(E,2Z)-4-Ethyl-2-hydroxyimino-5-nitro-hex-3-enamide (BioDeep_00000841757)
代谢物信息卡片
(E,2Z)-4-Ethyl-2-hydroxyimino-5-nitro-hex-3-enamide
化学式: C8H13N3O4 (215.0906018)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(=CC(=NO)C(=O)N)C(C)[N+](=O)[O-]
InChI: InChI=1S/C8H13N3O4/c1-3-6(5(2)11(14)15)4-7(10-13)8(9)12/h4-5,13H,3H2,1-2H3,(H2,9,12)/b6-4+,10-7-
描述信息
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D020030 - Nitric Oxide Donors
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D004791 - Enzyme Inhibitors
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Takashi Yoshida, Ryuji Inoue, Takashi Morii, Nobuaki Takahashi, Shinichiro Yamamoto, Yuji Hara, Makoto Tominaga, Shunichi Shimizu, Yoji Sato, Yasuo Mori. Nitric oxide activates TRP channels by cysteine S-nitrosylation.
Nature chemical biology.
2006 Nov; 2(11):596-607. doi:
10.1038/nchembio821. [PMID: 16998480] - Atsushi Nakajima, Kyoko Ueda, Masanori Takaoka, Hayato Kurata, Junji Takayama, Mamoru Ohkita, Yasuo Matsumura. Effects of pre- and post-ischemic treatments with FK409, a nitric oxide donor, on ischemia/reperfusion-induced renal injury and endothelin-1 production in rats.
Biological & pharmaceutical bulletin.
2006 Mar; 29(3):577-9. doi:
10.1248/bpb.29.577. [PMID: 16508172] - Atsushi Nakajima, Kyoko Ueda, Masanori Takaoka, Yoshiko Yoshimi, Yasuo Matsumura. Opposite effects of pre- and postischemic treatments with nitric oxide donor on ischemia/reperfusion-induced renal injury.
The Journal of pharmacology and experimental therapeutics.
2006 Mar; 316(3):1038-46. doi:
10.1124/jpet.105.092049. [PMID: 16306274] - Hayato Kurata, Masanori Takaoka, Yasuhiro Kubo, Tomoaki Katayama, Hidenobu Tsutsui, Junji Takayama, Mamoru Ohkita, Yasuo Matsumura. Protective effect of nitric oxide on ischemia/reperfusion-induced renal injury and endothelin-1 overproduction.
European journal of pharmacology.
2005 Jul; 517(3):232-9. doi:
10.1016/j.ejphar.2005.05.026. [PMID: 15975571] - Makoto Kurabayashi, Izumi Takeyoshi, Daisuke Yoshinari, Yukio Koibuchi, Takashi Ohki, Koshi Matsumoto, Yasuo Morishita. NO donor ameliorates ischemia-reperfusion injury of the rat liver with iNOS attenuation.
Journal of investigative surgery : the official journal of the Academy of Surgical Research.
2005 Jul; 18(4):193-200. doi:
10.1080/08941930500180156. [PMID: 16126630] - Hayato Kurata, Masanori Takaoka, Yasuhiro Kubo, Tomoaki Katayama, Hidenobu Tsutsui, Junji Takayama, Yasuo Matsumura. Nitric oxide protects against ischemic acute renal failure through the suppression of renal endothelin-1 overproduction.
Journal of cardiovascular pharmacology.
2004 Nov; 44 Suppl 1(?):S455-8. doi:
10.1097/01.fjc.0000166314.38258.a8. [PMID: 15838347] - Lesley J Bryan-Lluka, Marisa H Papacostas, Filip A Paczkowski, Janet C Wanstall. Nitric oxide donors inhibit 5-hydroxytryptamine (5-HT) uptake by the human 5-HT transporter (SERT).
British journal of pharmacology.
2004 Sep; 143(1):63-70. doi:
10.1038/sj.bjp.0705904. [PMID: 15302679] - E Totsuka, A Murata, A Nishimura, M Umehara, M Nara, H Ono, T Nozaki, M Takiguchi, N Wajima, K Takahashi, K Seino, S Narumi, K Hakamada, M Sasaki. Attenuation of canine warm ischemic small bowel injury by novel combination of nitric oxide donor, FK409, and cytokine suppressive anti-inflammatory agent FR167653.
Transplantation proceedings.
2004 Sep; 36(7):1988-90. doi:
10.1016/j.transproceed.2004.08.067. [PMID: 15518720] - Wilson Abrão Saad, Ismael Francisco Motta Siqueira Guarda, Luiz Antonio de Arruda Camargo, Gustavo Garcia, Laura Izabel Gutierrez, William Abrão Saad, Sylvio Simões, Renata Saad Guarda. Lateral hypothalamus lesions influences water and salt intake, and sodium and urine excretion, and arterial blood pressure induced by L-NAME and FK 409 injections into median preoptic nucleus in conscious rats.
Life sciences.
2004 Jun; 75(6):685-97. doi:
10.1016/j.lfs.2004.01.018. [PMID: 15172178] - Naoaki Morihara, Isao Sumioka, Toru Moriguchi, Naoto Uda, Eikai Kyo. Aged garlic extract enhances production of nitric oxide.
Life sciences.
2002 Jun; 71(5):509-17. doi:
10.1016/s0024-3205(02)01706-x. [PMID: 12052435] - M Aiba, I Takeyoshi, S Ohwada, Y Kawashima, K Iwanami, Y Sunose, T Yamada, H Tsutsumi, K Matsumoto, Y Morishita. Novel nitric oxide donor (FK409) ameliorates liver damage during extended liver resection with warm ischemia in dogs.
Journal of the American College of Surgeons.
2001 Sep; 193(3):264-71. doi:
10.1016/s1072-7515(01)01002-x. [PMID: 11548796] - S Kato, K Suzuki, H Ukawa, Y Komoike, K Takeuchi. Low gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in rats with cirrhosis and arthritis.
Digestive diseases and sciences.
2001 Aug; 46(8):1690-9. doi:
10.1023/a:1010601520497. [PMID: 11508669] - K Takeuchi, H Mizoguchi, H Araki, Y Komoike, K Suzuki. Lack of gastric toxicity of nitric oxide-releasing indomethacin, NCX-530, in experimental animals.
Digestive diseases and sciences.
2001 Aug; 46(8):1805-18. doi:
10.1023/a:1010638528675. [PMID: 11508687] - K Kawata, I Takeyoshi, K Iwanami, Y Sunose, M Aiba, S Ohwada, K Matsumoto, Y Morishita. A spontaneous nitric oxide donor ameliorates small bowel ischemia-reperfusion injury in dogs.
Digestive diseases and sciences.
2001 Aug; 46(8):1748-56. doi:
10.1023/a:1010670008202. [PMID: 11508678] - A Nishiyama, Y Fujisawa, T Fukui, M Rahman, N Kondo, Y Ogawa, L Fanzhu, Z Guoxing, S Kimura, Y Abe. Role of nitric oxide in regional blood flow in angiotensin II-induced hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2001 Jul; 24(4):421-7. doi:
10.1291/hypres.24.421. [PMID: 11510755] - S Itoh, Y Katoh, H Konishi, N Takaya, T Kimura, M Periasamy, H Yamaguchi. Nitric oxide regulates smooth-muscle-specific myosin heavy chain gene expression at the transcriptional level-possible role of SRF and YY1 through CArG element.
Journal of molecular and cellular cardiology.
2001 Jan; 33(1):95-107. doi:
10.1006/jmcc.2000.1279. [PMID: 11133226] - K Tashima, A Fujita, M Umeda, K Takeuchi. Lack of gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in the stomach of diabetic rats.
Life sciences.
2000 Aug; 67(13):1639-52. doi:
10.1016/s0024-3205(00)00746-3. [PMID: 10983857] - J Mohara, K Oshima, H Tsutsumi, I Takeyoshi, K Matsumoto, Y Morishita. FK409 ameliorates ischemia-reperfusion injury in heart transplantation following 12-hour cold preservation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
2000 Jul; 19(7):694-700. doi:
10.1016/s1053-2498(00)00122-4. [PMID: 10930819] - I Takeyoshi, Y Otani, D Yoshinari, Y Kawashima, S Ohwada, K Matsumoto, Y Morishita. Beneficial effects of novel nitric oxide donor (FK409) on pulmonary ischemia-reperfusion injury in rats.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
2000 Feb; 19(2):185-92. doi:
10.1016/s1053-2498(99)00113-8. [PMID: 10703696] - S H Wilson, P J Best, L O Lerman, D R Holmes, D M Richardson, A Lerman. Enhanced coronary vasoconstriction to oxidative stress product, 8-epi-prostaglandinF2 alpha, in experimental hypercholesterolemia.
Cardiovascular research.
1999 Dec; 44(3):601-7. doi:
10.1016/s0008-6363(99)00225-4. [PMID: 10690293] - K Kitaichi, L Wang, K Takagi, M Iwase, E Shibata, M Nadai, T Hasegawa. Decreased antipyrine clearance following endotoxin administration: in vivo evidence of the role of nitric oxide.
Antimicrobial agents and chemotherapy.
1999 Nov; 43(11):2697-701. doi:
10.1128/aac.43.11.2697. [PMID: 10543749] - J Weidenfeld, S Feldman, F G DeKeyser, H Ovadia. Effect of exogenous nitric oxide and inhibitors of nitric oxide synthase on the hypothalamic pituitary adrenal axis responses to neural stimuli.
Neuroendocrinology.
1999 Sep; 70(3):153-9. doi:
10.1159/000054471. [PMID: 10516477] - N Yonehara, M Yoshimura. Effect of nitric oxide on substance P release from the peripheral endings of primary afferent neurons.
Neuroscience letters.
1999 Aug; 271(3):199-201. doi:
10.1016/s0304-3940(99)00533-9. [PMID: 10507703] - K Kamata, T Hayashi. Effects of chronic treatment with the spontaneous nitric oxide releaser FK409 on vascular responses in established streptozotocin-induced diabetic rat.
Research communications in molecular pathology and pharmacology.
1999 Mar; 103(3):275-94. doi:
NULL. [PMID: 10509739] - Y Tanahashi, I Takeyoshi, M Aiba, S Ohwada, K Matsumoto, Y Morishita. The effects of FK409 on pulmonary ischemia-reperfusion injury in dogs.
Transplant international : official journal of the European Society for Organ Transplantation.
1999; 12(6):402-7. doi:
10.1007/s001470050249. [PMID: 10654350] - Y Matsumura, M Nishiura, S Deguchi, N Hashimoto, T Ogawa, R Seo. Protective effect of FK409, a spontaneous nitric oxide releaser, on ischemic acute renal failure in rats.
The Journal of pharmacology and experimental therapeutics.
1998 Dec; 287(3):1084-91. doi:
NULL. [PMID: 9864296] - H Ohmori, D K Dhar, Y Nakashima, M Hashimoto, S Masumura, N Nagasue. Beneficial effects of FK409, a novel nitric oxide donor, on reperfusion injury of rat liver.
Transplantation.
1998 Sep; 66(5):579-85. doi:
10.1097/00007890-199809150-00005. [PMID: 9753335] - Y Hirasawa, Y Kato, S Fukuyama, M Ohno, S Nishino, M Kato, Y Kita. Comparison of antiplatelet effects of two nitric oxide-donating agents, FR146801 and FK409.
Thrombosis and haemostasis.
1998 Mar; 79(3):620-4. doi:
10.1055/s-0037-1614956. [PMID: 9531052] - K Tadano, G Matsuo, T Hashimoto, Y Matsumura. Effects of FK409, a nitric oxide donor, on renal responses to renal nerve stimulation in anesthetized dogs.
European journal of pharmacology.
1998 Jan; 341(2-3):191-9. doi:
10.1016/s0014-2999(97)01424-6. [PMID: 9543240] - Y Kita, Y Hirasawa, Y Kato, K Ohkubo, M Ohno, S Nishino, M Kato, S Fukuyama. Comparison of hemodynamic effects of nitric oxide (NO) donors with different NO-releasing properties in rats.
Journal of cardiovascular pharmacology.
1997 Aug; 30(2):223-8. doi:
10.1097/00005344-199708000-00011. [PMID: 9269950] - S Fukuyama, Y Hirasawa, Y Kato, M Nishio, M Ohno, S Nishino, K Maeda, M Kato, Y Kita. Structure-activity relationships of spontaneous nitric oxide releasers, FK409 and its derivatives.
The Journal of pharmacology and experimental therapeutics.
1997 Jul; 282(1):236-42. doi:
NULL. [PMID: 9223559] - K Urabe, Y Matsumura, M Nishiura, K Maeda, S Morimoto. Renal hemodynamic and excretory responses in anesthetized rats to FK409, a novel nitric oxide donor.
European journal of pharmacology.
1997 Feb; 321(2):195-200. doi:
10.1016/s0014-2999(96)00945-4. [PMID: 9063688] - Y Kita, Y Hirasawa, S Fukuyama, K Ohkubo, Y Kato, H Takamatsu, M Ohno, S Nishino, M Kato, J Seki. Oral biological activities of spontaneous nitric oxide releasers are accounted for by their nitric oxide-releasing rates and oral absorption manners.
The Journal of pharmacology and experimental therapeutics.
1996 Feb; 276(2):421-5. doi:
NULL. [PMID: 8632305] - Y Kita, S Fukuyama, Y Hirasawa. Close correlation between nitric oxide (NO) formation from NO releasers and the biological activities of these agents in rats.
Japanese journal of pharmacology.
1995 Sep; 69(1):69-74. doi:
10.1254/jjp.69.69. [PMID: 8847834] - Y Hirasawa, M Nishio, K Maeda, K Yoshida, Y Kita. Comparison of antiplatelet effects of FK409, a spontaneous nitric oxide releaser, with those of TRK-100, a prostacyclin analogue.
European journal of pharmacology.
1995 Jan; 272(1):39-43. doi:
10.1016/0014-2999(94)0062s-5. [PMID: 7713147] - Y Kita, Y Hirasawa, K Yoshida, K Maeda. Antiplatelet activities of FK409, a new spontaneous NO releaser.
British journal of pharmacology.
1994 Oct; 113(2):385-8. doi:
10.1111/j.1476-5381.1994.tb17000.x. [PMID: 7834188] - Y Kita, T Sugimoto, Y Hirasawa, K Yoshida, K Maeda. Close correlation of the cardioprotective effect of FK409, a spontaneous NO releaser, with an increase in plasma cyclic GMP level.
British journal of pharmacology.
1994 Sep; 113(1):5-6. doi:
10.1111/j.1476-5381.1994.tb16165.x. [PMID: 7812632] - Y Kita, Y Hirasawa, K Maeda, M Nishio, K Yoshida. Spontaneous nitric oxide release accounts for the potent pharmacological actions of FK409.
European journal of pharmacology.
1994 May; 257(1-2):123-30. doi:
10.1016/0014-2999(94)90703-x. [PMID: 8082692]