Pentamethylmelamine (BioDeep_00000841751)
代谢物信息卡片
Pentamethylmelamine
化学式: C8H16N6 (196.1436376)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CNC1=NC(=NC(=N1)N(C)C)N(C)C
InChI: InChI=1S/C8H16N6/c1-9-6-10-7(13(2)3)12-8(11-6)14(4)5/h1-5H3,(H,9,10,11,12)
描述信息
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D000970 - Antineoplastic Agents
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dongsun Park, Tae Kyun Kim, Young Jin Choi, Sun Hee Lee, Dae-Kwon Bae, Goeun Yang, Yun-Hui Yang, Seong Soo Joo, Ehn-Kyoung Choi, Byeongwoo Ahn, Jong-Choon Kim, Kil-Soo Kim, Yun-Bae Kim. Increased nephrotoxicity after combined administration of melamine and cyanuric Acid in rats.
Laboratory animal research.
2011 Mar; 27(1):25-8. doi:
10.5625/lar.2011.27.1.25. [PMID: 21826156] - M Slavik, T R Narasimhan, C Riley, J Slavik. Changes in serum copper and zinc during treatment with anticancer drugs interfering with pyridoxal phosphate.
Advances in experimental medicine and biology.
1989; 258(?):235-42. doi:
10.1007/978-1-4613-0537-8_21. [PMID: 2516708] - J Dubois, G Atassi, M Hanocq, F Abikhalil. Pharmacokinetics and metabolism of hexamethylmelamine in mice bearing renal cell tumors.
Cancer chemotherapy and pharmacology.
1988; 22(4):282-8. doi:
10.1007/bf00254232. [PMID: 3139314] - I R Judson, C J Rutty, G Abel, M A Graham. Low central nervous system penetration of N2,N4,N6,-trihydroxymethyl-N2,N4,N6,-trimethylmelamine (Trimelamol): a cytotoxic s-triazine with reduced neurotoxicity.
British journal of cancer.
1986 May; 53(5):601-6. doi:
10.1038/bjc.1986.102. [PMID: 3087399] - J Dubois, G Atassi, M Hanocq, F Abikhalil. Pharmacokinetics and metabolism of hexamethylmelamine in mice after IP administration.
Cancer chemotherapy and pharmacology.
1986; 18(3):226-30. doi:
10.1007/bf00273391. [PMID: 3100080] - P J Klippert, A Hulshoff, G A Hofman, J Noordhoek. First-pass metabolism of pentamethylmelamine in the rat liver.
Cancer research.
1985 Mar; 45(3):983-6. doi:
NULL. [PMID: 3918792] - D Ross, S P Langdon, A Gescher, M F Stevens. Studies of the mode of action of antitumour triazenes and triazines-V. The correlation of the in vitro cytotoxicity and in vivo antitumour activity of hexamethylmelamine analogues with their metabolism.
Biochemical pharmacology.
1984 Apr; 33(7):1131-6. doi:
10.1016/0006-2952(84)90525-2. [PMID: 6424683] - P J Klippert, A Hulshoff, M J Mingels, G Hofman, J Noordhoek. Low oral bioavailability of hexamethylmelamine in the rat due to simultaneous hepatic and intestinal metabolism.
Cancer research.
1983 Jul; 43(7):3160-4. doi:
NULL. [PMID: 6406053] - J R Muindi, D R Newell, I E Smith, K R Harrap. Pentamethylmelamine (PMM): Phase I clinical and pharmacokinetic studies.
British journal of cancer.
1983 Jan; 47(1):27-33. doi:
10.1038/bjc.1983.3. [PMID: 6401427] - D J Stewart, J A Benvenuto, M Leavens, R G Smith, F Cabanillas, R S Benjamin, T L Loo. Human central nervous system pharmacology of pentamethylmelamine and its metabolites.
Journal of neuro-oncology.
1983; 1(4):357-64. doi:
10.1007/bf00165719. [PMID: 6432969] - E Garattini, T Colombo, M G Donelli, P Catalani, M Bianchi, M D'Incalci, C Pantarotto. Distribution, metabolism, and irreversible binding of hexamethylmelamine in mice bearing ovarian carcinoma.
Cancer chemotherapy and pharmacology.
1983; 11(1):51-5. doi:
10.1007/bf00257418. [PMID: 6411375] - T Colombo, M Broggini, A Gescher, M D'Incalci. Routes of elimination of hexamethylmelamine and pentamethylmelamine in the rat.
Xenobiotica; the fate of foreign compounds in biological systems.
1982 May; 12(5):315-21. doi:
10.3109/00498258209052471. [PMID: 6814076] - B R Leyland-Jones, P E Deesen, E S Casper, C W Young. Specific determination of pentamethylmelamine and its demethylated metabolites in human plasma by high pressure liquid chromatography.
Therapeutic drug monitoring.
1982; 4(2):185-90. doi:
10.1097/00007691-198206000-00005. [PMID: 6808715] - C J Rutty, D R Newell, J R Muindi, K R Harrap. The comparative pharmacokinetics of pentamethylmelamine in man, rat, and mouse.
Cancer chemotherapy and pharmacology.
1982; 8(1):105-11. doi:
10.1007/bf00292880. [PMID: 6807560] - M Broggini, C Rossi, T Colombo, M D'Incalci. Hexamethylmelamine and pentamethylmelamine tissue distribution in M5076/73A ovarian cancer-bearing mice.
Cancer treatment reports.
1982 Jan; 66(1):127-33. doi:
NULL. [PMID: 6796267] - D C Ihde, J S Dutcher, R C Young, R S Cordes, A L Barlock, S M Hubbard, R B Jones, M R Boyd. Phase I trial of pentamethylmelamine: a clinical and pharmacologic study.
Cancer treatment reports.
1981 Sep; 65(9-10):755-62. doi:
NULL. [PMID: 6791819] - M Broggini, T Colombo, M D'Incalci, M G Donnelli, A Gescher, S Garattini. Pharmacokinetics of hexamethylmelamine and pentamethylmelamine in mice.
Cancer treatment reports.
1981 Jul; 65(7-8):669-72. doi:
NULL. [PMID: 6788370] - E S Casper, R J Gralla, G R Lynch, B R Jones, T M Woodcock, C Gordon, D P Kelsen, C W Young. Phase I and pharmacological studies of pentamethylmelamine administered by 24-hour intravenous infusion.
Cancer research.
1981 Apr; 41(4):1402-6. doi:
NULL. [PMID: 6783296] - J A Benvenuto, D J Stewart, R S Benjamin, T L Loo. Pharmacology of pentamethylmelamine in humans.
Cancer research.
1981 Feb; 41(2):566-9. doi:
NULL. [PMID: 6778609] - T Colombo, L Torti, M D'Incalci. Dose-dependent pharmacokinetics of PMM in the rat.
Cancer chemotherapy and pharmacology.
1981; 5(3):201-3. doi:
10.1007/bf00258481. [PMID: 6794923] - J S Dutcher, R B Jones, M R Boyd. A sensitive and specific assay for pentamethylmelamine in plasma: applicability to clinical studies.
Cancer treatment reports.
1980 Jan; 64(1):99-104. doi:
NULL. [PMID: 6769585] - M M Ames, G Powis, J S Kovach, R T Eagan. Disposition and metabolism of pentamethylmelamine and hexamethylmelamine in rabbits and humans.
Cancer research.
1979 Dec; 39(12):5016-21. doi:
NULL. [PMID: 115586] - M M Ames, G Powis. Determination of pentamethylmelamine and hexamethylmelamine in plasma and urine by nitrogen-phosphorus gas-liquid chromatography.
Journal of chromatography.
1979 Jun; 174(1):245-9. doi:
10.1016/s0021-9673(00)87062-4. [PMID: 121123]
