Pyridoxal isonicotinoyl hydrazone (BioDeep_00000841899)
代谢物信息卡片
化学式: C14H14N4O3 (286.1066)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=NC=C(C(=C1O)C=NNC(=O)C2=CC=NC=C2)CO
InChI: InChI=1S/C14H14N4O3/c1-9-13(20)12(11(8-19)6-16-9)7-17-18-14(21)10-2-4-15-5-3-10/h2-7,19-20H,8H2,1H3,(H,18,21)/b17-7+
描述信息
D064449 - Sequestering Agents > D002614 - Chelating Agents > D007502 - Iron Chelating Agents
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Hengli Zhang, Min Wen, Jiayu Chen, Chaojie Yao, Xiao Lin, Zhongxiao Lin, Junnan Ru, Qichuan Zhuge, Su Yang. Pyridoxal Isonicotinoyl Hydrazone Improves Neurological Recovery by Attenuating Ferroptosis and Inflammation in Cerebral Hemorrhagic Mice.
BioMed research international.
2021; 2021(?):9916328. doi:
10.1155/2021/9916328
. [PMID: 34541001] - Christopher Trent Brewer, Lei Yang, Anne Edwards, Yan Lu, Jonathan Low, Jing Wu, Richard E Lee, Taosheng Chen. The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis.
Toxicological sciences : an official journal of the Society of Toxicology.
2019 03; 168(1):209-224. doi:
10.1093/toxsci/kfy294
. [PMID: 30517741] - Ján Stariat, Petra Kovaríková, Jirí Klimes, David B Lovejoy, Danuta S Kalinowski, Des R Richardson. HPLC methods for determination of two novel thiosemicarbazone anti-cancer drugs (N4mT and Dp44mT) in plasma and their application to in vitro plasma stability of these agents.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Jan; 877(3):316-22. doi:
10.1016/j.jchromb.2008.11.044
. [PMID: 19097949] - Petra Kovaríková, Zlata Mrkvicková, Jirí Klimes. Investigation of the stability of aromatic hydrazones in plasma and related biological material.
Journal of pharmaceutical and biomedical analysis.
2008 Jun; 47(2):360-70. doi:
10.1016/j.jpba.2008.01.011
. [PMID: 18294799] - H Kaiserová, G J M den Hartog, T Simůnek, L Schröterová, E Kvasnicková, A Bast. Iron is not involved in oxidative stress-mediated cytotoxicity of doxorubicin and bleomycin.
British journal of pharmacology.
2006 Dec; 149(7):920-30. doi:
10.1038/sj.bjp.0706930
. [PMID: 17031387] - T Simůnek, I Klimtová, J Kaplanová, M Sterba, Y Mazurová, M Adamcová, R Hrdina, V Gersl, P Ponka. Study of daunorubicin cardiotoxicity prevention with pyridoxal isonicotinoyl hydrazone in rabbits.
Pharmacological research.
2005 Mar; 51(3):223-31. doi:
10.1016/j.phrs.2004.08.005
. [PMID: 15661572] - Joan L Buss, Jiri Neuzil, Prem Ponka. Oxidative stress mediates toxicity of pyridoxal isonicotinoyl hydrazone analogs.
Archives of biochemistry and biophysics.
2004 Jan; 421(1):1-9. doi:
10.1016/j.abb.2003.09.044
. [PMID: 14678779] - Joan L Buss, Prem Ponka. Hydrolysis of pyridoxal isonicotinoyl hydrazone and its analogs.
Biochimica et biophysica acta.
2003 Jan; 1619(2):177-86. doi:
10.1016/s0304-4165(02)00478-6
. [PMID: 12527114] - Joan L Buss, Emmanuele Arduini, Prem Ponka. Mobilization of intracellular iron by analogs of pyridoxal isonicotinoyl hydrazone (PIH) is determined by the membrane permeability of the iron-chelator complexes.
Biochemical pharmacology.
2002 Dec; 64(12):1689-701. doi:
10.1016/s0006-2952(02)01426-0
. [PMID: 12445858] - J L Buss, J Neuzil, P Ponka. The role of oxidative stress in the toxicity of pyridoxal isonicotinoyl hydrazone (PIH) analogues.
Biochemical Society transactions.
2002 Aug; 30(4):755-7. doi:
10.1042/bst0300755
. [PMID: 12196187] - M Adamcová, J Machácková, V Gersl, V Pelouch, T Simůnek, I Klimtová, R Hrdina, P Ponka. Cardiac troponin T following repeated administration of pyridoxal isonicotinoyl hydrazone in rabbits.
Physiological research.
2002; 51(5):443-8. doi:
NULL
. [PMID: 12470196] - Des R Richardson. Therapeutic potential of iron chelators in cancer therapy.
Advances in experimental medicine and biology.
2002; 509(?):231-49. doi:
10.1007/978-1-4615-0593-8_12
. [PMID: 12572997] - N C Santos, R F Castilho, A R Meinicke, M Hermes-Lima. The iron chelator pyridoxal isonicotinoyl hydrazone inhibits mitochondrial lipid peroxidation induced by Fe(II)-citrate.
European journal of pharmacology.
2001 Sep; 428(1):37-44. doi:
10.1016/s0014-2999(01)01291-2
. [PMID: 11779035] - M Hermes-Lima, P Ponka, H M Schulman. The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) and its analogues prevent damage to 2-deoxyribose mediated by ferric iron plus ascorbate.
Biochimica et biophysica acta.
2000 Oct; 1523(2-3):154-60. doi:
10.1016/s0304-4165(00)00115-x
. [PMID: 11042379] - M Hermes-Lima, N C Santos, J Yan, M Andrews, H M Schulman, P Ponka. EPR spin trapping and 2-deoxyribose degradation studies of the effect of pyridoxal isonicotinoyl hydrazone (PIH) on *OH formation by the Fenton reaction.
Biochimica et biophysica acta.
1999 Feb; 1426(3):475-82. doi:
10.1016/s0304-4165(98)00167-6
. [PMID: 10076064] - C R Chitambar, P Boon, J P Wereley. Evaluation of transferrin and gallium-pyridoxal isonicotinoyl hydrazone as potential therapeutic agents to overcome lymphoid leukemic cell resistance to gallium nitrate.
Clinical cancer research : an official journal of the American Association for Cancer Research.
1996 Jun; 2(6):1009-15. doi:
NULL
. [PMID: 9816262] - A Crowe, E H Morgan. Effects of chelators on iron uptake and release by the brain in the rat.
Neurochemical research.
1994 Jan; 19(1):71-6. doi:
10.1007/bf00966731
. [PMID: 8139766] - N Sookvanichsilp, S Nakornchai, W Weerapradist. Toxicological study of pyridoxal isonicotinoyl hydrazone: acute and subchronic toxicity.
Drug and chemical toxicology.
1991; 14(4):395-403. doi:
10.3109/01480549109011641
. [PMID: 1811960] - C R Chitambar, Z Zivkovic-Gilgenbach. Influence of cellular iron status on the release of soluble transferrin receptor from human promyelocytic leukemic HL60 cells.
The Journal of laboratory and clinical medicine.
1990 Sep; 116(3):345-53. doi:
NULL
. [PMID: 2401848] - E J Sanders, E Cheung. Transferrin and iron requirements of embryonic mesoderm cells cultured in hydrated collagen matrices.
In vitro cellular & developmental biology : journal of the Tissue Culture Association.
1988 Jun; 24(6):581-7. doi:
10.1007/bf02629094
. [PMID: 3391934] - T J Flynn, L Friedman, T N Black, N W Klein. Methionine and iron as growth factors for rat embryos cultured in canine serum.
The Journal of experimental zoology.
1987 Nov; 244(2):319-24. doi:
10.1002/jez.1402440216
. [PMID: 3430125] - M S Tsao, G H Sanders, J W Grisham. Regulation of growth of cultured hepatic epithelial cells by transferrin.
Experimental cell research.
1987 Jul; 171(1):52-62. doi:
10.1016/0014-4827(87)90250-3
. [PMID: 3305046] - J H Brock, J Stevenson. Replacement of transferrin in serum-free cultures of mitogen-stimulated mouse lymphocytes by a lipophilic iron chelator.
Immunology letters.
1987 May; 15(1):23-5. doi:
10.1016/0165-2478(87)90071-x
. [PMID: 3610230] - B K Kim, H A Huebers, C A Finch. Effectiveness of oral iron chelators assayed in the rat.
American journal of hematology.
1987 Mar; 24(3):277-84. doi:
10.1002/ajh.2830240307
. [PMID: 3826055] - W Landschulz, P Ekblom. Iron delivery during proliferation and differentiation of kidney tubules.
The Journal of biological chemistry.
1985 Dec; 260(29):15580-4. doi:
. [PMID: 4066687]
- W Landschulz, I Thesleff, P Ekblom. A lipophilic iron chelator can replace transferrin as a stimulator of cell proliferation and differentiation.
The Journal of cell biology.
1984 Feb; 98(2):596-601. doi:
10.1083/jcb.98.2.596
. [PMID: 6693498] - S Avramovici-Grisaru, S Sarel, G Link, C Hershko. Syntheses of iron bis(pyridoxal isonicotinoylhydrazone)s and the in vivo iron-removal properties of some pyridoxal derivatives.
Journal of medicinal chemistry.
1983 Feb; 26(2):298-302. doi:
10.1021/jm00356a037
. [PMID: 6827549] - M J Pippard, D K Johnson, C A Finch. A rapid assay for evaluation of iron-chelating agents in rats.
Blood.
1981 Oct; 58(4):685-92. doi:
NULL
. [PMID: 7272500] - M Cikrt, P Ponka, E Necas, J Neuwirt. Biliary iron excretion in rats following pyridoxal isonicotinoyl hydrazone.
British journal of haematology.
1980 Jun; 45(2):275-83. doi:
10.1111/j.1365-2141.1980.tb07147.x
. [PMID: 7437326]