EF-5 (BioDeep_00000841893)
代谢物信息卡片
化学式: C8H7F5N4O3 (302.0438292)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CN(C(=N1)[N+](=O)[O-])CC(=O)NCC(C(F)(F)F)(F)F
InChI: InChI=1S/C8H7F5N4O3/c9-7(10,8(11,12)13)4-15-5(18)3-16-2-1-14-6(16)17(19)20/h1-2H,3-4H2,(H,15,18)
描述信息
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents
D011838 - Radiation-Sensitizing Agents
D000970 - Antineoplastic Agents
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yoann Joyard, Rabah Azzouz, Laurent Bischoff, Cyril Papamicaël, Daniel Labar, Anne Bol, Vanessa Bol, Pierre Vera, Vincent Grégoire, Vincent Levacher, Pierre Bohn. Synthesis of new 18F-radiolabeled silicon-based nitroimidazole compounds.
Bioorganic & medicinal chemistry.
2013 Jul; 21(13):3680-8. doi:
10.1016/j.bmc.2013.04.029. [PMID: 23665140] - Lilie L Lin, Antti Silvoniemi, James B Stubbs, Ramesh Rengan, Sami Suilamo, Olof Solin, Chaitanya Divgi, Olli Eskola, Jonathan M Sorger, Michael G Stabin, Alexander Kachur, Stephen M Hahn, Tove J Grönroos, Sarita Forsback, Sydney M Evans, Cameron J Koch, Heikki Minn. Radiation dosimetry and biodistribution of the hypoxia tracer (18)F-EF5 in oncologic patients.
Cancer biotherapy & radiopharmaceuticals.
2012 Sep; 27(7):412-9. doi:
10.1089/cbr.2011.1130. [PMID: 22897720] - Olli Eskola, Tove J Grönroos, Sarita Forsback, Johanna Tuomela, Gaber Komar, Jörgen Bergman, Pirkko Härkönen, Merja Haaparanta, Heikki Minn, Olof Solin. Tracer level electrophilic synthesis and pharmacokinetics of the hypoxia tracer [(18)F]EF5.
Molecular imaging and biology.
2012 Apr; 14(2):205-12. doi:
10.1007/s11307-011-0484-4. [PMID: 21448777] - Johanna M U Silvola, Antti Saraste, Sarita Forsback, V Jukka O Laine, Pekka Saukko, Suvi E Heinonen, Seppo Ylä-Herttuala, Anne Roivainen, Juhani Knuuti. Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice.
Arteriosclerosis, thrombosis, and vascular biology.
2011 May; 31(5):1011-5. doi:
10.1161/atvbaha.110.221440. [PMID: 21372297] - Cameron J Koch, Joshua S Scheuermann, Chaitanya Divgi, Kevin D Judy, Alexander V Kachur, Richard Freifelder, Janet S Reddin, Joel Karp, James B Stubbs, Stephen M Hahn, Jason Driesbaugh, Deborah Smith, Susan Prendergast, Sydney M Evans. Biodistribution and dosimetry of (18)F-EF5 in cancer patients with preliminary comparison of (18)F-EF5 uptake versus EF5 binding in human glioblastoma.
European journal of nuclear medicine and molecular imaging.
2010 Nov; 37(11):2048-59. doi:
10.1007/s00259-010-1517-y. [PMID: 20585774] - Mingda Han, Patrizia Trotta, Carl Coleman, Kersti K Linask. MCT-4, A511/Basigin and EF5 expression patterns during early chick cardiomyogenesis indicate cardiac cell differentiation occurs in a hypoxic environment.
Developmental dynamics : an official publication of the American Association of Anatomists.
2006 Jan; 235(1):124-31. doi:
10.1002/dvdy.20531. [PMID: 16110503] - Daniel W Nelson, Hongbin Cao, Yonghua Zhu, Bulbin Sunar-Reeder, Clara Y H Choi, James D Faix, J Martin Brown, Albert C Koong, Amato J Giaccia, Quynh-Thu Le. A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia.
Cancer research.
2005 Jul; 65(14):6151-8. doi:
10.1158/0008-5472.can-04-2602. [PMID: 16024616] - L Nadal-Desbarats, H Poptani, P Oprysko, W T Jenkins, T M Busch, D S Nelson, J D Glickson, C J Koch, S M Evans. Effects of hyperglycemia on oxygenation, radiosensitivity and bioenergetic status of subcutaneous RIF-1 tumors.
International journal of oncology.
2002 Jul; 21(1):103-10. doi:
10.3892/ijo.21.1.103. [PMID: 12063556] - L S Ziemer, C J Koch, A Maity, D P Magarelli, A M Horan, S M Evans. Hypoxia and VEGF mRNA expression in human tumors.
Neoplasia (New York, N.Y.).
2001 Nov; 3(6):500-8. doi:
10.1038/sj.neo.7900195. [PMID: 11774032] - C J Koch, S M Hahn, K Rockwell, J M Covey, W G McKenna, S M Evans. Pharmacokinetics of EF5 [2-(2-nitro-1-H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide] in human patients: implications for hypoxia measurements in vivo by 2-nitroimidazoles.
Cancer chemotherapy and pharmacology.
2001 Sep; 48(3):177-87. doi:
10.1007/s002800100324. [PMID: 11592338] - W R Dolbier, A R Li, C J Koch, C Y Shiue, A V Kachur. [18F]-EF5, a marker for PET detection of hypoxia: synthesis of precursor and a new fluorination procedure.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2001 Jan; 54(1):73-80. doi:
10.1016/s0969-8043(00)00102-0. [PMID: 11144255] - A P Meeson, M Argilla, K Ko, L Witte, R A Lang. VEGF deprivation-induced apoptosis is a component of programmed capillary regression.
Development (Cambridge, England).
1999 Apr; 126(7):1407-15. doi:
10.1242/dev.126.7.1407. [PMID: 10068634]