5-Amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one (BioDeep_00000841928)
代谢物信息卡片
化学式: C16H11F3N2O2 (320.07725819999996)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C(=C2C(=O)C=C(OC2=C1F)C3=CC(=C(C=C3)N)F)N)F
InChI: InChI=1S/C16H11F3N2O2/c1-6-13(18)15(21)12-10(22)5-11(23-16(12)14(6)19)7-2-3-9(20)8(17)4-7/h2-5H,20-21H2,1H3
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tahira Mehreen, Shabnum Aamir, Nadeem Ali Shah, Muhamamd Shahid, Irum Javed, Munayal Roghani, Arslan Roghani, Faizan Roghani. Effect Of The Flavonoid 6-Aminoflavone In Aspirin Induced Gastric Ulcer In Sprague-Dawely Rats: A Histomorphological Study.
Journal of Ayub Medical College, Abbottabad : JAMC.
2022 Oct; 34(Suppl 1)(4):S940-S943. doi:
10.55519/jamc-04-s4-10369. [PMID: 36550649] - Boris Itkin, Alastair Breen, Lyudmila Turyanska, Eduardo Omar Sandes, Tracey D Bradshaw, Andrea Irene Loaiza-Perez. New Treatments in Renal Cancer: The AhR Ligands.
International journal of molecular sciences.
2020 May; 21(10):. doi:
10.3390/ijms21103551. [PMID: 32443455] - Gabriela A Luzzani, Mariana A Callero, Anchala I Kuruppu, Valentina Trapani, Carolina Flumian, Laura Todaro, Tracey D Bradshaw, Andrea I Loaiza Perez. In Vitro Antitumor Effects of AHR Ligands Aminoflavone (AFP 464) and Benzothiazole (5F 203) in Human Renal Carcinoma Cells.
Journal of cellular biochemistry.
2017 12; 118(12):4526-4535. doi:
10.1002/jcb.26114. [PMID: 28471540] - Ashley M Brinkman, Guojun Chen, Yidan Wang, Curtis J Hedman, Nathan M Sherer, Thomas C Havighurst, Shaoqin Gong, Wei Xu. Aminoflavone-loaded EGFR-targeted unimolecular micelle nanoparticles exhibit anti-cancer effects in triple negative breast cancer.
Biomaterials.
2016 09; 101(?):20-31. doi:
10.1016/j.biomaterials.2016.05.041. [PMID: 27267625] - Mariana A Callero, Guadalupe V Suárez, Gabriela Luzzani, Boris Itkin, Binh Nguyen, Andrea I Loaiza-Perez. Aryl hydrocarbon receptor activation by aminoflavone: new molecular target for renal cancer treatment.
International journal of oncology.
2012 Jul; 41(1):125-34. doi:
10.3892/ijo.2012.1427. [PMID: 22485252] - Richard Wiegand, Jianmei Wu, Xianyi Sha, Patricia LoRusso, Elisabeth Heath, Jing Li. Validation and implementation of a liquid chromatography/tandem mass spectrometry assay to quantitate aminoflavone (NSC 686288) in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 May; 877(14-15):1460-4. doi:
10.1016/j.jchromb.2009.03.015. [PMID: 19349217] - Chi Chen, Linghua Meng, Xiaochao Ma, Kristopher W Krausz, Yves Pommier, Jeffrey R Idle, Frank J Gonzalez. Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone).
The Journal of pharmacology and experimental therapeutics.
2006 Sep; 318(3):1330-42. doi:
10.1124/jpet.106.105213. [PMID: 16775196] - L R Phillips, C Bramhall, J Buckley, T Wolfe, T L House, S F Stinson. Identification of the principal circulating metabolite of a synthetic 5,4'-diaminoflavone (NSC 686288), an antitumor agent, in the rat.
Journal of chromatography. B, Biomedical sciences and applications.
2000 May; 741(2):205-11. doi:
10.1016/s0378-4347(00)00094-3. [PMID: 10872590]