U0126 (BioDeep_00000841884)

   


代谢物信息卡片


1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene

化学式: C18H16N6S2 (380.0878)
中文名称: 1,4-二氨基-2,3-二氰基-1,4-双(邻氨基苯巯基)丁二烯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N
InChI: InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+

描述信息

C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C2149 - Mitogen-Activated Protein Kinase Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
D004791 - Enzyme Inhibitors
U0126 is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC50s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor[1][2][3][4].

同义名列表

2 个代谢物同义名

1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene; U0126



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Xiongfei Zhang, Jianping Chen, Beili Xi, Yutong Liu, Shaojun Wang, Ling Gu, Huanhuan Zhao, Li Tao, Yang Hua, Yan Wang, Meijuan Chen. Agrimoniin is a dual inhibitor of AKT and ERK pathways that inhibit pancreatic cancer cell proliferation. Phytotherapy research : PTR. 2023 May; ?(?):. doi: 10.1002/ptr.7867. [PMID: 37156642]
  • Liang Shao, Yan Yan, Nansu Wang, Qiongfang Tan, Yuying Huang, Lei Lei, Dongmei Yang, Ling Liu. Betulonic acid regulates oviduct epithelial cell inflammation through the TLR4, MAPK, and JAK/STAT signalling pathways. Reproduction, fertility, and development. 2023 May; 35(8):480-491. doi: 10.1071/rd21380. [PMID: 37142241]
  • Yanli Liu, Xia Gong, Juan Wang, Yongxiang Wang, Yong Zhang, Tao Li, Juan Yan, Min Zhou, Benzhong Zhang. Investigation of nickel sulfate-induced cytotoxicity and underlying toxicological mechanisms in human umbilical vein endothelial cells through oxidative stress, inflammation, apoptosis, and MAPK signaling pathways. Environmental toxicology. 2022 Aug; 37(8):2058-2071. doi: 10.1002/tox.23550. [PMID: 35499276]
  • Jihye Kim, Epameinondas Gousopoulos, Teresa M Faleschini, Matthias Hamburger, Olivier Potterat, Michael Detmar. Pheophorbide a identified in an Eupatorium perfoliatum extract is a novel lymphatic vascular activator. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Mar; 147(?):112664. doi: 10.1016/j.biopha.2022.112664. [PMID: 35131655]
  • Yong-Yun Zhu, Ying-Chun Zhao, Chuang Chen, Min Xie. CCL5 secreted by luminal B breast cancer cells induces polarization of M2 macrophages through activation of MEK/STAT3 signaling pathway via CCR5. Gene. 2022 Feb; 812(?):146100. doi: 10.1016/j.gene.2021.146100. [PMID: 34864094]
  • Yonghui Hou, Bingyu Zhou, Ming Ni, Min Wang, Lingli Ding, Ying Li, Yamei Liu, Wencai Zhang, Gang Li, Jiali Wang, Liangliang Xu. Nonwoven-based gelatin/polycaprolactone membrane loaded with ERK inhibitor U0126 for treatment of tendon defects. Stem cell research & therapy. 2022 01; 13(1):5. doi: 10.1186/s13287-021-02679-x. [PMID: 35012661]
  • Ziyin Li, Huiqin Chi, Wei Zhu, Guangyu Yang, Jia Song, Lijun Mo, Yitian Zhang, Yudi Deng, Feifei Xu, Jiani Yang, Zhini He, Xingfen Yang. Cadmium induces renal inflammation by activating the NLRP3 inflammasome through ROS/MAPK/NF-κB pathway in vitro and in vivo. Archives of toxicology. 2021 Nov; 95(11):3497-3513. doi: 10.1007/s00204-021-03157-2. [PMID: 34510229]
  • Ken Shirato, Jun Takanari, Takako Kizaki. Standardized Extract of Asparagus officinalis Stem Attenuates SARS-CoV-2 Spike Protein-Induced IL-6 and IL-1β Production by Suppressing p44/42 MAPK and Akt Phosphorylation in Murine Primary Macrophages. Molecules (Basel, Switzerland). 2021 Oct; 26(20):. doi: 10.3390/molecules26206189. [PMID: 34684771]
  • Myriam Mireault, Yong Xiao, Benoît Barbeau, Catherine Jumarie. Cadmium affects autophagy in the human intestinal cells Caco-2 through ROS-mediated ERK activation. Cell biology and toxicology. 2021 Sep; ?(?):. doi: 10.1007/s10565-021-09655-4. [PMID: 34580807]
  • Bharath Kumar Velmurugan, Jen-Tsun Lin, B Mahalakshmi, Chia-Chieh Lin, Yi-Ching Chuang, Yu-Sheng Lo, Hsin-Yu Ho, Ming-Ju Hsieh, Mu-Kuan Chen. Dehydrocrenatidine inhibits head and neck cancer cells invasion and migration by modulating JNK1/2 and ERK1/2 pathway and decreases MMP-2 expression. Environmental toxicology. 2021 Sep; 36(9):1848-1856. doi: 10.1002/tox.23305. [PMID: 34076342]
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  • Yutaka Gomita, Satoru Esumi, Soichiro Ushio, Yoshihisa Kitamura, Toshiaki Sendo, Hirotoshi Motoda, Shigeki Inoue, Hiroaki Araki, Yoshio Kano. Intracranial self-stimulation-reward or immobilization-aversion had different effects on neurite extension and the ERK pathway in neurotransmitter-sensitive mutant PC12 cells. Behavioural brain research. 2021 01; 396(?):112920. doi: 10.1016/j.bbr.2020.112920. [PMID: 32961216]
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  • Dongya Chai, Jiaqi Yuan, Xiang Zhu, Yueqin Zeng, Rongrong Yang, Yingjie Chen, Yuehu Wang, Yiping Zhou. Total Saponins from Paris forrestii Reverse Multidrug Resistance of MCF-7/ADM Cells by Suppression of P-gp via ERK Signaling Pathway. Biological & pharmaceutical bulletin. 2020 Dec; 43(12):1823-1830. doi: 10.1248/bpb.b20-00014. [PMID: 32963175]
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  • Consuelo Mori, Ángel G Valdivieso, Mariángeles Clauzure, María M Massip-Copiz, María Á Aguilar, Eduardo G A Cafferata, Tomás A Santa Coloma. Identification and characterization of human PEIG-1/GPRC5A as a 12-O-tetradecanoyl phorbol-13-acetate (TPA) and PKC-induced gene. Archives of biochemistry and biophysics. 2020 07; 687(?):108375. doi: 10.1016/j.abb.2020.108375. [PMID: 32339486]
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  • Zhenhua Fu, Lan Lin, Shiquan Liu, Mengbin Qin, Siwei He, Liye Zhu, Jiean Huang. Ginkgo Biloba Extract Inhibits Metastasis and ERK/Nuclear Factor kappa B (NF-κB) Signaling Pathway in Gastric Cancer. Medical science monitor : international medical journal of experimental and clinical research. 2019 Sep; 25(?):6836-6845. doi: 10.12659/msm.915146. [PMID: 31509521]
  • Yan Chen, Lin Chen, Duanyang Hong, Zongyue Chen, Jingyu Zhang, Lingyun Fu, Di Pan, Yanyan Zhang, Yini Xu, Shiquan Gan, Chaoda Xiao, Ling Tao, Xiangchun Shen. Baicalein inhibits fibronectin-induced epithelial-mesenchymal transition by decreasing activation and upregulation of calpain-2. Cell death & disease. 2019 04; 10(5):341. doi: 10.1038/s41419-019-1572-7. [PMID: 31000696]
  • Min Tao, Yingfeng Shi, Lunxian Tang, Yi Wang, Lu Fang, Wei Jiang, Tao Lin, Andong Qiu, Shougang Zhuang, Na Liu. Blockade of ERK1/2 by U0126 alleviates uric acid-induced EMT and tubular cell injury in rats with hyperuricemic nephropathy. American journal of physiology. Renal physiology. 2019 04; 316(4):F660-F673. doi: 10.1152/ajprenal.00480.2018. [PMID: 30648910]
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  • Hyun-Keun Kim, Seonung Lim, Min-Jung Bae, Wonwoo Lee, Sunyoung Kim. PG102 Upregulates IL-37 through p38, ERK, and Smad3 Pathways in HaCaT Keratinocytes. Mediators of inflammation. 2019; 2019(?):6085801. doi: 10.1155/2019/6085801. [PMID: 30918469]
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  • Ting Wang, Hang Ouyang, Hong Zhou, Longfei Xia, Xiaoyan Wang, Ting Wang. Pro‑atherogenic activation of A7r5 cells induced by the oxLDL/β2GPI/anti‑β2GPI complex. International journal of molecular medicine. 2018 Oct; 42(4):1955-1966. doi: 10.3892/ijmm.2018.3805. [PMID: 30085340]
  • Tongwang Luo, Huiyan Zhang, Qi Yu, Gang Liu, Mengfei Long, Kanglei Zhang, Wei Liu, Ruilong Song, Jianchun Bian, Jianhong Gu, Hui Zou, Xuezhong Liu, Yan Yuan, Zongping Liu. ERK1/2 MAPK promotes autophagy to suppress ER stress-mediated apoptosis induced by cadmium in rat proximal tubular cells. Toxicology in vitro : an international journal published in association with BIBRA. 2018 Oct; 52(?):60-69. doi: 10.1016/j.tiv.2018.06.001. [PMID: 29870746]
  • Xiaozhao Li, Chunyu Bao, Zhinan Ma, Boqun Xu, Xiaoyan Ying, Xiaoqiu Liu, Xuesen Zhang. Perfluorooctanoic acid stimulates ovarian cancer cell migration, invasion via ERK/NF-κB/MMP-2/-9 pathway. Toxicology letters. 2018 Sep; 294(?):44-50. doi: 10.1016/j.toxlet.2018.05.009. [PMID: 29753068]
  • Marie-Christin Schulz, Luise Schumann, Ulrike Rottkord, Hans-Ulrich Humpf, Michael Gekle, Gerald Schwerdt. Synergistic action of the nephrotoxic mycotoxins ochratoxin A and citrinin at nanomolar concentrations in human proximal tubule-derived cells. Toxicology letters. 2018 Jul; 291(?):149-157. doi: 10.1016/j.toxlet.2018.04.014. [PMID: 29673704]
  • Tao Chen, Kai Bi, Yanli Zhao, Xueliang Lyu, Zhixiao Gao, Ying Zhao, Yanping Fu, Jiasen Cheng, Jiatao Xie, Daohong Jiang. MAPKK Inhibitor U0126 Inhibits Plasmodiophora brassicae Development. Phytopathology. 2018 Jun; 108(6):711-720. doi: 10.1094/phyto-07-17-0240-r. [PMID: 29381451]
  • Xiaoqi Pan, Xu Wu, Dandan Yan, Cheng Peng, Chaolong Rao, Hong Yan. Acrylamide-induced oxidative stress and inflammatory response are alleviated by N-acetylcysteine in PC12 cells: Involvement of the crosstalk between Nrf2 and NF-κB pathways regulated by MAPKs. Toxicology letters. 2018 May; 288(?):55-64. doi: 10.1016/j.toxlet.2018.02.002. [PMID: 29426002]
  • Changjuan Shan, Haili Sun. Jasmonic acid-induced NO activates MEK1/2 in regulating the metabolism of ascorbate and glutathione in maize leaves. Protoplasma. 2018 May; 255(3):977-983. doi: 10.1007/s00709-017-1183-z. [PMID: 29138938]
  • Zhonghua Wang, Aijun Jiang, Jingwei Mei, Xinyan Zhang. 1α,25(OH)2-Vitamin D3 Inhibits C2C12 Cell Differentiation by Activating c-Src and ERK1/2. Clinical laboratory. 2018 May; 64(5):687-698. doi: 10.7754/clin.lab.2017.171016. [PMID: 29739041]
  • Chih-Yuan Fang, Ching-Zong Wu, Pei-Ni Chen, Yu-Chao Chang, Chun-Yi Chuang, Chih-Ting Lai, Shun-Fa Yang, Lo-Lin Tsai. Antimetastatic potentials of salvianolic acid A on oral squamous cell carcinoma by targeting MMP-2 and the c-Raf/MEK/ERK pathway. Environmental toxicology. 2018 May; 33(5):545-554. doi: 10.1002/tox.22542. [PMID: 29385302]
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