Telenzepine (BioDeep_00000841780)
代谢物信息卡片
Telenzepine
化学式: C19H22N4O2S (370.1463392)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C2C(=CS1)C(=O)NC3=CC=CC=C3N2C(=O)CN4CCN(CC4)C
InChI: InChI=1S/C19H22N4O2S/c1-13-18-14(12-26-13)19(25)20-15-5-3-4-6-16(15)23(18)17(24)11-22-9-7-21(2)8-10-22/h3-6,12H,7-11H2,1-2H3,(H,20,25)
描述信息
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Paul J M Savelkoul, Helena Janickova, Almar A M Kuipers, Robert J J Hageman, Patrick J Kamphuis, Vladimir Dolezal, Laus M Broersen. A specific multi-nutrient formulation enhances M1 muscarinic acetylcholine receptor responses in vitro.
Journal of neurochemistry.
2012 Feb; 120(4):631-40. doi:
10.1111/j.1471-4159.2011.07616.x. [PMID: 22146060] - Jonathan A Hern, Asma H Baig, Gregory I Mashanov, Berry Birdsall, John E T Corrie, Sebastian Lazareno, Justin E Molloy, Nigel J M Birdsall. Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules.
Proceedings of the National Academy of Sciences of the United States of America.
2010 Feb; 107(6):2693-8. doi:
10.1073/pnas.0907915107. [PMID: 20133736] - Gianluigi Tanda, Aaron L Ebbs, Theresa A Kopajtic, Lyn M Elias, Bettye L Campbell, Amy H Newman, Jonathan L Katz. Effects of muscarinic M1 receptor blockade on cocaine-induced elevations of brain dopamine levels and locomotor behavior in rats.
The Journal of pharmacology and experimental therapeutics.
2007 Apr; 321(1):334-44. doi:
10.1124/jpet.106.118067. [PMID: 17255465] - E Niebergall-Roth, S Teyssen, D Wetzel, M Hartel, C Beglinger, R L Riepl, M V Singer. Effects of telenzepine and L-364,718 on canine pancreatic secretion before and after vagotomy.
The American journal of physiology.
1997 Jun; 272(6 Pt 1):G1550-9. doi:
10.1152/ajpgi.1997.272.6.g1550. [PMID: 9227493] - S Teyssen, E Niebergall-Roth, A Rausch, C Beglinger, R L Riepl, S Chari, M V Singer. Comparison of the effects of the M1-receptor antagonist telenzepine and the CCK-receptor antagonist loxiglumide on the pancreatic secretory response to intraduodenal tryptophan in dogs.
Pancreas.
1996 Nov; 13(4):407-16. doi:
10.1097/00006676-199611000-00011. [PMID: 8899802] - D K Nelson, B Glasbrenner, G Dahmen, R L Riepl, P Malfertheiner, G Adler. M1 muscarinic mechanisms regulate intestinal-phase gallbladder physiology in humans.
The American journal of physiology.
1996 Nov; 271(5 Pt 1):G824-30. doi:
10.1152/ajpgi.1996.271.5.g824. [PMID: 8944697] - D K Nelson, O Pieramico, G Dahmen, J E Dominguez-Muñoz, P Malfertheiner, G Alder. M1-muscarinic mechanisms regulate interdigestive cycling of motor and secretory activity in human upper gut.
Digestive diseases and sciences.
1996 Oct; 41(10):2006-15. doi:
10.1007/bf02093604. [PMID: 8888715] - J R Martin. McN-A-343 increases renal sympathetic nerve activity and blood pressure by a muscarinic and a non-muscarinic mechanism in the rat.
Journal of autonomic pharmacology.
1996 Oct; 16(5):281-92. doi:
10.1111/j.1474-8673.1996.tb00362.x. [PMID: 9023672] - S Teyssen, E Niebergall, S T Chari, M V Singer. Comparison of two dose-response techniques to study the pancreatic secretory response to intraduodenal tryptophan in the absence and presence of the M1-receptor antagonist telenzepine.
Pancreas.
1995 May; 10(4):368-73. doi:
10.1097/00006676-199505000-00008. [PMID: 7792293] - C C Schuerer-Maly, W Kromer, B Flogerzi, L Varga, S Postius, F Halter. Effect of acute and chronic acid suppression on plasma gastrin release in the rat.
Alimentary pharmacology & therapeutics.
1992 Apr; 6(2):195-206. doi:
10.1111/j.1365-2036.1992.tb00263.x. [PMID: 1318089] - A Reinicke, P Müller, H G Dammann, B Simon. [Pharmacokinetics and tolerability of telenzepine in patients with compensated liver cirrhosis].
Arzneimittel-Forschung.
1990 Nov; 40(11):1239-41. doi:
NULL. [PMID: 2085337] - J A Nielsen, E E Mena, I H Williams, M R Nocerini, D Liston. Correlation of brain levels of 9-amino-1,2,3,4-tetrahydroacridine (THA) with neurochemical and behavioral changes.
European journal of pharmacology.
1989 Nov; 173(1):53-64. doi:
10.1016/0014-2999(89)90008-3. [PMID: 2606156] - S J Konturek, J Tasler, M Cieszkowski, K Szewczyk, W Kromer. Comparison of telenzepine, pirenzepine and atropine on gastric acid and pepsin secretion in response to histamine, pentagastrin, bethanechol, sham-feeding and feeding.
Digestion.
1989; 44(2):66-78. doi:
10.1159/000199894. [PMID: 2575551] - E Sturm, A Junker. Determination of telenzepine in human serum by gas chromatography-mass spectrometry.
Journal of chromatography.
1988 Aug; 430(1):43-51. doi:
10.1016/s0378-4347(00)83132-1. [PMID: 3215960] - F Lauterbach. Intestinal permeation of nonquaternary amines: a study with telenzepine and pirenzepine in the isolated mucosa of guinea pig jejunum and colon.
The Journal of pharmacology and experimental therapeutics.
1987 Dec; 243(3):1121-30. doi:
". [PMID: 3694528]