Rolafagrel (BioDeep_00000841875)
代谢物信息卡片
化学式: C14H12N2O2 (240.0899)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(=CC2=C1C=CC(=C2)C(=O)O)N3C=CN=C3
InChI: InChI=1S/C14H12N2O2/c17-14(18)11-2-1-10-3-4-13(8-12(10)7-11)16-6-5-15-9-16/h1-2,5-9H,3-4H2,(H,17,18)
描述信息
C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent
C471 - Enzyme Inhibitor
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- P Salvati, E Lamberti, R Ferrario, R G Ferrario, G Scampini, F Pugliese, P Barsotti, C Patrono. Long-term thromboxane-synthase inhibition prolongs survival in murine lupus nephritis.
Kidney international.
1995 Apr; 47(4):1168-75. doi:
10.1038/ki.1995.166. [PMID: 7783415] - P Tarugi, S Nicolini, L Albertazzi, L Marchi, S Calandra, P Salvati. The effect of a thromboxane A2 synthase inhibitor on the dyslipoproteinemia of an inbred rat strain with spontaneous age-related nephrotic syndrome.
Aging (Milan, Italy).
1994 Oct; 6(5):381-90. doi:
10.1007/bf03324269. [PMID: 7893785] - G Gatti, A Bartoli, D Bertin, M Strolin-Benedetti, E Perucca. Pharmacokinetic and pharmacodynamic studies following single and multiple doses of rolafagrel, a novel inhibitor of thromboxane synthase, in normal volunteers.
European journal of clinical pharmacology.
1994; 47(3):275-80. doi:
10.1007/bf02570508. [PMID: 7867681] - R C Li, D T Rossi, P K Narang. Concentration-dependent protein binding of a novel oral thromboxane synthase inhibitor--FCE 22,178.
Journal of clinical pharmacology.
1993 Oct; 33(10):933-5. doi:
10.1002/j.1552-4604.1993.tb01925.x. [PMID: 8227464] - R C Li, P K Narang, R C Lewis, N Z Hatfield, D T Rossi, D C Colborn. A phase I dose-ranging safety and pharmacokinetics study of a novel oral thromboxane synthase inhibitor, FCE 22, 178.
Journal of clinical pharmacology.
1993 Apr; 33(4):373-80. doi:
10.1002/j.1552-4604.1993.tb04672.x. [PMID: 8473553] - P S Kontessis, S L Jones, S E Barrow, P D Stratton, P Alessandrini, S De Cosmo, J M Ritter, G C Viberti. Effect of selective inhibition of thromboxane synthesis on renal function in diabetic nephropathy.
The Journal of laboratory and clinical medicine.
1993 Mar; 121(3):415-23. doi:
. [PMID: 8445289] - J Thomassin, R Battaglia, C Allievi, M G Castelli, M Strolin Benedetti. In vivo glucuronidation in rat and humans of 5,6-dihydro-7-(1H-imidazol-1-yl)-naphthalene-2-carboxylic acid, a selective inhibitor of thromboxane synthase.
Drug metabolism and disposition: the biological fate of chemicals.
1993 Jan; 21(1):151-5. doi:
NULL. [PMID: 8095210] - P Alessandrini, P Salvati, F Pugliese, G Ciabattoni, C Patrono. Inhibition by FCE 22178 of platelet and glomerular thromboxane synthase in animal and human kidney disease.
Advances in prostaglandin, thromboxane, and leukotriene research.
1991; 21B(?):707-10. doi:
NULL. [PMID: 1825400] - C Zoja, N Perico, D Corna, A Benigni, M Gabanelli, M Morigi, T Bertani, G Remuzzi. Thromboxane synthesis inhibition increases renal prostacyclin and prevents renal disease progression in rats with remnant kidney.
Journal of the American Society of Nephrology : JASN.
1990 Nov; 1(5):799-807. doi:
10.1681/asn.v15799. [PMID: 2133429] - P Salvati, C Ferti, R G Ferrario, E Lamberti, L Duzzi, G Bianchi, G Remuzzi, N Perico, A Benigni, P Braidotti. Role of enhanced glomerular synthesis of thromboxane A2 in progressive kidney disease.
Kidney international.
1990 Sep; 38(3):447-58. doi:
10.1038/ki.1990.225. [PMID: 2232487]
