Propargylglycine (BioDeep_00000841931)
代谢物信息卡片
Propargylglycine
化学式: C5H7NO2 (113.0477)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C#CCNCC(=O)O
InChI: InChI=1S/C5H7NO2/c1-2-3-6-4-5(7)8/h1,6H,3-4H2,(H,7,8)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Xiangxue Lu, Shixiang Wang, Sujuan Feng, Han Li. CSE/H2S system alleviates uremic accelerated atherosclerosis by regulating TGF-β/Smad3 pathway in 5/6 nephrectomy ApoE-/- mice.
BMC nephrology.
2020 12; 21(1):527. doi:
10.1186/s12882-020-02183-z. [PMID: 33276745] - Bec J Roldan, Andrea O Pajarillo, Jacob D Greenberg, Joyce E Karlinsey, Mauricio Cafiero, Elaine R Frawley, Larryn W Peterson. Propargylglycine-based antimicrobial compounds are targets of TolC-dependent efflux systems in Escherichia coli.
Bioorganic & medicinal chemistry letters.
2020 01; 30(2):126875. doi:
10.1016/j.bmcl.2019.126875. [PMID: 31836438] - Srijanani Kannan, Sri Rahavi Boovarahan, Jeyashri Rengaraju, Priyanka Prem, Gino A Kurian. Attenuation of cardiac ischemia-reperfusion injury by sodium thiosulfate is partially dependent on the effect of cystathione beta synthase in the myocardium.
Cell biochemistry and biophysics.
2019 Sep; 77(3):261-272. doi:
10.1007/s12013-019-00871-8. [PMID: 31065867] - Mai M Helmy, Maged W Helmy, Mahmoud M El-Mas. Upregulation of cystathionine-γ-lyase/hydrogen sulfide pathway underlies the celecoxib counteraction of cyclosporine-induced hypertension and renal insult in rats.
Prostaglandins & other lipid mediators.
2019 04; 141(?):1-10. doi:
10.1016/j.prostaglandins.2019.01.001. [PMID: 30658157] - Hongming Guo, Heng Zhou, Jing Zhang, Wenxue Guan, Sheng Xu, Wenbiao Shen, Guohua Xu, Yanjie Xie, Christine Helen Foyer. l-cysteine desulfhydrase-related H2 S production is involved in OsSE5-promoted ammonium tolerance in roots of Oryza sativa.
Plant, cell & environment.
2017 Sep; 40(9):1777-1790. doi:
10.1111/pce.12982. [PMID: 28474399] - Xie-Feng Ye, Yanfeng Xue, Tianxiao Ling, Yong Wang, Xiao-Na Yu, Changxin Cheng, Guosheng Feng, Liangbin Hu, Zhiqi Shi, Jian Chen. Cinnamaldehyde Ameliorates Cadmium-Inhibited Root Elongation in Tobacco Seedlings via Decreasing Endogenous Hydrogen Sulfide Production.
Molecules (Basel, Switzerland).
2016 Dec; 22(1):. doi:
10.3390/molecules22010015. [PMID: 28029133] - M Stojanovic, V Zivkovic, I Srejovic, V Jakovljevic, N Jeremic, D Djuric. The role of hydrogen sulfide in homocysteine-induced cardiodynamic effects and oxidative stress markers in the isolated rat heart.
Physiology international.
2016 Dec; 103(4):428-438. doi:
10.1556/2060.103.2016.4.3. [PMID: 28229626] - Yan Lin, Yulong Chen, Ninghong Zhu, Sihai Zhao, Jianglin Fan, Enqi Liu. Hydrogen sulfide inhibits development of atherosclerosis through up-regulating protein S-nitrosylation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Oct; 83(?):466-476. doi:
10.1016/j.biopha.2016.07.003. [PMID: 27427853] - Shaimaa S El-Sayed, Mohamed N M Zakaria, Rasha H Abdel-Ghany, Abdel A Abdel-Rahman. Cystathionine-γ lyase-derived hydrogen sulfide mediates the cardiovascular protective effects of moxonidine in diabetic rats.
European journal of pharmacology.
2016 Jul; 783(?):73-84. doi:
10.1016/j.ejphar.2016.04.054. [PMID: 27138707] - Qien Li, Zhaofeng Wang, Yanning Zhao, Xiaochen Zhang, Shuaijun Zhang, Letao Bo, Yao Wang, Yingfeng Ding, Lizhe An. Putrescine protects hulless barley from damage due to UV-B stress via H2S- and H2O2-mediated signaling pathways.
Plant cell reports.
2016 May; 35(5):1155-68. doi:
10.1007/s00299-016-1952-8. [PMID: 26910861] - Francisco J Luna-Vázquez, César Ibarra-Alvarado, Alejandra Rojas-Molina, Antonio Romo-Mancillas, Fabián H López-Vallejo, Mariana Solís-Gutiérrez, Juana I Rojas-Molina, Fausto Rivero-Cruz. Role of Nitric Oxide and Hydrogen Sulfide in the Vasodilator Effect of Ursolic Acid and Uvaol from Black Cherry Prunus serotina Fruits.
Molecules (Basel, Switzerland).
2016 Jan; 21(1):78. doi:
10.3390/molecules21010078. [PMID: 26771591] - Sang Jun Han, Jee In Kim, Jeen-Woo Park, Kwon Moo Park. Hydrogen sulfide accelerates the recovery of kidney tubules after renal ischemia/reperfusion injury.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2015 Sep; 30(9):1497-506. doi:
10.1093/ndt/gfv226. [PMID: 26142397] - Ye Liu, Huichen Zhao, Ye Qiang, Guanfang Qian, Shengxia Lu, Jicui Chen, Xiangdong Wang, Qingbo Guan, Yuantao Liu, Yuqin Fu. Effects of hydrogen sulfide on high glucose-induced glomerular podocyte injury in mice.
International journal of clinical and experimental pathology.
2015; 8(6):6814-20. doi:
". [PMID: 26261567] - Jingxiang Wu, Jionglin Wei, Xingji You, Xu Chen, Hongwei Zhu, Xiaoyan Zhu, Yujian Liu, Meiying Xu. Inhibition of hydrogen sulfide generation contributes to lung injury after experimental orthotopic lung transplantation.
The Journal of surgical research.
2013 Jun; 182(1):e25-33. doi:
10.1016/j.jss.2012.09.028. [PMID: 23122581] - Balasubramanian Srilatha, Paulpandi Muthulakshmi, P Ganesan Adaikan, Philip K Moore. Endogenous hydrogen sulfide insufficiency as a predictor of sexual dysfunction in aging rats.
The aging male : the official journal of the International Society for the Study of the Aging Male.
2012 Sep; 15(3):153-8. doi:
10.3109/13685538.2012.668722. [PMID: 22455401] - Van P Dam, Jennifer L Scott, Anthony Ross, Robert T Kinobe. Inhibition of cystathionine gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity.
European journal of pharmacology.
2012 Jun; 685(1-3):165-73. doi:
10.1016/j.ejphar.2012.04.030. [PMID: 22546230] - H D C Francescato, J R A Chierice, E C S Marin, F Q Cunha, R S Costa, C G A Silva, T M Coimbra. Effect of endogenous hydrogen sulfide inhibition on structural and functional renal disturbances induced by gentamicin.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2012 Mar; 45(3):244-9. doi:
10.1590/s0100-879x2012007500016. [PMID: 22331137] - Alexander Roy, Abdul H Khan, Mohammed T Islam, Minolfa C Prieto, Dewan S A Majid. Interdependency of cystathione γ-lyase and cystathione β-synthase in hydrogen sulfide-induced blood pressure regulation in rats.
American journal of hypertension.
2012 Jan; 25(1):74-81. doi:
10.1038/ajh.2011.149. [PMID: 21866187] - Heloísa Della Coletta Francescato, Evelyn Cristina Santana Marin, Fernando de Queiroz Cunha, Roberto Silva Costa, Cleonice Giovanini Alves da Silva, Terezila Machado Coimbra. Role of endogenous hydrogen sulfide on renal damage induced by adriamycin injection.
Archives of toxicology.
2011 Dec; 85(12):1597-606. doi:
10.1007/s00204-011-0717-y. [PMID: 21590344] - Ping Wang, Jian-Xin Zhang, Jian-Pin Gong, Lan-Fang Li, Pu-Le Jin, Cui-Min Ding. [Effects of hydrogen sulfide on pulmonary surfactant in rats with acute lung injury induced by lipopolysccharide].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2011 Nov; 27(4):485-9. doi:
NULL. [PMID: 22295533] - Zhi-Fang Chen, Bin Zhao, Xiu-Ying Tang, Wei Li, Lu-Lu Zhu, Chao-Shu Tang, Jun-Bao DU, Hong-Fang Jin. Hydrogen sulfide regulates vascular endoplasmic reticulum stress in apolipoprotein E knockout mice.
Chinese medical journal.
2011 Nov; 124(21):3460-7. doi:
NULL. [PMID: 22340159] - Yan Gao, Xiaoyi Yao, Yina Zhang, Weimin Li, Kai Kang, Liang Sun, Xueying Sun. The protective role of hydrogen sulfide in myocardial ischemia-reperfusion-induced injury in diabetic rats.
International journal of cardiology.
2011 Oct; 152(2):177-83. doi:
10.1016/j.ijcard.2010.07.012. [PMID: 21316771] - Erzsébet Zavaczki, Viktória Jeney, Anupam Agarwal, Abolfazl Zarjou, Melinda Oros, Mónika Katkó, Zsuzsa Varga, György Balla, József Balla. Hydrogen sulfide inhibits the calcification and osteoblastic differentiation of vascular smooth muscle cells.
Kidney international.
2011 Oct; 80(7):731-9. doi:
10.1038/ki.2011.212. [PMID: 21716261] - Guangdong Yang, Guanghua Tang, Ling Zhang, Lingyun Wu, Rui Wang. The pathogenic role of cystathionine γ-lyase/hydrogen sulfide in streptozotocin-induced diabetes in mice.
The American journal of pathology.
2011 Aug; 179(2):869-79. doi:
10.1016/j.ajpath.2011.04.028. [PMID: 21718679] - Ping Yuan, Hong Xue, Li Zhou, Linping Qu, Cheng Li, Zhen Wang, Jun Ni, Chen Yu, Tai Yao, Yu Huang, Rui Wang, Limin Lu. Rescue of mesangial cells from high glucose-induced over-proliferation and extracellular matrix secretion by hydrogen sulfide.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2011 Jul; 26(7):2119-26. doi:
10.1093/ndt/gfq749. [PMID: 21208996] - Heloísa Della Coletta Francescato, Fernando Queiroz Cunha, Roberto Silva Costa, Fernando Barbosa Júnior, Mirian Aparecida Boim, Carine Prisco Arnoni, Cleonice Giovanini Alves da Silva, Terezila Machado Coimbra. Inhibition of hydrogen sulphide formation reduces cisplatin-induced renal damage.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2011 Feb; 26(2):479-88. doi:
10.1093/ndt/gfq447. [PMID: 20656754] - Zhan-Zhi Zhao, Zuo Wang, Guo-Hua Li, Ren Wang, Jian-Miao Tan, Xuan Cao, Rong Suo, Zhi-Sheng Jiang. Hydrogen sulfide inhibits macrophage-derived foam cell formation.
Experimental biology and medicine (Maywood, N.J.).
2011 Feb; 236(2):169-76. doi:
10.1258/ebm.2010.010308. [PMID: 21321313] - Gang Tan, Shangha Pan, Jie Li, Xuesong Dong, Kai Kang, Mingyan Zhao, Xian Jiang, Jagat R Kanwar, Haiquan Qiao, Hongchi Jiang, Xueying Sun. Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats.
PloS one.
2011; 6(10):e25943. doi:
10.1371/journal.pone.0025943. [PMID: 22022478] - Seah-Fang Ang, Shabbir M Moochhala, Paul A MacAry, Madhav Bhatia. Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: involvement of substance P and ERK-NF-κB signaling.
PloS one.
2011; 6(9):e24535. doi:
10.1371/journal.pone.0024535. [PMID: 21931742] - Jing Zhang, Selena Wei Shan Sio, Shabbir Moochhala, Madhav Bhatia. Role of hydrogen sulfide in severe burn injury-induced inflammation in mice.
Molecular medicine (Cambridge, Mass.).
2010 Sep; 16(9-10):417-24. doi:
10.2119/molmed.2010.00027. [PMID: 20440442] - Kai Kang, Hong-chi Jiang, Ming-yan Zhao, Xue-ying Sun, Shang-ha Pan. [Protection of CSE/H2S system in hepatic ischemia reperfusion injury in rats].
Zhonghua wai ke za zhi [Chinese journal of surgery].
2010 Jun; 48(12):924-8. doi:
NULL. [PMID: 21055229] - Jonathan A W Stecyk, Nini Skovgaard, Göran E Nilsson, Tobias Wang. Vasoactivity of hydrogen sulfide in normoxic and anoxic turtles (Trachemys scripta).
American journal of physiology. Regulatory, integrative and comparative physiology.
2010 May; 298(5):R1225-39. doi:
10.1152/ajpregu.00521.2009. [PMID: 20164201] - Seah-Fang Ang, Shabbir M Moochhala, Madhav Bhatia. Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis.
Critical care medicine.
2010 Feb; 38(2):619-28. doi:
10.1097/ccm.0b013e3181c0df00. [PMID: 19851090] - Jenab N Sidhapuriwala, Siaw Wei Ng, Madhav Bhatia. Effects of hydrogen sulfide on inflammation in caerulein-induced acute pancreatitis.
Journal of inflammation (London, England).
2009 Dec; 6(?):35. doi:
10.1186/1476-9255-6-35. [PMID: 20040116] - Yang Zhuo, Pei-Fang Chen, Ao-Zhen Zhang, Han Zhong, Chang-Qing Chen, Yi-Zhun Zhu. Cardioprotective effect of hydrogen sulfide in ischemic reperfusion experimental rats and its influence on expression of survivin gene.
Biological & pharmaceutical bulletin.
2009 Aug; 32(8):1406-10. doi:
10.1248/bpb.32.1406. [PMID: 19652381] - Xiao-hong Zhou, Peng Wei, Xin-li Huang, Yi-ling Ling. [Role of endogenous and exogenous hydrogen sulfide in acute lung injury induced by LPS in rats].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2009 Aug; 25(3):289-94. doi:
NULL. [PMID: 21155215] - Yanfei Wang, Xia Zhao, Hongfang Jin, Hongling Wei, Wei Li, Dingfang Bu, Xiuying Tang, Yali Ren, Chaoshu Tang, Junbao Du. Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice.
Arteriosclerosis, thrombosis, and vascular biology.
2009 Feb; 29(2):173-9. doi:
10.1161/atvbaha.108.179333. [PMID: 18988885] - Lingyun Wu, Wei Yang, Xuming Jia, Guangdong Yang, Dessislava Duridanova, Kun Cao, Rui Wang. Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats.
Laboratory investigation; a journal of technical methods and pathology.
2009 Jan; 89(1):59-67. doi:
10.1038/labinvest.2008.109. [PMID: 19002107] - Y-Y P Mok, P K Moore. Hydrogen sulphide is pro-inflammatory in haemorrhagic shock.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2008 Nov; 57(11):512-8. doi:
10.1007/s00011-008-7231-6. [PMID: 19109743] - Pinpat Tripatara, Nimesh S A Patel, Massimo Collino, Margherita Gallicchio, Julius Kieswich, Sara Castiglia, Elisa Benetti, Keith N Stewart, Paul A J Brown, Mohammed M Yaqoob, Roberto Fantozzi, Christoph Thiemermann. Generation of endogenous hydrogen sulfide by cystathionine gamma-lyase limits renal ischemia/reperfusion injury and dysfunction.
Laboratory investigation; a journal of technical methods and pathology.
2008 Oct; 88(10):1038-48. doi:
10.1038/labinvest.2008.73. [PMID: 18679378] - Daniela Dal-Secco, Thiago M Cunha, Andressa Freitas, José Carlos Alves-Filho, Fabrício O Souto, Sandra Y Fukada, Renata Grespan, Nylane M N Alencar, Alberto F Neto, Marcos A Rossi, Sérgio H Ferreira, John S Hothersall, Fernando Q Cunha. Hydrogen sulfide augments neutrophil migration through enhancement of adhesion molecule expression and prevention of CXCR2 internalization: role of ATP-sensitive potassium channels.
Journal of immunology (Baltimore, Md. : 1950).
2008 Sep; 181(6):4287-98. doi:
10.4049/jimmunol.181.6.4287. [PMID: 18768887] - Madhav Bhatia, Jenab N Sidhapuriwala, Siaw Wei Ng, Ramasamy Tamizhselvi, Shabbir M Moochhala. Pro-inflammatory effects of hydrogen sulphide on substance P in caerulein-induced acute pancreatitis.
Journal of cellular and molecular medicine.
2008 Apr; 12(2):580-90. doi:
10.1111/j.1582-4934.2007.00131.x. [PMID: 18419599] - Huili Zhang, Liang Zhi, Shabbir Moochhala, Philip K Moore, Madhav Bhatia. Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-kappaB.
American journal of physiology. Lung cellular and molecular physiology.
2007 Apr; 292(4):L960-71. doi:
10.1152/ajplung.00388.2006. [PMID: 17209138] - Huili Zhang, Liang Zhi, Philip K Moore, Madhav Bhatia. Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse.
American journal of physiology. Lung cellular and molecular physiology.
2006 Jun; 290(6):L1193-201. doi:
10.1152/ajplung.00489.2005. [PMID: 16428267] - Masao Maekawa, Tadashi Okamura, Noriyuki Kasai, Yuuichi Hori, Karl H Summer, Ryuichi Konno. D-amino-acid oxidase is involved in D-serine-induced nephrotoxicity.
Chemical research in toxicology.
2005 Nov; 18(11):1678-82. doi:
10.1021/tx0500326. [PMID: 16300376] - Marika Collin, Farhana B M Anuar, Oliver Murch, Madhav Bhatia, Philip K Moore, Christoph Thiemermann. Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia.
British journal of pharmacology.
2005 Oct; 146(4):498-505. doi:
10.1038/sj.bjp.0706367. [PMID: 16100527] - Ling Li, Madhav Bhatia, Yi Zhun Zhu, Yi Chun Zhu, Raina Devi Ramnath, Zhong Jing Wang, Farhana Binte Mohammed Anuar, Matthew Whiteman, Manuel Salto-Tellez, Philip K Moore. Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2005 Jul; 19(9):1196-8. doi:
10.1096/fj.04-3583fje. [PMID: 15863703] - Madhav Bhatia, Fei Ling Wong, Di Fu, Hon Yen Lau, Shabbir M Moochhala, Philip K Moore. Role of hydrogen sulfide in acute pancreatitis and associated lung injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2005 Apr; 19(6):623-5. doi:
10.1096/fj.04-3023fje. [PMID: 15671155] - Ying-Yuan Pamela Mok, Mohammed Shirhan Bin Mohammed Atan, Cheong Yoke Ping, Wang Zhong Jing, Madhav Bhatia, Shabbir Moochhala, Philip K Moore. Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis.
British journal of pharmacology.
2004 Dec; 143(7):881-9. doi:
10.1038/sj.bjp.0706014. [PMID: 15504752] - Hui Yan, Jun-bao Du, Chao-shu Tang. [Changes of endogenous hydrogen sulfide (H2S) in hypertensive rats].
Zhonghua er ke za zhi = Chinese journal of pediatrics.
2004 Mar; 42(3):172-5. doi:
NULL. [PMID: 15144708] - Hui Yan, Junbao Du, Chaoshu Tang. The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats.
Biochemical and biophysical research communications.
2004 Jan; 313(1):22-7. doi:
10.1016/j.bbrc.2003.11.081. [PMID: 14672692] - S Ravanel, M Droux, R Douce. Methionine biosynthesis in higher plants. I. Purification and characterization of cystathionine gamma-synthase from spinach chloroplasts.
Archives of biochemistry and biophysics.
1995 Jan; 316(1):572-84. doi:
10.1006/abbi.1995.1077. [PMID: 7840669] - A Kawaji, T Sone, R Natsuki, M Isobe, E Takabatake, Y Yamaura. In vitro toxicity test of poisonous mushroom extracts with isolated rat hepatocytes.
The Journal of toxicological sciences.
1990 Aug; 15(3):145-56. doi:
10.2131/jts.15.145. [PMID: 2243367] - Y Yamaura, M Fukuhara, E Takabatake, N Ito, T Hashimoto. Hepatotoxic action of a poisonous mushroom, Amanita abrupta in mice and its toxic component.
Toxicology.
1986 Feb; 38(2):161-73. doi:
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