alpha-Methylhistamine (BioDeep_00000841793)

   


代谢物信息卡片


alpha-Methylhistamine

化学式: C6H11N3 (125.0952926)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CC1=CN=CN1)N
InChI: InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)

描述信息

An aralkylamino compound that is histamine bearing a methyl substituent at the alpha-position.
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D017442 - Histamine Agonists

同义名列表

1 个代谢物同义名

alpha-Methylhistamine



数据库引用编号

5 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Robert L Hudkins, Rita Raddatz, Ming Tao, Joanne R Mathiasen, Lisa D Aimone, Nadine C Becknell, Catherine P Prouty, Lars J S Knutsen, Mehran Yazdanian, Gilbert Moachon, Mark A Ator, John P Mallamo, Michael J Marino, Edward R Bacon, Michael Williams. Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist. Journal of medicinal chemistry. 2011 Jul; 54(13):4781-92. doi: 10.1021/jm200401v. [PMID: 21634396]
  • Thomas R Miller, John L Baranowski, Brian R Estvander, David G Witte, Tracy L Carr, Arlene M Manelli, Kathleen M Krueger, Marlon D Cowart, Jorge D Brioni, Timothy A Esbenshade. A robust and high-capacity [(35)S]GTPgammaS binding assay for determining antagonist and inverse agonist pharmacological parameters of histamine H(3) receptor ligands. Assay and drug development technologies. 2008 Jun; 6(3):339-49. doi: 10.1089/adt.2007.118. [PMID: 18593375]
  • Yuji Sugata, Mitsuhiro Okano, Tazuko Fujiwara, Rie Matsumoto, Hisashi Hattori, Miki Yamamoto, Masahiro Nishibori, Kazunori Nishizaki. Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses. Immunology. 2007 Jun; 121(2):266-75. doi: 10.1111/j.1365-2567.2007.02574.x. [PMID: 17346280]
  • Stefka V Valcheva-Kuzmanova, Petia B Popova, Ivan J Krasnaliev, Bistra Tz Galunska, Anna Belcheva, Walter Schunack. Protective effect of BP 2-94, a histamine H3-receptor agonist prodrug, in a model of carbon tetrachloride-induced hepatotoxicity in rats. Folia medica. 2004; 46(2):36-41. doi: NULL. [PMID: 15506549]
  • Robbie L McLeod, Charlie A Rizzo, Robert E West, Robert Aslanian, Kevin McCormick, Matthew Bryant, Yunsheng Hsieh, Walter Korfmacher, Garfield G Mingo, LoriAnn Varty, Shirley M Williams, Neng-Yang Shih, Robert W Egan, John A Hey. Pharmacological characterization of the novel histamine H3-receptor antagonist N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687). The Journal of pharmacology and experimental therapeutics. 2003 Jun; 305(3):1037-44. doi: 10.1124/jpet.103.049254. [PMID: 12649305]
  • S Kwiecień, T Brzozowski, P C Konturek, S J Konturek, M Pawlik, R Pajdo, D Drozdowicz, A Ptak, E G Hahn. Effect of central and peripheral actions of histamine and its metabolite N-alpha methyl histamine on gastric secretion and acute gastric lesions. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2001 Dec; 52(4 Pt 1):625-38. doi: NULL. [PMID: 11787763]
  • T Yamasaki, I Tamai, Y Matsumura. Activation of histamine H3 receptors inhibits renal noradrenergic neurotransmission in anesthetized dogs. American journal of physiology. Regulatory, integrative and comparative physiology. 2001 May; 280(5):R1450-6. doi: 10.1152/ajpregu.2001.280.5.r1450. [PMID: 11294767]
  • P C Konturek, S J Konturek, E Sito, N Kwiecien, W Obtulowicz, W Bielanski, E G Hahn. Luminal Nalpha-methyl histamine stimulates gastric acid secretion in duodenal ulcer patients via releasing gastrin. European journal of pharmacology. 2001 Jan; 412(2):181-5. doi: 10.1016/s0014-2999(01)00720-8. [PMID: 11165229]
  • T Brzozowski, P C Konturek, S J Konturek, S Kwiecień, R Pajdo, D Drozdowicz, A Ptak, M Pawlik, E G Hahn. Involvement of gastrin in gastric secretory and protective actions of N-alpha-methyl histamine. Journal of physiology, Paris. 2001 Jan; 95(1-6):89-98. doi: 10.1016/s0928-4257(01)00013-4. [PMID: 11595423]
  • H Stark, M Krause, A Rouleau, M Garbarg, J C Schwartz, W Schunack. Enzyme-catalyzed prodrug approaches for the histamine H3-receptor agonist (R)-alpha-methylhistamine. Bioorganic & medicinal chemistry. 2001 Jan; 9(1):191-8. doi: 10.1016/s0968-0896(00)00237-6. [PMID: 11197341]
  • S Murray, G W Taylor, Q N Karim, P Bliss, J Calam. N alpha-methylhistamine: association with Helicobacter pylori infection in humans and effects on gastric acid secretion. Clinica chimica acta; international journal of clinical chemistry. 2000 Nov; 301(1-2):181-92. doi: 10.1016/s0009-8981(00)00357-0. [PMID: 11020472]
  • A Rouleau, H Stark, W Schunack, J C Schwartz. Anti-inflammatory and antinociceptive properties of BP 2-94, a histamine H(3)-receptor agonist prodrug. The Journal of pharmacology and experimental therapeutics. 2000 Oct; 295(1):219-25. doi: NULL. [PMID: 10991982]
  • G Soldani, S Bertini, A Rouleau, J C Schwartz, G Coruzzi. Gastric antisecretory effects of compound BP 2-94: a histamine H3-receptor agonist prodrug. Digestive diseases and sciences. 1999 Dec; 44(12):2380-5. doi: 10.1023/a:1026606231771. [PMID: 10630485]
  • L W Fu, H L Pan, J C Longhurst. Endogenous histamine stimulates ischemically sensitive abdominal visceral afferents through H1 receptors. The American journal of physiology. 1997 12; 273(6):H2726-37. doi: 10.1152/ajpheart.1997.273.6.h2726. [PMID: 9435609]
  • N A Payne, J G Gerber. Effect of adenosine and histamine receptor stimulation on canine histamine release to pentagastrin. Digestion. 1997; 58(4):352-60. doi: 10.1159/000201465. [PMID: 9324162]
  • G Soldani, M Garbarg, L Intorre, S Bertini, A Rouleau, J C Schwartz. Modulation of pentagastrin-induced histamine release by histamine H3 receptors in the dog. Scandinavian journal of gastroenterology. 1996 Jul; 31(7):631-8. doi: 10.3109/00365529609009141. [PMID: 8819209]
  • L Givalois, P Siaud, M Mekaouche, G Ixart, F Malaval, I Assenmacher, G Barbanel. Involvement of central histamine in the early phase of ACTH and corticosterone responses to endotoxin in rats. Neuroendocrinology. 1996 Mar; 63(3):219-26. doi: 10.1159/000126961. [PMID: 8677010]
  • W A Fogel, L Tuomisto, W Andrzejewski, K Sasiak, C Maslinski. The effect of an ICV H3-agonist on plasma prolactin in portocaval shunted and sham operated rats. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 1996 Mar; 45 Suppl 1(?):S56-7. doi: 10.1007/bf03354087. [PMID: 8696931]
  • M C Allen, P Graham, G Morris. Histamine forming capacity (HFC) and its modulation by H3 receptor ligands in a model of bronchial hyper-responsiveness. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 1996 Mar; 45(3):118-22. doi: 10.1007/bf02265163. [PMID: 8689389]
  • S Kohno, S Nakao, K Ogawa, H Yamamura, T Nabe, K Ohata. Possible participation of histamine H3-receptors in the regulation of anaphylactic histamine release from isolated rat peritoneal mast cells. Japanese journal of pharmacology. 1994 Oct; 66(2):173-80. doi: 10.1254/jjp.66.173. [PMID: 7532731]
  • G Soldani, L Intorre, S Bertini, E Luchetti, G Coruzzi, G Bertaccini. Regulation of gastric acid secretion by histamine H3 receptors in the dog: an investigation into the site of action. Naunyn-Schmiedeberg's archives of pharmacology. 1994 Aug; 350(2):218-23. doi: 10.1007/bf00241100. [PMID: 7990981]
  • A Kjaer, U Knigge, A Rouleau, M Garbarg, J Warberg. Dehydration-induced release of vasopressin involves activation of hypothalamic histaminergic neurons. Endocrinology. 1994 Aug; 135(2):675-81. doi: 10.1210/endo.135.2.8033816. [PMID: 8033816]
  • K Yanai, J H Ryu, N Sakai, T Takahashi, R Iwata, T Ido, K Murakami, T Watanabe. Binding characteristics of a histamine H3-receptor antagonist, [3H]S-methylthioperamide: comparison with [3H](R)alpha-methylhistamine binding to rat tissues. Japanese journal of pharmacology. 1994 Jun; 65(2):107-12. doi: 10.1254/jjp.65.107. [PMID: 7967223]
  • S Yamasaki, E Sakurai, N Hikichi, N Sakai, K Maeyama, T Watanabe. The disposition of (R)-alpha-methylhistamine, a histamine H3-receptor agonist, in rats. The Journal of pharmacy and pharmacology. 1994 May; 46(5):371-4. doi: 10.1111/j.2042-7158.1994.tb03815.x. [PMID: 8083809]
  • A Kjaer, U Knigge, E L Madsen, P Søe-Jensen, F W Bach, J Warberg. Insulin/hypoglycemia-induced adrenocorticotropin and beta-endorphin release: involvement of hypothalamic histaminergic neurons. Endocrinology. 1993 May; 132(5):2213-20. doi: 10.1210/endo.132.5.8386615. [PMID: 8386615]
  • C E Navarro, R Otoya, A O Donoso. Stimulation of H3-histamine receptors increases the release of prolactin in male rats. Neuroendocrinology. 1993 Apr; 57(4):654-7. doi: 10.1159/000126421. [PMID: 8367032]
  • G Soldani, G Mengozzi, L Intorre, G De Giorgi, G Coruzzi, G Bertaccini. Histamine H3 receptor-mediated inhibition of gastric acid secretion in conscious dogs. Naunyn-Schmiedeberg's archives of pharmacology. 1993 Jan; 347(1):61-5. doi: 10.1007/bf00168773. [PMID: 8383301]
  • T Matsubara, M A Moskowitz, Z Huang. UK-14,304, R(-)-alpha-methyl-histamine and SMS 201-995 block plasma protein leakage within dura mater by prejunctional mechanisms. European journal of pharmacology. 1992 Dec; 224(2-3):145-50. doi: 10.1016/0014-2999(92)90798-9. [PMID: 1281776]