Guanosine 5-triphosphate (BioDeep_00000840667)

   


代谢物信息卡片


Guanosine 5-triphosphate

化学式: C10H12N5O14P3-4 (518.9593642)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=NC2=C(N1C3C(C(C(O3)COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])O)O)N=C(NC2=O)N
InChI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1

描述信息

同义名列表

1 个代谢物同义名

Guanosine 5-triphosphate



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(102)

BioCyc(0)

PlantCyc(0)

代谢反应

1064 个相关的代谢反应过程信息。

Reactome(926)

BioCyc(0)

WikiPathways(3)

Plant Reactome(6)

INOH(0)

PlantCyc(129)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Sapna I, A Jayadeep. Enzyme-treated red rice (Oryza sativa L.) bran extracts mitigate inflammatory markers in RAW 264.7 macrophage cells and exhibit anti-inflammatory efficacy greater/comparable to ferulic acid, catechin, γ-tocopherol, and γ-oryzanol. Journal of ethnopharmacology. 2024 Apr; 323(?):117616. doi: 10.1016/j.jep.2023.117616. [PMID: 38142877]
  • Lijun Shi, Chenguang Yang, Mingyuan Zhang, Kangning Li, Keying Wang, Li Jiao, Ruming Liu, Yunyun Wang, Ming Li, Yong Wang, Lu Ma, Shuxin Hu, Xin Bian. Dissecting the mechanism of atlastin-mediated homotypic membrane fusion at the single-molecule level. Nature communications. 2024 Mar; 15(1):2488. doi: 10.1038/s41467-024-46919-z. [PMID: 38509071]
  • Mengjie Zhu, Nan Wu, Jiayi Zhong, Chen Chen, Wenwen Liu, Yingdang Ren, Xifeng Wang, Huaibing Jin. N6-methyladenosine modification of the mRNA for a key gene in purine nucleotide metabolism regulates virus proliferation in an insect vector. Cell reports. 2024 Feb; 43(2):113821. doi: 10.1016/j.celrep.2024.113821. [PMID: 38368611]
  • Cody Aplin, Richard A Cerione. Probing the mechanism by which the retinal G protein transducin activates its biological effector PDE6. The Journal of biological chemistry. 2023 Dec; 300(2):105608. doi: 10.1016/j.jbc.2023.105608. [PMID: 38159849]
  • Huayin Bao, Wei Wang, Haibo Sun, Jianzhong Chen. Probing mutation-induced conformational transformation of the GTP/M-RAS complex through Gaussian accelerated molecular dynamics simulations. Journal of enzyme inhibition and medicinal chemistry. 2023 Dec; 38(1):2195995. doi: 10.1080/14756366.2023.2195995. [PMID: 37057639]
  • Man Zhang, Wenshuang Wang, Kaixin Liu, Chao Jia, Yuanyuan Hou, Gang Bai. Astragaloside IV protects against lung injury and pulmonary fibrosis in COPD by targeting GTP-GDP domain of RAS and downregulating the RAS/RAF/FoxO signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Nov; 120(?):155066. doi: 10.1016/j.phymed.2023.155066. [PMID: 37690229]
  • Cecilia Rodriguez-Furlan, Ariana Emami, Jaimie M Van Norman. Distinct ADP-ribosylation factor-GTP exchange factors govern the opposite polarity of two receptor kinases. Plant physiology. 2023 Oct; ?(?):. doi: 10.1093/plphys/kiad519. [PMID: 37787604]
  • Junying Li, Xueling Chang, Xiangming Chen, Ruiyu Ma, Renrong Qi, Wei Liu, Yan Li, Yi Wan, Qinqin Qiu, Qiance Shao, Aiqiao Liu, Kai Zhan. Effects of green tea powder on production performance, egg quality, and blood biochemical parameters in laying hens. Poultry science. 2023 Oct; 102(10):102924. doi: 10.1016/j.psj.2023.102924. [PMID: 37542941]
  • Heng Shi, Xinhai Zhao, Peng Qin, Xianling Zhou, Sisi Liu, Chuanchuan Sun, Qiuyu Cao, Shiping Zhu, Shengyun Sun. Green tea polyphenols alleviate kidney injury induced by di(2-ethylhexyl) phthalate in mice. American journal of nephrology. 2023 Sep; ?(?):. doi: 10.1159/000534106. [PMID: 37734331]
  • Yanan Wang, Kun Liu, Meishan Lu, Jiachen Shi, Yong-Jiang Xu, Yuanfa Liu. Comparative evaluation of static and dynamic simulated digestion models. Journal of the science of food and agriculture. 2023 Sep; 103(12):5893-5903. doi: 10.1002/jsfa.12692. [PMID: 37144349]
  • Jahanvi Ganotra, Bhawana Sharma, Brijesh Biswal, Deepak Bhardwaj, Narendra Tuteja. Emerging role of small GTPases and their interactome in plants to combat abiotic and biotic stress. Protoplasma. 2023 Jul; 260(4):1007-1029. doi: 10.1007/s00709-022-01830-6. [PMID: 36525153]
  • Tian-Tian Jiang, Cong-Lan Ji, Li-Jun Yu, Meng-Ke Song, Yan Li, Qiang Liao, Tuo Wei, Opeyemi Joshua Olatunji, Jian Zuo, Jun Han. Resveratrol-induced SIRT1 activation inhibits glycolysis-fueled angiogenesis under rheumatoid arthritis conditions independent of HIF-1α. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2023 Apr; ?(?):. doi: 10.1007/s00011-023-01728-w. [PMID: 37016140]
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  • Yongshun Zhou, Fanze Meng, Kai Han, Kaiyue Zhang, Jianfeng Gao, Fulong Chen. Screening and validating of endogenous reference genes in Chlorella sp. TLD 6B under abiotic stress. Scientific reports. 2023 01; 13(1):1555. doi: 10.1038/s41598-023-28311-x. [PMID: 36707665]
  • Yingjie Guo, Huan Zhang, Chen Yan, Birong Shen, Yue Zhang, Xiangyang Guo, Sha Sun, Fan Yu, Jiayun Yan, Ronghe Liu, Qianping Zhang, Di Zhang, Haiyang Liu, Yang Liu, Yaoyao Zhang, Wenlei Li, Jiangyu Qin, He Lv, Zhaoxia Wang, Yun Yuan, Jie-Feng Yang, Ya-Ting Zhong, Song Gao, Bing Zhou, Lei Liu, Deling Kong, Xiaojiang Hao, Junjie Hu, Quan Chen. Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction. Nature chemical biology. 2023 Jan; ?(?):. doi: 10.1038/s41589-022-01224-y. [PMID: 36635564]
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  • Qian-Zhi Ni, Bing Zhu, Yan Ji, Qian-Wen Zheng, Xin Liang, Ning Ma, Hao Jiang, Feng-Kun Zhang, Yu-Rong Shang, Yi-Kang Wang, Sheng Xu, Er-Bin Zhang, Yan-Mei Yuan, Tian-Wei Chen, Fen-Fen Yin, Hui-Jun Cao, Jing-Yi Huang, Ji Xia, Xu-Fen Ding, Xiao-Song Qiu, Kai Ding, Chao Song, Wen-Tao Zhou, Meng Wu, Kang Wang, Rui Lui, Qiu Lin, Wei Chen, Zhi-Gang Li, Shu-Qun Cheng, Xiao-Fan Wang, Dong Xie, Jing-Jing Li. PPDPF Promotes the Development of Mutant KRAS-Driven Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023 01; 10(2):e2202448. doi: 10.1002/advs.202202448. [PMID: 36453576]
  • Gianfranco Paccione, Miguel Á Robles-Ramos, Carlos Alfonso, Marta Sobrinos-Sanguino, William Margolin, Silvia Zorrilla, Begoña Monterroso, Germán Rivas. Lipid Surfaces and Glutamate Anions Enhance Formation of Dynamic Biomolecular Condensates Containing Bacterial Cell Division Protein FtsZ and Its DNA-Bound Regulator SlmA. Biochemistry. 2022 11; 61(22):2482-2489. doi: 10.1021/acs.biochem.2c00424. [PMID: 36315857]
  • Di Zhang, Bei Jing, Zhenni Chen, Xin Li, Huimei Shi, Yachun Zheng, Shiquan Chang, Guoping Zhao. Ferulic acid alleviates sciatica by inhibiting peripheral sensitization through the RhoA/p38MAPK signalling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov; 106(?):154420. doi: 10.1016/j.phymed.2022.154420. [PMID: 36115115]
  • Wei Liu, Chunxia G Cronin, Ziming Cao, Chengliang Wang, Jianbin Ruan, Sunitha Pulikkot, Alexxus Hall, Hao Sun, Alex Groisman, Yunfeng Chen, Anthony T Vella, Liang Hu, Bruce T Liang, Zhichao Fan. Nexinhib20 Inhibits Neutrophil Adhesion and β2 Integrin Activation by Antagonizing Rac-1-Guanosine 5'-Triphosphate Interaction. Journal of immunology (Baltimore, Md. : 1950). 2022 10; 209(8):1574-1585. doi: 10.4049/jimmunol.2101112. [PMID: 36165184]
  • Huiling Guo, Juan Wang, Su Ren, Lang-Fan Zheng, Yi-Xuan Zhuang, Dong-Lin Li, Hui-Hui Sun, Li-Ying Liu, Changchuan Xie, Ya-Ying Wu, Hong-Rui Wang, Xianming Deng, Peng Li, Tong-Jin Zhao. Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system. Nature communications. 2022 10; 13(1):6004. doi: 10.1038/s41467-022-33788-7. [PMID: 36224181]
  • Van A Ngo, Angel E Garcia. Millisecond molecular dynamics simulations of KRas-dimer formation and interfaces. Biophysical journal. 2022 10; 121(19):3730-3744. doi: 10.1016/j.bpj.2022.04.026. [PMID: 35462078]
  • Adriana Trutzenberg, Stefan Engelhardt, Lukas Weiß, Ralph Hückelhoven. Barley guanine nucleotide exchange factor HvGEF14 is an activator of the susceptibility factor HvRACB and supports host cell entry by Blumeria graminis f. sp. hordei. Molecular plant pathology. 2022 10; 23(10):1524-1537. doi: 10.1111/mpp.13246. [PMID: 35849420]
  • Wudtichai Wisuitiprot, Kornkanok Ingkaninan, Sirada Jones, Neti Waranuch. Effect of green tea extract loaded chitosan microparticles on facial skin: A split-face, double-blind, randomized placebo-controlled study. Journal of cosmetic dermatology. 2022 Sep; 21(9):4001-4008. doi: 10.1111/jocd.14707. [PMID: 34965006]
  • Guohua Lv, Myung Soo Ko, Tapojyoti Das, David Eliezer. Molecular and functional interactions of alpha-synuclein with Rab3a. The Journal of biological chemistry. 2022 09; 298(9):102239. doi: 10.1016/j.jbc.2022.102239. [PMID: 35809645]
  • Dustin E Bosch, William R Jeck, David P Siderovski. Self-activating G protein α subunits engage seven-transmembrane regulator of G protein signaling (RGS) proteins and a Rho guanine nucleotide exchange factor effector in the amoeba Naegleria fowleri. The Journal of biological chemistry. 2022 08; 298(8):102167. doi: 10.1016/j.jbc.2022.102167. [PMID: 35738399]
  • Kazuhiro Ito, Doshun Ito, Mina Goto, Sae Suzuki, Shinji Masuda, Koh Iba, Kensuke Kusumi. Regulation of ppGpp Synthesis and Its Impact on Chloroplast Biogenesis during Early Leaf Development in Rice. Plant & cell physiology. 2022 Jul; 63(7):919-931. doi: 10.1093/pcp/pcac053. [PMID: 35428891]
  • T Wang, M J Jin, L K Li. [The GTP-Bound form of Rab3D Promotes Lipid Droplet Growth in Adipocyte]. Molekuliarnaia biologiia. 2022 Jul; 56(4):564-573. doi: 10.31857/s0026898422040140. [PMID: 35964313]
  • Negar Shahsavari, Boyuan Wang, Yu Imai, Miho Mori, Sangkeun Son, Libang Liang, Nils Böhringer, Sylvie Manuse, Michael F Gates, Madeleine Morrissette, Rachel Corsetti, Josh L Espinoza, Chris L Dupont, Michael T Laub, Kim Lewis. A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP. mBio. 2022 06; 13(3):e0070022. doi: 10.1128/mbio.00700-22. [PMID: 35575547]
  • Giang Pham, Dong-Min Shin, Yoon Kim, Soo-Hwan Kim. Ran-GTP/-GDP-dependent nuclear accumulation of NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 and TGACG-BINDING FACTOR2 controls salicylic acid-induced leaf senescence. Plant physiology. 2022 06; 189(3):1774-1793. doi: 10.1093/plphys/kiac164. [PMID: 35417014]
  • Bikram D Pant, Seonghee Lee, Hee-Kyung Lee, Nick Krom, Pooja Pant, YoonJeong Jang, Kirankumar S Mysore. Overexpression of Arabidopsis nucleolar GTP-binding 1 (NOG1) proteins confers drought tolerance in rice. Plant physiology. 2022 06; 189(2):988-1004. doi: 10.1093/plphys/kiac078. [PMID: 35260897]
  • Chen Ling, Xingyong Chen, Weihuang Lin, Zhaoyu Geng. Green tea powder inclusion promoted hatchability through increased yolk antioxidant activity. Poultry science. 2022 May; 101(5):101804. doi: 10.1016/j.psj.2022.101804. [PMID: 35325830]
  • Kiran S Toti, John R Jimah, Veronica Salmaso, Jenny E Hinshaw, Kenneth A Jacobson. Synthesis and Effect of Conformationally Locked Carbocyclic Guanine Nucleotides on Dynamin. Biomolecules. 2022 04; 12(4):. doi: 10.3390/biom12040584. [PMID: 35454173]
  • Kunpeng Liu, Dongbo Qiu, Xue Liang, Yingqi Huang, Yao Wang, Xin Jia, Kun Li, Jingyuan Zhao, Cong Du, Xiusheng Qiu, Jun Cui, Zhendong Xiao, Yunfei Qin, Qi Zhang. Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy. Autophagy. 2022 04; 18(4):860-876. doi: 10.1080/15548627.2021.1961072. [PMID: 34382907]
  • Yachana Jha, Budheswar Dehury, S P Jeevan Kumar, Anurag Chaurasia, Udai B Singh, Manoj Kumar Yadav, U B Angadi, Rajiv Ranjan, Minaketan Tripathy, R B Subramanian, Sunil Kumar, Jesus Simal-Gandara. Delineation of molecular interactions of plant growth promoting bacteria induced β-1,3-glucanases and guanosine triphosphate ligand for antifungal response in rice: a molecular dynamics approach. Molecular biology reports. 2022 Apr; 49(4):2579-2589. doi: 10.1007/s11033-021-07059-5. [PMID: 34914086]
  • Natsumi Maruta, Yuri Trusov, Alan M Jones, Jose R Botella. Heterotrimeric G Proteins in Plants: Canonical and Atypical Gα Subunits. International journal of molecular sciences. 2021 Oct; 22(21):. doi: 10.3390/ijms222111841. [PMID: 34769272]
  • Johannes Kattan, Anne Doerr, Marileen Dogterom, Christophe Danelon. Shaping Liposomes by Cell-Free Expressed Bacterial Microtubules. ACS synthetic biology. 2021 10; 10(10):2447-2455. doi: 10.1021/acssynbio.1c00278. [PMID: 34585918]
  • Ying Liu, Xiaoyun Wang, Danhui Dong, Luqin Guo, Xiaonan Dong, Jing Leng, Bing Zhao, Yang-Dong Guo, Na Zhang. Research Advances in Heterotrimeric G-Protein α Subunits and Uncanonical G-Protein Coupled Receptors in Plants. International journal of molecular sciences. 2021 Aug; 22(16):. doi: 10.3390/ijms22168678. [PMID: 34445383]
  • Jianzhong Chen, Lifei Wang, Wei Wang, Haibo Sun, Laixue Pang, Huayin Bao. Conformational transformation of switch domains in GDP/K-Ras induced by G13 mutants: An investigation through Gaussian accelerated molecular dynamics simulations and principal component analysis. Computers in biology and medicine. 2021 08; 135(?):104639. doi: 10.1016/j.compbiomed.2021.104639. [PMID: 34247129]
  • Krishnakanth Baratam, Kirtika Jha, Anand Srivastava. Flexible pivoting of dynamin pleckstrin homology domain catalyzes fission: insights into molecular degrees of freedom. Molecular biology of the cell. 2021 07; 32(14):1306-1319. doi: 10.1091/mbc.e20-12-0794. [PMID: 33979205]
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  • Wenbin Zhou, Bangjie Zhu, Fang Kou, Shenglan Qi, Chunming Lv, Yu Cheng, Hai Wei. Targeted Metabolic Profiling and PRM Analysis of Proteins Revealed Impaired Polyunsaturated Fatty Acid Metabolism and GTP Metabolism in the Brainstem of Spontaneously Hypertensive Rats. Journal of proteome research. 2021 06; 20(6):3305-3314. doi: 10.1021/acs.jproteome.1c00208. [PMID: 33999640]
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