merbarone (BioDeep_00000841713)
代谢物信息卡片
化学式: C11H9N3O3S (263.0365)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)NC(=O)C2C(=O)NC(=S)NC2=O
InChI: InChI=1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5,7H,(H,12,15)(H2,13,14,16,17,18)
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Xinrui Li, Jing Liu, Liang Ma, Ping Fu. Pharmacological urate-lowering approaches in chronic kidney disease.
European journal of medicinal chemistry.
2019 Mar; 166(?):186-196. doi:
10.1016/j.ejmech.2019.01.043. [PMID: 30769179] - M Kallio, J Lähdetie. Effects of the DNA topoisomerase II inhibitor merbarone in male mouse meiotic divisions in vivo: cell cycle arrest and induction of aneuploidy.
Environmental and molecular mutagenesis.
1997; 29(1):16-27. doi:
10.1002/(sici)1098-2280(1997)29:1<16::aid-em3>3.0.co;2-b. [PMID: 9020303] - H Anderson, M Roberge. Topoisomerase II inhibitors affect entry into mitosis and chromosome condensation in BHK cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
1996 Jan; 7(1):83-90. doi:
NULL. [PMID: 8788036] - M Slavik, P Y Liu, E H Kraut, R B Natale, L E Flaherty, V K Sondak. Evaluation of merbarone (NSC 336628) in disseminated malignant melanoma. A Southwest Oncology Group study.
Investigational new drugs.
1995; 13(2):143-7. doi:
10.1007/bf00872863. [PMID: 8617577] - R C Flanigan, J H Saiers, M Wolf, E H Kraut, A Y Smith, B Blumenstein, E D Crawford. Phase II evaluation of merbarone in renal cell carcinoma.
Investigational new drugs.
1994; 12(2):147-9. doi:
10.1007/bf00874446. [PMID: 7860233] - J F Muindi, Y W Stevens, R P Warrell, C W Young. In vitro differential metabolism of merbarone by xanthine oxidase and microsomal flavoenzymes. The role of reactive oxygen species.
Drug metabolism and disposition: the biological fate of chemicals.
1993 May; 21(3):410-4. doi:
. [PMID: 8100495] - J G Supko, L Malspeis. Characterization of the urinary metabolites of merbarone in cancer patients.
Drug metabolism and disposition: the biological fate of chemicals.
1991 Jan; 19(1):263-73. doi:
NULL. [PMID: 1673412] - J J Dimaggio, R P Warrell, J Muindi, Y W Stevens, S J Lee, D A Lowenthal, I Haines, T D Walsh, L Baltzer, S Yaldaei. Phase I clinical and pharmacological study of merbarone.
Cancer research.
1990 Feb; 50(4):1151-5. doi:
NULL. [PMID: 2297763] - R P Warrell, J Muindi, Y W Stevens, M Isaacs, C W Young. Induction of profound hypouricemia by a non-sedating thiobarbiturate.
Metabolism: clinical and experimental.
1989 Jun; 38(6):550-4. doi:
10.1016/0026-0495(89)90215-1. [PMID: 2725294] - Y Nakagawa, R A Kramer. Nephrotoxicity of 5-(N-phenylcarboxamido)-2-thiobarbituric acid in the Fischer 344 rat.
Cancer chemotherapy and pharmacology.
1989; 25(2):109-13. doi:
10.1007/bf00692349. [PMID: 2598397] - Y W Stevens, T D Walsh, M P Fanucchi. Quantitation of merbarone in human plasma by high-performance liquid chromatography.
Journal of chromatography.
1987 Apr; 416(1):203-6. doi:
10.1016/0378-4347(87)80503-0. [PMID: 3597638] - B H Kemmenoe, L Malspeis. Distribution of [2-14C]merbarone in mice by autoradiography of whole-body cryosections.
Cancer research.
1987 Feb; 47(4):1135-42. doi:
NULL. [PMID: 3802094] - A Glover, H G Chun, L M Kleinman, D A Cooney, J Plowman, C K Grieshaber, L Malspeis, B Leyland-Jones. Merbarone: an antitumor agent entering clinical trials.
Investigational new drugs.
1987; 5(2):137-43. doi:
10.1007/bf00203538. [PMID: 3308762]
