2-(2-(4-(2-Fluoroethoxy)phenyl)-5,7-dimethylpyrazolo(1,5-a)pyrimidin-3-yl)-N,N-diethylacetamide (BioDeep_00000841938)
代谢物信息卡片
2-(2-(4-(2-Fluoroethoxy)phenyl)-5,7-dimethylpyrazolo(1,5-a)pyrimidin-3-yl)-N,N-diethylacetamide
化学式: C22H27FN4O2 (398.2117934)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(CC)C(=O)CC1=C2N=C(C=C(N2N=C1C3=CC=C(C=C3)OCCF)C)C
InChI: InChI=1S/C22H27FN4O2/c1-5-26(6-2)20(28)14-19-21(17-7-9-18(10-8-17)29-12-11-23)25-27-16(4)13-15(3)24-22(19)27/h7-10,13H,5-6,11-12,14H2,1-4H3
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Danxi Li, Di Hu, Yuta Ochi, Wakiko Arakaki, Aya Mawatari, Mika Shigeta, Yuping Wu, Emi Hayashinaka, Hiroyuki Neyama, Tsuyoshi Tahara, Yasuhiro Wada, Feng Li, Hisashi Doi, Yasuyoshi Watanabe, Yilong Cui. Regional neuroinflammation induced by peripheral infection contributes to fatigue-like symptoms: a [18F]DPA-714 positron emission tomography study in rats.
Frontiers in immunology.
2023; 14(?):1261256. doi:
10.3389/fimmu.2023.1261256. [PMID: 38022622] - Jingguo Wang, Lei Jin, Xiang Zhang, Hai Yu, Jingjie Ge, Bo Deng, Ming Li, Chuantao Zuo, Xiangjun Chen. Activated microglia by 18F-DPA714 PET in a case of anti-LGI1 autoimmune encephalitis.
Journal of neuroimmunology.
2022 07; 368(?):577879. doi:
10.1016/j.jneuroim.2022.577879. [PMID: 35504188] - Swati Shah, Sanhita Sinharay, Reema Patel, Jeffrey Solomon, Ji Hyun Lee, William Schreiber-Stainthorp, Falguni Basuli, Xiang Zhang, Katie R Hagen, Rebecca Reeder, Paul Wakim, Louis M Huzella, Dragan Maric, Reed F Johnson, Dima A Hammoud. PET imaging of TSPO expression in immune cells can assess organ-level pathophysiology in high-consequence viral infections.
Proceedings of the National Academy of Sciences of the United States of America.
2022 04; 119(15):e2110846119. doi:
10.1073/pnas.2110846119. [PMID: 35385353] - Marloes H J Hagens, Sandeep V Golla, Martijn T Wijburg, Maqsood Yaqub, Dennis Heijtel, Martijn D Steenwijk, Patrick Schober, John J P Brevé, Robert C Schuit, Tristan A Reekie, Michael Kassiou, Anne-Marie van Dam, Albert D Windhorst, Joep Killestein, Frederik Barkhof, Bart N M van Berckel, Adriaan A Lammertsma. In vivo assessment of neuroinflammation in progressive multiple sclerosis: a proof of concept study with [18F]DPA714 PET.
Journal of neuroinflammation.
2018 Nov; 15(1):314. doi:
10.1186/s12974-018-1352-9. [PMID: 30424780] - Fiona Henderson, Philippa J Hart, Jesus M Pradillo, Michael Kassiou, Lidan Christie, Kaye J Williams, Herve Boutin, Adam McMahon. Multi-modal imaging of long-term recovery post-stroke by positron emission tomography and matrix-assisted laser desorption/ionisation mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2018 May; 32(9):721-729. doi:
10.1002/rcm.8090. [PMID: 29484723] - Thomas Keller, Anna Krzyczmonik, Sarita Forsback, Francisco R López Picón, Anna K Kirjavainen, Jatta Takkinen, Johan Rajander, Fanny Cacheux, Annelaure Damont, Frédéric Dollé, Juha O Rinne, Merja Haaparanta-Solin, Olof Solin. Radiosynthesis and Preclinical Evaluation of [18F]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats.
Molecular imaging and biology.
2017 Oct; 19(5):736-745. doi:
10.1007/s11307-016-1040-z. [PMID: 28083825] - Sandeep S V Golla, Ronald Boellaard, Vesa Oikonen, Anja Hoffmann, Bart N M van Berckel, Albert D Windhorst, Jere Virta, Erik T Te Beek, Geert Jan Groeneveld, Merja Haaparanta-Solin, Pauliina Luoto, Nina Savisto, Olof Solin, Ray Valencia, Andrea Thiele, Jonas Eriksson, Robert C Schuit, Adriaan A Lammertsma, Juha O Rinne. Parametric Binding Images of the TSPO Ligand 18F-DPA-714.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2016 Oct; 57(10):1543-1547. doi:
10.2967/jnumed.116.173013. [PMID: 27261521] - Dieter Ory, Andrey Postnov, Michel Koole, Sofie Celen, Bart de Laat, Alfons Verbruggen, Koen Van Laere, Guy Bormans, Cindy Casteels. Quantification of TSPO overexpression in a rat model of local neuroinflammation induced by intracerebral injection of LPS by the use of [(18)F]DPA-714 PET.
European journal of nuclear medicine and molecular imaging.
2016 Jan; 43(1):163-172. doi:
10.1007/s00259-015-3172-9. [PMID: 26323575] - Sonia Lavisse, Daniel García-Lorenzo, Marie-Anne Peyronneau, Benedetta Bodini, Claire Thiriez, Bertrand Kuhnast, Claude Comtat, Philippe Remy, Bruno Stankoff, Michel Bottlaender. Optimized Quantification of Translocator Protein Radioligand ¹⁸F-DPA-714 Uptake in the Brain of Genotyped Healthy Volunteers.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2015 Jul; 56(7):1048-54. doi:
10.2967/jnumed.115.156083. [PMID: 26025960] - Sandeep S V Golla, Ronald Boellaard, Vesa Oikonen, Anja Hoffmann, Bart N M van Berckel, Albert D Windhorst, Jere Virta, Merja Haaparanta-Solin, Pauliina Luoto, Nina Savisto, Olof Solin, Ray Valencia, Andrea Thiele, Jonas Eriksson, Robert C Schuit, Adriaan A Lammertsma, Juha O Rinne. Quantification of [18F]DPA-714 binding in the human brain: initial studies in healthy controls and Alzheimer's disease patients.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2015 May; 35(5):766-72. doi:
10.1038/jcbfm.2014.261. [PMID: 25649991] - Samuel D Banister, Corinne Beinat, Shane M Wilkinson, Bin Shen, Cecilia Bartoli, Silvia Selleri, Eleonora Da Pozzo, Claudia Martini, Frederick T Chin, Michael Kassiou. Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO).
European journal of medicinal chemistry.
2015 Mar; 93(?):392-400. doi:
10.1016/j.ejmech.2015.02.004. [PMID: 25725375] - Caterina Vicidomini, Mariarosaria Panico, Adelaide Greco, Sara Gargiulo, Anna Rita Daniela Coda, Antonella Zannetti, Matteo Gramanzini, Giovanni N Roviello, Mario Quarantelli, Bruno Alfano, Bertrand Tavitian, Frederic Dollé, Marco Salvatore, Arturo Brunetti, Sabina Pappatà. In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET.
Nuclear medicine and biology.
2015 Mar; 42(3):309-16. doi:
10.1016/j.nucmedbio.2014.11.009. [PMID: 25537727] - Vincent Médran-Navarrete, Nicholas Bernards, Bertrand Kuhnast, Annelaure Damont, Géraldine Pottier, Marie-Anne Peyronneau, Michael Kassiou, Frank Marguet, Frédéric Puech, Raphaël Boisgard, Frédéric Dollé. [18F]DPA-C5yne, a novel fluorine-18-labelled analogue of DPA-714: radiosynthesis and preliminary evaluation as a radiotracer for imaging neuroinflammation with PET.
Journal of labelled compounds & radiopharmaceuticals.
2014 May; 57(6):410-8. doi:
10.1002/jlcr.3199. [PMID: 24764161] - Yoony Y J Gent, Karin Weijers, Carla F M Molthoff, Albert D Windhorst, Marc C Huisman, Michael Kassiou, Gerrit Jansen, Adriaan A Lammertsma, Conny J van der Laken. Promising potential of new generation translocator protein tracers providing enhanced contrast of arthritis imaging by positron emission tomography in a rat model of arthritis.
Arthritis research & therapy.
2014 Mar; 16(2):R70. doi:
10.1186/ar4509. [PMID: 24625077] - Marie-Anne Peyronneau, Wadad Saba, Sébastien Goutal, Annelaure Damont, Frédéric Dollé, Michael Kassiou, Michel Bottlaender, Héric Valette. Metabolism and quantification of [(18)F]DPA-714, a new TSPO positron emission tomography radioligand.
Drug metabolism and disposition: the biological fate of chemicals.
2013 Jan; 41(1):122-31. doi:
10.1124/dmd.112.046342. [PMID: 23065531] - Nicolas Arlicot, Johnny Vercouillie, Maria-João Ribeiro, Clovis Tauber, Yann Venel, Jean-Louis Baulieu, Serge Maia, Philippe Corcia, Michael G Stabin, Aaron Reynolds, Michael Kassiou, Denis Guilloteau. Initial evaluation in healthy humans of [18F]DPA-714, a potential PET biomarker for neuroinflammation.
Nuclear medicine and biology.
2012 May; 39(4):570-8. doi:
10.1016/j.nucmedbio.2011.10.012. [PMID: 22172392] - Michelle L James, Roger R Fulton, Johnny Vercoullie, David J Henderson, Lucette Garreau, Sylvie Chalon, Frederic Dolle, Barbara Costa, Silvia Selleri, Denis Guilloteau, Michael Kassiou. DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2008 May; 49(5):814-22. doi:
10.2967/jnumed.107.046151. [PMID: 18413395]