N-Hydroxybenzenecarboximidamide (BioDeep_00000841880)
代谢物信息卡片
化学式: C7H8N2O (136.0637)
中文名称: 苄氨肟
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)C(=NO)N
InChI: InChI=1S/C7H8N2O/c8-7(9-10)6-4-2-1-3-5-6/h1-5,10H,(H2,8,9)
描述信息
A member of the class of amidoximes obtained by formal condensation of the carbonyl group of benzamide with hydroxylamine.
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:83354
- PubChem: 7259353
- ChEMBL: CHEMBL335598
- CAS: 69289-27-6
- CAS: 613-92-3
- MetaboLights: MTBLC83354
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Takayuki Shibata, Ryosuke Shimamura, Yuji Yamamoto, Hiroki Sakurai, Junya Fujita, Asako Yamayoshi, Toshimitsu Nemoto, Tsutomu Kabashima. A Facile Method for the Quantification of Urinary Uracil Concentration by a Uracil-Specific Fluorescence Derivatization Reaction.
Chemical & pharmaceutical bulletin.
2021; 69(8):768-772. doi:
10.1248/cpb.c21-00221
. [PMID: 34334520] - Gudrun Ott, Debora Reichmann, Cornelia Boerger, Ingolf Cascorbi, Florian Bittner, Ralf-Rainer Mendel, Thomas Kunze, Bernd Clement, Antje Havemeyer. Functional characterization of protein variants encoded by nonsynonymous single nucleotide polymorphisms in MARC1 and MARC2 in healthy Caucasians.
Drug metabolism and disposition: the biological fate of chemicals.
2014 Apr; 42(4):718-25. doi:
10.1124/dmd.113.055202
. [PMID: 24423752] - Heyka H Jakobs, Michal Mikula, Antje Havemeyer, Adriana Strzalkowska, Monika Borowa-Chmielak, Artur Dzwonek, Marta Gajewska, Ewa E Hennig, Jerzy Ostrowski, Bernd Clement. The N-reductive system composed of mitochondrial amidoxime reducing component (mARC), cytochrome b5 (CYB5B) and cytochrome b5 reductase (CYB5R) is regulated by fasting and high fat diet in mice.
PloS one.
2014; 9(8):e105371. doi:
10.1371/journal.pone.0105371
. [PMID: 25144769] - Nina Krompholz, Carmen Krischkowski, Debora Reichmann, Dieter Garbe-Schönberg, Ralf-R Mendel, Florian Bittner, Bernd Clement, Antje Havemeyer. The mitochondrial Amidoxime Reducing Component (mARC) is involved in detoxification of N-hydroxylated base analogues.
Chemical research in toxicology.
2012 Nov; 25(11):2443-50. doi:
10.1021/tx300298m
. [PMID: 22924387] - Christiane Reeh, Judith Wundt, Bernd Clement. N,N'-dihydroxyamidines: a new prodrug principle to improve the oral bioavailability of amidines.
Journal of medicinal chemistry.
2007 Dec; 50(26):6730-4. doi:
10.1021/jm701259d
. [PMID: 18052320] - Bernd Clement, Sabine Mau, Stephanie Deters, Antje Havemeyer. Hepatic, extrahepatic, microsomal, and mitochondrial activation of the N-hydroxylated prodrugs benzamidoxime, guanoxabenz, and Ro 48-3656 ([[1-[(2s)-2-[[4-[(hydroxyamino)iminomethyl]benzoyl]amino]-1-oxopropyl]-4-piperidinyl]oxy]-acetic acid).
Drug metabolism and disposition: the biological fate of chemicals.
2005 Nov; 33(11):1740-7. doi:
10.1124/dmd.105.005249
. [PMID: 16118330] - Susanne Andersson, Yvonne Hofmann, Asa Nordling, Xue-qing Li, Sabina Nivelius, Tommy B Andersson, Magnus Ingelman-Sundberg, Inger Johansson. Characterization and partial purification of the rat and human enzyme systems active in the reduction of N-hydroxymelagatran and benzamidoxime.
Drug metabolism and disposition: the biological fate of chemicals.
2005 Apr; 33(4):570-8. doi:
10.1124/dmd.104.002972
. [PMID: 15640373] - B Clement, M Immel, S Schmitt, U Steinmann. Biotransformation of benzamidine and benzamidoxime in vivo.
Archiv der Pharmazie.
1993 Oct; 326(10):807-12. doi:
10.1002/ardp.19933261008
. [PMID: 8267515]