(E)-3-(6-Acetamidopyridin-3-yl)-N-[2-[2,4-dichloro-N-methyl-3-[(2-methylquinolin-8-yl)oxymethyl]anilino]-2-oxoethyl]prop-2-enamide (BioDeep_00000841968)
代谢物信息卡片
(E)-3-(6-Acetamidopyridin-3-yl)-N-[2-[2,4-dichloro-N-methyl-3-[(2-methylquinolin-8-yl)oxymethyl]anilino]-2-oxoethyl]prop-2-enamide
化学式: C30H27Cl2N5O4 (591.1440001999999)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=NC2=C(C=CC=C2OCC3=C(C=CC(=C3Cl)N(C)C(=O)CNC(=O)C=CC4=CN=C(C=C4)NC(=O)C)Cl)C=C1
InChI: InChI=1S/C30H27Cl2N5O4/c1-18-7-10-21-5-4-6-25(30(21)35-18)41-17-22-23(31)11-12-24(29(22)32)37(3)28(40)16-34-27(39)14-9-20-8-13-26(33-15-20)36-19(2)38/h4-15H,16-17H2,1-3H3,(H,34,39)(H,33,36,38)/b14-9+
描述信息
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D065168 - Bradykinin Receptor Antagonists
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Cecylia S Lupala, Patricia Gomez-Gutierrez, Juan J Perez. New insights into the stereochemical requirements of the bradykinin B2 receptor antagonists binding.
Journal of computer-aided molecular design.
2016 Jan; 30(1):85-101. doi:
10.1007/s10822-015-9890-z. [PMID: 26697880] - Yuji Kamata, Tomoe Fujita, Tetsuki Kato, Izumi Hayashi, Maya Kurosaka, Makoto Katori, Yoshikuni Fujita, Masataka Majima. An ATP-sensitive potassium channel blocker suppresses sodium-induced hypertension through increased secretion of urinary kallikrein.
Hypertension research : official journal of the Japanese Society of Hypertension.
2009 Mar; 32(3):220-6. doi:
10.1038/hr.2008.33. [PMID: 19262486] - R Costa, D M Marotta, M N Manjavachi, E S Fernandes, J F Lima-Garcia, A F Paszcuk, N L M Quintão, L Juliano, S D Brain, J B Calixto. Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice.
British journal of pharmacology.
2008 Jul; 154(5):1094-103. doi:
10.1038/bjp.2008.172. [PMID: 18454165] - Kazuhisa Arakawa, Izumi Takeyoshi, Yoshihiko Akao, Osamu Totsuka, Koshi Matsumoto, Yasuo Morishita. Bradykinin B2 receptor antagonist FR173657 ameliorates small bowel ischemia-reperfusion injury in dogs.
Digestive diseases and sciences.
2005 Jan; 50(1):27-36. doi:
10.1007/s10620-005-1273-1. [PMID: 15712633] - Masanori Fujii, Atsuyuki Wada, Masato Ohnishi, Takayoshi Tsutamoto, Takehiro Matsumoto, Takashi Yamamoto, Tomoyuki Takayama, Tomohiro Dohke, Takahiro Isono, Yutaka Eguchi, Minoru Horie. Endogenous bradykinin suppresses myocardial fibrosis through the cardiac-generated endothelin system under chronic angiotensin-converting enzyme inhibition in heart failure.
Journal of cardiovascular pharmacology.
2004 Nov; 44 Suppl 1(?):S346-9. doi:
10.1097/01.fjc.0000166265.09550.7c. [PMID: 15838317] - Hirokazu Okada, Yusuke Watanabe, Tomohiro Kikuta, Tatsuya Kobayashi, Yoshihiko Kanno, Takeshi Sugaya, Hiromichi Suzuki. Bradykinin decreases plasminogen activator inhibitor-1 expression and facilitates matrix degradation in the renal tubulointerstitium under angiotensin-converting enzyme blockade.
Journal of the American Society of Nephrology : JASN.
2004 Sep; 15(9):2404-13. doi:
10.1097/01.asn.0000136132.20189.95. [PMID: 15339989] - Yoshitaka Hirayama, Kikuo Miyayasu, Kaoru Yamagami, Takumi Imai, Yoshitaka Ohkubo, Seitaro Mutoh. Effect of FK3657, a non-peptide bradykinin B2 receptor antagonist, on allergic airway disease models.
European journal of pharmacology.
2003 Apr; 467(1-3):197-203. doi:
10.1016/s0014-2999(03)01631-5. [PMID: 12706475] - Naoki Hashimoto, Izumi Takeyoshi, Hirofumi Tsutsumi, Yutaka Sunose, Masahiko Tokumine, Osamu Totsuka, Susumu Ohwada, Takao Yokoe, Koshi Matsumoto, Yasuo Morishita. Effects of a bradykinin B(2) receptor antagonist, FR173657, on pulmonary ischemia-reperfusion injury in dogs.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
2002 Sep; 21(9):1022-9. doi:
10.1016/s1053-2498(02)00405-9. [PMID: 12231374] - Izumi Hayashi, Hideki Amano, Satoko Yoshida, Kazuhisa Kamata, Mariko Kamata, Madoka Inukai, Tomoe Fujita, Yuji Kumagai, Sen-ichi Furudate, Masataka Majima. Suppressed angiogenesis in kininogen-deficiencies.
Laboratory investigation; a journal of technical methods and pathology.
2002 Jul; 82(7):871-80. doi:
10.1097/01.lab.0000018885.36823.d6. [PMID: 12118089] - Zhongmin Qiu, Qi Liu, Dehua Guo, Xiangchun Fu. [The effect of bradykinin B(2) receptor antagonist on cough reactivity in a sensitized guinea pig model].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
2002 Feb; 25(2):74-7. doi:
". [PMID: 11953101] - Mitsuhiro Hirata, Izumi Hayashi, Kuniko Yoshimura, Ken-ichiro Ishii, Kazui Soma, Takashi Ohwada, Akira Kakita, Masataka Majima. Blockade of bradykinin B(2) receptor suppresses acute pancreatitis induced by obstruction of the pancreaticobiliary duct in rats.
British journal of pharmacology.
2002 Jan; 135(1):29-36. doi:
10.1038/sj.bjp.0704462. [PMID: 11786477] - I Hayashi, K Ishihara, Y Kumagai, M Majima. Proinflammatory characteristics of a nonpeptide bradykinin mimic, FR190997, in vivo.
British journal of pharmacology.
2001 Aug; 133(8):1296-306. doi:
10.1038/sj.bjp.0704208. [PMID: 11498515] - M Tramontana, A Lecci, S Meini, X Montserrat, J Pascual, S Giuliani, L Quartara, C A Maggi. Differences between peptide and nonpeptide B(2) bradykinin receptor antagonists in blocking bronchoconstriction and hypotension induced by bradykinin in anesthetized Guinea pigs.
The Journal of pharmacology and experimental therapeutics.
2001 Mar; 296(3):1051-7. doi:
NULL. [PMID: 11181940] - T Fujita, Y Kumagai, Y Ikeda, N Inamura, T Iwata, M Ogino, M Majima. Involvement of the renal kallikrein-kinin system in furosemide-induced natriuresis in rats.
Japanese journal of pharmacology.
2000 Oct; 84(2):133-9. doi:
10.1254/jjp.84.133. [PMID: 11128035] - T Suzuki, M Katori, T Fujita, Y Kumagai, M Majima. Involvement of the renal kallikrein-kinin system in K(+)-induced diuresis and natriuresis in anesthetized rats.
European journal of pharmacology.
2000 Jul; 399(2-3):223-7. doi:
10.1016/s0014-2999(00)00382-4. [PMID: 10884523] - C Bandeira-Melo, A S Calheiros, P M Silva, R S Cordeiro, M M Teixeira, M A Martins. Suppressive effect of distinct bradykinin B2 receptor antagonist on allergen-evoked exudation and leukocyte infiltration in sensitized rats.
British journal of pharmacology.
1999 May; 127(2):315-20. doi:
10.1038/sj.bjp.0702536. [PMID: 10385228] - M Watanabe, S Yoshihara, T Abe, M Oyama, O Arisaka. Effects of the orally active non-peptide bradykinin B2 receptor antagonist, FR173657, on plasma extravasation in guinea pig airways.
European journal of pharmacology.
1999 Feb; 367(2-3):373-8. doi:
10.1016/s0014-2999(98)00964-9. [PMID: 10079013] - I Hayashi, M Majima. Reduction of sodium deoxycholic acid-induced scratching behaviour by bradykinin B2 receptor antagonists.
British journal of pharmacology.
1999 Jan; 126(1):197-204. doi:
10.1038/sj.bjp.0702296. [PMID: 10051136] - A Ueno, H Naraba, S Oh-ishi. Mouse paw edema induced by a novel bradykinin agonist and its inhibition by B2-antagonists.
Japanese journal of pharmacology.
1998 Sep; 78(1):109-11. doi:
10.1254/jjp.78.109. [PMID: 9804073] - T Mori, T Imamura. Inhibition of guinea pig skin allergic reactions by nonpeptide bradykinin B2 receptor antagonist FR173657.
International archives of allergy and immunology.
1998 Aug; 116(4):278-83. doi:
10.1159/000023956. [PMID: 9693277] - M Majima, N Kawashima, I Hiroshi, M Katori. Effects of an orally active non-peptide bradykinin B2 receptor antagonist, FR173657, on plasma exudation in rat carrageenin-induced pleurisy.
British journal of pharmacology.
1997 Jun; 121(4):723-30. doi:
10.1038/sj.bjp.0701194. [PMID: 9208140] - T Griesbacher, F J Legat. Effects of FR173657, a non-peptide B2 antagonist, on kinin-induced hypotension, visceral and peripheral oedema formation and bronchoconstriction.
British journal of pharmacology.
1997 Mar; 120(5):933-9. doi:
10.1038/sj.bjp.0700966. [PMID: 9138701] - I Aramori, J Zenkoh, N Morikawa, N O'Donnell, M Asano, K Nakamura, M Iwami, H Kojo, Y Notsu. Novel subtype-selective nonpeptide bradykinin receptor antagonists FR167344 and FR173657.
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1997 Feb; 51(2):171-6. doi:
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