Palonosetron, (3aR)- (BioDeep_00000841838)
代谢物信息卡片
Palonosetron, (3aR)-
化学式: C19H24N2O (296.18885339999997)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC2CN(C(=O)C3=CC=CC(=C23)C1)C4CN5CCC4CC5
InChI: InChI=1S/C19H24N2O/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20/h2,4,6,13,15,17H,1,3,5,7-12H2/t15-,17+/m0/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Pengfei Li, Ping Ma, Yan Wang, Weihang Tong, Jing Wang, Cheng Wu, Lihong Liu. Liquid chromatography-electrospray quadrupole linear ion trap mass spectrometry method for the quantitation of palonosetron in human plasma and urine: Application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 May; 895-896(?):10-6. doi:
10.1016/j.jchromb.2012.03.001. [PMID: 22465199] - U Dogan, G Yavas, M Tekinalp, C Yavas, O Y Ata, K Ozdemir. Evaluation of the acute effect of palonosetron on transmural dispersion of myocardial repolarization.
European review for medical and pharmacological sciences.
2012 Apr; 16(4):462-8. doi:
NULL. [PMID: 22696873] - Woon-Seok Kang, Sung-Yun Kim, Jong-Chan Son, Ju-Deok Kim, Hasmizy Bin Muhammad, Seong-Hyop Kim, Tae-Gyoon Yoon, Tae-Yop Kim. The effect of dexmedetomidine on the adjuvant propofol requirement and intraoperative hemodynamics during remifentanil-based anesthesia.
Korean journal of anesthesiology.
2012 Feb; 62(2):113-8. doi:
10.4097/kjae.2012.62.2.113. [PMID: 22379564] - Shuyan Yang, Feng Qin, Dan Wang, Ning Li, Famei Li, Zhili Xiong. Determination of palonosetron in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2012 Jan; 57(?):13-8. doi:
10.1016/j.jpba.2011.08.038. [PMID: 21937184] - Synia Haub, Yvonne Ritze, Inga Ladel, Karolin Saum, Astrid Hubert, Astrid Spruss, Christian Trautwein, Stephan C Bischoff. Serotonin receptor type 3 antagonists improve obesity-associated fatty liver disease in mice.
The Journal of pharmacology and experimental therapeutics.
2011 Dec; 339(3):790-8. doi:
10.1124/jpet.111.181834. [PMID: 21903748] - Seong-Bae Hwang, Hye-Yoon Lee, Hoon-Yub Kim, Eun-Sook Lee, Jeoung-Won Bae. Life-threatening acute hyponatremia with generalized seizure induced by low-dose cyclophosphamide in a patient with breast cancer.
Journal of breast cancer.
2011 Dec; 14(4):345-8. doi:
10.4048/jbc.2011.14.4.345. [PMID: 22323925] - Toshiaki Takahashi, Yukiko Nakamura, Asuka Tsuya, Haruyasu Murakami, Masahiro Endo, Nobuyuki Yamamoto. Pharmacokinetics of aprepitant and dexamethasone after administration of chemotherapeutic agents and effects of plasma substance P concentration on chemotherapy-induced nausea and vomiting in Japanese cancer patients.
Cancer chemotherapy and pharmacology.
2011 Sep; 68(3):653-9. doi:
10.1007/s00280-010-1519-2. [PMID: 21125277] - Yuanyuan Wang, Yongqing Wang, Peipei Zhang, Zhihong Lu, Ying Gu, Ning Ou. Determination of palonosetron in human urine by LC-MS/MS.
Bioanalysis.
2011 Jun; 3(12):1337-42. doi:
10.4155/bio.11.110. [PMID: 21679028] - Tetsuro Ohno, Mitsuhiro Yanai, Hiroyuki Ando, Yoshitaka Toyomasu, Atsushi Ogawa, Hiroki Morita, Kyoichi Ogata, Erito Mochiki, Takayuki Asao, Hiroyuki Kuwano. Rikkunshito, a traditional Japanese medicine, suppresses cisplatin-induced anorexia in humans.
Clinical and experimental gastroenterology.
2011; 4(?):291-6. doi:
10.2147/ceg.s26297. [PMID: 22235173] - Albert Tuca. Use of granisetron transdermal system in the prevention of chemotherapy-induced nausea and vomiting: a review.
Cancer management and research.
2009 Dec; 2(?):1-12. doi:
10.2147/cmar.s4953. [PMID: 21188092] - Mitsue Saito, Kenjiro Aogi, Ikuo Sekine, Hirohisa Yoshizawa, Yasuhiro Yanagita, Hiroshi Sakai, Kenichi Inoue, Chiyoe Kitagawa, Takashi Ogura, Shoichi Mitsuhashi. Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy: a double-blind, double-dummy, randomised, comparative phase III trial.
The Lancet. Oncology.
2009 Feb; 10(2):115-24. doi:
10.1016/s1470-2045(08)70313-9. [PMID: 19135415] - Ian N Olver. Prevention of chemotherapy-induced nausea and vomiting: focus on fosaprepitant.
Therapeutics and clinical risk management.
2008 Apr; 4(2):501-6. doi:
10.2147/tcrm.s2345. [PMID: 18728837] - Y F Li, S Fu, W Hu, J H Liu, K W Finkel, D M Gershenson, J J Kavanagh. Systemic anticancer therapy in gynecological cancer patients with renal dysfunction.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society.
2007 Jul; 17(4):739-63. doi:
10.1111/j.1525-1438.2007.00847.x. [PMID: 17309673] - Li Ding, Yan Chen, Lin Yang, Aidong Wen. Determination of palonosetron in human plasma by liquid chromatography-electrospray ionization-mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2007 Jun; 44(2):575-80. doi:
10.1016/j.jpba.2006.10.019. [PMID: 17127028] - Ajit Shah, Timothy DeGroot, Glen Apseloff. Pharmacokinetic evaluation and safety profile of a 15-minute versus 30-second infusion of palonosetron in healthy subjects.
Journal of clinical pharmacology.
2006 Oct; 46(10):1139-45. doi:
10.1177/0091270006291625. [PMID: 16988202] - Thomas L Hunt, Susan C Gallagher, Michael T Cullen, Ajit K Shah. Evaluation of safety and pharmacokinetics of consecutive multiple-day dosing of palonosetron in healthy subjects.
Journal of clinical pharmacology.
2005 May; 45(5):589-96. doi:
10.1177/0091270005275061. [PMID: 15831783] - Ajit K Shah, Thomas L Hunt, Susan C Gallagher, Michael T Cullen. Pharmacokinetics of palonosetron in combination with aprepitant in healthy volunteers.
Current medical research and opinion.
2005 Apr; 21(4):595-601. doi:
10.1185/030079905x40481. [PMID: 15899109] - Matti Aapro. 5-HT(3)-receptor antagonists in the management of nausea and vomiting in cancer and cancer treatment.
Oncology.
2005; 69(2):97-109. doi:
10.1159/000087979. [PMID: 16131816] - Randall Stoltz, Simona Parisi, Ajit Shah, Alberto Macciocchi. Pharmacokinetics, metabolism and excretion of intravenous [l4C]-palonosetron in healthy human volunteers.
Biopharmaceutics & drug disposition.
2004 Nov; 25(8):329-37. doi:
10.1002/bdd.410. [PMID: 15378559] - Randall Stoltz, Jong-Chol Cyong, Ajit Shah, Simona Parisi. Pharmacokinetic and safety evaluation of palonosetron, a 5-hydroxytryptamine-3 receptor antagonist, in U.S. and Japanese healthy subjects.
Journal of clinical pharmacology.
2004 May; 44(5):520-31. doi:
10.1177/0091270004264641. [PMID: 15102873] - P Eisenberg, F R MacKintosh, P Ritch, P A Cornett, A Macciocchi. Efficacy, safety and pharmacokinetics of palonosetron in patients receiving highly emetogenic cisplatin-based chemotherapy: a dose-ranging clinical study.
Annals of oncology : official journal of the European Society for Medical Oncology.
2004 Feb; 15(2):330-7. doi:
10.1093/annonc/mdh047. [PMID: 14760130] - M Asif A Siddiqui, Lesley J Scott. Palonosetron.
Drugs.
2004; 64(10):1125-32; discussion 1133. doi:
10.2165/00003495-200464100-00006. [PMID: 15139789] - Peter Eisenberg, Jazmin Figueroa-Vadillo, Rosalio Zamora, Veena Charu, Julio Hajdenberg, Alan Cartmell, Alberto Macciocchi, Steven Grunberg. Improved prevention of moderately emetogenic chemotherapy-induced nausea and vomiting with palonosetron, a pharmacologically novel 5-HT3 receptor antagonist: results of a phase III, single-dose trial versus dolasetron.
Cancer.
2003 Dec; 98(11):2473-82. doi:
10.1002/cncr.11817. [PMID: 14635083] - Steven M Grunberg, James M Koeller. Palonosetron: a unique 5-HT3-receptor antagonist for the prevention of chemotherapy-induced emesis.
Expert opinion on pharmacotherapy.
2003 Dec; 4(12):2297-303. doi:
10.1517/14656566.4.12.2297. [PMID: 14640928]