3-((2-Carboxybiphenyl-4-yl)methyl)-2-cyclopropyl-7-methyl-3H-imidazo(4,5-b)pyridine (BioDeep_00000841955)
代谢物信息卡片
化学式: C24H21N3O2 (383.1634)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C2C(=NC=C1)N(C(=N2)C3CC3)CC4=CC=C(C=C4)C5=CC=CC=C5C(=O)O
InChI: InChI=1S/C24H21N3O2/c1-15-12-13-25-23-21(15)26-22(18-10-11-18)27(23)14-16-6-8-17(9-7-16)19-4-2-3-5-20(19)24(28)29/h2-9,12-13,18H,10-11,14H2,1H3,(H,28,29)
描述信息
D057911 - Angiotensin Receptor Antagonists > D047228 - Angiotensin II Type 1 Receptor Blockers
同义名列表
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- K Matsumoto, R Morishita, A Moriguchi, N Tomita, Y Yo, T Nishii, T Nakamura, J Higaki, T Ogihara. Prevention of renal damage by angiotensin II blockade, accompanied by increased renal hepatocyte growth factor in experimental hypertensive rats.
Hypertension (Dallas, Tex. : 1979).
1999 Aug; 34(2):279-84. doi:
10.1161/01.hyp.34.2.279. [PMID: 10454454] - Y Uehara, N Hirawa, Y Kawabata, A Numabe, T Gomi, T Ikeda, M Omata. Angiotensin II subtype-1 receptor antagonists improve hemodynamic and renal changes without affecting glucose metabolisms in genetic rat model of non-insulin-dependent diabetes mellitus.
American journal of hypertension.
1999 Jan; 12(1 Pt 1):21-7. doi:
10.1016/s0895-7061(98)00276-3. [PMID: 10075380] - M Kakiki, H Ishihara. Pharmacokinetics, metabolism and pharmacodynamics of a benzimidazole angiotensin II type 1 receptor antagonist in the beagle dog and cynomologus monkey.
Xenobiotica; the fate of foreign compounds in biological systems.
1998 Jan; 28(1):77-91. doi:
10.1080/004982598239777. [PMID: 9493321] - M Kakiki, K Morohashi, M Nomura, T Omura, T Horie. Expression of aldosterone synthase cytochrome P450 (P450aldo) mRNA in rat adrenal glomerulosa cells by angiotensin II type 1 receptor.
Endocrine research.
1997 Nov; 23(4):277-95. doi:
10.1080/07435809709031858. [PMID: 9430819] - S Kim, H Wanibuchi, A Hamaguchi, K Miura, S Yamanaka, H Iwao. Angiotensin blockade improves cardiac and renal complications of type II diabetic rats.
Hypertension (Dallas, Tex. : 1979).
1997 Nov; 30(5):1054-61. doi:
10.1161/01.hyp.30.5.1054. [PMID: 9369255] - M Kakiki, K Morohashi, M Nomura, T Omura, T Horie. Regulation of aldosterone synthase cytochrome P450 (CYP11B2) and 11 beta-hydroxylase cytochrome P450 (CYP11B1) expression in rat adrenal zona glomerulosa cells by low sodium diet and angiotensin II receptor antagonists.
Biological & pharmaceutical bulletin.
1997 Sep; 20(9):962-8. doi:
10.1248/bpb.20.962. [PMID: 9331977] - M Kakiki, K Tadano. Localization and disposition of a non-peptide angiotensin II type 1 receptor antagonist, and its glucuronide metabolite, in rat.
Xenobiotica; the fate of foreign compounds in biological systems.
1997 Jul; 27(7):723-32. doi:
10.1080/004982597240307. [PMID: 9253148] - T Seki, K Yamazaki, M Kayano. Determination of angiotensin II receptor antagonist (E4177) in human plasma and urine by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Jan; 688(1):101-6. doi:
10.1016/s0378-4347(97)88061-9. [PMID: 9029319] - M Sugano, N Makino, T Yanaga. The effects of renin-angiotensin system inhibition on aortic cholesterol content in cholesterol-fed rabbits.
Atherosclerosis.
1996 Nov; 127(1):123-9. doi:
10.1016/s0021-9150(96)05942-4. [PMID: 9006812] - M Kakiki, T Horie. Localization of a novel non-peptide angiotensin II type 1 receptor antagonist, E4177, in rat adrenal glomerulosa.
Biological & pharmaceutical bulletin.
1996 Oct; 19(10):1357-61. doi:
10.1248/bpb.19.1357. [PMID: 8913512] - K Song, M Miyazaki, H Okunishi, K Ishii, S Takai, N Shiota, S Kim, F A Mendelsohn. Localization and quantitation of active renin in monkey kidney by radioinhibitor binding and in vitro autoradiography.
American journal of hypertension.
1994 Jun; 7(6):529-35. doi:
10.1093/ajh/7.6.529. [PMID: 7917151]
