Xanthine amine congener (BioDeep_00000841886)
代谢物信息卡片
Xanthine amine congener
化学式: C21H28N6O4 (428.2171928)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3=CC=C(C=C3)OCC(=O)NCCN
InChI: InChI=1S/C21H28N6O4/c1-3-11-26-19-17(20(29)27(12-4-2)21(26)30)24-18(25-19)14-5-7-15(8-6-14)31-13-16(28)23-10-9-22/h5-8H,3-4,9-13,22H2,1-2H3,(H,23,28)(H,24,25)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Romain Duroux, Antonella Ciancetta, Philip Mannes, Jinha Yu, Shireesha Boyapati, Elizabeth Gizewski, Said Yous, Francisco Ciruela, John A Auchampach, Zhan-Guo Gao, Kenneth A Jacobson. Bitopic fluorescent antagonists of the A2A adenosine receptor based on pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine functionalized congeners.
MedChemComm.
2017 Aug; 8(8):1659-1667. doi:
10.1039/c7md00247e. [PMID: 29250307] - Eszter Kozma, P Suresh Jayasekara, Lucia Squarcialupi, Silvia Paoletta, Stefano Moro, Stephanie Federico, Giampiero Spalluto, Kenneth A Jacobson. Fluorescent ligands for adenosine receptors.
Bioorganic & medicinal chemistry letters.
2013 Jan; 23(1):26-36. doi:
10.1016/j.bmcl.2012.10.112. [PMID: 23200243] - S J Briddon, R J Middleton, Y Cordeaux, F M Flavin, J A Weinstein, M W George, B Kellam, S J Hill. Quantitative analysis of the formation and diffusion of A1-adenosine receptor-antagonist complexes in single living cells.
Proceedings of the National Academy of Sciences of the United States of America.
2004 Mar; 101(13):4673-8. doi:
10.1073/pnas.0400420101. [PMID: 15070776] - K A Jacobson, Z G Gao, A Chen, D Barak, S A Kim, K Lee, A Link, P V Rompaey, S van Calenbergh, B T Liang. Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides.
Journal of medicinal chemistry.
2001 Nov; 44(24):4125-36. doi:
10.1021/jm010232o. [PMID: 11708915] - X Ji, Y C Kim, D G Ahern, J Linden, K A Jacobson. [3H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors.
Biochemical pharmacology.
2001 Mar; 61(6):657-63. doi:
10.1016/s0006-2952(01)00531-7. [PMID: 11266650] - Y C Kim, X Ji, N Melman, J Linden, K A Jacobson. Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors.
Journal of medicinal chemistry.
2000 Mar; 43(6):1165-72. doi:
10.1021/jm990421v. [PMID: 10737749] - X D Ji, K A Jacobson. Use of the triazolotriazine [3H]ZM 241385 as a radioligand at recombinant human A2B adenosine receptors.
Drug design and discovery.
1999 Nov; 16(3):217-26. doi:
NULL. [PMID: 10624567] - J Linden, T Thai, H Figler, X Jin, A S Robeva. Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.
Molecular pharmacology.
1999 Oct; 56(4):705-13. doi:
NULL. [PMID: 10496952] - S Takasuga, T Katada, M Ui, O Hazeki. Enhancement by adenosine of insulin-induced activation of phosphoinositide 3-kinase and protein kinase B in rat adipocytes.
The Journal of biological chemistry.
1999 Jul; 274(28):19545-50. doi:
10.1074/jbc.274.28.19545. [PMID: 10391887] - D B Pearse, T E Dahms, E M Wagner. Microsphere-induced bronchial artery vasodilation: role of adenosine, prostacyclin, and nitric oxide.
The American journal of physiology.
1998 03; 274(3):H760-8. doi:
10.1152/ajpheart.1998.274.3.h760. [PMID: 9530186] - J Kim, J Wess, A M van Rhee, T Schöneberg, K A Jacobson. Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor.
The Journal of biological chemistry.
1995 Jun; 270(23):13987-97. doi:
10.1074/jbc.270.23.13987. [PMID: 7775460] - C F Neely, I M Keith. A1 adenosine receptor antagonists block ischemia-reperfusion injury of the lung.
The American journal of physiology.
1995 Jun; 268(6 Pt 1):L1036-46. doi:
10.1152/ajplung.1995.268.6.l1036. [PMID: 7611426] - H O Kim, X D Ji, N Melman, M E Olah, G L Stiles, K A Jacobson. Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.
Journal of medicinal chemistry.
1994 Sep; 37(20):3373-82. doi:
10.1021/jm00046a022. [PMID: 7932565] - N A Ismail, A A Shaheen, M M el-Sawalhi, Y M Megahed. Combined effect of adenosine, alpha adrenergic and adenosine antagonists on serum insulin and insulin secretion from rat pancreatic islets.
The International journal of biochemistry.
1994 Mar; 26(3):381-6. doi:
10.1016/0020-711x(94)90058-2. [PMID: 8187934] - F Suzuki, J Shimada, H Mizumoto, A Karasawa, K Kubo, H Nonaka, A Ishii, T Kawakita. Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.
Journal of medicinal chemistry.
1992 Aug; 35(16):3066-75. doi:
10.1021/jm00094a022. [PMID: 1501234] - K A Jacobson, G L Stiles, X D Ji. Chemical modification and irreversible inhibition of striatal A2a adenosine receptors.
Molecular pharmacology.
1992 Jul; 42(1):123-33. doi:
NULL. [PMID: 1635550] - X D Ji, G L Stiles, P J van Galen, K A Jacobson. Characterization of human striatal A2-adenosine receptors using radioligand binding and photoaffinity labeling.
Journal of receptor research.
1992; 12(2):149-69. doi:
10.3109/10799899209074789. [PMID: 1583620] - M Freissmuth, E Selzer, W Schütz. Interactions of purified bovine brain A1-adenosine receptors with G-proteins. Reciprocal modulation of agonist and antagonist binding.
The Biochemical journal.
1991 May; 275 ( Pt 3)(?):651-6. doi:
10.1042/bj2750651. [PMID: 1903924] - S Barone, P C Churchill, K A Jacobson. Adenosine receptor prodrugs: towards kidney-selective dialkylxanthines.
The Journal of pharmacology and experimental therapeutics.
1989 Jul; 250(1):79-85. doi:
NULL. [PMID: 2746513] - P C Churchill, K A Jacobson, M C Churchill. XAC, a functionalized congener of 1,3-dialkylxanthine, antagonizes A1 adenosine receptor-mediated inhibition of renin secretion in vitro.
Archives internationales de pharmacodynamie et de therapie.
1987 Dec; 290(2):293-301. doi:
NULL. [PMID: 3328570] - N F Rossi, P C Churchill, K A Jacobson, A E Leahy. Further characterization of the renovascular effects of N6-cyclohexyladenosine in the isolated perfused rat kidney.
The Journal of pharmacology and experimental therapeutics.
1987 Mar; 240(3):911-5. doi:
NULL. [PMID: 3559983]