Thioflosulide (BioDeep_00000841905)
代谢物信息卡片
化学式: C16H13F2NO3S2 (369.0304892)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CS(=O)(=O)NC1=C(C=C2C(=C1)CCC2=O)SC3=C(C=C(C=C3)F)F
InChI: InChI=1S/C16H13F2NO3S2/c1-24(21,22)19-13-6-9-2-4-14(20)11(9)8-16(13)23-15-5-3-10(17)7-12(15)18/h3,5-8,19H,2,4H2,1H3
描述信息
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Maria G Sciulli, Giulia Renda, Marta L Capone, Stefania Tacconelli, Emanuela Ricciotti, Stefano Manarini, Virgilio Evangelista, Antonio Rebuzzi, Paola Patrignani. Heterogeneity in the suppression of platelet cyclooxygenase-1 activity by aspirin in coronary heart disease.
Clinical pharmacology and therapeutics.
2006 Aug; 80(2):115-25. doi:
10.1016/j.clpt.2006.04.011. [PMID: 16890573] - N Turull, J Queralt. Effect of the COX-2 selective inhibitor l-745,337 on inflammation and organ prostaglandin E2 (PGE2) levels in adjuvant arthritic rats.
Inflammation.
2000 Dec; 24(6):533-45. doi:
10.1023/a:1007025423232. [PMID: 11128051] - A Turull, J Queralt. Selective cyclooxygenase-2 (COX-2) inhibitors reduce anti-Mycobacterium antibodies in adjuvant arthritic rats.
Immunopharmacology.
2000 Jan; 46(1):71-7. doi:
10.1016/s0162-3109(99)00159-9. [PMID: 10665781] - S A McCartney, J A Mitchell, P D Fairclough, M J Farthing, T D Warner. Selective COX-2 inhibitors and human inflammatory bowel disease.
Alimentary pharmacology & therapeutics.
1999 Aug; 13(8):1115-7. doi:
10.1046/j.1365-2036.1999.00585.x. [PMID: 10468690] - F Giuliano, T D Warner. Ex vivo assay to determine the cyclooxygenase selectivity of non-steroidal anti-inflammatory drugs.
British journal of pharmacology.
1999 Apr; 126(8):1824-30. doi:
10.1038/sj.bjp.0702518. [PMID: 10372826] - R F Parrott, S V Vellucci. Comparison of the antipyretic actions of indomethacin and L-745,337, a selective cyclooxygenase-2 inhibitor, in endotoxin-treated prepubertal pigs.
General pharmacology.
1998 Jan; 30(1):65-9. doi:
10.1016/s0306-3623(97)00069-4. [PMID: 9457483] - P Patrignani, G Santini, M R Panara, M G Sciulli, A Greco, M T Rotondo, M di Giamberardino, J Maclouf, G Ciabattoni, C Patrono. Induction of prostaglandin endoperoxide synthase-2 in human monocytes associated with cyclo-oxygenase-dependent F2-isoprostane formation.
British journal of pharmacology.
1996 Jul; 118(5):1285-93. doi:
10.1111/j.1476-5381.1996.tb15535.x. [PMID: 8818355] - D Praticó, G A FitzGerald. Generation of 8-epiprostaglandin F2alpha by human monocytes. Discriminate production by reactive oxygen species and prostaglandin endoperoxide synthase-2.
The Journal of biological chemistry.
1996 Apr; 271(15):8919-24. doi:
10.1074/jbc.271.15.8919. [PMID: 8621535] - M R Panara, A Greco, G Santini, M G Sciulli, M T Rotondo, R Padovano, M di Giamberardino, F Cipollone, F Cuccurullo, C Patrono. Effects of the novel anti-inflammatory compounds, N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulphonamide (NS-398) and 5-methanesulphonamido-6-(2,4-difluorothio-phenyl)-1-inda none (L-745,337), on the cyclo-oxygenase activity of human blood prostaglandin endoperoxide synthases.
British journal of pharmacology.
1995 Nov; 116(5):2429-34. doi:
10.1111/j.1476-5381.1995.tb15091.x. [PMID: 8581280] - C C Chan, S Boyce, C Brideau, A W Ford-Hutchinson, R Gordon, D Guay, R G Hill, C S Li, J Mancini, M Penneton. Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach.
The Journal of pharmacology and experimental therapeutics.
1995 Sep; 274(3):1531-7. doi:
NULL. [PMID: 7562530]