4-(2-(1-(4-Chlorocinnamyl)piperazin-4-yl)ethyl)benzoic acid (BioDeep_00000840684)
代谢物信息卡片
4-(2-(1-(4-Chlorocinnamyl)piperazin-4-yl)ethyl)benzoic acid
化学式: C22H25ClN2O2 (384.1604)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCN1CCC2=CC=C(C=C2)C(=O)O)CC=CC3=CC=C(C=C3)Cl
InChI: InChI=1S/C22H25ClN2O2/c23-21-9-5-18(6-10-21)2-1-12-24-14-16-25(17-15-24)13-11-19-3-7-20(8-4-19)22(26)27/h1-10H,11-17H2,(H,26,27)/b2-1+
描述信息
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents
D009676 - Noxae > D000963 - Antimetabolites
D004791 - Enzyme Inhibitors
同义名列表
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Yasuhisa Yamashita, Masahide Nishibori, Takato Terada, Naoki Isobe, Masayuki Shimada. Gonadotropin-induced delta14-reductase and delta7-reductase gene expression in cumulus cells during meiotic resumption of porcine oocytes.
Endocrinology.
2005 Jan; 146(1):186-94. doi:
10.1210/en.2004-0617. [PMID: 15459117] - L M Refolo, M A Pappolla, J LaFrancois, B Malester, S D Schmidt, T Thomas-Bryant, G S Tint, R Wang, M Mercken, S S Petanceska, K E Duff. A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease.
Neurobiology of disease.
2001 Oct; 8(5):890-9. doi:
10.1006/nbdi.2001.0422. [PMID: 11592856] - C Roux, C Wolf, N Mulliez, W Gaoua, V Cormier, F Chevy, D Citadelle. Role of cholesterol in embryonic development.
The American journal of clinical nutrition.
2000 05; 71(5 Suppl):1270S-9S. doi:
10.1093/ajcn/71.5.1270s. [PMID: 10799401] - W T O'Brien, G Xu, G S Tint, G Salen, R J Servatius. Blocking cholesterol synthesis impairs acquisition of the classically conditioned eyeblink response.
Integrative physiological and behavioral science : the official journal of the Pavlovian Society.
2000 Apr; 35(2):120-31. doi:
10.1007/bf02688771. [PMID: 11021337] - A Honda, G Salen, S Shefer, A K Batta, M Honda, G Xu, G S Tint, Y Matsuzaki, J Shoda, N Tanaka. Bile acid synthesis in the Smith-Lemli-Opitz syndrome: effects of dehydrocholesterols on cholesterol 7alpha-hydroxylase and 27-hydroxylase activities in rat liver.
Journal of lipid research.
1999 Aug; 40(8):1520-8. doi:
. [PMID: 10428990] - G Xu, R J Servatius, S Shefer, G S Tint, W T O'Brien, A K Batta, G Salen. Relationship between abnormal cholesterol synthesis and retarded learning in rats.
Metabolism: clinical and experimental.
1998 Jul; 47(7):878-82. doi:
10.1016/s0026-0495(98)90130-5. [PMID: 9667239] - G Xu, G Salen, M Lea, G S Tint, L B Nguyen, A K Batta, T S Chen, S Shefer. Blocking late cholesterol biosynthesis inhibits the growth of transplanted Morris hepatomas (7288CTC) in rats.
Hepatology (Baltimore, Md.).
1996 Aug; 24(2):440-5. doi:
10.1002/hep.510240224. [PMID: 8690417] - A Honda, S Shefer, G Salen, G Xu, A K Batta, G S Tint, M Honda, T C Chen, M F Holick. Regulation of the last two enzymatic reactions in cholesterol biosynthesis in rats: effects of BM 15.766, cholesterol, cholic acid, lovastatin, and their combinations.
Hepatology (Baltimore, Md.).
1996 Aug; 24(2):435-9. doi:
10.1002/hep.510240223. [PMID: 8690416] - C Wolf, F Chevy, J Pham, M Kolf-Clauw, D Citadelle, N Mulliez, C Roux. Changes in serum sterols of rats treated with 7-dehydrocholesterol-delta 7-reductase inhibitors: comparison to levels in humans with Smith-Lemli-Opitz syndrome.
Journal of lipid research.
1996 Jun; 37(6):1325-33. doi:
NULL. [PMID: 8808767] - G Salen, G S Tint, G Xu, A K Batta, M Irons, E R Elias. Abnormal cholesterol biosynthesis in the Smith-Lemli-Opitz syndrome.
The Italian journal of gastroenterology.
1995 Dec; 27(9):506-8. doi:
NULL. [PMID: 8919321] - G Xu, G Salen, S Shefer, G C Ness, T S Chen, Z Zhao, L Salen, G S Tint. Treatment of the cholesterol biosynthetic defect in Smith-Lemli-Opitz syndrome reproduced in rats by BM 15.766.
Gastroenterology.
1995 Oct; 109(4):1301-7. doi:
10.1016/0016-5085(95)90592-8. [PMID: 7557099] - M C Weiss, E Baumgart, H D Fahimi, H Pill, W Rebel, F Hartig. [Elevation of 7-dehydrocholesterol concentrations in serum and liver and pericentral peroxisome proliferation in hepatocytes of rats after inhibition of cholesterol biosynthesis by BM 15,766].
Berliner und Munchener tierarztliche Wochenschrift.
1995 Feb; 108(2):66-9. doi:
. [PMID: 7786281] - G Xu, G Salen, S Shefer, G C Ness, T S Chen, Z Zhao, G S Tint. Reproducing abnormal cholesterol biosynthesis as seen in the Smith-Lemli-Opitz syndrome by inhibiting the conversion of 7-dehydrocholesterol to cholesterol in rats.
The Journal of clinical investigation.
1995 Jan; 95(1):76-81. doi:
10.1172/jci117678. [PMID: 7814648] - J Pill, E C Witte, F H Schmidt. Reduction of BM 15.766-induced 7-dehydrocholesterol accumulation by bezafibrate and mevinolin in rats. A non-isotopic in vivo test system for compounds reducing cholesterol synthesis.
Naunyn-Schmiedeberg's archives of pharmacology.
1990 Jun; 341(6):552-6. doi:
10.1007/bf00171736. [PMID: 2392158] - E Baumgart, K Stegmeier, F H Schmidt, H D Fahimi. Proliferation of peroxisomes in pericentral hepatocytes of rat liver after administration of a new hypocholesterolemic agent (BM 15766). Sex-dependent ultrastructural differences.
Laboratory investigation; a journal of technical methods and pathology.
1987 May; 56(5):554-64. doi:
. [PMID: 3573722] - J Aufenanger, J Pill, F H Schmidt, K Stegmeier. The effects of BM 15.766, an inhibitor of 7-dehydrocholesterol delta 7-reductase, on cholesterol biosynthesis in primary rat hepatocytes.
Biochemical pharmacology.
1986 Mar; 35(6):911-6. doi:
10.1016/0006-2952(86)90076-6. [PMID: 3754141] - J Pill, F H Schmidt, K Stegmeier, E C Witte. Effects of BM 15.766 on serum lipids in rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
1985 Oct; 17(10):543-4. doi:
10.1055/s-2007-1013600. [PMID: 3840766] - J J Berberich, R V Andrews, G E Folk. Effects of cold exposure on urinary catecholamines in arctic lemmings.
Comparative biochemistry and physiology. C: Comparative pharmacology.
1977; 58(2C):133-5. doi:
10.1016/0306-4492(77)90093-4. [PMID: 23926]
