10-Hydroxynortriptyline (BioDeep_00000841805)

   


代谢物信息卡片


10-Hydroxynortriptyline

化学式: C19H21NO (279.1623056)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CNCCC=C1C2=CC=CC=C2CC(C3=CC=CC=C31)O
InChI: InChI=1S/C19H21NO/c1-20-12-6-11-16-15-8-3-2-7-14(15)13-19(21)18-10-5-4-9-17(16)18/h2-5,7-11,19-21H,6,12-13H2,1H3/b16-11-

描述信息

同义名列表

1 个代谢物同义名

10-Hydroxynortriptyline



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Naomi T Jessurun, Annemieke Vermeulen Windsant, Oenone Mikes, Eugène P van Puijenbroek, Rob J van Marum, Koen Grootens, Hieronymus J Derijks. Inhibition of CYP2D6 with low dose (5 mg) paroxetine in patients with high 10-hydroxynortriptyline serum levels-A prospective pharmacokinetic study. British journal of clinical pharmacology. 2021 03; 87(3):1529-1532. doi: 10.1111/bcp.14455. [PMID: 32621544]
  • Karen Hodgson, Katherine Tansey, Mojca Zvezdana Dernovsek, Joanna Hauser, Neven Henigsberg, Wolfgang Maier, Ole Mors, Anna Placentino, Marcella Rietschel, Daniel Souery, Rebecca Smith, Ian W Craig, Anne E Farmer, Katherine J Aitchison, Sarah Belsey, Sarah Belsy, Oliver S P Davis, Rudolf Uher, Peter McGuffin. Genetic differences in cytochrome P450 enzymes and antidepressant treatment response. Journal of psychopharmacology (Oxford, England). 2014 Feb; 28(2):133-41. doi: 10.1177/0269881113512041. [PMID: 24257813]
  • Kishore Kumar Hotha, L K Ravindranath, K N Jaya Veera, K Kishore Kumar, Y Ramachandra Reddy, B Jagadeesh, D V Narayana Rao, D Vijaya Bharathi, Ramesh Mullangi. Development and validation of a highly sensitive LC-MS/MS method for simultaneous quantitation of nortriptyline and 10-hydroxynortriptyline in human plasma: application to a human pharmacokinetic study. Biomedical chromatography : BMC. 2010 Oct; 24(10):1113-9. doi: 10.1002/bmc.1413. [PMID: 20853465]
  • Gitte Bonke, Berit P Jensen. Fast and sensitive LC-MS/MS assay for quantification of nortriptyline and its active metabolites E- and Z-10-hydroxynortriptyline in human plasma. Bioanalysis. 2010 Sep; 2(9):1553-60. doi: 10.4155/bio.10.89. [PMID: 21083284]
  • Patrice Forget, Bernard le Polain de Waroux, Pierre Wallemacq, Jean-Luc Gala. Life-threatening dextromethorphan intoxication associated with interaction with amitriptyline in a poor CYP2D6 metabolizer: a single case re-exposure study. Journal of pain and symptom management. 2008 Jul; 36(1):92-6. doi: 10.1016/j.jpainsymman.2007.09.006. [PMID: 18359183]
  • Che Zhang, Zi-Liang Tu, Qi-Bin Wang, Xiao-Li Cheng, Peng-Hua Zhang. [Influence of ORM1 polymorphism on serum concentration of free nortriptyline]. Yao xue xue bao = Acta pharmaceutica Sinica. 2007 Aug; 42(8):843-8. doi: . [PMID: 17944232]
  • Ada M Loughhead, Zachary N Stowe, D Jeffrey Newport, James C Ritchie, C Lindsay DeVane, Michael J Owens. Placental passage of tricyclic antidepressants. Biological psychiatry. 2006 Feb; 59(3):287-90. doi: 10.1016/j.biopsych.2005.06.040. [PMID: 16271264]
  • Thomas B Ejsing, Kristian Linnet. Influence of P-glycoprotein inhibition on the distribution of the tricyclic antidepressant nortriptyline over the blood-brain barrier. Human psychopharmacology. 2005 Mar; 20(2):149-53. doi: 10.1002/hup.667. [PMID: 15624117]
  • K Laine, G Tybring, S Härtter, K Andersson, J O Svensson, J Widén, L Bertilsson. Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test. Clinical pharmacology and therapeutics. 2001 Oct; 70(4):327-35. doi: . [PMID: 11673748]
  • S Morita, K Shimoda, T Someya, Y Yoshimura, K Kamijima, N Kato. Steady-state plasma levels of nortriptyline and its hydroxylated metabolites in Japanese patients: impact of CYP2D6 genotype on the hydroxylation of nortriptyline. Journal of clinical psychopharmacology. 2000 Apr; 20(2):141-9. doi: 10.1097/00004714-200004000-00005. [PMID: 10770451]
  • Q Y Yue, Z H Zhong, G Tybring, P Dalén, M L Dahl, L Bertilsson, F Sjöqvist. Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes. Clinical pharmacology and therapeutics. 1998 Oct; 64(4):384-90. doi: 10.1016/s0009-9236(98)90069-8. [PMID: 9797795]
  • G Tybring, J Nordin, J Widén. High-performance liquid chromatography-mass spectrometry for the quantification of nortriptyline and 10-hydroxynortriptyline in plasma. Journal of chromatography. B, Biomedical sciences and applications. 1998 Sep; 716(1-2):382-6. doi: 10.1016/s0378-4347(98)00299-0. [PMID: 9824256]
  • P Dalén, M L Dahl, M L Bernal Ruiz, J Nordin, L Bertilsson. 10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes. Clinical pharmacology and therapeutics. 1998 Apr; 63(4):444-52. doi: 10.1016/s0009-9236(98)90040-6. [PMID: 9585799]
  • F Coudoré, A Besson, C Courteix, A Eschalier, J Lavarenne, J Fialip. Pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites in streptozocin-induced diabetic rats. General pharmacology. 1996 Jul; 27(5):803-7. doi: 10.1016/0306-3623(95)02082-9. [PMID: 8842682]
  • F Coudore, A Besson, A Eschalier, J Lavarenne, J Fialip. Plasma and brain pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites after one and six half-life repeated administrations to rats. General pharmacology. 1996 Mar; 27(2):215-9. doi: 10.1016/0306-3623(95)02008-x. [PMID: 8919634]
  • M L Dahl, L Bertilsson, C Nordin. Steady-state plasma levels of nortriptyline and its 10-hydroxy metabolite: relationship to the CYP2D6 genotype. Psychopharmacology. 1996 Feb; 123(4):315-9. doi: 10.1007/bf02246640. [PMID: 8867869]
  • K Shimoda, T Noguchi, S Morita, Y Ozeki, M Shibasaki, T Someya, S Takahashi. Interindividual variations of desmethylation and hydroxylation of amitriptyline in a Japanese psychiatric population. Journal of clinical psychopharmacology. 1995 Jun; 15(3):175-81. doi: 10.1097/00004714-199506000-00005. [PMID: 7635994]
  • C Nordin, L Bertilsson. Active hydroxymetabolites of antidepressants. Emphasis on E-10-hydroxy-nortriptyline. Clinical pharmacokinetics. 1995 Jan; 28(1):26-40. doi: 10.2165/00003088-199528010-00004. [PMID: 7712660]
  • F Coudoré, J Fialip, A Eschalier, J Lavarenne. Mice plasma and brain pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites after half-life repeated administration. Comparison with acute administration. Fundamental & clinical pharmacology. 1994; 8(6):525-31. doi: 10.1111/j.1472-8206.1994.tb00833.x. [PMID: 7721229]
  • X H Zhang, P Yu, N F Gu, J L Yin, W D Jiang. [Relationship between amitriptyline metabolism and polymorphic debrisoquine hydroxylation in native Chinese volunteers]. Yao xue xue bao = Acta pharmaceutica Sinica. 1993; 28(2):85-91. doi: NULL. [PMID: 8328289]
  • C Nordin. CSF/plasma ratio of 10-hydroxynortriptyline is influenced by sex and body height. Psychopharmacology. 1993; 113(2):222-4. doi: 10.1007/bf02245701. [PMID: 7855185]
  • U Breyer-Pfaff, B Pfandl, K Nill, E Nusser, C Monney, M Jonzier-Perey, D Baettig, P Baumann. Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes. Clinical pharmacology and therapeutics. 1992 Oct; 52(4):350-8. doi: 10.1038/clpt.1992.155. [PMID: 1424408]
  • S Kanba, K Matsumoto, M Nibuya, E Suzuki, N Kinoshita, F Shintani, G Yagi. Nortriptyline response in elderly depressed patients. Progress in neuro-psychopharmacology & biological psychiatry. 1992 May; 16(3):301-9. doi: 10.1016/0278-5846(92)90081-o. [PMID: 1589587]
  • S L Anliker, M Hamilton, R J Bopp, M J Goldberg. Sensitive method for the quantitation of nortriptyline and 10-hydroxynortriptyline in human plasma by capillary gas chromatography with electron-capture detection. Journal of chromatography. 1992 Jan; 573(1):141-5. doi: 10.1016/0378-4347(92)80487-b. [PMID: 1564093]
  • K L Wisner, J M Perel. Serum nortriptyline levels in nursing mothers and their infants. The American journal of psychiatry. 1991 Sep; 148(9):1234-6. doi: 10.1176/ajp.148.9.1234. [PMID: 1883004]
  • M L Dahl, C Nordin, L Bertilsson. Enantioselective hydroxylation of nortriptyline in human liver microsomes, intestinal homogenate, and patients treated with nortriptyline. Therapeutic drug monitoring. 1991 May; 13(3):189-94. doi: 10.1097/00007691-199105000-00001. [PMID: 1926270]
  • K Otani, S Kaneko, L Bertilsson. Studies on active transport of (E)-10-hydroxynortriptyline in the kidney and brain of rats: effects of propranolol and quinidine. Pharmacology & toxicology. 1991 May; 68(5):380-3. doi: 10.1111/j.1600-0773.1991.tb01256.x. [PMID: 1946183]
  • L Bertilsson, K Otani, M L Dahl, C Nordin, A Aberg-Wistedt. Stereoselective efflux of (E)-10-hydroxynortriptyline enantiomers from the cerebrospinal fluid of depressed patients. Pharmacology & toxicology. 1991 Feb; 68(2):100-3. doi: 10.1111/j.1600-0773.1991.tb02044.x. [PMID: 1852713]
  • C Nordin, L Bertilsson, M L Dahl, B Resul, G Toresson, F Sjöqvist. Treatment of depression with E-10-hydroxynortriptyline--a pilot study on biochemical effects and pharmacokinetics. Psychopharmacology. 1991; 103(3):287-90. doi: 10.1007/bf02244280. [PMID: 2057534]
  • L S Schneider, T B Cooper, R F Suckow, S A Lyness, C Haugen, R Palmer, R B Sloane. Relationship of hydroxynortriptyline to nortriptyline concentration and creatinine clearance in depressed elderly outpatients. Journal of clinical psychopharmacology. 1990 Oct; 10(5):333-7. doi: NULL. [PMID: 2258449]
  • T I Lundgren, L Slørdal, R Jaeger, J E Whist, J Aarbakke. An automated method for the determination of nortriptyline and its isomeric 10-hydroxylated metabolites in plasma by high pressure liquid chromatography. Pharmacology & toxicology. 1990 Aug; 67(2):132-5. doi: 10.1111/j.1600-0773.1990.tb00798.x. [PMID: 2255664]
  • I R Katz, G M Simpson, V Jethanandani, T Cooper, C Muhly. Steady state pharmacokinetics of nortriptyline in the frail elderly. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 1989 Sep; 2(3):229-36. doi: 10.1016/0893-133x(89)90026-2. [PMID: 2789662]
  • L F Gram, K Brøsen, P Kragh-Sørensen, P Christensen. Steady-state plasma levels of E- and Z-10-OH-nortriptyline in nortriptyline-treated patients: significance of concurrent medication and the sparteine oxidation phenotype. Therapeutic drug monitoring. 1989 Sep; 11(5):508-14. doi: 10.1097/00007691-198909000-00003. [PMID: 2815225]
  • M L Dahl-Puustinen, E Dumont, L Bertilsson. Glucuronidation of E-10-hydroxynortriptyline in human liver, kidney, and intestine. Organ-specific differences in enantioselectivity. Drug metabolism and disposition: the biological fate of chemicals. 1989 Jul; 17(4):433-6. doi: NULL. [PMID: 2571485]
  • M L Dahl-Puustinen, T L Perry, E Dumont, C von Bahr, C Nordin, L Bertilsson. Stereoselective disposition of racemic E-10-hydroxynortriptyline in human beings. Clinical pharmacology and therapeutics. 1989 Jun; 45(6):650-6. doi: 10.1038/clpt.1989.86. [PMID: 2731406]
  • U Breyer-Pfaff, H Giedke, H J Gaertner, K Nill. Validation of a therapeutic plasma level range in amitriptyline treatment of depression. Journal of clinical psychopharmacology. 1989 Apr; 9(2):116-21. doi: 10.1097/00004714-198904000-00008. [PMID: 2723128]
  • R E McCue, A Georgotas, R F Suckow, T B Cooper. 10-Hydroxynortriptyline and treatment effects in elderly depressed patients. The Journal of neuropsychiatry and clinical neurosciences. 1989; 1(2):176-80. doi: 10.1176/jnp.1.2.176. [PMID: 2521060]
  • R E McCue, A Georgotas, N Nagachandran, M Abdul Basir, E A Go, R F Suckow, T B Cooper. Plasma levels of nortriptyline and 10-hydroxynortriptyline and treatment-related electrocardiographic changes in the elderly depressed. Journal of psychiatric research. 1989; 23(1):73-9. doi: 10.1016/0022-3956(89)90019-8. [PMID: 2754630]
  • B J Lukey, D R Jones, J H Wright, H E Hurst. Relationships among nortriptyline, 10-OH(E)nortriptyline, and 10-OH(Z)nortriptyline steady-state plasma levels and nortriptyline dosage. Therapeutic drug monitoring. 1989; 11(3):221-7. doi: 10.1097/00007691-198905000-00001. [PMID: 2728080]
  • L S Schneider, T B Cooper, J A Severson, T Zemplenyi, R B Sloane. Electrocardiographic changes with nortriptyline and 10-hydroxynortriptyline in elderly depressed outpatients. Journal of clinical psychopharmacology. 1988 Dec; 8(6):402-8. doi: . [PMID: 3069881]
  • P Liu. [Relation of plasma levels and clinical response to amitriptyline in treating endogenous depression]. Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry. 1988 Oct; 21(5):263-6, 318. doi: NULL. [PMID: 3234157]
  • R C Young, G S Alexopoulos, R Shindledecker, A K Dhar, H Kutt. Plasma 10-hydroxynortriptyline and therapeutic response in geriatric depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 1988 Sep; 1(3):213-5. doi: 10.1016/0893-133x(88)90019-x. [PMID: 3251501]
  • E Nusser, K Nill, U Breyer-Pfaff. Enantioselective formation and disposition of (E)- and (Z)-10-hydroxynortriptyline. Drug metabolism and disposition: the biological fate of chemicals. 1988 May; 16(3):509-11. doi: NULL. [PMID: 2900750]
  • R C Young, A K Dhar, H Kutt, G S Alexopoulos. Isomers of 10-hydroxynortriptyline in geriatric depression. Therapeutic drug monitoring. 1988; 10(2):164-7. doi: 10.1097/00007691-198802000-00008. [PMID: 3381232]
  • C Nordin, P Collste, K Otani, M Scheinin. Effects of nortriptyline and its 10-hydroxy metabolite on plasma noradrenaline (NA) concentrations, heart rate and blood pressure during intravenous NA infusion. Methods and findings in experimental and clinical pharmacology. 1987 Oct; 9(10):691-6. doi: NULL. [PMID: 2964548]
  • R C Young, G S Alexopoulos, A K Dhar, H Kutt. Plasma 10-hydroxynortriptyline and renal function in elderly depressives. Biological psychiatry. 1987 Oct; 22(10):1283-7. doi: 10.1016/0006-3223(87)90039-4. [PMID: 3663780]
  • C Nordin, L Bertilsson, B Siwers. Clinical and biochemical effects during treatment of depression with nortriptyline: the role of 10-hydroxynortriptyline. Clinical pharmacology and therapeutics. 1987 Jul; 42(1):10-9. doi: 10.1038/clpt.1987.101. [PMID: 2439250]
  • R Malmgren, A Aberg-Wistedt, L Bertilsson. Serotonin uptake inhibition during treatment of depression with nortriptyline caused by parent drug and not by 10-hydroxymetabolites. Psychopharmacology. 1987; 92(2):169-72. doi: 10.1007/bf00177910. [PMID: 2440073]
  • L Bertilsson, C Nordin, K Otani, B Resul, M Scheinin, B Siwers, F Sjöqvist. Disposition of single oral doses of E-10-hydroxynortriptyline in healthy subjects, with some observations on pharmacodynamic effects. Clinical pharmacology and therapeutics. 1986 Sep; 40(3):261-7. doi: 10.1038/clpt.1986.173. [PMID: 3742932]
  • P Baumann, M Jonzier-Perey, L Koeb, A Küpfer, D Tinguely, J Schöpf. Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin. International clinical psychopharmacology. 1986 Apr; 1(2):102-12. doi: 10.1097/00004850-198604000-00002. [PMID: 3571939]
  • P M Edelbroek, A C Linssen, F G Zitman, H G Rooymans, F A de Wolff. Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain. Clinical pharmacology and therapeutics. 1986 Feb; 39(2):156-62. doi: 10.1038/clpt.1986.27. [PMID: 3510800]
  • E H Rubin, J T Biggs, S H Preskorn. Nortriptyline pharmacokinetics and plasma levels: implications for clinical practice. The Journal of clinical psychiatry. 1985 Oct; 46(10):418-24. doi: NULL. [PMID: 3900052]
  • C Nordin, L Bertilsson, B Siwers. CSF and plasma levels of nortriptyline and its 10-hydroxy metabolite. British journal of clinical pharmacology. 1985 Oct; 20(4):411-3. doi: 10.1111/j.1365-2125.1985.tb05086.x. [PMID: 4074608]
  • R C Young, G S Alexopoulos, C A Shamoian, E Kent, A K Dhar, H Kutt. Plasma 10-hydroxynortriptyline and ECG changes in elderly depressed patients. The American journal of psychiatry. 1985 Jul; 142(7):866-8. doi: 10.1176/ajp.142.7.866. [PMID: 4014510]
  • C Nordin, B Siwers, J Benitez, L Bertilsson. Plasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients--relationship to the debrisoquine hydroxylation metabolic ratio. British journal of clinical pharmacology. 1985 Jun; 19(6):832-5. doi: 10.1111/j.1365-2125.1985.tb02723.x. [PMID: 4027124]
  • D S Robinson, T B Cooper, D Howard, J Corcella, D Albright. Amitriptyline and hydroxylated metabolite plasma levels in depressed outpatients. Journal of clinical psychopharmacology. 1985 Apr; 5(2):83-8. doi: 10.1097/00004714-198504000-00005. [PMID: 3988974]
  • R C Young, G S Alexopoulos, C A Shamoian, M W Manley, A K Dhar, H Kutt. Plasma 10-hydroxynortriptyline in elderly depressed patients. Clinical pharmacology and therapeutics. 1984 Apr; 35(4):540-4. doi: 10.1038/clpt.1984.74. [PMID: 6705454]
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  • R C Young, G S Alexopoulos, C A Shamoian, A K Dhar, H Kutt. Heart failure associated with high plasma 10-hydroxynortriptyline levels. The American journal of psychiatry. 1984 Mar; 141(3):432-3. doi: 10.1176/ajp.141.3.432. [PMID: 6703113]
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