alpha-Fluoromethylhistidine (BioDeep_00000841037)
代谢物信息卡片
alpha-Fluoromethylhistidine
化学式: C7H10FN3O2 (187.07570120000003)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(NC=N1)CC(CF)(C(=O)O)N
InChI: InChI=1S/C7H10FN3O2/c8-3-7(9,6(12)13)1-5-2-10-4-11-5/h2,4H,1,3,9H2,(H,10,11)(H,12,13)/t7-/m1/s1
描述信息
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D002491 - Central Nervous System Agents
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Gustavo Provensi, Roberta Fabbri, Leonardo Munari, Alessia Costa, Elisabetta Baldi, Corrado Bucherelli, Patrizio Blandina, Maria Beatrice Passani. Histaminergic Neurotransmission as a Gateway for the Cognitive Effect of Oleoylethanolamide in Contextual Fear Conditioning.
The international journal of neuropsychopharmacology.
2017 05; 20(5):392-399. doi:
10.1093/ijnp/pyw110. [PMID: 28339575] - Katsuya Nagai, Akira Niijima, Toshihiko Yamano, Hiroto Otani, Nobuaki Okumra, Nobuo Tsuruoka, Masaaki Nakai, Yoshinobu Kiso. Possible role of L-carnosine in the regulation of blood glucose through controlling autonomic nerves.
Experimental biology and medicine (Maywood, N.J.).
2003 Nov; 228(10):1138-45. doi:
10.1177/153537020322801007. [PMID: 14610252] - Jerzy Jochem. Endogenous central histamine-induced reversal of critical hemorrhagic hypotension in rats: studies with L-histidine.
Shock (Augusta, Ga.).
2003 Oct; 20(4):332-7. doi:
10.1097/01.shk.0000081665.84347.a3. [PMID: 14501947] - Robert I Henkin. Comments to the editor concerning the paper entitled 'Histidine suppresses food intake through its conversion into neuronal histamine' by Yoshimatsu et al.
Experimental biology and medicine (Maywood, N.J.).
2002 Sep; 227(8):559; author reply 560. doi:
10.1177/153537020222700801. [PMID: 12192095] - M Kitano, P Norlén, R Håkanson. Gastric submucosal microdialysis: a method to study gastrin- and food-evoked mobilization of ECL-cell histamine in conscious rats.
Regulatory peptides.
2000 Jan; 86(1-3):113-23. doi:
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European journal of pharmacology.
2000 Jan; 387(1):R5-7. doi:
10.1016/s0014-2999(99)00803-1. [PMID: 10633171] - D Chen, C M Zhao, K Andersson, B Meister, P Panula, R Håkanson. ECL cell morphology.
The Yale journal of biology and medicine.
1998 May; 71(3-4):217-31. doi:
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Cell and tissue research.
1998 Feb; 291(2):315-23. doi:
10.1007/s004410051001. [PMID: 9426318] - J Bugajski, A Gadek-Michalska, A Ołowska, J Borycz, R Głód. Central histaminergic mechanisms mediate the vasopressin-induced pituitary adrenocortical stimulation.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
1996 Dec; 47(4):649-59. doi:
. [PMID: 9116332] - R Grilli, V Sibilia, A Torsello, F Pagani, M Guidi, M Luoni, C Netti, E E Müller. Role of the neuronal histaminergic system in the regulation of somatotropic function: comparison between the neonatal and the adult rat.
The Journal of endocrinology.
1996 Nov; 151(2):195-201. doi:
10.1677/joe.0.1510195. [PMID: 8958779] - H A Campos, Y Acuña, L Magaldi, A Israel. Alpha-fluoromethylhistidine, an inhibitor of histamine biosynthesis, causes arterial hypertension.
Naunyn-Schmiedeberg's archives of pharmacology.
1996 Nov; 354(5):627-32. doi:
10.1007/bf00170838. [PMID: 8938662] - K Andersson, E Lindström, D Chen, H J Monstein, A Boketoft, R Håkanson. Depletion of enterochromaffin-like cell histamine increases histidine decarboxylase and chromogranin A mRNA levels in rat stomach by a gastrin-independent mechanism.
Scandinavian journal of gastroenterology.
1996 Oct; 31(10):959-65. doi:
10.3109/00365529609003114. [PMID: 8898415] - N Engel, G Cricco, C Davio, G Martin, M Croci, C Fitzsimons, R Bergoc, E Rivera. Histamine regulates the expression of histidine decarboxylase in N-nitroso-N-methylurea (NMU)-induced mammary tumors in rats.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
1996 Mar; 45 Suppl 1(?):S64-5. doi:
10.1007/bf03354091. [PMID: 8696935] - R K Tuominen, L Tuomisto, P T Männistö. Effect of modified brain histamine contents on prolactin and thyrotropin secretion in male rats.
European journal of endocrinology.
1996 Feb; 134(2):209-14. doi:
10.1530/eje.0.1340209. [PMID: 8630521] - K Fujimoto, Y Gotoh, S Ogata, S Tsunada, T Ohyama, A Ootani, K Okamoto, T Sakata. Histaminergic control of mucosal repair in the small intestine.
Obesity research.
1995 Dec; 3 Suppl 5(?):795S-799S. doi:
10.1002/j.1550-8528.1995.tb00502.x. [PMID: 8653565] - A Kjaer, P J Larsen, U Knigge, J Warberg. Dehydration stimulates hypothalamic gene expression of histamine synthesis enzyme: importance for neuroendocrine regulation of vasopressin and oxytocin secretion.
Endocrinology.
1995 May; 136(5):2189-97. doi:
10.1210/endo.136.5.7720668. [PMID: 7720668] - J Bugajski, A Gadek-Michalska, J Borycz, A J Bugajski, R Głód. Histaminergic components in carbachol-induced pituitary-adrenocortical activity.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
1994 Sep; 45(3):419-28. doi:
. [PMID: 7841454] - A Kjaer, U Knigge, A Rouleau, M Garbarg, J Warberg. Dehydration-induced release of vasopressin involves activation of hypothalamic histaminergic neurons.
Endocrinology.
1994 Aug; 135(2):675-81. doi:
10.1210/endo.135.2.8033816. [PMID: 8033816] - L Tuomisto, A Yamatodani, J Jolkkonen, E L Sainio, M M Airaksinen. Inhibition of brain histamine synthesis increases food intake and attenuates vasopressin response to salt loading in rats.
Methods and findings in experimental and clinical pharmacology.
1994 Jun; 16(5):355-9. doi:
NULL. [PMID: 7934314] - J Bugajski, A Gadek-Michalska, J Borycz, A J Bugajski. Central histaminergic mechanisms in the corticosterone response to clonidine.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
1993 Sep; 44(3):303-12. doi:
. [PMID: 8241531] - C Kamei, Y Okumura, S Tsujimoto, K Tasaka. Role of hypothalamic histamine in stimulating the corticosterone release in rats.
Archives internationales de pharmacodynamie et de therapie.
1993 Sep; 325(?):35-50. doi:
NULL. [PMID: 8110028] - C E Navarro, R Otoya, A O Donoso. Stimulation of H3-histamine receptors increases the release of prolactin in male rats.
Neuroendocrinology.
1993 Apr; 57(4):654-7. doi:
10.1159/000126421. [PMID: 8367032] - E Sakurai, S Yamasaki, Y Iizuka, N Hikichi, K Maeyama, T Watanabe. Enantioselective pharmacokinetics of alpha-fluoromethylhistidine in rats and its comparison with histidine.
The Journal of pharmacy and pharmacology.
1992 Nov; 44(11):921-5. doi:
10.1111/j.2042-7158.1992.tb03237.x. [PMID: 1361538] - A Ray, S Puri, A K Chakravarty, P Sen. Central histaminergic involvement during stress in rats.
Indian journal of experimental biology.
1992 Aug; 30(8):724-8. doi:
NULL. [PMID: 1360944] - K Fujimoto, I Imamura, D N Granger, H Wada, T Sakata, P Tso. Histamine and histidine decarboxylase are correlated with mucosal repair in rat small intestine after ischemia-reperfusion.
The Journal of clinical investigation.
1992 Jan; 89(1):126-33. doi:
10.1172/jci115552. [PMID: 1729265] - S Puri, A Ray, A K Chakravarty, P Sen. Role of histaminergic mechanisms in the regulation of some stress responses in rats.
Pharmacology, biochemistry, and behavior.
1991 Aug; 39(4):847-50. doi:
10.1016/0091-3057(91)90042-z. [PMID: 1763102] - N M Horno, E O Alvarez. The participation of histaminergic receptors of the rostral hypothalamus on the tonic release of luteinizing hormone (LH) in adult spayed rats under estrogen and progesterone treatment.
Journal of neural transmission. General section.
1991; 83(1-2):97-105. doi:
10.1007/bf01244456. [PMID: 2018632] - V F Akins, S L Bealer. Central nervous system histamine regulates peripheral sympathetic activity.
The American journal of physiology.
1991 Jan; 260(1 Pt 2):H218-24. doi:
10.1152/ajpheart.1991.260.1.h218. [PMID: 1992801] - A Kjaer, U Knigge, L Olsen, H Vilhardt, J Warberg. Mediation of the stress-induced prolactin release by hypothalamic histaminergic neurons and the possible involvement of vasopressin in this response.
Endocrinology.
1991 Jan; 128(1):103-10. doi:
10.1210/endo-128-1-103. [PMID: 1986913] - E Sakurai, H Niwa, S Yamasaki, K Maeyama, T Watanabe. The disposition of a histidine decarboxylase inhibitor (S)-alpha-fluoromethylhistidine in rats.
The Journal of pharmacy and pharmacology.
1990 Dec; 42(12):857-60. doi:
10.1111/j.2042-7158.1990.tb07040.x. [PMID: 1983148] - L Hammar, S Henningsson, A C Henningsson, L E Appelgren, H Tjälve, J Kollonitsch. Autoradiography of 3H-alpha-fluoromethyl histidine in mice: correlation with the kidney histidine decarboxylase activity.
Pharmacology & toxicology.
1990 Jul; 67(1):61-8. doi:
10.1111/j.1600-0773.1990.tb00783.x. [PMID: 2395817] - C Netti, F Guidobono, V Sibilia, F Pagani, I Villa, A Pecile. A selective role for brain histamine in prolactin release induced by opiates.
Agents and actions.
1990 Apr; 30(1-2):223-5. doi:
10.1007/bf01969044. [PMID: 2142564] - M Garbarg, H Pollard, M D Trung Tuong, J C Schwartz, C Gros. Sensitive radioimmunoassays for histamine and tele-methylhistamine in the brain.
Journal of neurochemistry.
1989 Dec; 53(6):1724-30. doi:
10.1111/j.1471-4159.1989.tb09237.x. [PMID: 2809587] - N Itowi, A Yamatodani, R Cacabelos, M Goto, H Wada. Effect of histamine depletion on circadian variations of corticotropin and corticosterone in rats.
Neuroendocrinology.
1989 Aug; 50(2):187-92. doi:
10.1159/000125220. [PMID: 2550838] - N M Horno, E O Alvarez. The probable role of histamine in the rostral hypothalamus on the prolactin and luteinizing hormone release induced by estrogen in conscious spayed rats.
Journal of neural transmission. General section.
1989; 78(3):249-64. doi:
10.1007/bf01249233. [PMID: 2803701] - N Hirasawa, K Ohuchi, K Kawarasaki, M Watanabe, S Tsurufuji. Occurrence of histamine-production-increasing factor in the postanaphylactic phase of allergic inflammation.
International archives of allergy and applied immunology.
1989; 88(4):386-93. doi:
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Canadian journal of physiology and pharmacology.
1987 Oct; 65(10):2154-7. doi:
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Brain research bulletin.
1987 Aug; 19(2):165-73. doi:
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Agents and actions.
1987 Apr; 20(3-4):236-8. doi:
10.1007/bf02074679. [PMID: 3604804] - S Suzuki, K Nakano. Possible role of endogenous histamine in mediation of LPS-induced secretion of corticosterone in mice.
Biochemical pharmacology.
1986 Sep; 35(18):3039-43. doi:
10.1016/0006-2952(86)90383-7. [PMID: 3753516] - A M Seltzer, A O Donoso, E Podestá. Restraint stress stimulation of prolactin and ACTH secretion: role of brain histamine.
Physiology & behavior.
1986; 36(2):251-5. doi:
10.1016/0031-9384(86)90012-0. [PMID: 3008205] - K Maeyama, A Ohno, Y Taguchi, T Watanabe, H Wada. Effects of alpha-fluoromethylhistidine on increase in histidine decarboxylase activity of maternal mouse kidney observed during late pregnancy and evidence for its non-mast cell origin by using estrogen and W/WV mice.
Japanese journal of pharmacology.
1985 Oct; 39(2):145-51. doi:
10.1254/jjp.39.145. [PMID: 3841376] - T F August, D G Musson, S S Hwang, D E Duggan, K F Hooke, I J Roman, R J Ferguson, W F Bayne. Bioanalysis and disposition of alpha-fluoromethylhistidine, a new histidine decarboxylase inhibitor.
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1985 Aug; 74(8):871-5. doi:
10.1002/jps.2600740814. [PMID: 4032273] - G Granerus, J H Olafsson, G Roupe. Treatment of two mastocytosis patients with a histidine decarboxylase inhibitor.
Agents and actions.
1985 Apr; 16(3-4):244-8. doi:
10.1007/bf01983151. [PMID: 4013913] - J H Olafsson. Cutaneous and systemic mastocytosis in adults. A clinical, histopathological and immunological evaluation in relation to histamine metabolism.
Acta dermato-venereologica. Supplementum.
1985; 115(?):1-43. doi:
. [PMID: 3901645] - T A Slotkin, J Bartolome, W L Whitmore. Developmental effects of alpha-fluoromethylhistidine, an irreversible inhibitor of histidine decarboxylase, on growth and on levels and turnover of catecholamines.
Life sciences.
1983 Nov; 33(21):2137-45. doi:
10.1016/0024-3205(83)90338-7. [PMID: 6645794] - M T Bauza, D Lagunoff. Histidine uptake by isolated rat peritoneal mast cells. Effect of inhibition of histidine decarboxylase by alpha-fluoromethylhistidine.
Biochemical pharmacology.
1983 Jan; 32(1):59-63. doi:
10.1016/0006-2952(83)90652-4. [PMID: 6830620] - K Maeyama, T Watanabe, Y Taguchi, A Yamatodani, H Wada. Effect of alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase, on histamine levels in mouse tissues.
Biochemical pharmacology.
1982 Jul; 31(14):2367-70. doi:
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