9-[5-(Hydroxymethyl)tetrahydrofuran-2-yl]-9h-purin-6-ol (BioDeep_00000841988)
代谢物信息卡片
9-[5-(Hydroxymethyl)tetrahydrofuran-2-yl]-9h-purin-6-ol
化学式: C10H12N4O3 (236.0909362)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(OC1CO)N2C=NC3=C2N=CNC3=O
InChI: InChI=1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)
描述信息
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
D009676 - Noxae > D000963 - Antimetabolites > D015224 - Dideoxynucleosides
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Julie Høgh, Malene Hove-Skovsgaard, Marco Gelpi, Anne Marie Reimer Jensen, Jan Gerstoft, Thomas Benfield, Heidi Storgaard, Susanne Dam Nielsen. Insulin resistance in people living with HIV is associated with exposure to thymidine analogues and/or didanosine and prior immunodeficiency.
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NULL. [PMID: 19334329] - Yiguang Jin, Ping Ai, Rui Xin, Ying Tian, Junxing Dong, Dawei Chen, Wei Wang. Self-assembled drug delivery systems: Part 3. In vitro/in vivo studies of the self-assembled nanoparticulates of cholesteryl acyl didanosine.
International journal of pharmaceutics.
2009 Feb; 368(1-2):207-14. doi:
10.1016/j.ijpharm.2008.10.009. [PMID: 19007871] - Sonia Hernández-Díaz, Allen A Mitchell, Katherine E Kelley, Antonia M Calafat, Russ Hauser. Medications as a potential source of exposure to phthalates in the U.S. population.
Environmental health perspectives.
2009 Feb; 117(2):185-9. doi:
10.1289/ehp.11766. [PMID: 19270786] - Yiguang Jin, Ping Ai, Rui Xin, Dawei Chen. Morphological transformation of self-assembled nanostructures prepared from cholesteryl acyl didanosine and the optimal formulation of nanoparticulate systems: effects of solvents, acyl chain length and poloxamer 188.
Journal of colloid and interface science.
2008 Oct; 326(1):275-82. doi:
10.1016/j.jcis.2008.07.014. [PMID: 18672249] - . Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients.
AIDS (London, England).
2008 Sep; 22(14):F17-24. doi:
10.1097/qad.0b013e32830fe35e. [PMID: 18753925] - B Hernández-Novoa, A Antela, C Gutiérrez, J A Pérez-Molina, M J Pérez-Elías, F Dronda, A Moreno, J L Casado, C Page, M Pumares, J C Galán, S Moreno. Effect of food on the antiviral activity of didanosine enteric-coated capsules: a pilot comparative study.
HIV medicine.
2008 Apr; 9(4):187-91. doi:
10.1111/j.1468-1293.2008.00543.x. [PMID: 18298579] - Sanjay K Jain, Yashwant Gupta, Anekant Jain, Asheesh R Saxena, Piush Khare, Aviral Jain. Mannosylated gelatin nanoparticles bearing an anti-HIV drug didanosine for site-specific delivery.
Nanomedicine : nanotechnology, biology, and medicine.
2008 Mar; 4(1):41-8. doi:
10.1016/j.nano.2007.11.004. [PMID: 18207463] - Stefania Notari, Carmine Mancone, Tonino Alonzi, Marco Tripodi, Pasquale Narciso, Paolo Ascenzi. Determination of abacavir, amprenavir, didanosine, efavirenz, nevirapine, and stavudine concentration in human plasma by MALDI-TOF/TOF.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Mar; 863(2):249-57. doi:
10.1016/j.jchromb.2008.01.009. [PMID: 18258495] - Matthias Mehling, Henning Drechsler, Jens Kuhle, Martin Hardmeier, Ruediger Doerries, Stephan Ruegg, Achim Gass. Adaptation of antiretroviral therapy in human immunodeficiency virus infection with central nervous system involvement.
Journal of neurovirology.
2008 Jan; 14(1):78-84. doi:
10.1080/13550280701793940. [PMID: 18300078] - Jesús Santos, Rosario Palacios, Fernando Lozano, Manuel López, María Carmen Gálvez, Javier de la Torres, Luis Fernando López-Cortés, María José Ríos, Antonio Rivero. Long-term assessment of didanosine, lamivudine, and efavirenz in antiretroviral-naive patients: 3-year follow-up.
AIDS research and human retroviruses.
2008 Jan; 24(1):24-6. doi:
10.1089/aid.2007.0142. [PMID: 18275344] - Carlos Illana Esteban. [Cordyceps sinensis, a fungi used in the Chinese traditional medicine].
Revista iberoamericana de micologia.
2007 Dec; 24(4):259-62. doi:
10.1016/s1130-1406(07)70052-9. [PMID: 18095756] - V Svedhem, T Bergroth, K Lidman, A Sönnerborg. Presence of M184I/V in minor HIV-1 populations of patients with lamivudine and/or didanosine treatment failure.
HIV medicine.
2007 Nov; 8(8):504-10. doi:
10.1111/j.1468-1293.2007.00502.x. [PMID: 17944683] - Anna Canestri, Papa Salif Sow, Muriel Vray, Fatou Ngom, Souleymane M'boup, Coumba Toure Kane, Eric Delaporte, Mandoumé Gueye, Gilles Peytavin, Pierre Marie Girard, Roland Landman. Poor efficacy and tolerability of stavudine, didanosine, and efavirenz-based regimen in treatment-naive patients in Senegal.
MedGenMed : Medscape general medicine.
2007 Oct; 9(4):7. doi:
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Journal of acquired immune deficiency syndromes (1999).
2007 Oct; 46(2):174-80. doi:
10.1097/qai.0b013e31814258c0. [PMID: 17667333] - Matilde Sánchez-Conde, Rosario Palacios, José Sanz, Sonia Rodríguez-Novoa, Pablo Rivas, Jesús Santos, Julio Sola, Victor Asensi, Carmen de Mendoza, Vicente Estrada, Pablo Barreiro, Juan González-Lahoz, Inmaculada Jiménez-Nacher, Vincent Soriano. Efficacy and safety of a once daily regimen with efavirenz, lamivudine, and didanosine, with and without food, as initial therapy for HIV Infection: the ELADI study.
AIDS research and human retroviruses.
2007 Oct; 23(10):1237-41. doi:
10.1089/aid.2006.0029. [PMID: 17961110] - Selwyn H Lowe, Elisabeth van Leeuwen, Jacqueline A H Droste, Fulco van der Veen, Peter Reiss, Joep M A Lange, David M Burger, Sjoerd Repping, Jan M Prins. Semen quality and drug concentrations in seminal plasma of patients using a didanosine or didanosine plus tenofovir containing antiretroviral regimen.
Therapeutic drug monitoring.
2007 Oct; 29(5):566-70. doi:
10.1097/ftd.0b013e31811fef29. [PMID: 17898645] - James H Willig, Andrew O Westfall, Jeroan Allison, Nicholas Van Wagoner, Pei-Wen Chang, James Raper, Michael S Saag, Michael J Mugavero. Nucleoside reverse-transcriptase inhibitor dosing errors in an outpatient HIV clinic in the electronic medical record era.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2007 Sep; 45(5):658-61. doi:
10.1086/520653. [PMID: 17683005] - Katyna Borroto-Esoda, Joshua M Waters, Andrew S Bae, Jeanette L Harris, John E Hinkle, Joseph B Quinn, Frank S Rousseau. Baseline genotype as a predictor of virological failure to emtricitabine or stavudine in combination with didanosine and efavirenz.
AIDS research and human retroviruses.
2007 Aug; 23(8):988-95. doi:
10.1089/aid.2006.0310. [PMID: 17725415] - Ross E McKinney, John Rodman, Chengcheng Hu, Paula Britto, Michael Hughes, Mary Elizabeth Smith, Leslie K Serchuck, Joyce Kraimer, Alberto A Ortiz, Patricia Flynn, Ram Yogev, Stephen Spector, Linda Draper, Paul Tran, Melissa Scites, Ruth Dickover, Adriana Weinberg, Coleen Cunningham, Elaine Abrams, M Robert Blum, Gregory E Chittick, Laurie Reynolds, Mobeen Rathore. Long-term safety and efficacy of a once-daily regimen of emtricitabine, didanosine, and efavirenz in HIV-infected, therapy-naive children and adolescents: Pediatric AIDS Clinical Trials Group Protocol P1021.
Pediatrics.
2007 Aug; 120(2):e416-23. doi:
10.1542/peds.2006-0925. [PMID: 17646352] - Heidi M Crane, Bryan Kestenbaum, Robert D Harrington, Mari M Kitahata. Amprenavir and didanosine are associated with declining kidney function among patients receiving tenofovir.
AIDS (London, England).
2007 Jul; 21(11):1431-9. doi:
10.1097/qad.0b013e3281fc9320. [PMID: 17589189] - Carlo Torti, Giuseppe Lapadula, Pablo Barreiro, Vicente Soriano, Sundhiya Mandalia, Annalisa De Silvestri, Fredy Suter, Franco Maggiolo, Andrea Antinori, Francesco Antonucci, Renato Maserati, Issa El Hamad, Piera Pierotti, Laura Sighinolfi, Guglielmo Migliorino, Nicoletta Ladisa, Giampiero Carosi. CD4+ T cell evolution and predictors of its trend before and after tenofovir/didanosine backbone in the presence of sustained undetectable HIV plasma viral load.
The Journal of antimicrobial chemotherapy.
2007 Jun; 59(6):1141-7. doi:
10.1093/jac/dkm100. [PMID: 17434879] - Kathryn Anastos, Dalian Lu, Qiuhu Shi, Phyllis C Tien, Robert C Kaplan, Nancy A Hessol, Steven Cole, Cheryl Vigen, Mardge Cohen, Mary Young, Jessica Justman. Association of serum lipid levels with HIV serostatus, specific antiretroviral agents, and treatment regimens.
Journal of acquired immune deficiency syndromes (1999).
2007 May; 45(1):34-42. doi:
10.1097/qai.0b013e318042d5fe. [PMID: 17460470] - Henriëtte J Scherpbier, Vincent Bekker, Dasja Pajkrt, Suzanne Jurriaans, Joep M A Lange, Taco W Kuijpers. Once-daily highly active antiretroviral therapy for HIV-infected children: safety and efficacy of an efavirenz-containing regimen.
Pediatrics.
2007 Mar; 119(3):e705-15. doi:
10.1542/peds.2006-1367. [PMID: 17308244] - G J Claas, B Jülg, F D Goebel, Johannes R Bogner. Metabolic and anthropometric changes one year after switching from didanosine/stavudine to tenofovir in HIV-infected patients.
European journal of medical research.
2007 Feb; 12(2):54-60. doi:
. [PMID: 17369118] - Dhrmarajan Sriram, Perumal Yogeeswari, Nagell Raveendra Babu, Purna Nagashree Kurre. Synthesis and in vitro anti-HIV activities of didanosine prodrugs.
Journal of enzyme inhibition and medicinal chemistry.
2007 Feb; 22(1):51-5. doi:
10.1080/14756360600988831. [PMID: 17373547] - Philippe Flandre, Colombe Chappey, Anne Genevieve Marcelin, Kirk Ryan, Jen-Fue Maa, Mike Bates, Daniel Seekins, Marie Charlotte Bernard, Vincent Calvez, Jean Michel Molina. Phenotypic susceptibility to didanosine is associated with antiviral activity in treatment-experienced patients with HIV-1 infection.
The Journal of infectious diseases.
2007 Feb; 195(3):392-8. doi:
10.1086/510754. [PMID: 17205478] - Jean-Michel Molina, Valérie Journot, André Furco, Pierre Palmer, Nathalie De Castro, François Raffi, Philippe Morlat, Thierry May, Corinne Rancinan, Geneviève Chêne. Five-year follow up of once-daily therapy with emtricitabine, didanosine and efavirenz (Montana ANRS 091 trial).
Antiviral therapy.
2007; 12(3):417-22. doi:
NULL. [PMID: 17591032] - Hua-Ying Zhou, Yu-Huang Zheng, Chun-Ying Zhang, Jun Chen, Yan He, Pei-Pei Ding, Hui Li. Evaluation of human immunodeficiency virus type 1-infected Chinese patients treated with highly active antiretroviral therapy for two years.
Viral immunology.
2007; 20(1):180-7. doi:
10.1089/vim.2006.0047. [PMID: 17425432] - David Asboe, Ian G Williams, Ruth L Goodall, Janet H Darbyshire, Malcolm H Hooker, Abdel G Babiker. A virological benefit from an induction/maintenance strategy: the Forte trial.
Antiviral therapy.
2007; 12(1):47-54. doi:
NULL. [PMID: 17503747] - Gerald Friedland, Saye Khoo, Christopher Jack, Umesh Lalloo. Administration of efavirenz (600 mg/day) with rifampicin results in highly variable levels but excellent clinical outcomes in patients treated for tuberculosis and HIV.
The Journal of antimicrobial chemotherapy.
2006 Dec; 58(6):1299-302. doi:
10.1093/jac/dkl399. [PMID: 17032686] - Francesc Vidal, Joan Carles Domingo, Jordi Guallar, Maria Saumoy, Begoña Cordobilla, Rainel Sánchez de la Rosa, Marta Giralt, Maria Luisa Alvarez, Miguel López-Dupla, Ferran Torres, Francesc Villarroya, Tomas Cihlar, Pere Domingo. In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells.
Antimicrobial agents and chemotherapy.
2006 Nov; 50(11):3824-32. doi:
10.1128/aac.00437-06. [PMID: 16940060] - V Reliquet, C Allavena, C François-Brunet, P Perré, V Bellein, M Garré, T May, F Souala, J-M Besnier, F Raffi. Long-term assessment of nevirapine-containing highly active antiretroviral therapy in antiretroviral-naive HIV-infected patients: 3-year follow-up of the VIRGO study.
HIV medicine.
2006 Oct; 7(7):431-6. doi:
10.1111/j.1468-1293.2006.00402.x. [PMID: 16925728] - Jose Luis Blanco, Alejandra Biglia, Elisa De Lazzari, Josep Mallolas, Esteban Martinez, Tomás Pumarola, María Larrousse, Ana Milinkovic, Agathe León, Montserrat Lonca, Montserrat Laguno, Josep María Gatell. Antiretroviral activity of didanosine in patients with different clusters of reverse transcriptase mutations.
AIDS (London, England).
2006 Sep; 20(14):1891-2. doi:
10.1097/01.aids.0000244210.33876.26. [PMID: 16954732] - Chulapan Engchanil, Pope Kosalaraksa, Pagakrong Lumbiganon, Viraphong Lulitanond, Piyaporn Pongjunyakul, Ruengsin Thuennadee, Sasithorn Tungsawad, Olan Suwan-apichon. Therapeutic potential of chloroquine added to zidovudine plus didanosine for HIV-1 infected children.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2006 Aug; 89(8):1229-36. doi:
. [PMID: 17048434] - Christopher M Cirino, Virginia L Kan. Hypokalemia in HIV patients on tenofovir.
AIDS (London, England).
2006 Aug; 20(12):1671-3. doi:
10.1097/01.aids.0000238416.05819.09. [PMID: 16868451] - José Miguel Benito, Mariola López, Celia Ballesteros, Sara Lozano, Laura Capa, Pablo Barreiro, José Sempere, Juan Gonzalez-Lahoz, Vincent Soriano. Immunological and virological effects of structured treatment interruptions following exposure to hydroxyurea plus didanosine.
AIDS research and human retroviruses.
2006 Aug; 22(8):734-43. doi:
10.1089/aid.2006.22.734. [PMID: 16910828] - Sabiha Hussain, Abeer Khayat, Asad Tolaymat, Mobeen H Rathore. Nephrotoxicity in a child with perinatal HIV on tenofovir, didanosine and lopinavir/ritonavir.
Pediatric nephrology (Berlin, Germany).
2006 Jul; 21(7):1034-6. doi:
10.1007/s00467-006-0109-3. [PMID: 16773419] - T Nicole Clark, Catherine A White, Michael G Bartlett. Determination of didanosine in maternal plasma, amniotic fluid, fetal and placental tissues by high-performance liquid chromatography-tandem mass spectrometry.
Biomedical chromatography : BMC.
2006 Jun; 20(6-7):605-11. doi:
10.1002/bmc.651. [PMID: 16779780] - Eric Balestre, Michel Dupon, Sophie Capdepont, Rodolphe Thiébaut, Sébastien Boucher, Hervé Fleury, François Dabis, Bernard Masquelier. Virological response to HIV-1 nucleoside/nucleotide reverse transcriptase inhibitors-based, tenofovir DF-including regimens in the ANRS Aquitaine Cohort.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.
2006 Jun; 36(2):95-9. doi:
10.1016/j.jcv.2006.02.002. [PMID: 16556509] - M Cruciani, G Liuzzi, A Chirianni, S Audagnotto, S Bonora, A Di Biagio, A Sinicco, M Bassetti, G Gatti. Penetration of didanosine in semen of HIV-1-infected men.
The Journal of antimicrobial chemotherapy.
2006 Jun; 57(6):1244-7. doi:
10.1093/jac/dkl111. [PMID: 16556633] - Sophie Capdepont, Valérie Aurillac-Lavignolle, Muriel Faure, Michel Dupon, Philippe Morlat, Jean-Marie Ragnaud, Geneviève Chêne, Hervé Fleury, Bernard Masquelier. An additive/subtractive genotypic score as a determinant of the virological response to didanosine in HIV-1 infected patients.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.
2006 May; 36(1):36-42. doi:
10.1016/j.jcv.2006.01.008. [PMID: 16513416] - Teresa García-Benayas, Ana Lucía Rendón, Sonia Rodríguez-Novóa, Ana Barrios, Ivana Maida, Francisco Blanco, Pablo Barreiro, Pablo Rivas, Juan González-Lahoz, Vincent Soriano. Higher risk of hyperglycemia in HIV-infected patients treated with didanosine plus tenofovir.
AIDS research and human retroviruses.
2006 Apr; 22(4):333-7. doi:
10.1089/aid.2006.22.333. [PMID: 16623636] - Margaret Johnson, Beatriz Grinsztejn, Claudia Rodriguez, Jeffrey Coco, Edwin DeJesus, Adriano Lazzarin, Kenneth Lichtenstein, Victoria Wirtz, Anna Rightmire, Linda Odeshoo, Colin McLaren. 96-week comparison of once-daily atazanavir/ritonavir and twice-daily lopinavir/ritonavir in patients with multiple virologic failures.
AIDS (London, England).
2006 Mar; 20(5):711-8. doi:
10.1097/01.aids.0000216371.76689.63. [PMID: 16514301] - Robert W Robey, Zhirong Zhan, Richard L Piekarz, Ganesh L Kayastha, Tito Fojo, Susan E Bates. Increased MDR1 expression in normal and malignant peripheral blood mononuclear cells obtained from patients receiving depsipeptide (FR901228, FK228, NSC630176).
Clinical cancer research : an official journal of the American Association for Cancer Research.
2006 Mar; 12(5):1547-55. doi:
10.1158/1078-0432.ccr-05-1423. [PMID: 16533780] - Simone Schramm Andrade, Eunice Kazue Kano, Tatiane Maria de Lima Souza Brioschi, Eunice Emiko Mori Koono, Cristina Helena dos Reis Serra, Valentina Porta. Bioavailability study of two oral formulations of didanosine in healthy volunteers.
Arzneimittel-Forschung.
2006; 56(5):359-64. doi:
10.1055/s-0031-1296734. [PMID: 16821647] - Hélène C F Côté, Alex B Magil, Marianne Harris, Brian J Scarth, Izabelle Gadawski, Nancy Wang, Eugenia Yu, Benita Yip, Nadia Zalunardo, Ron Werb, Robert Hogg, P Richard Harrigan, Julio S Montaner. Exploring mitochondrial nephrotoxicity as a potential mechanism of kidney dysfunction among HIV-infected patients on highly active antiretroviral therapy.
Antiviral therapy.
2006; 11(1):79-86. doi:
NULL. [PMID: 16518963]