(2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylidene]undecanoic acid (BioDeep_00000841796)
Antitumor activity
代谢物信息卡片
化学式: C21H30O6 (378.204228)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCC/C(C(O)=O)=C\C1=C(C)C(C(OC)=C(OC)C1=O)=O
InChI: InChI=1S/C21H30O6/c1-5-6-7-8-9-10-11-12-15(21(24)25)13-16-14(2)17(22)19(26-3)20(27-4)18(16)23/h13H,5-12H2,1-4H3,(H,24,25)/b15-13+
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor
E3330 (APX-3330) is a direct, orally active and selective inhibitor of Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. E3330 is able to impair tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α in pancreatic cancer. E3330 shows anticancer activities[1][2][3][4][5].
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jianxin Diao, Huijie Fan, Jia Zhang, Xiuqiong Fu, Rongxin Liao, Peng Zhao, Wei Huang, Shiying Huang, Huajun Liao, Jieying Yu, Dongmei Pan, Ming Wang, Wei Xiao, Xiaomin Wen. Activation of APE1 modulates Nrf2 protected against acute liver injury by inhibit hepatocyte ferroptosis and promote hepatocyte autophagy.
International immunopharmacology.
2024 Jan; 128(?):111529. doi:
10.1016/j.intimp.2024.111529. [PMID: 38244516] - Yi-Ting Wang, Der-Wan Tzeng, Chun-Yu Wang, Jing-Yin Hong, Jia-Ling Yang. APE1/Ref-1 prevents oxidative inactivation of ERK for G1-to-S progression following lead acetate exposure.
Toxicology.
2013 Mar; 305(?):120-9. doi:
10.1016/j.tox.2013.01.010. [PMID: 23370007] - Laura Cesaratto, Erika Codarin, Carlo Vascotto, Antonio Leonardi, Mark R Kelley, Claudio Tiribelli, Gianluca Tell. Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell lines.
PloS one.
2013; 8(8):e70909. doi:
10.1371/journal.pone.0070909. [PMID: 23967134] - A A Nanji, S M Sadrzadeh, U Khettry, P Thomas, T Yamanaka. Protective effects of a novel quinone derivative, (2E)-3-[5-(2,3 dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2-propanoic acid on experimental alcoholic liver injury.
The Journal of pharmacology and experimental therapeutics.
1993 Aug; 266(2):1085-90. doi:
. [PMID: 8394904] - J Nagakawa, K Hirota, I Hishinuma, K Miyamoto, J Sonoda, T Yamanaka, K Katayama, I Yamatsu. Protective effect of E3330, a novel quinone derivative, in galactosamine-induced hepatitis in rats.
The Journal of pharmacology and experimental therapeutics.
1993 Jan; 264(1):496-500. doi:
. [PMID: 8423547] - J Nagakawa, I Hishinuma, K Miyamoto, K Hirota, S Abe, T Yamanaka, K Katayama, I Yamatsu. Protective effects of (2E)-3-[5-(2,3-dimethoxy-6-methyl-1,4- benzoquinoyl)]-2-nonyl-2-propenoic acid on endotoxin-mediated hepatitis in mice.
The Journal of pharmacology and experimental therapeutics.
1992 Jul; 262(1):145-50. doi:
NULL. [PMID: 1625194]