2-Hydroxybutanoate (BioDeep_00000840856)
代谢物信息卡片
2-Hydroxybutanoate
化学式: C4H7O3- (103.0395172)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C(=O)[O-])O
InChI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Seyed Ali Rasooli, Rozita Fathi, Farhad Ahmadi-Kani Golzar, Masoumeh Baghersalimi. The effect of circuit resistance training on plasma levels of amino acids, alpha-hydroxybutyrate, mannose, and urinary levels of glycine conjugated adducts in obese adolescent boys.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
2021 Jun; 46(6):561-570. doi:
10.1139/apnm-2020-0171. [PMID: 33151749] - Ding Shi, Ren Yan, Longxian Lv, Huiyong Jiang, Yingfeng Lu, Jifang Sheng, Jiaojiao Xie, Wenrui Wu, Jiafeng Xia, Kaijin Xu, Silan Gu, Yanfei Chen, Chenjie Huang, Jing Guo, Yiling Du, Lanjuan Li. The serum metabolome of COVID-19 patients is distinctive and predictive.
Metabolism: clinical and experimental.
2021 05; 118(?):154739. doi:
10.1016/j.metabol.2021.154739. [PMID: 33662365] - Rohit Sharma, Bryn Reinstadler, Kristin Engelstad, Owen S Skinner, Erin Stackowitz, Ronald G Haller, Clary B Clish, Kerry Pierce, Melissa A Walker, Robert Fryer, Devin Oglesbee, Xiangling Mao, Dikoma C Shungu, Ashok Khatri, Michio Hirano, Darryl C De Vivo, Vamsi K Mootha. Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity.
The Journal of clinical investigation.
2021 01; 131(2):. doi:
10.1172/jci136055. [PMID: 33463549] - Rui Lin, Meiyu Piao, Yan Song, Chunyan Liu. Quercetin Suppresses AOM/DSS-Induced Colon Carcinogenesis through Its Anti-Inflammation Effects in Mice.
Journal of immunology research.
2020; 2020(?):9242601. doi:
10.1155/2020/9242601. [PMID: 32537472] - Chulhun Park, Nileshkumar Meghani, Hardik Amin, Phuong H-L Tran, Thao T-D Tran, Van H Nguyen, Beom-Jin Lee. The roles of short and long chain fatty acids on physicochemical properties and improved cancer targeting of albumin-based fattigation-platform nanoparticles containing doxorubicin.
International journal of pharmaceutics.
2019 Jun; 564(?):124-135. doi:
10.1016/j.ijpharm.2019.04.038. [PMID: 30991133] - Matthew J Peterson, Sheena Geoghegan, Larry W Lawhorne. An Exploratory Analysis of Potential New Biomarkers of Cognitive Function.
The journals of gerontology. Series A, Biological sciences and medical sciences.
2019 02; 74(3):299-305. doi:
10.1093/gerona/gly122. [PMID: 29846522] - Jing Chou, Rui Liu, Jiaying Yu, Xiaowei Liu, Xinshu Zhao, Ying Li, Liyan Liu, Changhao Sun. Fasting serum α‑hydroxybutyrate and pyroglutamic acid as important metabolites for detecting isolated post-challenge diabetes based on organic acid profiles.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Nov; 1100-1101(?):6-16. doi:
10.1016/j.jchromb.2018.09.004. [PMID: 30267980] - Wenli Li, Meiling Ji, Yandie Lin, Yi Miao, Simin Chen, Hao Li. DEPP/DEPP1/C10ORF10 regulates hepatic glucose and fat metabolism partly via ROS-induced FGF21.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2018 10; 32(10):5459-5469. doi:
10.1096/fj.201800357r. [PMID: 29702025] - Prapimporn Chattranukulchai Shantavasinkul, Michael J Muehlbauer, James R Bain, Olga R Ilkayeva, Damian M Craig, Christopher B Newgard, Laura P Svetkey, Svati H Shah, Alfonso Torquati. Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.
2018 Aug; 14(8):1126-1132. doi:
10.1016/j.soard.2018.03.033. [PMID: 29805089] - Domenico Tricò, Hetty Prinsen, Cosimo Giannini, Robin de Graaf, Christoph Juchem, Fangyong Li, Sonia Caprio, Nicola Santoro, Raimund I Herzog. Elevated α-Hydroxybutyrate and Branched-Chain Amino Acid Levels Predict Deterioration of Glycemic Control in Adolescents.
The Journal of clinical endocrinology and metabolism.
2017 07; 102(7):2473-2481. doi:
10.1210/jc.2017-00475. [PMID: 28482070] - Prashant K Sarswat, Yogendra Kumar Mishra, Michael L Free. Fabrication and response of alpha-hydroxybutyrate sensors for rapid assessment of cardiometabolic disease risk.
Biosensors & bioelectronics.
2017 Mar; 89(Pt 1):334-342. doi:
10.1016/j.bios.2016.07.019. [PMID: 27453438] - Abdelilah Arredouani, Matteo Stocchero, Nicola Culeddu, Julia El-Sayed Moustafa, Jean Tichet, Beverley Balkau, Thierry Brousseau, Marco Manca, Mario Falchi. Metabolomic Profile of Low-Copy Number Carriers at the Salivary α-Amylase Gene Suggests a Metabolic Shift Toward Lipid-Based Energy Production.
Diabetes.
2016 Nov; 65(11):3362-3368. doi:
10.2337/db16-0315. [PMID: 27436124] - Agnieszka Klupczynska, Szymon Plewa, Wojciech Dyszkiewicz, Mariusz Kasprzyk, Natalia Sytek, Zenon J Kokot. Determination of low-molecular-weight organic acids in non-small cell lung cancer with a new liquid chromatography-tandem mass spectrometry method.
Journal of pharmaceutical and biomedical analysis.
2016 Sep; 129(?):299-309. doi:
10.1016/j.jpba.2016.07.028. [PMID: 27454081] - Yi Wang, Gary G Deng, Kelvin P Davies. Novel insights into development of diabetic bladder disorder provided by metabolomic analysis of the rat nondiabetic and diabetic detrusor and urothelial layer.
American journal of physiology. Endocrinology and metabolism.
2016 08; 311(2):E471-9. doi:
10.1152/ajpendo.00134.2016. [PMID: 27354236] - Domenico Ciavardelli, Fabrizio Piras, Ada Consalvo, Claudia Rossi, Mirco Zucchelli, Carmine Di Ilio, Valerio Frazzini, Carlo Caltagirone, Gianfranco Spalletta, Stefano L Sensi. Medium-chain plasma acylcarnitines, ketone levels, cognition, and gray matter volumes in healthy elderly, mildly cognitively impaired, or Alzheimer's disease subjects.
Neurobiology of aging.
2016 07; 43(?):1-12. doi:
10.1016/j.neurobiolaging.2016.03.005. [PMID: 27255810] - Jeff Cobb, Andrea Eckhart, Alison Motsinger-Reif, Bernadette Carr, Leif Groop, Ele Ferrannini. α-Hydroxybutyric Acid Is a Selective Metabolite Biomarker of Impaired Glucose Tolerance.
Diabetes care.
2016 Jun; 39(6):988-95. doi:
10.2337/dc15-2752. [PMID: 27208342] - Konrad Sarosiek, Kirk L Pappan, Ankit V Gandhi, Shivam Saxena, Christopher Y Kang, Heather McMahon, Galina I Chipitsyna, David S Tichansky, Hwyda A Arafat. Conserved Metabolic Changes in Nondiabetic and Type 2 Diabetic Bariatric Surgery Patients: Global Metabolomic Pilot Study.
Journal of diabetes research.
2016; 2016(?):3467403. doi:
10.1155/2016/3467403. [PMID: 26881244] - Xu-guang Shi, Zhong-jie Zou, Mei-yin Wu, Yuan-gui Zeng, Zhi-cheng Lian, Man-ting Huang, Meng-juan Gong. [Metabonomics Study on Urine 1H-NMR in Chronic Superficial Gastritis Patients with Pi-qi Deficiency Syndrome/Pi-Wei Dampness-heat Syndrome].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2015 Dec; 35(12):1427-32. doi:
. [PMID: 26882602] - M Trent Herdman, Natthida Sriboonvorakul, Stije J Leopold, Sam Douthwaite, Sanjib Mohanty, M Mahtab Uddin Hassan, Richard J Maude, Hugh W F Kingston, Katherine Plewes, Prakaykaew Charunwatthana, Kamolrat Silamut, Charles J Woodrow, Aniruddha Ghose, Kesinee Chotinavich, Md Amir Hossain, M Abul Faiz, Saroj Mishra, Natchanun Leepipatpiboon, Nicholas J White, Nicholas P J Day, Joel Tarning, Arjen M Dondorp. The role of previously unmeasured organic acids in the pathogenesis of severe malaria.
Critical care (London, England).
2015 Sep; 19(?):317. doi:
10.1186/s13054-015-1023-5. [PMID: 26343146] - Ebru Selin Selen, Zeinab Bolandnazar, Marco Tonelli, Daniel E Bütz, Julia A Haviland, Warren P Porter, Fariba M Assadi-Porter. NMR Metabolomics Show Evidence for Mitochondrial Oxidative Stress in a Mouse Model of Polycystic Ovary Syndrome.
Journal of proteome research.
2015 Aug; 14(8):3284-91. doi:
10.1021/acs.jproteome.5b00307. [PMID: 26076986] - E Muscelli, S Frascerra, A Casolaro, S Baldi, A Mari, W Gall, J Cobb, E Ferrannini. The amino acid response to a mixed meal in patients with type 2 diabetes: effect of sitagliptin treatment.
Diabetes, obesity & metabolism.
2014 Nov; 16(11):1140-7. doi:
10.1111/dom.12350. [PMID: 25040945] - Elizabeth Joseloff, Wei Sha, Sara C Bell, Diana R Wetmore, Kay A Lawton, Michael V Milburn, John A Ryals, Lining Guo, Marianne S Muhlebach. Serum metabolomics indicate altered cellular energy metabolism in children with cystic fibrosis.
Pediatric pulmonology.
2014 May; 49(5):463-72. doi:
10.1002/ppul.22859. [PMID: 23847148] - M Gołębiowski, M Cerkowniak, A Urbanek, M Dawgul, W Kamysz, M I Boguś, D Sosnowska, P Stepnowski. Antimicrobial activity of untypical lipid compounds in the cuticular and internal lipids of four fly species.
Journal of applied microbiology.
2014 Feb; 116(2):269-87. doi:
10.1111/jam.12370. [PMID: 24238211] - Ele Ferrannini, Andrea Natali, Stefania Camastra, Monica Nannipieri, Andrea Mari, Klaus-Peter Adam, Michael V Milburn, Gabi Kastenmüller, Jerzy Adamski, Tiinamaija Tuomi, Valeriya Lyssenko, Leif Groop, Walter E Gall. Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance.
Diabetes.
2013 May; 62(5):1730-7. doi:
10.2337/db12-0707. [PMID: 23160532] - Philip J Saylor, Edward D Karoly, Matthew R Smith. Prospective study of changes in the metabolomic profiles of men during their first three months of androgen deprivation therapy for prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2012 Jul; 18(13):3677-85. doi:
10.1158/1078-0432.ccr-11-3209. [PMID: 22589396] - Shin Nishiumi, Takashi Kobayashi, Atsuki Ikeda, Tomoo Yoshie, Megumi Kibi, Yoshihiro Izumi, Tatsuya Okuno, Nobuhide Hayashi, Seiji Kawano, Tadaomi Takenawa, Takeshi Azuma, Masaru Yoshida. A novel serum metabolomics-based diagnostic approach for colorectal cancer.
PloS one.
2012; 7(7):e40459. doi:
10.1371/journal.pone.0040459. [PMID: 22792336] - Alexandros Pechlivanis, Sarantos Kostidis, Ploutarchos Saraslanidis, Anatoli Petridou, George Tsalis, Vassilis Mougios, Helen G Gika, Emmanuel Mikros, Georgios A Theodoridis. (1)H NMR-based metabonomic investigation of the effect of two different exercise sessions on the metabolic fingerprint of human urine.
Journal of proteome research.
2010 Dec; 9(12):6405-16. doi:
10.1021/pr100684t. [PMID: 20932058] - Walter E Gall, Kirk Beebe, Kay A Lawton, Klaus-Peter Adam, Matthew W Mitchell, Pamela J Nakhle, John A Ryals, Michael V Milburn, Monica Nannipieri, Stefania Camastra, Andrea Natali, Ele Ferrannini. alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population.
PloS one.
2010 May; 5(5):e10883. doi:
10.1371/journal.pone.0010883. [PMID: 20526369] - Richard S Lord, J Alexander Bralley. Clinical applications of urinary organic acids. Part I: Detoxification markers.
Alternative medicine review : a journal of clinical therapeutic.
2008 Sep; 13(3):205-15. doi:
NULL. [PMID: 18950247] - Iola F Duarte, Brian J Goodfellow, António Barros, John G Jones, Cristina Barosa, Luisa Diogo, Paula Garcia, Ana M Gil. Metabolic characterisation of plasma in juveniles with glycogen storage disease type 1a (GSD1a) by high-resolution (1)H NMR spectroscopy.
NMR in biomedicine.
2007 Jun; 20(4):401-12. doi:
10.1002/nbm.1073. [PMID: 17149801] - K R Kim, J Lee, D Ha, J Jeon, H G Park, J H Kim. Enantiomeric separation and discrimination of 2-hydroxy acids as O-trifluoroacetylated (S)-(+)-3-methyl-2-butyl esters by achiral dual-capillary column gas chromatography.
Journal of chromatography. A.
2000 Mar; 874(1):91-100. doi:
10.1016/s0021-9673(00)00072-8. [PMID: 10768503] - T Bamba, T Ihara. [Methionine malabsorption syndrome].
Ryoikibetsu shokogun shirizu.
1998; ?(19 Pt 2):576-7. doi:
NULL. [PMID: 9645139] - S G Hasselbalch, G M Knudsen, J Jakobsen, L P Hageman, S Holm, O B Paulson. Blood-brain barrier permeability of glucose and ketone bodies during short-term starvation in humans.
The American journal of physiology.
1995 Jun; 268(6 Pt 1):E1161-6. doi:
10.1152/ajpendo.1995.268.6.e1161. [PMID: 7611392] - V Walker, G A Mills. Effects of birth asphyxia on urinary organic acid excretion.
Biology of the neonate.
1992; 61(3):162-72. doi:
10.1159/000243739. [PMID: 1610944] - S Klein, O B Holland, R R Wolfe. Importance of blood glucose concentration in regulating lipolysis during fasting in humans.
The American journal of physiology.
1990 Jan; 258(1 Pt 1):E32-9. doi:
10.1152/ajpendo.1990.258.1.e32. [PMID: 2405701] - M A Staten, D E Matthews, P E Cryer, D M Bier. Epinephrine's effect on metabolic rate is independent of changes in plasma insulin or glucagon.
The American journal of physiology.
1989 Aug; 257(2 Pt 1):E185-92. doi:
10.1152/ajpendo.1989.257.2.e185. [PMID: 2569829] - R S Eriksson, L Thunberg, U J Eriksson. Effects of interrupted insulin treatment on fetal outcome of pregnant diabetic rats.
Diabetes.
1989 Jun; 38(6):764-72. doi:
10.2337/diab.38.6.764. [PMID: 2656344] - B M LaGrange, V L Hood. Ketoacid production in acute respiratory and metabolic acidosis and alkalosis in rats.
The American journal of physiology.
1989 Mar; 256(3 Pt 2):F437-45. doi:
10.1152/ajprenal.1989.256.3.f437. [PMID: 2923222] - M L Halperin, B L Margolis, L A Robinson, R M Halperin, M L West, R A Bear. The urine osmolal gap: a clue to estimate urine ammonium in 'hybrid' types of metabolic acidosis.
Clinical and investigative medicine. Medecine clinique et experimentale.
1988 Jun; 11(3):198-202. doi:
NULL. [PMID: 3135965] - D Molnár, T Decsi, G Soltész. Resting energy expenditure and food-induced thermogenesis in diabetic children receiving continuous subcutaneous insulin infusion.
Diabetes research (Edinburgh, Scotland).
1988 Mar; 7(3):117-21. doi:
NULL. [PMID: 3046818] - M Funahashi, K Funahashi, C Wakasugi, I Shikata. Identification of alpha-hydroxybutyrate in rabbit serum after ethanol ingestion.
Nihon hoigaku zasshi = The Japanese journal of legal medicine.
1986 Dec; 40(6):821-3. doi:
NULL. [PMID: 3560524] - T Kuhara, T Shinka, Y Inoue, M Matsumoto, M Yoshino, Y Sakaguchi, I Matsumoto. Studies of urinary organic acid profiles of a patient with dihydrolipoyl dehydrogenase deficiency.
Clinica chimica acta; international journal of clinical chemistry.
1983 Sep; 133(2):133-40. doi:
10.1016/0009-8981(83)90398-4. [PMID: 6688766] - J Kleinbaum, H Shamoon. Impaired counterregulation of hypoglycemia in insulin-dependent diabetes mellitus.
Diabetes.
1983 Jun; 32(6):493-8. doi:
10.2337/diab.32.6.493. [PMID: 6354777] - J Feigenbaum, J Yanai, R Blass. Possible DA agonist properties of naloxone.
The International journal of neuroscience.
1982 Nov; 17(3):139-44. doi:
10.3109/00207458208985915. [PMID: 6302020] - P Henry, R A Saunders. The performance of the 'CentrifiChem' parallel fast analyser using packaged reagents.
Annals of clinical biochemistry.
1975 May; 12(3):119-25. doi:
10.1177/000456327501200125. [PMID: 15637919]