Lopaschuk. Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase.
Diabetes.
2009 Aug; 58(8):1766-75. doi:
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PLoS genetics.
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Journal of molecular and cellular cardiology.
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Free radical biology & medicine.
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10.1016/j.freeradbiomed.2009.02.008. [PMID: 19245829] - Ralph A Defronzo. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.
Diabetes.
2009 Apr; 58(4):773-95. doi:
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The New England journal of medicine.
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American journal of physiology. Endocrinology and metabolism.
2008 Sep; 295(3):E678-85. doi:
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American journal of physiology. Heart and circulatory physiology.
2008 Jul; 295(1):H185-96. doi:
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American journal of physiology. Heart and circulatory physiology.
2008 Jul; 295(1):H105-12. doi:
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Obesity (Silver Spring, Md.).
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Journal of neurochemistry.
2006 Apr; 97(2):424-34. doi:
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Biochimica et biophysica acta.
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Journal of lipid research.
2006 Feb; 47(2):431-9. doi:
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Acta physiologica Scandinavica.
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Journal of cellular biochemistry.
2005 Jun; 95(3):571-88. doi:
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Journal of cellular physiology.
2005 May; 203(2):439-46. doi:
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