N-Methylnicotinic acid (BioDeep_00000840659)

   

BioNovoGene_Lab2019


代谢物信息卡片


N-Methylnicotinic acid

化学式: C7H8NO2+ (138.0555008)
中文名称: 葫芦巴碱 盐酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C[N+]1=CC=CC(=C1)C(=O)O
InChI: InChI=1S/C7H7NO2/c1-8-4-2-3-6(5-8)7(9)10/h2-5H,1H3/p+1

描述信息

A pyridinium ion consisting of nicotinic acid having a methyl substituent on the pyridine nitrogen.

同义名列表

1 个代谢物同义名

N-Methylnicotinic acid



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Hiroshi Ashihara, Yuling Yin, Riko Katahira, Shin Watanabe, Tetsuro Mimura, Hamako Sasamoto. Comparison of the formation of nicotinic acid conjugates in leaves of different plant species. Plant physiology and biochemistry : PPB. 2012 Nov; 60(?):190-5. doi: 10.1016/j.plaphy.2012.08.007. [PMID: 22983143]
  • Nele Friedrich, Kathrin Budde, Tillmann Wolf, Arne Jungnickel, Anne Grotevendt, Miriam Dressler, Henry Völzke, Matthias Blüher, Matthias Nauck, Tobias Lohmann, Henri Wallaschofksi. Short-term changes of the urine metabolome after bariatric surgery. Omics : a journal of integrative biology. 2012 Nov; 16(11):612-20. doi: 10.1089/omi.2012.0066. [PMID: 23095112]
  • Delia-Irina Corol, Catherine Ravel, Mariann Raksegi, Zoltan Bedo, Gilles Charmet, Michael H Beale, Peter R Shewry, Jane L Ward. Effects of genotype and environment on the contents of betaine, choline, and trigonelline in cereal grains. Journal of agricultural and food chemistry. 2012 May; 60(21):5471-81. doi: 10.1021/jf3008794. [PMID: 22559314]
  • Aashish S Morani, Subhash L Bodhankar, V Mohan, Prasad A Thakurdesai. Ameliorative effects of standardized extract from Trigonella foenum-graecum L. seeds on painful peripheral neuropathy in rats. Asian Pacific journal of tropical medicine. 2012 May; 5(5):385-90. doi: 10.1016/s1995-7645(12)60064-9. [PMID: 22546656]
  • Yuling Yin, Shin Watanabe, Hiroshi Ashihara. Metabolic fate of 14C-labelled nicotinamide and adenine in germinating propagules of the mangrove Bruguiera gymnorrhiza. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2012 May; 67(5-6):319-26. doi: 10.1515/znc-2012-5-612. [PMID: 22888538]
  • Linda Jeanguenin, Aurora Lara-Núñez, Dmitry A Rodionov, Andrei L Osterman, Nataliya Y Komarova, Doris Rentsch, Jesse F Gregory, Andrew D Hanson. Comparative genomics and functional analysis of the NiaP family uncover nicotinate transporters from bacteria, plants, and mammals. Functional & integrative genomics. 2012 Mar; 12(1):25-34. doi: 10.1007/s10142-011-0255-y. [PMID: 21953179]
  • Payal Chawla, Amit Chawla, Neeru Vasudeva, Surendra Kumar Sharma. A review of chemistry and biological activities of the genus Aerva--a desert plant. Acta poloniae pharmaceutica. 2012 Mar; 69(2):171-7. doi: NULL. [PMID: 22568031]
  • Andreas Plischke, Young Hae Choi, Paul M Brakefield, Peter G L Klinkhamer, Maaike Bruinsma. Metabolomic plasticity in GM and non-GM potato leaves in response to aphid herbivory and virus infection. Journal of agricultural and food chemistry. 2012 Feb; 60(6):1488-93. doi: 10.1021/jf204864y. [PMID: 22243672]
  • Kurt D Kausch, Anatoly P Sobolev, Ravinder K Goyal, Tahira Fatima, Rekha Laila-Beevi, Robert A Saftner, Avtar K Handa, Autar K Mattoo. Methyl jasmonate deficiency alters cellular metabolome, including the aminome of tomato (Solanum lycopersicum L.) fruit. Amino acids. 2012 Feb; 42(2-3):843-56. doi: 10.1007/s00726-011-1000-5. [PMID: 21814797]
  • Laura Sánchez-Hernández, Leonor Nozal, Maria Luisa Marina, Antonio L Crego. Determination of nonprotein amino acids and betaines in vegetable oils by flow injection triple-quadrupole tandem mass spectrometry: a screening method for the detection of adulterations of olive oils. Journal of agricultural and food chemistry. 2012 Feb; 60(4):896-903. doi: 10.1021/jf202857y. [PMID: 22229859]
  • J Walker, B Rohm, R Lang, M W Pariza, T Hofmann, V Somoza. Identification of coffee components that stimulate dopamine release from pheochromocytoma cells (PC-12). Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Feb; 50(2):390-8. doi: 10.1016/j.fct.2011.09.041. [PMID: 22019894]
  • Szymon Zubek, Sebastian Mielcarek, Katarzyna Turnau. Hypericin and pseudohypericin concentrations of a valuable medicinal plant Hypericum perforatum L. are enhanced by arbuscular mycorrhizal fungi. Mycorrhiza. 2012 Feb; 22(2):149-56. doi: 10.1007/s00572-011-0391-1. [PMID: 21626142]
  • Lone G Rasmussen, Hanne Winning, Francesco Savorani, Henrik Toft, Thomas M Larsen, Lars O Dragsted, Arne Astrup, Søren B Engelsen. Assessment of the effect of high or low protein diet on the human urine metabolome as measured by NMR. Nutrients. 2012 Feb; 4(2):112-31. doi: 10.3390/nu4020112. [PMID: 22413065]
  • Yosra Belaïd-Nouira, Hayfa Bakhta, Mohamed Bouaziz, Imen Flehi-Slim, Zohra Haouas, Hassen Ben Cheikh. Study of lipid profile and parieto-temporal lipid peroxidation in AlCl₃ mediated neurotoxicity. Modulatory effect of fenugreek seeds. Lipids in health and disease. 2012 Jan; 11(?):16. doi: 10.1186/1476-511x-11-16. [PMID: 22280491]
  • J Zhou, L Chan, S Zhou. Trigonelline: a plant alkaloid with therapeutic potential for diabetes and central nervous system disease. Current medicinal chemistry. 2012; 19(21):3523-31. doi: 10.2174/092986712801323171. [PMID: 22680628]
  • Majambu Mbikay. Therapeutic Potential of Moringa oleifera Leaves in Chronic Hyperglycemia and Dyslipidemia: A Review. Frontiers in pharmacology. 2012; 3(?):24. doi: 10.3389/fphar.2012.00024. [PMID: 22403543]
  • Sonia Silvente, Anatoly P Sobolev, Miguel Lara. Metabolite adjustments in drought tolerant and sensitive soybean genotypes in response to water stress. PloS one. 2012; 7(6):e38554. doi: 10.1371/journal.pone.0038554. [PMID: 22685583]
  • D A Spratt, M Daglia, A Papetti, M Stauder, D O'Donnell, L Ciric, A Tymon, B Repetto, C Signoretto, Y Houri-Haddad, M Feldman, D Steinberg, S Lawton, P Lingström, J Pratten, E Zaura, G Gazzani, C Pruzzo, M Wilson. Evaluation of plant and fungal extracts for their potential antigingivitis and anticaries activity. Journal of biomedicine & biotechnology. 2012; 2012(?):510198. doi: 10.1155/2012/510198. [PMID: 22500094]
  • Fabien Baldacci-Cresp, Christine Chang, Mickaël Maucourt, Catherine Deborde, Julie Hopkins, Philippe Lecomte, Stéphane Bernillon, Renaud Brouquisse, Annick Moing, Pierre Abad, Didier Hérouart, Alain Puppo, Bruno Favery, Pierre Frendo. (Homo)glutathione deficiency impairs root-knot nematode development in Medicago truncatula. PLoS pathogens. 2012 Jan; 8(1):e1002471. doi: 10.1371/journal.ppat.1002471. [PMID: 22241996]
  • Philipp Schulz, Jenny Neukermans, Katrien Van der Kelen, Per Mühlenbock, Frank Van Breusegem, Graham Noctor, Markus Teige, Michael Metzlaff, Matthew A Hannah. Chemical PARP inhibition enhances growth of Arabidopsis and reduces anthocyanin accumulation and the activation of stress protective mechanisms. PloS one. 2012; 7(5):e37287. doi: 10.1371/journal.pone.0037287. [PMID: 22662141]
  • Khang Wei Ong, Annie Hsu, Benny Kwong Huat Tan. Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes. PloS one. 2012; 7(3):e32718. doi: 10.1371/journal.pone.0032718. [PMID: 22412912]
  • Ji-Yin Zhou, Shi-Wen Zhou, Sheng-Ya Zeng, Jian-Yun Zhou, Ming-Jin Jiang, Yan He. Hypoglycemic and Hypolipidemic Effects of Ethanolic Extract of Mirabilis jalapa L. Root on Normal and Diabetic Mice. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):257374. doi: 10.1155/2012/257374. [PMID: 22474494]
  • Etsuko Muraki, Yukie Hayashi, Hiroshige Chiba, Nobuyo Tsunoda, Keizo Kasono. Dose-dependent effects, safety and tolerability of fenugreek in diet-induced metabolic disorders in rats. Lipids in health and disease. 2011 Dec; 10(?):240. doi: 10.1186/1476-511x-10-240. [PMID: 22188728]
  • Yuling Yin, Hamako Sasamoto, Hiroshi Ashihara. Pyridine metabolism and trigonelline synthesis in leaves of the mangrove legume trees Derris indica (Millettia pinnata) and Caesalpinia crista. Natural product communications. 2011 Dec; 6(12):1835-8. doi: . [PMID: 22312719]
  • Natalina Cavaco Bicho, Antóanto Eduardo Leitão, José Cochicho Ramalho, Nuno Bartolomeu De Alvarenga, Fernando Cebola Lidon. Identification of nutritional descriptors of roasting intensity in beverages of Arabica and Robusta coffee beans. International journal of food sciences and nutrition. 2011 Dec; 62(8):865-71. doi: 10.3109/09637486.2011.588594. [PMID: 22032554]
  • Stine Krogh Steffensen, Hans Albert Pedersen, Rodrigo Labouriau, Anne G Mortensen, Bente Laursen, Rosa M de Troiani, Elke J Noellemeyer, Dagmar Janovska, Helena Stavelikova, Andreu Taberner, Carsten Christophersen, Inge S Fomsgaard. Variation of polyphenols and betaines in aerial parts of young, field-grown Amaranthus genotypes. Journal of agricultural and food chemistry. 2011 Nov; 59(22):12073-82. doi: 10.1021/jf202969e. [PMID: 22007946]
  • Roman Lang, Anika Wahl, Timo Stark, Thomas Hofmann. Urinary N-methylpyridinium and trigonelline as candidate dietary biomarkers of coffee consumption. Molecular nutrition & food research. 2011 Nov; 55(11):1613-23. doi: 10.1002/mnfr.201000656. [PMID: 21618426]
  • Damien Lacroix, Soizic Prado, Dennis Kamoga, John Kasenene, Bernard Bodo. Structure and in vitro antiparasitic activity of constituents of Citropsis articulata root bark. Journal of natural products. 2011 Oct; 74(10):2286-9. doi: 10.1021/np2004825. [PMID: 21985060]
  • Sascha Gille, Kun Cheng, Mary E Skinner, Aaron H Liepman, Curtis G Wilkerson, Markus Pauly. Deep sequencing of voodoo lily (Amorphophallus konjac): an approach to identify relevant genes involved in the synthesis of the hemicellulose glucomannan. Planta. 2011 Sep; 234(3):515-26. doi: 10.1007/s00425-011-1422-z. [PMID: 21538106]
  • Madhesh Murugesan, Ramalingam Revathi, Vaiyapuri Manju. Cardioprotective effect of fenugreek on isoproterenol-induced myocardial infarction in rats. Indian journal of pharmacology. 2011 Sep; 43(5):516-9. doi: 10.4103/0253-7613.84957. [PMID: 22021992]
  • Young-Shick Hong, Clara Cilindre, Gerard Liger-Belair, Philippe Jeandet, Norbert Hertkorn, Philippe Schmitt-Kopplin. Metabolic influence of Botrytis cinerea infection in champagne base wine. Journal of agricultural and food chemistry. 2011 Jul; 59(13):7237-45. doi: 10.1021/jf200664t. [PMID: 21604814]
  • Eamon P Rafferty, Alastair R Wylie, Chris T Elliott, Olivier P Chevallier, David J Grieve, Brian D Green. In Vitro and In Vivo Effects of Natural Putative Secretagogues of Glucagon-Like Peptide-1 (GLP-1). Scientia pharmaceutica. 2011 Jul; 79(3):615-21. doi: 10.3797/scipharm.1104-16. [PMID: 21886907]
  • Hélène Ferry-Dumazet, Laurent Gil, Catherine Deborde, Annick Moing, Stéphane Bernillon, Dominique Rolin, Macha Nikolski, Antoine de Daruvar, Daniel Jacob. MeRy-B: a web knowledgebase for the storage, visualization, analysis and annotation of plant NMR metabolomic profiles. BMC plant biology. 2011 Jun; 11(?):104. doi: 10.1186/1471-2229-11-104. [PMID: 21668943]
  • Laura Sánchez-Hernández, María Castro-Puyana, María Luisa Marina, Antonio L Crego. Determination of betaines in vegetable oils by capillary electrophoresis tandem mass spectrometry--application to the detection of olive oil adulteration with seed oils. Electrophoresis. 2011 Jun; 32(11):1394-401. doi: 10.1002/elps.201100005. [PMID: 21520150]
  • Christian Fork, Tim Bauer, Stefan Golz, Andreas Geerts, Jessica Weiland, Domenico Del Turco, Edgar Schömig, Dirk Gründemann. OAT2 catalyses efflux of glutamate and uptake of orotic acid. The Biochemical journal. 2011 Jun; 436(2):305-12. doi: 10.1042/bj20101904. [PMID: 21446918]
  • Dayene do Carmo Carvalho, Maisa Ribeiro Pereira Lima Brigagão, Marcelo Henrique dos Santos, Fernanda Borges Araújo de Paula, Alexandre Giusti-Paiva, Luciana Azevedo. Organic and conventional Coffea arabica L.: a comparative study of the chemical composition and physiological, biochemical and toxicological effects in Wistar rats. Plant foods for human nutrition (Dordrecht, Netherlands). 2011 Jun; 66(2):114-21. doi: 10.1007/s11130-011-0221-9. [PMID: 21523414]
  • Catherine Fontenelle, Carlos Blanco, Morgane Arrieta, Virginie Dufour, Annie Trautwetter. Resistance to organic hydroperoxides requires ohr and ohrR genes in Sinorhizobium meliloti. BMC microbiology. 2011 May; 11(?):100. doi: 10.1186/1471-2180-11-100. [PMID: 21569462]
  • Ute Boettler, Katharina Sommerfeld, Nadine Volz, Gudrun Pahlke, Nicole Teller, Veronika Somoza, Roman Lang, Thomas Hofmann, Doris Marko. Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression. The Journal of nutritional biochemistry. 2011 May; 22(5):426-40. doi: 10.1016/j.jnutbio.2010.03.011. [PMID: 20655719]
  • Ulla Mueller, Tanja Sauer, Ingrid Weigel, Rohtraud Pichner, Monika Pischetsrieder. Identification of H₂O₂ as a major antimicrobial component in coffee. Food & function. 2011 May; 2(5):265-72. doi: 10.1039/c0fo00180e. [PMID: 21779565]
  • M J Martínez Bueno, S Uclés, M D Hernando, E Dávoli, A R Fernández-Alba. Evaluation of selected ubiquitous contaminants in the aquatic environment and their transformation products. A pilot study of their removal from a sewage treatment plant. Water research. 2011 Mar; 45(6):2331-41. doi: 10.1016/j.watres.2011.01.011. [PMID: 21333319]
  • Hiroshi Ashihara, Yuling Yin, Shin Watanabe. Nicotinamide metabolism in ferns: formation of nicotinic acid glucoside. Plant physiology and biochemistry : PPB. 2011 Mar; 49(3):275-9. doi: 10.1016/j.plaphy.2010.12.008. [PMID: 21251843]
  • Jorge Mc Mondego, Ramon O Vidal, Marcelo F Carazzolle, Eric K Tokuda, Lucas P Parizzi, Gustavo Gl Costa, Luiz Fp Pereira, Alan C Andrade, Carlos A Colombo, Luiz Ge Vieira, Gonçalo Ag Pereira. An EST-based analysis identifies new genes and reveals distinctive gene expression features of Coffea arabica and Coffea canephora. BMC plant biology. 2011 Feb; 11(?):30. doi: 10.1186/1471-2229-11-30. [PMID: 21303543]
  • Joana Carrola, Cláudia M Rocha, António S Barros, Ana M Gil, Brian J Goodfellow, Isabel M Carreira, João Bernardo, Ana Gomes, Vitor Sousa, Lina Carvalho, Iola F Duarte. Metabolic signatures of lung cancer in biofluids: NMR-based metabonomics of urine. Journal of proteome research. 2011 Jan; 10(1):221-30. doi: 10.1021/pr100899x. [PMID: 21058631]
  • Weidong Xie, Yunan Zhao, Yaou Zhang. Traditional chinese medicines in treatment of patients with type 2 diabetes mellitus. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):726723. doi: 10.1155/2011/726723. [PMID: 21584252]
  • Maria Daglia, Adele Papetti, Dora Mascherpa, Pietro Grisoli, Giovanni Giusto, Peter Lingström, Jonathan Pratten, Caterina Signoretto, David A Spratt, Michael Wilson, Egija Zaura, Gabriella Gazzani. Plant and fungal food components with potential activity on the development of microbial oral diseases. Journal of biomedicine & biotechnology. 2011; 2011(?):274578. doi: 10.1155/2011/274578. [PMID: 22013381]
  • Masafumi Saito, Tohru Nemoto, Satoshi Tobimatsu, Midori Ebata, Yulan Le, Kei Nakajima. Coffee consumption and cystatin-C-based estimated glomerular filtration rates in healthy young adults: results of a clinical trial. Journal of nutrition and metabolism. 2011; 2011(?):146865. doi: 10.1155/2011/146865. [PMID: 21773013]
  • Tamara Bakuradze, Roman Lang, Thomas Hofmann, Herbert Stiebitz, Gerhard Bytof, Ingo Lantz, Matthias Baum, Gerhard Eisenbrand, Christine Janzowski. Antioxidant effectiveness of coffee extracts and selected constituents in cell-free systems and human colon cell lines. Molecular nutrition & food research. 2010 Dec; 54(12):1734-43. doi: 10.1002/mnfr.201000147. [PMID: 20589861]
  • Muniasamy Neerathilingam, David E Volk, Swapna Sarkar, Todd M Alam, M Kathleen Alam, G A Shakeel Ansari, Bruce A Luxon. 1H NMR-based metabonomic investigation of tributyl phosphate exposure in rats. Toxicology letters. 2010 Nov; 199(1):10-6. doi: 10.1016/j.toxlet.2010.07.013. [PMID: 20688139]
  • Radha Moorthy, K M Prabhu, P S Murthy. Anti-hyperglycemic compound (GII) from fenugreek (Trigonella foenum-graecum Linn.) seeds, its purification and effect in diabetes mellitus. Indian journal of experimental biology. 2010 Nov; 48(11):1111-8. doi: ". [PMID: 21117451]
  • Mena Ritota, Federico Marini, Paolo Sequi, Massimiliano Valentini. Metabolomic characterization of Italian sweet pepper (Capsicum annum L.) by means of HRMAS-NMR spectroscopy and multivariate analysis. Journal of agricultural and food chemistry. 2010 Sep; 58(17):9675-84. doi: 10.1021/jf1015957. [PMID: 20715777]
  • Laura Sánchez-Hernández, Patrycja Puchalska, Carmen García-Ruiz, Antonio L Crego, Maria Luisa Marina. Determination of trigonelline in seeds and vegetable oils by capillary electrophoresis as a novel marker for the detection of adulterations in olive oils. Journal of agricultural and food chemistry. 2010 Jul; 58(13):7489-96. doi: 10.1021/jf100550b. [PMID: 20550116]
  • Joseph L McClay, Daniel E Adkins, Nancy G Isern, Thomas M O'Connell, Jan B Wooten, Barbara K Zedler, Madhukar S Dasika, Bradley Todd Webb, Bobbie-Jo Webb-Robertson, Joel G Pounds, Edward L Murrelle, Mark F Leppert, Edwin J C G van den Oord. (1)H nuclear magnetic resonance metabolomics analysis identifies novel urinary biomarkers for lung function. Journal of proteome research. 2010 Jun; 9(6):3083-90. doi: 10.1021/pr1000048. [PMID: 20408573]
  • R Calvani, A Miccheli, G Capuani, A Tomassini Miccheli, C Puccetti, M Delfini, A Iaconelli, G Nanni, G Mingrone. Gut microbiome-derived metabolites characterize a peculiar obese urinary metabotype. International journal of obesity (2005). 2010 Jun; 34(6):1095-8. doi: 10.1038/ijo.2010.44. [PMID: 20212498]
  • Elizabeth Allen, Annick Moing, Timothy Md Ebbels, Mickaël Maucourt, A Deri Tomos, Dominique Rolin, Mark A Hooks. Correlation Network Analysis reveals a sequential reorganization of metabolic and transcriptional states during germination and gene-metabolite relationships in developing seedlings of Arabidopsis. BMC systems biology. 2010 May; 4(?):62. doi: 10.1186/1752-0509-4-62. [PMID: 20465807]
  • Gerald Blunden, Peter F Morse, Imre Mathe, Judit Hohmann, Alan T Critchleye, Stephen Morrell. Betaine yields from marine algal species utilized in the preparation of seaweed extracts used in agriculture. Natural product communications. 2010 Apr; 5(4):581-5. doi: ". [PMID: 20433077]
  • Kati Hanhineva, Riitta Törrönen, Isabel Bondia-Pons, Jenna Pekkinen, Marjukka Kolehmainen, Hannu Mykkänen, Kaisa Poutanen. Impact of dietary polyphenols on carbohydrate metabolism. International journal of molecular sciences. 2010 Mar; 11(4):1365-402. doi: 10.3390/ijms11041365. [PMID: 20480025]
  • Nicolas Maunoury, Miguel Redondo-Nieto, Marie Bourcy, Willem Van de Velde, Benoit Alunni, Philippe Laporte, Patricia Durand, Nicolas Agier, Laetitia Marisa, Danièle Vaubert, Hervé Delacroix, Gérard Duc, Pascal Ratet, Lawrence Aggerbeck, Eva Kondorosi, Peter Mergaert. Differentiation of symbiotic cells and endosymbionts in Medicago truncatula nodulation are coupled to two transcriptome-switches. PloS one. 2010 Mar; 5(3):e9519. doi: 10.1371/journal.pone.0009519. [PMID: 20209049]
  • N Satheeshkumar, Pulok K Mukherjee, S Bhadra, B P Saha. Acetylcholinesterase enzyme inhibitory potential of standardized extract of Trigonella foenum graecum L and its constituents. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2010 Mar; 17(3-4):292-5. doi: 10.1016/j.phymed.2009.06.006. [PMID: 19576740]
  • Roman Lang, Anika Wahl, Thomas Skurk, Erkan Firat Yagar, Ludger Schmiech, Rudolf Eggers, Hans Hauner, Thomas Hofmann. Development of a hydrophilic liquid interaction chromatography-high-performance liquid chromatography-tandem mass spectrometry based stable isotope dilution analysis and pharmacokinetic studies on bioactive pyridines in human plasma and urine after coffee consumption. Analytical chemistry. 2010 Feb; 82(4):1486-97. doi: 10.1021/ac902616k. [PMID: 20073472]
  • Ngoc Minh Pham, Daigo Yoshida, Makiko Morita, Guang Yin, Kengo Toyomura, Keizo Ohnaka, Ryoichi Takayanagi, Suminori Kono. The relation of coffee consumption to serum uric Acid in Japanese men and women aged 49-76 years. Journal of nutrition and metabolism. 2010; 2010(?):. doi: 10.1155/2010/930757. [PMID: 20798877]
  • Hiroshi Ashihara, Yuling Yin, Wei-Wei Deng, Shin Watanabe. Pyridine salvage and nicotinic acid conjugate synthesis in leaves of mangrove species. Phytochemistry. 2010 Jan; 71(1):47-53. doi: 10.1016/j.phytochem.2009.09.033. [PMID: 19913262]
  • O Yoshinari, K Igarashi. Anti-diabetic effect of trigonelline and nicotinic acid, on KK-A(y) mice. Current medicinal chemistry. 2010; 17(20):2196-202. doi: 10.2174/092986710791299902. [PMID: 20423301]
  • Riko Katahira, Hiroshi Ashihara. Profiles of the biosynthesis and metabolism of pyridine nucleotides in potatoes (Solanum tuberosum L.). Planta. 2009 Dec; 231(1):35-45. doi: 10.1007/s00425-009-1023-2. [PMID: 19820966]
  • Gianmaria F Ferrazzano, Ivana Amato, Aniello Ingenito, Antonino De Natale, Antonino Pollio. Anti-cariogenic effects of polyphenols from plant stimulant beverages (cocoa, coffee, tea). Fitoterapia. 2009 Jul; 80(5):255-62. doi: 10.1016/j.fitote.2009.04.006. [PMID: 19397954]
  • Dianne M Tapiolas, Bruce F Bowden, Eliane Abou-Mansour, Richard H Willis, Jason R Doyle, Andrew N Muirhead, Catherine Liptrot, Lyndon E Llewellyn, Carsten W W Wolff, Anthony D Wright, Cherie A Motti. Eusynstyelamides A, B, and C, nNOS inhibitors, from the ascidian Eusynstyela latericius. Journal of natural products. 2009 Jun; 72(6):1115-20. doi: 10.1021/np900099j. [PMID: 19505081]
  • Orie Yoshinari, Hideyo Sato, Kiharu Igarashi. Anti-diabetic effects of pumpkin and its components, trigonelline and nicotinic acid, on Goto-Kakizaki rats. Bioscience, biotechnology, and biochemistry. 2009 May; 73(5):1033-41. doi: 10.1271/bbb.80805. [PMID: 19420712]
  • Iwao Akashi, Keisuke Kagami, Toshihiko Hirano, Kitaro Oka. Protective effects of coffee-derived compounds on lipopolysaccharide/D-galactosamine induced acute liver injury in rats. The Journal of pharmacy and pharmacology. 2009 Apr; 61(4):473-8. doi: 10.1211/jpp/61.04.0009. [PMID: 19298694]
  • Bin Na Hong, Tae Hoo Yi, Sun Yeou Kim, Tong Ho Kang. High-dosage pyridoxine-induced auditory neuropathy and protection with coffee in mice. Biological & pharmaceutical bulletin. 2009 Apr; 32(4):597-603. doi: 10.1248/bpb.32.597. [PMID: 19336890]
  • Mouhssin Oufir, Nadine Schulz, Patan Shaik Sha Vallikhan, Eva Wilhelm, Kornel Burg, Jean-Francois Hausman, Lucien Hoffmann, Cedric Guignard. Simultaneous measurement of proline and related compounds in oak leaves by high-performance ligand-exchange chromatography and electrospray ionization mass spectrometry for environmental stress studies. Journal of chromatography. A. 2009 Feb; 1216(7):1094-9. doi: 10.1016/j.chroma.2008.12.030. [PMID: 19135675]
  • Roman Lang, Erkan Firat Yagar, Rudolf Eggers, Thomas Hofmann. Quantitative investigation of trigonelline, nicotinic acid, and nicotinamide in foods, urine, and plasma by means of LC-MS/MS and stable isotope dilution analysis. Journal of agricultural and food chemistry. 2008 Dec; 56(23):11114-21. doi: 10.1021/jf802838s. [PMID: 19007232]
  • Yuling Yin, Ayu Matsui, Masaaki Sakuta, Hiroshi Ashihara. Changes in pyridine metabolism profile during growth of trigonelline-forming Lotus japonicus cell cultures. Phytochemistry. 2008 Dec; 69(17):2891-8. doi: 10.1016/j.phytochem.2008.10.002. [PMID: 19007947]
  • Jinchun Sun, Laura K Schnackenberg, Ricky D Holland, Thomas C Schmitt, Glenn H Cantor, Yvonne P Dragan, Richard D Beger. Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Aug; 871(2):328-40. doi: 10.1016/j.jchromb.2008.04.008. [PMID: 18472313]
  • David A Lightfoot. Soybean genomics: Developments through the use of cultivar 'Forrest'. International journal of plant genomics. 2008; 2008(?):793158. doi: 10.1155/2008/793158. [PMID: 18483614]
  • Shruti Chopra, Sanjay K Motwani, Farhan J Ahmad, Roop K Khar. Simple, sensitive, selective and validated spectrophotometric methods for the estimation of a biomarker trigonelline from polyherbal gels. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2007 Nov; 68(3):516-22. doi: 10.1016/j.saa.2006.12.021. [PMID: 17336136]
  • Ayu Matsui, Yuling Yin, Keiko Yamanaka, Midori Iwasaki, Hiroshi Ashihara. Metabolic fate of nicotinamide in higher plants. Physiologia plantarum. 2007 Oct; 131(2):191-200. doi: 10.1111/j.1399-3054.2007.00959.x. [PMID: 18251891]
  • N Bodor, E Tóth-Sarudy, T Holm, I Pallagi, E Vass, P Buchwald, U Langel. Novel, cell-penetrating molecular transporters with flexible backbones and permanently charged side-chains. The Journal of pharmacy and pharmacology. 2007 Aug; 59(8):1065-76. doi: 10.1211/jpp.59.8.0003. [PMID: 17725848]
  • Markus Godejohann. Hydrophilic interaction chromatography coupled to nuclear magnetic resonance spectroscopy and mass spectroscopy--a new approach for the separation and identification of extremely polar analytes in bodyfluids. Journal of chromatography. A. 2007 Jul; 1156(1-2):87-93. doi: 10.1016/j.chroma.2006.10.053. [PMID: 17097667]
  • Ana Amélia P Almeida, Adriana Farah, Daniela A M Silva, Elzíria A Nunan, M Beatriz A Glória. Antibacterial activity of coffee extracts and selected coffee chemical compounds against enterobacteria. Journal of agricultural and food chemistry. 2006 Nov; 54(23):8738-43. doi: 10.1021/jf0617317. [PMID: 17090115]
  • Martin B Lee, Malina K Storer, John W Blunt, Michael Lever. Validation of (1)H NMR spectroscopy as an analytical tool for methylamine metabolites in urine. Clinica chimica acta; international journal of clinical chemistry. 2006 Mar; 365(1-2):264-9. doi: 10.1016/j.cca.2005.09.004. [PMID: 16257400]
  • Yong Chen, Shao-lin Shen, Huai-xia Chen, Jun Pan, Feng-mei Han. [HPLC-MSn analysis of trigonelline and its metabolites in rat urine]. Yao xue xue bao = Acta pharmaceutica Sinica. 2006 Mar; 41(3):216-20. doi: ". [PMID: 16758990]
  • R Mungur, A D M Glass, D B Goodenow, D A Lightfoot. Metabolite fingerprinting in transgenic Nicotiana tabacum altered by the Escherichia coli glutamate dehydrogenase gene. Journal of biomedicine & biotechnology. 2005 Jun; 2005(2):198-214. doi: 10.1155/jbb.2005.198. [PMID: 16046826]
  • Ramalingam Saravanan, Leelavinothan Pari. Antihyperlipidemic and antiperoxidative effect of Diasulin, a polyherbal formulation in alloxan induced hyperglycemic rats. BMC complementary and alternative medicine. 2005 Jun; 5(?):14. doi: 10.1186/1472-6882-5-14. [PMID: 15969768]
  • Marielle Charles-Bernard, Karin Kraehenbuehl, Andreas Rytz, Deborah D Roberts. Interactions between volatile and nonvolatile coffee components. 1. Screening of nonvolatile components. Journal of agricultural and food chemistry. 2005 Jun; 53(11):4417-25. doi: 10.1021/jf048021q. [PMID: 15913304]
  • Wen-Jye Yen, Bor-Sen Wang, Lee-Wen Chang, Pin-Der Duh. Antioxidant properties of roasted coffee residues. Journal of agricultural and food chemistry. 2005 Apr; 53(7):2658-63. doi: 10.1021/jf0402429. [PMID: 15796608]
  • Chia-Ying Li, Chung-Hua Lin, Tian-Shung Wu. Quantitative analysis of camptothecin derivatives in Nothapodytes foetida using 1H-NMR method. Chemical & pharmaceutical bulletin. 2005 Mar; 53(3):347-9. doi: 10.1248/cpb.53.347. [PMID: 15744115]
  • Chihiro Tohda, Tomoharu Kuboyama, Katsuko Komatsu. Search for natural products related to regeneration of the neuronal network. Neuro-Signals. 2005; 14(1-2):34-45. doi: 10.1159/000085384. [PMID: 15956813]
  • Marianne Defernez, Yvonne M Gunning, Adrian J Parr, Louise V T Shepherd, Howard V Davies, Ian J Colquhoun. NMR and HPLC-UV profiling of potatoes with genetic modifications to metabolic pathways. Journal of agricultural and food chemistry. 2004 Oct; 52(20):6075-85. doi: 10.1021/jf049522e. [PMID: 15453669]
  • S Slow, W E Miller, D O McGregor, M B Lee, M Lever, P M George, S T Chambers. Trigonelline is not responsible for the acute increase in plasma homocysteine following ingestion of instant coffee. European journal of clinical nutrition. 2004 Sep; 58(9):1253-6. doi: 10.1038/sj.ejcn.1601957. [PMID: 15054441]
  • Sandy Slow, Michael Lever, Martin B Lee, Peter M George, Stephen T Chambers. Betaine analogues alter homocysteine metabolism in rats. The international journal of biochemistry & cell biology. 2004 May; 36(5):870-80. doi: 10.1016/j.biocel.2003.10.001. [PMID: 15006639]
  • Sheikh Julfikar Hossain, Hitoshi Aoshima, Hirofumi Koda, Yoshinobu Kiso. Effects of coffee components on the response of GABA(A) receptors expressed in Xenopus oocytes. Journal of agricultural and food chemistry. 2003 Dec; 51(26):7568-75. doi: 10.1021/jf0303971. [PMID: 14664509]
  • D S Akaffou, C L Ky, P Barre, S Hamon, J Louarn, M Noirot. Identification and mapping of a major gene (Ft1) involved in fructification time in the interspecific cross Coffea pseudozanguebariae x C. liberica var. Dewevrei: impact on caffeine content and seed weight. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. 2003 May; 106(8):1486-90. doi: 10.1007/s00122-003-1207-2. [PMID: 12750792]
  • Huai-qing Zhao, Yan Qu, Xue-ya Wang, Xin-yan Lu, Xue-hang Zhang, Masao Hattori. [Determination of trigonelline by HPLC and study on its pharmacokinetics]. Yao xue xue bao = Acta pharmaceutica Sinica. 2003 Apr; 38(4):279-82. doi: NULL. [PMID: 12889128]
  • R Rojas-Andrade, C M Cerda-García-Rojas, J T Frías-Hernández, L Dendooven, V Olalde-Portugal, A C Ramos-Valdivia. Changes in the concentration of trigonelline in a semi-arid leguminous plant (Prosopis laevigata) induced by an arbuscular mycorrhizal fungus during the presymbiotic phase. Mycorrhiza. 2003 Mar; 13(1):49-52. doi: 10.1007/s00572-002-0201-x. [PMID: 12634919]
  • Jinghua Zhang, Naoki Nishimura, Akira Okubo, Sunao Yamazaki. Development of an analytical method for the determination of betaines in higher plants by capillary electrophoresis at low pH. Phytochemical analysis : PCA. 2002 Jul; 13(4):189-94. doi: 10.1002/pca.639. [PMID: 12184170]
  • M Daglia, R Tarsi, A Papetti, P Grisoli, C Dacarro, C Pruzzo, Gabriella Gazzani. Antiadhesive effect of green and roasted coffee on Streptococcus mutans' adhesive properties on saliva-coated hydroxyapatite beads. Journal of agricultural and food chemistry. 2002 Feb; 50(5):1225-9. doi: 10.1021/jf010958t. [PMID: 11853508]
  • M Al-Habori, A Raman, M J Lawrence, P Skett. In vitro effect of fenugreek extracts on intestinal sodium-dependent glucose uptake and hepatic glycogen phosphorylase A. International journal of experimental diabetes research. 2001; 2(2):91-9. doi: 10.1155/edr.2001.91. [PMID: 12369721]