Oxazolone (BioDeep_00000841725)
代谢物信息卡片
4-ethoxymethylene-2-phenyl-2-oxazolin-5-one
化学式: C12H11NO3 (217.0738896)
中文名称: 4-乙氧基亚甲基-2-苯基恶唑啉-5-酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC=C1C(=O)OC(=N1)C2=CC=CC=C2
InChI: InChI=1S/C12H11NO3/c1-2-15-8-10-12(14)16-11(13-10)9-6-4-3-5-7-9/h3-8H,2H2,1H3/b10-8-
描述信息
D007155 - Immunologic Factors
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yunji Bae, Taeyoung Kim, Nojune Park, Sangho Choi, Dongkeun Yi, Silvia Soto, Nelson Zamora, Sunam Kim, Minhye Yang. Ameliorative Effects of Daphnopsis costaricensis Extract against Oxazolone-Induced Atopic Dermatitis-like Lesions in BALB/c Mice.
Nutrients.
2022 Oct; 14(21):. doi:
10.3390/nu14214521. [PMID: 36364783] - Tae-Kyeong Lee, Dae Won Kim, Ji Hyeon Ahn, Choong-Hyun Lee, Jae-Chul Lee, Soon Sung Lim, Il Jun Kang, Seongkweon Hong, Soo Young Choi, Moo-Ho Won, Joon Ha Park. Protective Effects of Topical Administration of Laminarin in Oxazolone-Induced Atopic Dermatitis-like Skin Lesions.
Marine drugs.
2022 Oct; 20(11):. doi:
10.3390/md20110669. [PMID: 36354992] - Hao Dong, Chenjie Feng, Xiyunyi Cai, Yuanyuan Hao, Xinyue Gu, Lei Cai, Shuting Wu, Jiamin Chen, Zhou Liu, Wen Xie, Xuanren Lu, Hongfa Qian, Yulin Liu, Yiming Cao, Junlin Zhu, Jiayi Xu, Yanjie Zhou, Shuangyu Ma, Sha Yang, Yufeng Shi, Haojiang Yu, Minjie Shi, Yurong Wang, Harvest F Gu, Lei Fan, Liang Wu. 7-Methoxyisoflavone ameliorates atopic dermatitis symptoms by regulating multiple signaling pathways and reducing chemokine production.
Scientific reports.
2022 05; 12(1):8760. doi:
10.1038/s41598-022-12695-3. [PMID: 35610286] - Banzragch Dorjsembe, Chu Won Nho, Yongsoo Choi, Jin-Chul Kim. Extract from Black Soybean Cultivar A63 Extract Ameliorates Atopic Dermatitis-like Skin Inflammation in an Oxazolone-Induced Murine Model.
Molecules (Basel, Switzerland).
2022 Apr; 27(9):. doi:
10.3390/molecules27092751. [PMID: 35566102] - Xiao Xiao Wu, Wing Sum Siu, Chi Ling Wat, Chung Lap Chan, Chi Man Koon, Xiang Li, Wen Cheng, Hui Ma, Miranda Sin Man Tsang, Christopher Wai-Kei Lam, Ping Chung Leung, Clara Bik San Lau, Chun-Kwok Wong. Effects of topical application of a tri-herb formula on inflammatory dry-skin condition in mice with oxazolone-induced atopic dermatitis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Oct; 91(?):153691. doi:
10.1016/j.phymed.2021.153691. [PMID: 34425472] - Yuying Guo, Cong Ding, Tao Chang, Weitang Yuan, Xin Liu. VISTA-Ig ameliorates OXA-induced allergic dermatitis symptoms in mice.
Immunopharmacology and immunotoxicology.
2021 Jun; 43(3):380-385. doi:
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Immunopharmacology and immunotoxicology.
2021 Apr; 43(2):192-202. doi:
10.1080/08923973.2021.1878214. [PMID: 33504231] - Erle Dang, George Man, Dale Lee, Debbie A Crumrine, Theodora M Mauro, Peter M Elias, Mao-Qiang Man. Mutations in 3β-hydroxysteroid-δ8, δ7-isomerase paradoxically benefit epidermal permeability barrier homeostasis in mice.
Experimental dermatology.
2021 03; 30(3):384-389. doi:
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Journal of controlled release : official journal of the Controlled Release Society.
2021 01; 329(?):731-742. doi:
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Scientific reports.
2020 11; 10(1):20237. doi:
10.1038/s41598-020-77281-x. [PMID: 33214595] - Evangelos Mavridis, Eleftherios Bermperoglou, Eleni Pontiki, Dimitra Hadjipavlou-Litina. 5-(4H)-Oxazolones and Their Benzamides as Potential Bioactive Small Molecules.
Molecules (Basel, Switzerland).
2020 Jul; 25(14):. doi:
10.3390/molecules25143173. [PMID: 32664550] - Min-Jeong Heo, Soo Young Choi, Chanmi Lee, Yeong Min Choi, In-Sook An, Seunghee Bae, Sungkwan An, Jin Hyuk Jung. Perphenazine Attenuates the Pro-Inflammatory Responses in Mouse Models of Th2-Type Allergic Dermatitis.
International journal of molecular sciences.
2020 May; 21(9):. doi:
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Scientific reports.
2020 03; 10(1):4493. doi:
10.1038/s41598-020-61424-1. [PMID: 32161331] - Luting Zeng, Yingqin Liu, Congcong Xing, Yijie Huang, Xin Sun, Guangchen Sun. Saponin from Periploca forrestii Schltr Mitigates Oxazolone-Induced Atopic Dermatitis via Modulating Macrophage Activation.
Mediators of inflammation.
2020; 2020(?):4346367. doi:
10.1155/2020/4346367. [PMID: 33122966] - Sullim Lee, Hyun Jegal, Sim-Kyu Bong, Kyeong-No Yoon, No-June Park, Myoung-Sook Shin, Min Hye Yang, Yong Kee Kim, Su-Nam Kim. Anti-Atopic Effect of Acorn Shell Extract on Atopic Dermatitis-Like Lesions in Mice and Its Active Phytochemicals.
Biomolecules.
2019 12; 10(1):. doi:
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Molecules (Basel, Switzerland).
2019 Dec; 25(1):. doi:
10.3390/molecules25010076. [PMID: 31878303] - Priscilla B Pail, Gabriela W Neculqueo, Giovana P Maccari, Pedro C Chagastelles, Raquel D S Freitas, Ana P A Dagnino, Maria M Campos. The role of kinin B1 and B2 receptors in the mouse model of oxazolone-induced atopic dermatitis.
International immunopharmacology.
2019 Jul; 72(?):62-73. doi:
10.1016/j.intimp.2019.03.063. [PMID: 30959373] - Xuemei Sun, Xiukun Huang, Xunshuai Zhu, Lin Liu, Siyan Mo, Hongyuan Wang, Xiugui Wei, Shunyu Lu, Facheng Bai, Dandan Wang, Xing Lin, Jun Lin. HBOA ameliorates CCl4-incuded liver fibrosis through inhibiting TGF-β1/Smads, NF-κB and ERK signaling pathways.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Jul; 115(?):108901. doi:
10.1016/j.biopha.2019.108901. [PMID: 31079002] - Huan He, Xiaoxiao Gao, Xiaomin Wang, Xin Li, Xiaoxue Jiang, Zhehui Xie, Ke Ma, Jun Ma, Kazuo Umezawa, Yuyang Zhang. Comparison of anti-atopic dermatitis activities between DHMEQ and tacrolimus ointments in mouse model without stratum corneum.
International immunopharmacology.
2019 Jun; 71(?):43-51. doi:
10.1016/j.intimp.2019.03.015. [PMID: 30877873] - Jonghwan Jegal, No-June Park, Tae-Young Kim, Sangho Choi, Sang Woo Lee, Jin Hang, Su-Nam Kim, Min Hye Yang. Effect of Topically Applied Wikstroemia dolichantha Diels on the Development of Atopic Dermatitis-Like Skin Symptoms in Mice.
Nutrients.
2019 Apr; 11(4):. doi:
10.3390/nu11040914. [PMID: 31018627] - Malavattu G Prasad, Chapala V Lakshmi, Naresh K Katari, Krishnan Anand, Manojit Pal, Sreekantha B Jonnalagadda. Synthesis of 2-Substituted 4-Arylidene-5(4H)-oxazolones as Potential Cytotoxic Agents in the Presence of Lemon Juice as a Biocatalyst.
Combinatorial chemistry & high throughput screening.
2019; 22(9):625-634. doi:
10.2174/1386207322666191024105150. [PMID: 31696809] - Verónica Moner, Estibalitz Fernández, Ana Cristina Calpena, Adriana Garcia-Herrera, Mercedes Cócera, Olga López. A lamellar body mimetic system for the treatment of oxazolone-induced atopic dermatitis in hairless mice.
Journal of dermatological science.
2018 May; 90(2):172-179. doi:
10.1016/j.jdermsci.2018.01.010. [PMID: 29395580] - Sullim Lee, No-June Park, Sim-Kyu Bong, Jonghwan Jegal, Sang-A Park, Su-Nam Kim, Min Hye Yang. Ameliorative effects of Juniperus rigida fruit on oxazolone- and 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice.
Journal of ethnopharmacology.
2018 Mar; 214(?):160-167. doi:
10.1016/j.jep.2017.12.022. [PMID: 29258854] - Jonghwan Jegal, No-June Park, Sang-A Park, Sim-Kyu Bong, Hyun Jegal, Su-Nam Kim, Min Hye Yang. Juniperus chinensis Fruits Attenuate Oxazolone- and 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis Symptoms in Mice.
Biological & pharmaceutical bulletin.
2018; 41(2):259-265. doi:
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PloS one.
2018; 13(5):e0197487. doi:
10.1371/journal.pone.0197487. [PMID: 29791477] - Jonghwan Jegal, No-June Park, Sim-Kyu Bong, Hyun Jegal, Su-Nam Kim, Min Hye Yang. Dioscorea quinqueloba Ameliorates Oxazolone- and 2,4-Dinitrochlorobenzene-induced Atopic Dermatitis Symptoms in Murine Models.
Nutrients.
2017 Dec; 9(12):. doi:
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Journal of dermatological science.
2017 Nov; 88(2):184-191. doi:
10.1016/j.jdermsci.2017.07.017. [PMID: 28807557] - Przemysław Krawczyk, Beata Jędrzejewska, Piotr Cysewski, Tomasz Janek. Synthesis, photophysical and biological properties of a new oxazolone fluorescent probe for bioimaging: an experimental and theoretical study.
Organic & biomolecular chemistry.
2017 Oct; 15(42):8952-8966. doi:
10.1039/c7ob02439h. [PMID: 29043360] - Soichiro Adachi, Namiko Hoshi, Jun Inoue, Eiichiro Yasutomi, Takafumi Otsuka, Ramesh Dhakhwa, Zi Wang, Yuna Koo, Toshihiro Takamatsu, Yuriko Matsumura, Haruka Yamairi, Daisuke Watanabe, Makoto Ooi, Toshihito Tanahashi, Shin Nishiumi, Masaru Yoshida, Takeshi Azuma. Indigo Naturalis Ameliorates Oxazolone-Induced Dermatitis but Aggravates Colitis by Changing the Composition of Gut Microflora.
International archives of allergy and immunology.
2017; 173(1):23-33. doi:
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Animal science journal = Nihon chikusan Gakkaiho.
2016 Dec; 87(12):1554-1561. doi:
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Experimental dermatology.
2016 09; 25(9):725-7. doi:
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Molecular medicine reports.
2016 Aug; 14(2):1173-9. doi:
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Molecules (Basel, Switzerland).
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Experimental and molecular pathology.
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Archives of dermatological research.
2015 Nov; 307(9):781-92. doi:
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Immunology.
2015 Sep; 146(1):50-8. doi:
10.1111/imm.12478. [PMID: 25959240] - Na Young Yoon, Min young Jung, Dong Hye Kim, Hae Jin Lee, Eung Ho Choi. Topical glucocorticoid or pimecrolimus treatment suppresses thymic stromal lymphopoietin-related allergic inflammatory mechanism in an oxazolone-induced atopic dermatitis murine model.
Archives of dermatological research.
2015 Sep; 307(7):569-81. doi:
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Archives of dermatological research.
2015 Apr; 307(3):219-27. doi:
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PloS one.
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Immunology.
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Nature.
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Clinical and investigative medicine. Medecine clinique et experimentale.
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Cell.
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The Journal of pharmacology and experimental therapeutics.
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PloS one.
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Comparative medicine.
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Colloids and surfaces. B, Biointerfaces.
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Inflammation.
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Journal of the American Society for Mass Spectrometry.
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Toxicology.
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International journal of dermatology.
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Analytical and bioanalytical chemistry.
2011 Sep; 401(4):1377-84. doi:
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European journal of dermatology : EJD.
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Combinatorial chemistry & high throughput screening.
2011 May; 14(4):267-78. doi:
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Journal of dermatological science.
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The American journal of pathology.
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Journal of the science of food and agriculture.
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Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2010 Jun; 8(6):568-74. doi:
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Journal of immunology (Baltimore, Md. : 1950).
2010 Feb; 184(3):1339-47. doi:
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The Journal of allergy and clinical immunology.
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International archives of allergy and immunology.
2010; 151(2):98-106. doi:
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International archives of allergy and immunology.
2010; 152(2):87-97. doi:
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Yao xue xue bao = Acta pharmaceutica Sinica.
2010 Jan; 45(1):37-42. doi:
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Journal of dermatological science.
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The Journal of allergy and clinical immunology.
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The Journal of investigative dermatology.
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World journal of gastroenterology.
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Journal of the American Society for Mass Spectrometry.
2009 Feb; 20(2):334-9. doi:
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Photodermatology, photoimmunology & photomedicine.
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European journal of immunology.
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Gastroenterology.
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The Journal of investigative dermatology.
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Molecular immunology.
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Journal of ethnopharmacology.
2007 Apr; 110(3):419-27. doi:
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Biological & pharmaceutical bulletin.
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Planta medica.
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The Journal of pharmacy and pharmacology.
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The Journal of pharmacology and experimental therapeutics.
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International immunopharmacology.
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Developmental and comparative immunology.
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