6H-Dipyrido[3,2-b:2,3-e][1,4]diazepin-6-one, 11-ethyl-5,11-dihydro-5-methyl-8-[2-[(1-oxido-4-quinolinyl)oxy]ethyl]- (BioDeep_00000841832)
代谢物信息卡片
化学式: C25H23N5O3 (441.18008080000004)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN1C2=C(C=CC=N2)N(C(=O)C3=C1N=CC(=C3)CCOC4=CC=[N+](C5=CC=CC=C54)[O-])C
InChI: InChI=1S/C25H23N5O3/c1-3-29-23-19(25(31)28(2)21-9-6-12-26-24(21)29)15-17(16-27-23)11-14-33-22-10-13-30(32)20-8-5-4-7-18(20)22/h4-10,12-13,15-16H,3,11,14H2,1-2H3
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yongmei Li, W George Lai, Andrea Whitcher-Johnstone, Carl A Busacca, Magnus C Eriksson, Jon C Lorenz, Donald J Tweedie. Metabolic switching of BILR 355 in the presence of ritonavir. I. Identifying an unexpected disproportionate human metabolite.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Jun; 40(6):1122-9. doi:
10.1124/dmd.111.044354. [PMID: 22393120] - Yongmei Li, Jun Xu, W George Lai, Andrea Whitcher-Johnstone, Donald J Tweedie. Metabolic switching of BILR 355 in the presence of ritonavir. II. Uncovering novel contributions by gut bacteria and aldehyde oxidase.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Jun; 40(6):1130-7. doi:
10.1124/dmd.111.044362. [PMID: 22393121] - F Huang, L Allen, D B Huang, F Moy, R Vinisko, T Nguyen, L Rowland, T R MacGregor, M A Castles, P Robinson. Evaluation of steady-state pharmacokinetic interactions between ritonavir-boosted BILR 355, a non-nucleoside reverse transcriptase inhibitor, and lamivudine/zidovudine in healthy subjects.
Journal of clinical pharmacy and therapeutics.
2012 Feb; 37(1):81-8. doi:
10.1111/j.1365-2710.2010.01235.x. [PMID: 21128991] - Fenglei Huang, Paul Scholl, David B Huang, Thomas R MacGregor, Richard Vinisko, Mark A Castles, Frank Berger, Patrick Robinson. Coadministration with lopinavir and ritonavir decreases exposure to BILR 355, a nonnucleoside reverse transcriptase inhibitor, in healthy volunteers.
Journal of clinical pharmacology.
2011 Jul; 51(7):1061-70. doi:
10.1177/0091270010376971. [PMID: 20705951] - Fenglei Huang, Michael Koenen-Bergmann, Thomas R Macgregor, Arne Ring, Susan Hattox, Patrick Robinson. Pharmacokinetic and safety evaluation of BILR 355, a second-generation nonnucleoside reverse transcriptase inhibitor, in healthy volunteers.
Antimicrobial agents and chemotherapy.
2008 Dec; 52(12):4300-7. doi:
10.1128/aac.00363-08. [PMID: 18824608]