1,4-Dihydro-9h-imidazo[1,2-a]purin-9-one (BioDeep_00000841340)
代谢物信息卡片
化学式: C7H5N5O (175.0494)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CN2C(=O)C3=C(NC2=N1)N=CN3
InChI: InChI=1S/C7H5N5O/c13-6-4-5(10-3-9-4)11-7-8-1-2-12(6)7/h1-3H,(H,8,11)(H,9,10)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Adam Z Thelen, Patrick J O'Brien. Recognition of 1,N2-ethenoguanine by alkyladenine DNA glycosylase is restricted by a conserved active-site residue.
The Journal of biological chemistry.
2020 02; 295(6):1685-1693. doi:
10.1074/jbc.ra119.011459. [PMID: 31882538] - Alexandra Dimitri, Angela K Goodenough, F Peter Guengerich, Suse Broyde, David A Scicchitano. Transcription processing at 1,N2-ethenoguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase.
Journal of molecular biology.
2008 Jan; 375(2):353-66. doi:
10.1016/j.jmb.2007.10.057. [PMID: 18022639] - Jeong-Yun Choi, Hong Zang, Karen C Angel, Ivan D Kozekov, Angela K Goodenough, Carmelo J Rizzo, F Peter Guengerich. Translesion synthesis across 1,N2-ethenoguanine by human DNA polymerases.
Chemical research in toxicology.
2006 Jun; 19(6):879-86. doi:
10.1021/tx060051v. [PMID: 16780368] - Hauh-Jyun Candy Chen, Wei-Loong Chiu. Association between cigarette smoking and urinary excretion of 1,N2-ethenoguanine measured by isotope dilution liquid chromatography-electrospray ionization/tandem mass spectrometry.
Chemical research in toxicology.
2005 Oct; 18(10):1593-9. doi:
10.1021/tx050145p. [PMID: 16533024] - Hong Zang, Angela K Goodenough, Jeong-Yun Choi, Adriana Irimia, Lioudmila V Loukachevitch, Ivan D Kozekov, Karen C Angel, Carmelo J Rizzo, Martin Egli, F Peter Guengerich. DNA adduct bypass polymerization by Sulfolobus solfataricus DNA polymerase Dpo4: analysis and crystal structures of multiple base pair substitution and frameshift products with the adduct 1,N2-ethenoguanine.
The Journal of biological chemistry.
2005 Aug; 280(33):29750-64. doi:
10.1074/jbc.m504756200. [PMID: 15965231] - Thierry Douki, Francette Odin, Sylvain Caillat, Alain Favier, Jean Cadet. Predominance of the 1,N2-propano 2'-deoxyguanosine adduct among 4-hydroxy-2-nonenal-induced DNA lesions.
Free radical biology & medicine.
2004 Jul; 37(1):62-70. doi:
10.1016/j.freeradbiomed.2004.04.013. [PMID: 15183195] - Luis Mariano Gonzalez-Reche, Holger Martin Koch, Tobias Weiss, Johannes Müller, Hans Drexler, Jürgen Angerer. Analysis of ethenoguanine adducts in human urine using high performance liquid chromatography-tandem mass spectrometry.
Toxicology letters.
2002 Aug; 134(1-3):71-7. doi:
10.1016/s0378-4274(02)00165-0. [PMID: 12191863] - Murat Saparbaev, Sophie Langouët, Cyril V Privezentzev, F Peter Guengerich, Hongliang Cai, Rhoderick H Elder, Jacques Laval. 1,N(2)-ethenoguanine, a mutagenic DNA adduct, is a primary substrate of Escherichia coli mismatch-specific uracil-DNA glycosylase and human alkylpurine-DNA-N-glycosylase.
The Journal of biological chemistry.
2002 Jul; 277(30):26987-93. doi:
10.1074/jbc.m111100200. [PMID: 12016206] - E J Morinello, A J Ham, A Ranasinghe, R Sangaiah, J A Swenberg. Simultaneous quantitation of N(2),3-ethenoguanine and 1,N(2)-ethenoguanine with an immunoaffinity/gas chromatography/high-resolution mass spectrometry assay.
Chemical research in toxicology.
2001 Mar; 14(3):327-34. doi:
10.1021/tx0002076. [PMID: 11258983] - S Langouët, A N Mican, M Müller, S P Fink, L J Marnett, S A Muhle, F P Guengerich. Misincorporation of nucleotides opposite five-membered exocyclic ring guanine derivatives by escherichia coli polymerases in vitro and in vivo: 1,N2-ethenoguanine, 5,6,7,9-tetrahydro-9-oxoimidazo[1, 2-a]purine, and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1, 2-a]purine.
Biochemistry.
1998 Apr; 37(15):5184-93. doi:
10.1021/bi972327r. [PMID: 9548749]
