5-(4-Methoxybenzylidene)-1,3-thiazolidine-2,4-dione (BioDeep_00000841980)
代谢物信息卡片
化学式: C11H9NO3S (235.03031239999999)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC=C(C=C1)C=C2C(=O)NC(=O)S2
InChI: InChI=1S/C11H9NO3S/c1-15-8-4-2-7(3-5-8)6-9-10(13)12-11(14)16-9/h2-6H,1H3,(H,12,13,14)/b9-6-
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Caifeng Xie, Wang Jingjing, Xiaolu Li, Fei Zeng, Liang Ma, Chunyan Li, Zhe Wei, Aihua Peng, Lijuan Chen. Protective effect of SKLB010 against D-galactosamine/lipopolysaccharide-induced acute liver failure via nuclear factor-κB signaling pathway in macrophages.
International immunopharmacology.
2014 Aug; 21(2):261-8. doi:
10.1016/j.intimp.2014.05.012. [PMID: 24861250] - Zhi-Zhi Chen, Zheng-Lin Wang, Chong-Yang Deng, Hao Zheng, Xian-Huo Wang, Liang Ma, Xia Ye, Ying-Hua Ma, Cai-Feng Xie, Li-Juan Chen, Yu-Quan Wei. (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione protects rats from carbon tetrachloride-induced liver injury and fibrogenesis.
World journal of gastroenterology.
2012 Feb; 18(7):654-61. doi:
10.3748/wjg.v18.i7.654. [PMID: 22363136] - Xia Ye, Minghai Tang, Juan Liu, Xianhuo Wang, Liang Ma, Hao Zheng, Jia Hu, Xiang Chen, Xingmei Duan, Lijuan Chen. Development and validation of a UPLC-MS/MS method for quantification of SKLB010, an investigational anti-inflammatory compound, and its application to pharmacokinetic studies in beagle dogs.
Journal of pharmaceutical and biomedical analysis.
2011 Sep; 56(2):366-72. doi:
10.1016/j.jpba.2011.05.031. [PMID: 21680128] - Yinghua Ma, Xianhuo Wang, Xiaohua Wu, Xin Wei, Liang Ma, Hao Zheng, Baowen Qi, Wei Zhu, Youfu Luo, Yuquan Wei, Lijuan Chen. (Z)-5-(4-methoxybenzylidene) thiazolidine-2, 4-dione ameliorates the adjuvant-induced arthritis via inhibiting the migration of macrophage and down-regulating the cytokine mRNA expression.
International immunopharmacology.
2010 Nov; 10(11):1456-62. doi:
10.1016/j.intimp.2010.08.022. [PMID: 20837171] - Youfu Luo, Liang Ma, Hao Zheng, Lijuan Chen, Rui Li, Chunmei He, Shengyong Yang, Xia Ye, Zhizhi Chen, Zicheng Li, Yan Gao, Jing Han, Gu He, Li Yang, Yuquan Wei. Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice.
Journal of medicinal chemistry.
2010 Jan; 53(1):273-81. doi:
10.1021/jm901183d. [PMID: 19904929] - Chun-Mei He, Lu-Lu Cai, Hao Zheng, Liang Ma, You-Fu Luo, Li-Juan Chen. [SKLB-102 inhibits acute hepatitis induced by concanavalin A in mice].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2009 Jul; 40(4):697-9, 711. doi:
NULL. [PMID: 19764576]