Guanosine-diphosphate (BioDeep_00000840695)
代谢物信息卡片
Guanosine-diphosphate
化学式: C10H12N5O11P2-3 (440.0008562)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=NC2=C(N1C3C(C(C(O3)COP(=O)([O-])OP(=O)([O-])[O-])O)O)N=C(NC2=O)N
InChI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1
相关代谢途径
Reactome(88)
- Metabolism
- Visual phototransduction
- Sensory Perception
- Metabolism of proteins
- Post-translational protein modification
- Disease
- Amino acid and derivative metabolism
- Diseases of signal transduction by growth factor receptors and second messengers
- FLT3 signaling in disease
- Drug ADME
- Asparagine N-linked glycosylation
- Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
- Synthesis of substrates in N-glycan biosythesis
- Metabolism of lipids
- Transport of small molecules
- Aquaporin-mediated transport
- Developmental Biology
- Signaling Pathways
- Signaling by Rho GTPases
- RHO GTPase Effectors
- Cell Cycle
- Cell Cycle, Mitotic
- M Phase
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3
- Immune System
- Innate Immune System
- Purine metabolism
- Nucleotide metabolism
- Azathioprine ADME
- Signaling by Receptor Tyrosine Kinases
- Signaling by VEGF
- VEGFA-VEGFR2 Pathway
- Cellular responses to stimuli
- Cellular responses to stress
- Infectious disease
- Gene expression (Transcription)
- RNA Polymerase II Transcription
- Generic Transcription Pathway
- Transcriptional Regulation by TP53
- Adaptive Immune System
- Class I MHC mediated antigen processing & presentation
- Infection with Mycobacterium tuberculosis
- Leishmania infection
- Bacterial Infection Pathways
- Parasitic Infection Pathways
- Selenoamino acid metabolism
- The tricarboxylic acid cycle
- Carbohydrate metabolism
- Glucose metabolism
- The citric acid (TCA) cycle and respiratory electron transport
- Pyruvate metabolism and Citric Acid (TCA) cycle
- Citric acid cycle (TCA cycle)
- Integration of energy metabolism
- Lysine catabolism
- Neuronal System
- Transmission across Chemical Synapses
- HIV Infection
- Host Interactions of HIV factors
- Metabolism of RNA
- tRNA processing
- Viral Infection Pathways
- Signaling by GPCR
- GPCR ligand binding
- GPCR downstream signalling
- G alpha (i) signalling events
- Olfactory Signaling Pathway
- Hemostasis
- Cell surface interactions at the vascular wall
- Gluconeogenesis
- Sphingolipid metabolism
- Glycosphingolipid metabolism
- Opioid Signalling
- Transport to the Golgi and subsequent modification
- N-glycan antennae elongation in the medial/trans-Golgi
- Blood group systems biosynthesis
- ABO blood group biosynthesis
- Glycosphingolipid biosynthesis
- Signaling by ERBB2 in Cancer
- Platelet homeostasis
- Signaling by Nuclear Receptors
- ESR-mediated signaling
- Extra-nuclear estrogen signaling
- Death Receptor Signaling
- p75 NTR receptor-mediated signalling
- Cytokine Signaling in Immune system
- Signaling by CSF1 (M-CSF) in myeloid cells
- Signaling by PDGFR in disease
- Signaling by KIT in disease
BioCyc(0)
PlantCyc(0)
代谢反应
744 个相关的代谢反应过程信息。
Reactome(735)
- Drug ADME:
APAP + UDP-GlcA ⟶ APAP-GlcA + UDP - Azathioprine ADME:
6MP + H2O + NAD ⟶ 6TU + H+ + NADH - Drug ADME:
IMP + carbovir ⟶ Ino + xenobiotic - Azathioprine ADME:
6MP + H2O + NAD ⟶ 6TU + H+ + NADH - Drug ADME:
IMP + carbovir ⟶ Ino + xenobiotic - Azathioprine ADME:
6MP + H2O + NAD ⟶ 6TU + H+ + NADH - Drug ADME:
IMP + carbovir ⟶ Ino + xenobiotic - Azathioprine ADME:
6MP + H2O + NAD ⟶ 6TU + H+ + NADH - Drug ADME:
IMP + carbovir ⟶ Ino + xenobiotic - Azathioprine ADME:
6MP + H2O + NAD ⟶ 6TU + H+ + NADH - Drug ADME:
AMP + abacavir ⟶ Ade-Rib + xenobiotic - Azathioprine ADME:
6MP + H2O + NAD ⟶ 6TU + H+ + NADH - Drug ADME:
IMP + carbovir ⟶ Ino + xenobiotic - Azathioprine ADME:
6MP + H2O + NAD ⟶ 6TU + H+ + NADH - Drug ADME:
IMP + carbovir ⟶ Ino + xenobiotic - Azathioprine ADME:
6MP + H2O + NAD ⟶ 6TU + H+ + NADH - Drug ADME:
IMP + carbovir ⟶ Ino + xenobiotic - Azathioprine ADME:
6MP + H2O + NAD ⟶ 6TU + H+ + NADH - Drug ADME:
IMP + carbovir ⟶ Ino + xenobiotic - Azathioprine ADME:
6MP + H2O + NAD ⟶ 6TU + H+ + NADH - Signaling Pathways:
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - Signaling by GPCR:
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - GPCR downstream signalling:
H2O + cAMP ⟶ AMP - G alpha (q) signalling events:
GTP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) ⟶ GDP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
Ade-Rib ⟶ ADORA2A,B:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (q) signalling events:
Heterotrimeric G-protein Gq/11 (inactive) + Ligand:GPCR complexes that activate Gq/11 ⟶ Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (q) signalling events:
Heterotrimeric G-protein Gq/11 (inactive) + Ligand:GPCR complexes that activate Gq/11 ⟶ Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (q) signalling events:
Heterotrimeric G-protein Gq/11 (inactive) + Ligand:GPCR complexes that activate Gq/11 ⟶ Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
Ade-Rib + AdoR ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (q) signalling events:
Heterotrimeric G-protein Gq/11 (inactive) + Ligand:GPCR complexes that activate Gq/11 ⟶ Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (q) signalling events:
GTP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) ⟶ GDP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (q) signalling events:
Heterotrimeric G-protein Gq/11 (inactive) + Ligand:GPCR complexes that activate Gq/11 ⟶ Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA2A,B + Ade-Rib ⟶ ADORA2A,B:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (q) signalling events:
Heterotrimeric G-protein Gq/11 (inactive) + Ligand:GPCR complexes that activate Gq/11 ⟶ Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G alpha (q) signalling events:
GTP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) ⟶ GDP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (q) signalling events:
Heterotrimeric G-protein Gq/11 (inactive) + Ligand:GPCR complexes that activate Gq/11 ⟶ Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) - Synthesis of dolichyl-phosphate mannose:
DOLP + GDP-Man ⟶ DOLP-Man + GDP - Synthesis of dolichyl-phosphate mannose:
DOLP + GDP-Man ⟶ DOLP-Man + GDP - Synthesis of dolichyl-phosphate mannose:
DOLP + GDP-Man ⟶ DOLP-Man + GDP - Olfactory Signaling Pathway:
GTP + odorant:Olfactory Receptor:GNAL:GDP:GNB1:GNG13 ⟶ GDP + odorant:Olfactory Receptor:GNAL:GTP:GNB1:GNG13 - Sensory Perception:
GTP + odorant:Olfactory Receptor:GNAL:GDP:GNB1:GNG13 ⟶ GDP + odorant:Olfactory Receptor:GNAL:GTP:GNB1:GNG13 - G alpha (i) signalling events:
ATP ⟶ PPi + cAMP - G alpha (i) signalling events:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (i) signalling events:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (i) signalling events:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (i) signalling events:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Platelet activation, signaling and aggregation:
2AG + H2O ⟶ AA + Glycerol + H+ - Signal amplification:
TBXA2R + thromboxane A2 ⟶ TBXA2R:TXA2 - Thromboxane signalling through TP receptor:
TBXA2R + thromboxane A2 ⟶ TBXA2R:TXA2 - G alpha (12/13) signalling events:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Platelet activation, signaling and aggregation:
3AG + H2O ⟶ AA + Glycerol + H+ - Signal amplification:
GTP + TP receptor:Thromboxane A2:G-protein Gq (inactive) ⟶ GDP + TP receptor:Thromboxane A2:G-protein Gq (active) - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Platelet activation, signaling and aggregation:
2AG + H2O ⟶ AA + Glycerol + H+ - Signal amplification:
Heterotrimeric G-protein Gi (inactive) + P2RY12:ADP ⟶ ADP:P2RY12:G-protein Gi (inactive) - Thromboxane signalling through TP receptor:
Heterotrimeric G-protein Gq/11 (inactive) + TBXA2R:TXA2 ⟶ TP receptor:Thromboxane A2:G-protein Gq (inactive) - G alpha (12/13) signalling events:
G-protein G12/G13 (inactive) + Ligand:GPCR complexes that activate G12/13 ⟶ Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Platelet activation, signaling and aggregation:
2AG + H2O ⟶ AA + Glycerol + H+ - Signal amplification:
Heterotrimeric G-protein Gi (inactive) + P2RY12:ADP ⟶ ADP:P2RY12:G-protein Gi (inactive) - Thromboxane signalling through TP receptor:
GTP + TP receptor:Thromboxane A2:G-protein Gq (inactive) ⟶ GDP + TP receptor:Thromboxane A2:G-protein Gq (active) - G alpha (12/13) signalling events:
G-protein G12/G13 (inactive) + Ligand:GPCR complexes that activate G12/13 ⟶ Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). - Hemostasis:
3AG + H2O ⟶ AA + Glycerol + H+ - Platelet activation, signaling and aggregation:
3AG + H2O ⟶ AA + Glycerol + H+ - Signal amplification:
Heterotrimeric G-protein Gq/11 (inactive) + TBXA2R:TXA2 ⟶ TP receptor:Thromboxane A2:G-protein Gq (inactive) - G alpha (12/13) signalling events:
G-protein G12/G13 (inactive) + Ligand:GPCR complexes that activate G12/13 ⟶ Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Platelet activation, signaling and aggregation:
2AG + H2O ⟶ AA + Glycerol + H+ - Signal amplification:
Heterotrimeric G-protein Gq/11 (inactive) + TBXA2R:TXA2 ⟶ TP receptor:Thromboxane A2:G-protein Gq (inactive) - Thromboxane signalling through TP receptor:
Heterotrimeric G-protein Gq/11 (inactive) + TBXA2R:TXA2 ⟶ TP receptor:Thromboxane A2:G-protein Gq (inactive) - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Platelet activation, signaling and aggregation:
2AG + H2O ⟶ AA + Glycerol + H+ - Signal amplification:
Heterotrimeric G-protein Gi (inactive) + P2RY12:ADP ⟶ ADP:P2RY12:G-protein Gi (inactive) - Thromboxane signalling through TP receptor:
Heterotrimeric G-protein Gq/11 (inactive) + TBXA2R:TXA2 ⟶ TP receptor:Thromboxane A2:G-protein Gq (inactive) - G alpha (12/13) signalling events:
G-protein G12/G13 (inactive) + Ligand:GPCR complexes that activate G12/13 ⟶ Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Platelet activation, signaling and aggregation:
2AG + H2O ⟶ AA + Glycerol + H+ - Signal amplification:
Heterotrimeric G-protein Gi (inactive) + P2RY12:ADP ⟶ ADP:P2RY12:G-protein Gi (inactive) - Thromboxane signalling through TP receptor:
Heterotrimeric G-protein Gq/11 (inactive) + TBXA2R:TXA2 ⟶ TP receptor:Thromboxane A2:G-protein Gq (inactive) - G alpha (12/13) signalling events:
G-protein G12/G13 (inactive) + Ligand:GPCR complexes that activate G12/13 ⟶ Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Platelet activation, signaling and aggregation:
2AG + H2O ⟶ AA + Glycerol + H+ - Signal amplification:
Tbxa2r + thromboxane A2 ⟶ TBXA2R:TXA2 - Thromboxane signalling through TP receptor:
Tbxa2r + thromboxane A2 ⟶ TBXA2R:TXA2 - G alpha (12/13) signalling events:
Heterotrimeric G-protein G12 (inactive) + Ligand:GPCR complexes that activate G12/13 ⟶ Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Platelet activation, signaling and aggregation:
2AG + H2O ⟶ AA + Glycerol + H+ - Signal amplification:
Heterotrimeric G-protein Gi (inactive) + P2RY12:ADP ⟶ ADP:P2RY12:G-protein Gi (inactive) - Thromboxane signalling through TP receptor:
Heterotrimeric G-protein Gq/11 (inactive) + TBXA2R:TXA2 ⟶ TP receptor:Thromboxane A2:G-protein Gq (inactive) - Hemostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Platelet activation, signaling and aggregation:
2AG + H2O ⟶ AA + Glycerol + H+ - Signal amplification:
tbxa2r + thromboxane A2 ⟶ TBXA2R:TXA2 - Thromboxane signalling through TP receptor:
tbxa2r + thromboxane A2 ⟶ TBXA2R:TXA2 - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
ADORA1,3 + Ade-Rib ⟶ ADORA1,3:Ade-Rib - GPCR downstream signalling:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G alpha (12/13) signalling events:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - Thromboxane signalling through TP receptor:
GTP + TP receptor:Thromboxane A2:G-protein Gq (inactive) ⟶ GDP + TP receptor:Thromboxane A2:G-protein Gq (active) - Thromboxane signalling through TP receptor:
Heterotrimeric G-protein Gq/11 (inactive) + TBXA2R:TXA2 ⟶ TP receptor:Thromboxane A2:G-protein Gq (inactive) - G alpha (i) signalling events:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - G alpha (i) signalling events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Platelet homeostasis:
H2O + PAF ⟶ CH3COO- + lyso-PAF - Prostacyclin signalling through prostacyclin receptor:
Prostacyclin:prostacyclin receptor:G-protein Gs (active) ⟶ G-protein beta-gamma complex + Gs:GTP + PTGIR + Prostacyclin - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
5PHL + H2O ⟶ 2AMAS + Pi + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Lysine catabolism:
Oxygen + PPCA ⟶ H2O2 + P6C - Neuronal System:
DA + SAM ⟶ 3MT + SAH - Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH - Neurotransmitter receptors and postsynaptic signal transmission:
Kainate Receptors + L-Glu ⟶ Kainate receptor-glutamate complex - GABA receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - GABA B receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Activation of GABAB receptors:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Adenylate cyclase inhibitory pathway:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Opioid Signalling:
ATP ⟶ PPi + cAMP - G-protein mediated events:
ATP ⟶ PPi + cAMP - Neuronal System:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Transmission across Chemical Synapses:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Neurotransmitter receptors and postsynaptic signal transmission:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - GABA receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - GABA B receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Activation of GABAB receptors:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Adenylate cyclase inhibitory pathway:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - G alpha (i) signalling events:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - Opioid Signalling:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G-protein mediated events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Opioid Signalling:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G-protein mediated events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Adenylate cyclase inhibitory pathway:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Neuronal System:
DA + SAM ⟶ 3MT + SAH - Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH - Neurotransmitter receptors and postsynaptic signal transmission:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - GABA receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - GABA B receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Activation of GABAB receptors:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - G alpha (i) signalling events:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - Opioid Signalling:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G-protein mediated events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Adenylate cyclase inhibitory pathway:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Neuronal System:
DA + SAM ⟶ 3MT + SAH - Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH - Neurotransmitter receptors and postsynaptic signal transmission:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - GABA receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - GABA B receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Activation of GABAB receptors:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Signaling Pathways:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by GPCR:
H2O + cAMP ⟶ AMP - GPCR downstream signalling:
H2O + cAMP ⟶ AMP - G alpha (i) signalling events:
ATP ⟶ PPi + cAMP - Opioid Signalling:
ATP ⟶ PPi + cAMP - G-protein mediated events:
ATP ⟶ PPi + cAMP - Adenylate cyclase inhibitory pathway:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Neuronal System:
3MT + H2O + Oxygen ⟶ H2O2 + HVA + ammonia - Transmission across Chemical Synapses:
3MT + H2O + Oxygen ⟶ H2O2 + HVA + ammonia - Neurotransmitter receptors and postsynaptic signal transmission:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - GABA receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - GABA B receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Activation of GABAB receptors:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - G alpha (i) signalling events:
Heterotrimeric G-protein Gi (inactive) + Ligand:GPCR complexes that activate Gi ⟶ Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) - Opioid Signalling:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G-protein mediated events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Adenylate cyclase inhibitory pathway:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Neuronal System:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Transmission across Chemical Synapses:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Neurotransmitter receptors and postsynaptic signal transmission:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - GABA receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - GABA B receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Activation of GABAB receptors:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Neuronal System:
DA + SAM ⟶ 3MT + SAH - Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH - Neurotransmitter receptors and postsynaptic signal transmission:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - GABA receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - GABA B receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Activation of GABAB receptors:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Adenylate cyclase inhibitory pathway:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Opioid Signalling:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G-protein mediated events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Vesicle-mediated transport:
DAB2,LDLRAP1 + LDL:LDLR complex ⟶ DAB2,LDLRAP1:LDLR:LDL - Membrane Trafficking:
DAB2,LDLRAP1 + LDL:LDLR complex ⟶ DAB2,LDLRAP1:LDLR:LDL - Translocation of SLC2A4 (GLUT4) to the plasma membrane:
GGC-RAB8A,10,13,14:GDP + GTP ⟶ GDP + GGC-RAB8A,10,13,14:GTP - Opioid Signalling:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G-protein mediated events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Adenylate cyclase inhibitory pathway:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Neuronal System:
DA + SAM ⟶ 3MT + SAH - Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH - Neurotransmitter receptors and postsynaptic signal transmission:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - GABA receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - GABA B receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Activation of GABAB receptors:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Opioid Signalling:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G-protein mediated events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Adenylate cyclase inhibitory pathway:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Neuronal System:
DA + SAM ⟶ 3MT + SAH - Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH - Neurotransmitter receptors and postsynaptic signal transmission:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - GABA receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - GABA B receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Activation of GABAB receptors:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Neuronal System:
DA + SAM ⟶ 3MT + SAH - Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH - Neurotransmitter receptors and postsynaptic signal transmission:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - GABA receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - GABA B receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Activation of GABAB receptors:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Adenylate cyclase inhibitory pathway:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - G alpha (i) signalling events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Opioid Signalling:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G-protein mediated events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Opioid Signalling:
ATP ⟶ PPi + cAMP - G-protein mediated events:
ATP ⟶ PPi + cAMP - Adenylate cyclase inhibitory pathway:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Neuronal System:
DA + SAM ⟶ 3MT + SAH - Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH - Neurotransmitter receptors and postsynaptic signal transmission:
Edited Kainate receptors + L-Glu ⟶ Edited Kainate Receptor-glutamate complex - GABA receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - GABA B receptor activation:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Activation of GABAB receptors:
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) ⟶ Adenylate cyclase (Mg2+ cofactor) + G alpha-olf:GDP complex + G-protein alpha (i):GDP - Neuronal System:
DA + SAM ⟶ 3MT + SAH - Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH - Neurotransmitter receptors and postsynaptic signal transmission:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - GABA receptor activation:
GABA + GABBR1:GABBR2 ⟶ GABBR1:GABBR2:GABA - GABA B receptor activation:
GABA + GABBR1:GABBR2 ⟶ GABBR1:GABBR2:GABA - Activation of GABAB receptors:
GABA B receptor G-protein beta-gamma complex + Kir heterotetramers ⟶ GABA B receptor G-protein beta-gamma and Kir3 channel complex - Adenylate cyclase inhibitory pathway:
G alpha-olf:GTP + G-protein alpha (i):GTP:Adenylate cyclase ⟶ (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) - Opioid Signalling:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G-protein mediated events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - ADP signalling through P2Y purinoceptor 12:
ADP:P2RY12:G-protein Gi (inactive) + GTP ⟶ ADP:P2RY12:G-protein Gi (active) + GDP - Thrombin signalling through proteinase activated receptors (PARs):
PAR3, 4 ⟶ PAR N-teminal fragments + Thrombin-activated PARs - Developmental Biology:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - Axon guidance:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - Semaphorin interactions:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - Sema4D in semaphorin signaling:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - Sema4D induced cell migration and growth-cone collapse:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - Integration of energy metabolism:
A0A3Q1LHN3 + cAMP ⟶ RAPGEF3:cAMP complex - Regulation of insulin secretion:
A0A3Q1LHN3 + cAMP ⟶ RAPGEF3:cAMP complex - Free fatty acids regulate insulin secretion:
ATP + CoA-SH + PALM ⟶ AMP + PALM-CoA + PPi - Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion:
G-alpha(q)11,14,15,Q:GDP:G-beta:G-gamma + GTP ⟶ G-alpha(q)11,14,15,Q:G-beta:G-gamma + GDP - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion:
A0A3Q1LHN3 + cAMP ⟶ RAPGEF3:cAMP complex - G alpha (z) signalling events:
GTP + Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) ⟶ ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) + GDP - Death Receptor Signaling:
TNF(1-233) trimer ⟶ TNF(1-76) trimer + TNF- trimer, soluble form - p75 NTR receptor-mediated signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Cell death signalling via NRAGE, NRIF and NADE:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - NRAGE signals death through JNK:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Thrombin signalling through proteinase activated receptors (PARs):
F2RL3 + Heterotrimeric G-protein Gq/11 (inactive) ⟶ Thrombin-activated PARs:Gq (inactive) - G alpha (z) signalling events:
GTP + Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) ⟶ ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) + GDP - G alpha (12/13) signalling events:
ADRA1A,B,D:ADR,NAd + G-protein G12/G13 (inactive) ⟶ Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). - Death Receptor Signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - p75 NTR receptor-mediated signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Cell death signalling via NRAGE, NRIF and NADE:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - NRAGE signals death through JNK:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Integration of energy metabolism:
cAMP + epac-1 ⟶ RAPGEF3:cAMP complex - Regulation of insulin secretion:
cAMP + epac-1 ⟶ RAPGEF3:cAMP complex - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion:
cAMP + epac-1 ⟶ RAPGEF3:cAMP complex - Developmental Biology:
H2O + PALM-C3,4-GAP43 ⟶ GAP43 + PALM - Axon guidance:
H2O + PALM-C3,4-GAP43 ⟶ GAP43 + PALM - Semaphorin interactions:
R-Ras-GTP ⟶ Pi + R-Ras-GDP - Sema4D in semaphorin signaling:
R-Ras-GTP ⟶ Pi + R-Ras-GDP - Sema4D induced cell migration and growth-cone collapse:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA:GTP - ADP signalling through P2Y purinoceptor 12:
Heterotrimeric G-protein Gi (inactive) + P2RY12:ADP ⟶ ADP:P2RY12:G-protein Gi (inactive) - Thrombin signalling through proteinase activated receptors (PARs):
Heterotrimeric G-protein Gq/11 (inactive) + Thrombin-activated PARs ⟶ Thrombin-activated PARs:Gq (inactive) - G alpha (z) signalling events:
ADRA2A,B,C:ADR,NAd + Heterotrimeric G-protein Gz (inactive) ⟶ Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) - Death Receptor Signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - p75 NTR receptor-mediated signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Cell death signalling via NRAGE, NRIF and NADE:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - NRAGE signals death through JNK:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Developmental Biology:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Axon guidance:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Semaphorin interactions:
R-Ras-GTP ⟶ Pi + R-Ras-GDP - Sema4D in semaphorin signaling:
R-Ras-GTP ⟶ Pi + R-Ras-GDP - Sema4D induced cell migration and growth-cone collapse:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - Integration of energy metabolism:
F1PW07 + cAMP ⟶ RAPGEF3:cAMP complex - Regulation of insulin secretion:
F1PW07 + cAMP ⟶ RAPGEF3:cAMP complex - Free fatty acids regulate insulin secretion:
ATP + CoA-SH + PALM ⟶ AMP + PALM-CoA + PPi - Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion:
G-alpha(q)11,14,15,Q:GDP:G-beta:G-gamma + GTP ⟶ G-alpha(q)11,14,15,Q:G-beta:G-gamma + GDP - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion:
F1PW07 + cAMP ⟶ RAPGEF3:cAMP complex - G alpha (z) signalling events:
ADRA2A,B,C:ADR,NAd + Heterotrimeric G-protein Gz (inactive) ⟶ Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) - G alpha (12/13) signalling events:
ADRA1A,B,D:ADR,NAd + G-protein G12/G13 (inactive) ⟶ Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). - Death Receptor Signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - p75 NTR receptor-mediated signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Cell death signalling via NRAGE, NRIF and NADE:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - NRAGE signals death through JNK:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Integration of energy metabolism:
E7FDC9 + cAMP ⟶ RAPGEF3:cAMP complex - Regulation of insulin secretion:
E7FDC9 + cAMP ⟶ RAPGEF3:cAMP complex - Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion:
G-alpha(q)11,14,15,Q:GDP:G-beta:G-gamma + GTP ⟶ G-alpha(q)11,14,15,Q:G-beta:G-gamma + GDP - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion:
E7FDC9 + cAMP ⟶ RAPGEF3:cAMP complex - Developmental Biology:
CEBPE gene:RARA:RXRA + atRA ⟶ CEBPE gene:RXRA:RARA:atRA - Axon guidance:
H2O + Q6DG93 ⟶ PALM + Q6DG93 - Semaphorin interactions:
R-Ras-GTP ⟶ Pi + R-Ras-GDP - Sema4D in semaphorin signaling:
R-Ras-GTP ⟶ Pi + R-Ras-GDP - Sema4D induced cell migration and growth-cone collapse:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Integration of energy metabolism:
Homologues of RAPGEF3 + cAMP ⟶ RAPGEF3:cAMP complex - Regulation of insulin secretion:
Homologues of RAPGEF3 + cAMP ⟶ RAPGEF3:cAMP complex - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion:
Homologues of RAPGEF3 + cAMP ⟶ RAPGEF3:cAMP complex - G alpha (z) signalling events:
G alpha (z):GDP:RGS16,17,20 ⟶ G-protein alpha (z):GDP - G alpha (q) signalling events:
2AG + H2O ⟶ AA + Glycerol + H+ - Death Receptor Signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - p75 NTR receptor-mediated signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Cell death signalling via NRAGE, NRIF and NADE:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - NRAGE signals death through JNK:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Death Receptor Signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - p75 NTR receptor-mediated signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Cell death signalling via NRAGE, NRIF and NADE:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - NRAGE signals death through JNK:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Developmental Biology:
CEBPE gene:RARA:RXRA + atRA ⟶ CEBPE gene:RXRA:RARA:atRA - Axon guidance:
H2O + igl ⟶ PALM + igl - Semaphorin interactions:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA:GTP - Sema4D in semaphorin signaling:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA:GTP - Sema4D induced cell migration and growth-cone collapse:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA:GTP - Integration of energy metabolism:
Epac + cAMP ⟶ RAPGEF3:cAMP complex - Regulation of insulin secretion:
Epac + cAMP ⟶ RAPGEF3:cAMP complex - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion:
Epac + cAMP ⟶ RAPGEF3:cAMP complex - Integration of energy metabolism:
A0A3Q2UAA9 + cAMP ⟶ RAPGEF3:cAMP complex - Regulation of insulin secretion:
A0A3Q2UAA9 + cAMP ⟶ RAPGEF3:cAMP complex - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion:
A0A3Q2UAA9 + cAMP ⟶ RAPGEF3:cAMP complex - G alpha (z) signalling events:
ADRA2A,B,C:ADR,NAd + Heterotrimeric G-protein Gz (inactive) ⟶ Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) - Death Receptor Signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - p75 NTR receptor-mediated signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Cell death signalling via NRAGE, NRIF and NADE:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - NRAGE signals death through JNK:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Developmental Biology:
CEBPE gene:RARA:RXRA + atRA ⟶ CEBPE gene:RXRA:RARA:atRA - Axon guidance:
A0A1D5NTK5 + H2O ⟶ A0A1D5NTK5 + PALM - Semaphorin interactions:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - Sema4D in semaphorin signaling:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - Sema4D induced cell migration and growth-cone collapse:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - Thrombin signalling through proteinase activated receptors (PARs):
Heterotrimeric G-protein Gq/11 (inactive) + Thrombin-activated PARs ⟶ Thrombin-activated PARs:Gq (inactive) - Developmental Biology:
Early cornified envelope + Lamellar body ⟶ Cornified envelope - Axon guidance:
H2O + NEUM_HUMAN ⟶ NEUM_HUMAN + PALM - Semaphorin interactions:
R-Ras-GTP ⟶ Pi + R-Ras-GDP - Sema4D in semaphorin signaling:
R-Ras-GTP ⟶ Pi + R-Ras-GDP - Sema4D induced cell migration and growth-cone collapse:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - ADP signalling through P2Y purinoceptor 12:
Heterotrimeric G-protein Gi (inactive) + P2RY12:ADP ⟶ ADP:P2RY12:G-protein Gi (inactive) - ADP signalling through P2Y purinoceptor 1:
Heterotrimeric G-protein Gq/11 (inactive) + P2RY1:ADP ⟶ ADP:P2RY1:G-protein Gq/11 (inactive) - Thrombin signalling through proteinase activated receptors (PARs):
Heterotrimeric G-protein Gq/11 (inactive) + Thrombin-activated PARs ⟶ Thrombin-activated PARs:Gq (inactive) - Integration of energy metabolism:
PKA:AKAP79:IQGAP1 Complex + cAMP ⟶ PRKACA,PRKACB,PRKACG + cAMP:PKA:AKAP79:IQGAP1 Complex - Regulation of insulin secretion:
PKA:AKAP79:IQGAP1 Complex + cAMP ⟶ PRKACA,PRKACB,PRKACG + cAMP:PKA:AKAP79:IQGAP1 Complex - Acetylcholine regulates insulin secretion:
AcCho + Muscarinic Acetylcholine Receptor M3 ⟶ Muscarinic Acetylcholine Receptor M3:Acetylcholine Complex - Free fatty acids regulate insulin secretion:
ATP + CoA-SH + PALM ⟶ AMP + PALM-CoA + PPi - Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion:
G-alpha(q)11,14,15,Q:GDP:G-beta:G-gamma + GTP ⟶ G-alpha(q)11,14,15,Q:G-beta:G-gamma + GDP - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion:
PKA:AKAP79:IQGAP1 Complex + cAMP ⟶ PRKACA,PRKACB,PRKACG + cAMP:PKA:AKAP79:IQGAP1 Complex - Signaling by Receptor Tyrosine Kinases:
AcK685- p-Y705,S727-STAT3 dimer + H2O ⟶ CH3COO- + p-Y705,S727-STAT3 dimer - Signaling by VEGF:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - VEGFA-VEGFR2 Pathway:
L-Arg + Oxygen + TPNH ⟶ L-Cit + NO + TPN - G alpha (z) signalling events:
ATP ⟶ PPi + cAMP - Death Receptor Signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - p75 NTR receptor-mediated signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Cell death signalling via NRAGE, NRIF and NADE:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - NRAGE signals death through JNK:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Integration of energy metabolism:
Q8VCC8 + cAMP ⟶ RAPGEF3:cAMP complex - Regulation of insulin secretion:
Q8VCC8 + cAMP ⟶ RAPGEF3:cAMP complex - Free fatty acids regulate insulin secretion:
ATP + CoA-SH + PALM ⟶ AMP + PALM-CoA + PPi - Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion:
G-alpha(q)11,14,15,Q:GDP:G-beta:G-gamma + GTP ⟶ G-alpha(q)11,14,15,Q:G-beta:G-gamma + GDP - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion:
Q8VCC8 + cAMP ⟶ RAPGEF3:cAMP complex - ADP signalling through P2Y purinoceptor 12:
Heterotrimeric G-protein Gi (inactive) + P2RY12:ADP ⟶ ADP:P2RY12:G-protein Gi (inactive) - Thrombin signalling through proteinase activated receptors (PARs):
Heterotrimeric G-protein Gq/11 (inactive) + Thrombin-activated PARs ⟶ Thrombin-activated PARs:Gq (inactive) - Developmental Biology:
Early cornified envelope + Lamellar body ⟶ Cornified envelope - Axon guidance:
H2O + PALM-C3,4-GAP43 ⟶ Gap43 + PALM - Semaphorin interactions:
R-Ras-GTP ⟶ Pi + R-Ras-GDP - Sema4D in semaphorin signaling:
R-Ras-GTP ⟶ Pi + R-Ras-GDP - Sema4D induced cell migration and growth-cone collapse:
GTP + RhoA,B,C:GDP ⟶ GDP + RhoA,B,C:GTP - G alpha (z) signalling events:
ADRA2A,B,C:ADR,NAd + Heterotrimeric G-protein Gz (inactive) ⟶ Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) - Death Receptor Signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - p75 NTR receptor-mediated signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Cell death signalling via NRAGE, NRIF and NADE:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - NRAGE signals death through JNK:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Integration of energy metabolism:
Q9Z1C8 + cAMP ⟶ RAPGEF3:cAMP complex - Regulation of insulin secretion:
Q9Z1C8 + cAMP ⟶ RAPGEF3:cAMP complex - Free fatty acids regulate insulin secretion:
ATP + CoA-SH + PALM ⟶ AMP + PALM-CoA + PPi - Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion:
G-alpha(q)11,14,15,Q:GDP:G-beta:G-gamma + GTP ⟶ G-alpha(q)11,14,15,Q:G-beta:G-gamma + GDP - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion:
Q9Z1C8 + cAMP ⟶ RAPGEF3:cAMP complex - G alpha (z) signalling events:
GTP + Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) ⟶ ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) + GDP - G alpha (12/13) signalling events:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - Death Receptor Signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - p75 NTR receptor-mediated signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Cell death signalling via NRAGE, NRIF and NADE:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - NRAGE signals death through JNK:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Developmental Biology:
Early cornified envelope + Lamellar body ⟶ Cornified envelope - Axon guidance:
H2O + PALM-C3,4-GAP43 ⟶ Gap43 + PALM - Semaphorin interactions:
R-Ras-GTP ⟶ Pi + R-Ras-GDP - Sema4D in semaphorin signaling:
R-Ras-GTP ⟶ Pi + R-Ras-GDP - Sema4D induced cell migration and growth-cone collapse:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - Signaling Pathways:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Signaling by GPCR:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - GPCR downstream signalling:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G alpha (i) signalling events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G alpha (q) signalling events:
2AG + H2O ⟶ AA + Glycerol + H+ - G alpha (12/13) signalling events:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - Metabolism:
CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine - Integration of energy metabolism:
PKA tetramer:4xcAMP ⟶ cAMP:PKA regulatory subunit - Regulation of insulin secretion:
ATP + CoA-SH + PALM ⟶ AMP + PALM-CoA + PPi - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion:
GTP + RAP1A:GDP ⟶ GDP + RAP1:GTP - Signaling Pathways:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Signaling by GPCR:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - GPCR downstream signalling:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G alpha (i) signalling events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G alpha (q) signalling events:
2AG + H2O ⟶ AA + Glycerol + H+ - G alpha (12/13) signalling events:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - Integration of energy metabolism:
I3L7Z0 + cAMP ⟶ RAPGEF3:cAMP complex - Regulation of insulin secretion:
I3L7Z0 + cAMP ⟶ RAPGEF3:cAMP complex - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion:
I3L7Z0 + cAMP ⟶ RAPGEF3:cAMP complex - Developmental Biology:
Early cornified envelope + Lamellar body ⟶ Cornified envelope - Axon guidance:
A0A5G2R7G3 + H2O ⟶ A0A5G2R7G3 + PALM - Semaphorin interactions:
R-Ras-GTP ⟶ Pi + R-Ras-GDP - Sema4D in semaphorin signaling:
R-Ras-GTP ⟶ Pi + R-Ras-GDP - Sema4D induced cell migration and growth-cone collapse:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - G alpha (z) signalling events:
ADRA2A,B,C:ADR,NAd + Heterotrimeric G-protein Gz (inactive) ⟶ Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) - Death Receptor Signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - p75 NTR receptor-mediated signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Cell death signalling via NRAGE, NRIF and NADE:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - NRAGE signals death through JNK:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - ADP signalling through P2Y purinoceptor 12:
Heterotrimeric G-protein Gi (inactive) + P2RY12:ADP ⟶ ADP:P2RY12:G-protein Gi (inactive) - Thrombin signalling through proteinase activated receptors (PARs):
Heterotrimeric G-protein Gq/11 (inactive) + Thrombin-activated PARs ⟶ Thrombin-activated PARs:Gq (inactive) - ADP signalling through P2Y purinoceptor 12:
ADP:P2RY12:G-protein Gi (inactive) + GTP ⟶ ADP:P2RY12:G-protein Gi (active) + GDP - Thrombin signalling through proteinase activated receptors (PARs):
PAR3, 4 ⟶ PAR N-teminal fragments + Thrombin-activated PARs - Integration of energy metabolism:
F6PS10 + cAMP ⟶ RAPGEF3:cAMP complex - Regulation of insulin secretion:
F6PS10 + cAMP ⟶ RAPGEF3:cAMP complex - Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion:
G-alpha(q)11,14,15,Q:GDP:G-beta:G-gamma + GTP ⟶ G-alpha(q)11,14,15,Q:G-beta:G-gamma + GDP - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion:
F6PS10 + cAMP ⟶ RAPGEF3:cAMP complex - Developmental Biology:
CEBPE gene:RARA:RXRA + atRA ⟶ CEBPE gene:RXRA:RARA:atRA - Axon guidance:
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 + GTP + RAC1:GDP ⟶ EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP + GDP - Semaphorin interactions:
R-Ras-GTP ⟶ Pi + R-Ras-GDP - Sema4D in semaphorin signaling:
R-Ras-GTP ⟶ Pi + R-Ras-GDP - Sema4D induced cell migration and growth-cone collapse:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - G alpha (z) signalling events:
GTP + Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) ⟶ ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) + GDP - G alpha (q) signalling events:
GTP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) ⟶ GDP + Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) - Death Receptor Signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - p75 NTR receptor-mediated signalling:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Cell death signalling via NRAGE, NRIF and NADE:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - NRAGE signals death through JNK:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - G alpha (z) signalling events:
G-protein alpha (z):GTP + rgs1 ⟶ G alpha (z):GTP:RGS16,17,20 - G alpha (z) signalling events:
G-protein alpha (z):GTP + SST2 ⟶ G alpha (z):GTP:RGS16,17,20 - Nervous system development:
H2O + PALM-C3,4-GAP43 ⟶ GAP43 + PALM - Nervous system development:
H2O + Q6DG93 ⟶ PALM + Q6DG93 - Nervous system development:
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 + GTP + RAC1:GDP ⟶ EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP + GDP - Nervous system development:
A0A5G2R7G3 + H2O ⟶ A0A5G2R7G3 + PALM - Nervous system development:
A0A1D5NTK5 + H2O ⟶ A0A1D5NTK5 + PALM - Nervous system development:
H2O + PALM-C3,4-GAP43 ⟶ Gap43 + PALM - Nervous system development:
GTP + RAC1:GDP ⟶ GDP + RAC1:GTP - Nervous system development:
GTP + RhoA,B,C:GDP ⟶ GDP + RHOA/B/C:GTP - Nervous system development:
H2O + igl ⟶ PALM + igl - Nervous system development:
H2O + PALM-C3,4-GAP43 ⟶ Gap43 + PALM - Nervous system development:
H2O + NEUM_HUMAN ⟶ NEUM_HUMAN + PALM - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Class I MHC mediated antigen processing & presentation:
TPNH + dioxygen ⟶ H+ + O2.- + TPN - Antigen Presentation: Folding, assembly and peptide loading of class I MHC:
SAR1B:GTP + SEC23:SEC24 ⟶ SAR1B:GTP:SEC23:SEC24 - Vesicle-mediated transport:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Membrane Trafficking:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Intra-Golgi and retrograde Golgi-to-ER traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Intra-Golgi traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Rab regulation of trafficking:
H2O + RAB7:GTP ⟶ Pi + RAB7:GDP - TBC/RABGAPs:
H2O + RAB7:GTP ⟶ Pi + RAB7:GDP - Vesicle-mediated transport:
GGA1,2,3:RAB5:GTP:RABGEF1 + TBC1D3 ⟶ TBC1D3:GGA:RAB5:GTP:RABGEF1 - Membrane Trafficking:
GGA1,2,3:RAB5:GTP:RABGEF1 + TBC1D3 ⟶ TBC1D3:GGA:RAB5:GTP:RABGEF1 - Rab regulation of trafficking:
GGA1,2,3:RAB5:GTP:RABGEF1 + TBC1D3 ⟶ TBC1D3:GGA:RAB5:GTP:RABGEF1 - TBC/RABGAPs:
GGA1,2,3:RAB5:GTP:RABGEF1 + TBC1D3 ⟶ TBC1D3:GGA:RAB5:GTP:RABGEF1 - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Class I MHC mediated antigen processing & presentation:
TPNH + dioxygen ⟶ H+ + O2.- + TPN - Antigen Presentation: Folding, assembly and peptide loading of class I MHC:
SAR1B:GTP + SEC23:SEC24 ⟶ SAR1B:GTP:SEC23:SEC24 - Vesicle-mediated transport:
DAB2,LDLRAP1 + LDL:LDLR complex ⟶ DAB2,LDLRAP1:LDLR:LDL - Membrane Trafficking:
DAB2,LDLRAP1 + LDL:LDLR complex ⟶ DAB2,LDLRAP1:LDLR:LDL - Intra-Golgi and retrograde Golgi-to-ER traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Intra-Golgi traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Rab regulation of trafficking:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - TBC/RABGAPs:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - Vesicle-mediated transport:
DAB2,LDLRAP1 + LDL:LDLR complex ⟶ DAB2,LDLRAP1:LDLR:LDL - Membrane Trafficking:
DAB2,LDLRAP1 + LDL:LDLR complex ⟶ DAB2,LDLRAP1:LDLR:LDL - Rab regulation of trafficking:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - TBC/RABGAPs:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - Vesicle-mediated transport:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Membrane Trafficking:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Intra-Golgi and retrograde Golgi-to-ER traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Intra-Golgi traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Rab regulation of trafficking:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - TBC/RABGAPs:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - Vesicle-mediated transport:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Membrane Trafficking:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Intra-Golgi and retrograde Golgi-to-ER traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Intra-Golgi traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Rab regulation of trafficking:
GGA1,2,3:RAB5:GTP:RABGEF1 + RN-tre ⟶ TBC1D3:GGA:RAB5:GTP:RABGEF1 - TBC/RABGAPs:
GGA1,2,3:RAB5:GTP:RABGEF1 + RN-tre ⟶ TBC1D3:GGA:RAB5:GTP:RABGEF1 - Vesicle-mediated transport:
HPR:APOL1:APOA1:HDL3 + Hemoglobin Dimer ⟶ Hemoglobin:HPR:APOL1:APOA1:HDL3 - Membrane Trafficking:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Intra-Golgi and retrograde Golgi-to-ER traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Intra-Golgi traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Rab regulation of trafficking:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - TBC/RABGAPs:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Class I MHC mediated antigen processing & presentation:
TPNH + dioxygen ⟶ H+ + O2.- + TPN - Antigen Presentation: Folding, assembly and peptide loading of class I MHC:
COPII vesicle with MHC class I + GDP + H2O ⟶ A0A1L1RNL7 + Antigen peptide bound class I MHC + GTP + SAR1B:GDP + SEC23A + SEC24 + SEC31A - Intra-Golgi and retrograde Golgi-to-ER traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Intra-Golgi traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Rab regulation of trafficking:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - TBC/RABGAPs:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Class I MHC mediated antigen processing & presentation:
TPNH + dioxygen ⟶ H+ + O2.- + TPN - Antigen Presentation: Folding, assembly and peptide loading of class I MHC:
COPII vesicle with MHC class I + GDP + H2O ⟶ Antigen peptide bound class I MHC + GTP + SAR1B:GDP + SC13_HUMAN + SEC23A + SEC24 + SEC31A - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Class I MHC mediated antigen processing & presentation:
TPNH + dioxygen ⟶ H+ + O2.- + TPN - Antigen Presentation: Folding, assembly and peptide loading of class I MHC:
COPII vesicle with MHC class I + GDP + H2O ⟶ Antigen peptide bound class I MHC + GTP + Q9D1M0 + SAR1B:GDP + SEC24 + Sec23a + Sec31a - Vesicle-mediated transport:
DAB2,LDLRAP1 + LDL:LDLR complex ⟶ DAB2,LDLRAP1:LDLR:LDL - Membrane Trafficking:
DAB2,LDLRAP1 + LDL:LDLR complex ⟶ DAB2,LDLRAP1:LDLR:LDL - Intra-Golgi and retrograde Golgi-to-ER traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Intra-Golgi traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Rab regulation of trafficking:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - TBC/RABGAPs:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - Vesicle-mediated transport:
ARF1:GTP + CYTH1,2,3,4 ⟶ ARF1:GTP:CYTH1,2,3,4 - Membrane Trafficking:
ARF1:GTP + CYTH1,2,3,4 ⟶ ARF1:GTP:CYTH1,2,3,4 - Rab regulation of trafficking:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - TBC/RABGAPs:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - Vesicle-mediated transport:
DAB2,LDLRAP1 + LDL:LDLR complex ⟶ DAB2,LDLRAP1:LDLR:LDL - Membrane Trafficking:
DAB2,LDLRAP1 + LDL:LDLR complex ⟶ DAB2,LDLRAP1:LDLR:LDL - Intra-Golgi and retrograde Golgi-to-ER traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Intra-Golgi traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Rab regulation of trafficking:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - TBC/RABGAPs:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Class I MHC mediated antigen processing & presentation:
TPNH + dioxygen ⟶ H+ + O2.- + TPN - Antigen Presentation: Folding, assembly and peptide loading of class I MHC:
COPII vesicle with MHC class I + GDP + H2O ⟶ Antigen peptide bound class I MHC + GTP + Q5XFW8 + SAR1B:GDP + SEC24 + Sec23a + Sec31a - Vesicle-mediated transport:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Membrane Trafficking:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Intra-Golgi and retrograde Golgi-to-ER traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Intra-Golgi traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Rab regulation of trafficking:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - TBC/RABGAPs:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - Vesicle-mediated transport:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Membrane Trafficking:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Intra-Golgi and retrograde Golgi-to-ER traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Rab regulation of trafficking:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - TBC/RABGAPs:
H2O + RAB7A:GTP ⟶ Pi + RAB7A:GDP - Vesicle-mediated transport:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Membrane Trafficking:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Intra-Golgi and retrograde Golgi-to-ER traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Intra-Golgi traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Rab regulation of trafficking:
GGA1,2,3:RAB5:GTP:RABGEF1 + Homologues of TBC1D3 ⟶ TBC1D3:GGA:RAB5:GTP:RABGEF1 - TBC/RABGAPs:
GGA1,2,3:RAB5:GTP:RABGEF1 + Homologues of TBC1D3 ⟶ TBC1D3:GGA:RAB5:GTP:RABGEF1 - Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Adaptive Immune System:
Rap1 cAMP-GEFs + cAMP ⟶ Rap1 cAMP-GEFs:cAMP - Class I MHC mediated antigen processing & presentation:
TPNH + dioxygen ⟶ H+ + O2.- + TPN - Antigen Presentation: Folding, assembly and peptide loading of class I MHC:
COPII vesicle with MHC class I + GDP + H2O ⟶ A0A5G2R7E5 + Antigen peptide bound class I MHC + GTP + SAR1B:GDP + SEC23A + SEC24 + SEC31A - Vesicle-mediated transport:
DAB2,LDLRAP1 + LDL:LDLR complex ⟶ DAB2,LDLRAP1:LDLR:LDL - Membrane Trafficking:
DAB2,LDLRAP1 + LDL:LDLR complex ⟶ DAB2,LDLRAP1:LDLR:LDL - Intra-Golgi and retrograde Golgi-to-ER traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Intra-Golgi traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Rab regulation of trafficking:
GGA1,2,3:RAB5:GTP:RABGEF1 + TBC1D3 ⟶ TBC1D3:GGA:RAB5:GTP:RABGEF1 - TBC/RABGAPs:
GGA1,2,3:RAB5:GTP:RABGEF1 + TBC1D3 ⟶ TBC1D3:GGA:RAB5:GTP:RABGEF1 - Intra-Golgi traffic:
ARF1:GTP + TRIP11:cargo ⟶ ARF1:GTP:TRIP11:cargo - Sensory perception of taste:
GTP + TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 ⟶ GDP + TAS2R:ligand:GNAT3:GTP:GNB1,3:GNG13 - Sensory perception of sweet, bitter, and umami (glutamate) taste:
GTP + TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 ⟶ GDP + TAS2R:ligand:GNAT3:GTP:GNB1,3:GNG13 - Carbohydrate metabolism:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Carbohydrate metabolism:
L-gulonate + NAD ⟶ 3-dehydro-L-gulonate + H+ + NADH - Carbohydrate metabolism:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Carbohydrate metabolism:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Carbohydrate metabolism:
H2O + Heparan(3)-PGs ⟶ CH3COO- + Heparan(4)-PGs - Carbohydrate metabolism:
L-gulonate + NAD ⟶ 3-dehydro-L-gulonate + H+ + NADH - Carbohydrate metabolism:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Carbohydrate metabolism:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Carbohydrate metabolism:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Carbohydrate metabolism:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Carbohydrate metabolism:
ATP + PYR + carbon dioxide ⟶ ADP + OAA + Pi - Carbohydrate metabolism:
D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN - Blood group systems biosynthesis:
GDP-Fuc + Type 2 chain ⟶ GDP + O antigen - Lewis blood group biosynthesis:
GDP-Fuc + Type 1 chain ⟶ GDP + LeA - Blood group systems biosynthesis:
CMP-Neu5Ac + Type 1 chain ⟶ CMP + Type 1 MSGG - Lewis blood group biosynthesis:
CMP-Neu5Ac + Type 1 chain ⟶ CMP + Type 1 MSGG - Blood group systems biosynthesis:
CMP-Neu5Ac + Type 1 MSGG ⟶ CMP + Type 1 DSGG - Lewis blood group biosynthesis:
CMP-Neu5Ac + Type 1 MSGG ⟶ CMP + Type 1 DSGG - Blood group systems biosynthesis:
CMP-Neu5Ac + Type 1 chain ⟶ CMP + Type 1 MSGG - Lewis blood group biosynthesis:
CMP-Neu5Ac + Type 1 chain ⟶ CMP + Type 1 MSGG - Blood group systems biosynthesis:
CMP-Neu5Ac + Type 1 chain ⟶ CMP + Type 1 MSGG - Lewis blood group biosynthesis:
CMP-Neu5Ac + Type 1 chain ⟶ CMP + Type 1 MSGG - Blood group systems biosynthesis:
CMP-Neu5Ac + Type 1 chain ⟶ CMP + Type 1 MSGG - Lewis blood group biosynthesis:
CMP-Neu5Ac + Type 1 chain ⟶ CMP + Type 1 MSGG - Blood group systems biosynthesis:
CMP-Neu5Ac + Type 1 chain ⟶ CMP + Type 1 MSGG - Lewis blood group biosynthesis:
CMP-Neu5Ac + Type 1 chain ⟶ CMP + Type 1 MSGG - Blood group systems biosynthesis:
CMP-Neu5Ac + Type 1 chain ⟶ CMP + Type 1 MSGG - Lewis blood group biosynthesis:
CMP-Neu5Ac + Type 1 chain ⟶ CMP + Type 1 MSGG - Blood group systems biosynthesis:
GDP-Fuc + Type 1 chain ⟶ GDP + LeA - Lewis blood group biosynthesis:
GDP-Fuc + Type 1 chain ⟶ GDP + LeA - Blood group systems biosynthesis:
GDP-Fuc + Type 1 chain ⟶ GDP + LeA - Lewis blood group biosynthesis:
GDP-Fuc + Type 1 chain ⟶ GDP + LeA - Blood group systems biosynthesis:
CMP-Neu5Ac + Type 1 chain ⟶ CMP + Type 1 MSGG - Lewis blood group biosynthesis:
CMP-Neu5Ac + Type 1 chain ⟶ CMP + Type 1 MSGG - Blood group systems biosynthesis:
CMP-Neu5Ac + Type 1 chain ⟶ CMP + Type 1 MSGG - Lewis blood group biosynthesis:
CMP-Neu5Ac + Type 1 chain ⟶ CMP + Type 1 MSGG - Clathrin-mediated endocytosis:
DNM:GTP + PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers ⟶ PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP - Clathrin-mediated endocytosis:
DAB2,LDLRAP1 + LDL:LDLR complex ⟶ DAB2,LDLRAP1:LDLR:LDL - Clathrin-mediated endocytosis:
DAB2,LDLRAP1 + LDL:LDLR complex ⟶ DAB2,LDLRAP1:LDLR:LDL - Clathrin-mediated endocytosis:
DAB2,LDLRAP1 + LDL:LDLR complex ⟶ DAB2,LDLRAP1:LDLR:LDL - Clathrin-mediated endocytosis:
DAB2,LDLRAP1 + LDL:LDLR complex ⟶ DAB2,LDLRAP1:LDLR:LDL - Clathrin-mediated endocytosis:
DNM:GTP + PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers ⟶ PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Post-translational protein modification:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - RAB geranylgeranylation:
RABGGTA:RABGGTB:CHMs:GGPP + RABs:GDP ⟶ RGGT:CHMs:RABs:GDP - Metabolism of proteins:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - Post-translational protein modification:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - RAB geranylgeranylation:
CHM + RABGGTA:RABGGTB + geranylgeranyl diphosphate ⟶ RABGGTA:RABGGTB:CHMs:GGPP - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Post-translational protein modification:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - RAB geranylgeranylation:
CHM + RABGGTA:RABGGTB + geranylgeranyl diphosphate ⟶ RABGGTA:RABGGTB:CHMs:GGPP - Metabolism of proteins:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - Post-translational protein modification:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - RAB geranylgeranylation:
RABGGTA:RABGGTB + chm + geranylgeranyl diphosphate ⟶ RABGGTA:RABGGTB:CHMs:GGPP - Metabolism of proteins:
NAD + SPM + eif5a ⟶ 1,3-diaminopropane + H+ + NADH + eif5a - Post-translational protein modification:
NAD + SPM + eif5a ⟶ 1,3-diaminopropane + H+ + NADH + eif5a - RAB geranylgeranylation:
CHMs + RABGGTA:RABGGTB + geranylgeranyl diphosphate ⟶ RABGGTA:RABGGTB:CHMs:GGPP - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH + Q9GU68 - Post-translational protein modification:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH + Q9GU68 - RAB geranylgeranylation:
RABGGTA:RABGGTB + Rep + geranylgeranyl diphosphate ⟶ RABGGTA:RABGGTB:CHMs:GGPP - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Post-translational protein modification:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - RAB geranylgeranylation:
CHMs + RABGGTA:RABGGTB + geranylgeranyl diphosphate ⟶ RABGGTA:RABGGTB:CHMs:GGPP - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Post-translational protein modification:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - RAB geranylgeranylation:
CHMs + RABGGTA:RABGGTB + geranylgeranyl diphosphate ⟶ RABGGTA:RABGGTB:CHMs:GGPP - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Post-translational protein modification:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - RAB geranylgeranylation:
RGGT:CHMs:RABs:GDP + geranylgeranyl diphosphate ⟶ CHMs:GGC-RABs:GDP + PPi + RGGTA:RGGTB:GGPP - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Post-translational protein modification:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - RAB geranylgeranylation:
Chm + RABGGTA:RABGGTB + geranylgeranyl diphosphate ⟶ RABGGTA:RABGGTB:CHMs:GGPP - Metabolism of proteins:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - Post-translational protein modification:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - RAB geranylgeranylation:
CHM + RABGGTA:RABGGTB + geranylgeranyl diphosphate ⟶ RABGGTA:RABGGTB:CHMs:GGPP - Metabolism of proteins:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - Post-translational protein modification:
NAD + SPM ⟶ 1,3-diaminopropane + H+ + NADH - RAB geranylgeranylation:
CHMs + RABGGTA:RABGGTB + geranylgeranyl diphosphate ⟶ RABGGTA:RABGGTB:CHMs:GGPP - RAB geranylgeranylation:
RABGGTA:RABGGTB + chm + geranylgeranyl diphosphate ⟶ RABGGTA:RABGGTB:CHMs:GGPP - Disease:
ADORA2B + Ade-Rib ⟶ ADORA2B:Ade-Rib - Infectious disease:
ADORA2B + Ade-Rib ⟶ ADORA2B:Ade-Rib - Leishmania infection:
ADORA2B + Ade-Rib ⟶ ADORA2B:Ade-Rib - Leishmania parasite growth and survival:
ADORA2B + Ade-Rib ⟶ ADORA2B:Ade-Rib - Anti-inflammatory response favouring Leishmania parasite infection:
ADORA2B + Ade-Rib ⟶ ADORA2B:Ade-Rib - ADORA2B mediated anti-inflammatory cytokines production:
ADORA2B + Ade-Rib ⟶ ADORA2B:Ade-Rib - Parasitic Infection Pathways:
Adenylate cyclase (Mg2+ cofactor) + Gs:GTP ⟶ Gs-activated adenylate cyclase - G alpha (s) signalling events:
H2O + cAMP ⟶ AMP - G alpha (s) signalling events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G alpha (s) signalling events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G alpha (s) signalling events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G alpha (s) signalling events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G alpha (s) signalling events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - G alpha (s) signalling events:
H2O + cAMP ⟶ AMP - G alpha (s) signalling events:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Metabolism of proteins:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Post-translational protein modification:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Metabolism of proteins:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Post-translational protein modification:
EIF5A + NAD + SPM ⟶ 1,3-diaminopropane + EIF5A(Dhp) + H+ + NADH - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Metabolism of proteins:
NAD + SPM + eif5a ⟶ 1,3-diaminopropane + H+ + NADH + eif5a - Post-translational protein modification:
NAD + SPM + eif5a ⟶ 1,3-diaminopropane + H+ + NADH + eif5a - Asparagine N-linked glycosylation:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein:
DOLP + UDP-GlcNAc ⟶ GlcNAcDOLDP + UMP
BioCyc(0)
WikiPathways(0)
Plant Reactome(6)
- Metabolism and regulation:
ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA - Carbohydrate metabolism:
Suc ⟶ 1-kestose + beta-D-glucose - GDP-mannose metabolism:
Fru(6)P ⟶ Man6P - Mannosyl-chito-dolichol biosynthesis:
UDP-GlcNAc + dolichyl-phosphate ⟶ N-acetylglucosaminyl-diphosphodolichol + UMP - Responses to stimuli: biotic stimuli and stresses:
H+ + O2.- ⟶ H2O2 + Oxygen - Cell Death and immunity:
H+ + O2.- ⟶ H2O2 + Oxygen
INOH(0)
PlantCyc(3)
- pyrimidine salvage pathway:
H2O + UMP ⟶ phosphate + uridine - pyrimidine salvage pathway:
H2O + UMP ⟶ phosphate + uridine - pyrimidine salvage pathway:
H2O + UMP ⟶ phosphate + uridine
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。