5-Isoxazoleacetic acid, alpha-amino-3-chloro-4,5-dihydro- (BioDeep_00000840649)

   


代谢物信息卡片


5-Isoxazoleacetic acid, alpha-amino-3-chloro-4,5-dihydro-

化学式: C5H7ClN2O3 (178.0145182)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(ON=C1Cl)C(C(=O)O)N
InChI: InChI=1S/C5H7ClN2O3/c6-3-1-2(11-8-3)4(7)5(9)10/h2,4H,1,7H2,(H,9,10)

描述信息

D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
D009676 - Noxae > D000963 - Antimetabolites
D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors

同义名列表

1 个代谢物同义名

5-Isoxazoleacetic acid, alpha-amino-3-chloro-4,5-dihydro-



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • K Maeda, Y Nakajima, T Motoyama, Y Kitou, T Kosaki, T Saito, T Nishiuchi, K Kanamaru, H Osada, T Kobayashi, M Kimura. Effects of acivicin on growth, mycotoxin production and virulence of phytopathogenic fungi. Letters in applied microbiology. 2014 Oct; 59(4):377-83. doi: 10.1111/lam.12289. [PMID: 24863673]
  • Christoph Mathieu, Amaia González Salgado, Corina Wirdnam, Stefan Meier, Marianne Suter Grotemeyer, Ehud Inbar, Pascal Mäser, Dan Zilberstein, Erwin Sigel, Peter Bütikofer, Doris Rentsch. Trypanosoma brucei eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids. The Biochemical journal. 2014 Oct; 463(1):9-18. doi: 10.1042/bj20140719. [PMID: 24988048]
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  • Bram Flahou, Freddy Haesebrouck, Koen Chiers, Kim Van Deun, Lina De Smet, Bart Devreese, Isabel Vandenberghe, Herman Favoreel, Annemieke Smet, Frank Pasmans, Katharina D'Herde, Richard Ducatelle. Gastric epithelial cell death caused by Helicobacter suis and Helicobacter pylori γ-glutamyl transpeptidase is mainly glutathione degradation-dependent. Cellular microbiology. 2011 Dec; 13(12):1933-55. doi: 10.1111/j.1462-5822.2011.01682.x. [PMID: 21899697]
  • Mechteld A R Vermeulen, Jeffrey de Jong, Mathijs J Vaessen, Paul Am van Leeuwen, Alexander P J Houdijk. Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity. World journal of gastroenterology. 2011 Mar; 17(12):1569-73. doi: 10.3748/wjg.v17.i12.1569. [PMID: 21472123]
  • Raffaella Priora, Lucia Coppo, Antonios Margaritis, Danila Di Giuseppe, Simona Frosali, Domenico Summa, Jongyun Heo, Paolo Di Simplicio. The control of S-thiolation by cysteine via gamma-glutamyltranspeptidase and thiol exchanges in erythrocytes and plasma of diamide-treated rats. Toxicology and applied pharmacology. 2010 Feb; 242(3):333-43. doi: 10.1016/j.taap.2009.11.003. [PMID: 19909765]
  • Marie H Hanigan, Danyelle M Townsend, Arthur J L Cooper. Metabolism of cisplatin to a nephrotoxin. Toxicology. 2009 Mar; 257(3):174-5; author reply 176. doi: 10.1016/j.tox.2008.12.014. [PMID: 19135119]
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  • Beatriz Goñi-Allo, Elena Puerta, Brian O Mathúna, Isabel Hervias, Berta Lasheras, Rafael de la Torre, Norberto Aguirre. On the role of tyrosine and peripheral metabolism in 3,4-methylenedioxymethamphetamine-induced serotonin neurotoxicity in rats. Neuropharmacology. 2008 Apr; 54(5):885-900. doi: 10.1016/j.neuropharm.2008.01.007. [PMID: 18329670]
  • Anke Grzam, Melinda N Martin, Rüdiger Hell, Andreas J Meyer. gamma-Glutamyl transpeptidase GGT4 initiates vacuolar degradation of glutathione S-conjugates in Arabidopsis. FEBS letters. 2007 Jul; 581(17):3131-8. doi: 10.1016/j.febslet.2007.05.071. [PMID: 17561001]
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  • Mojgan Djavaheri-Mergny, Marie-José Accaoui, Dany Rouillard, Juana Wietzerbin. Gamma-glutamyl transpeptidase activity mediates NF-kappaB activation through lipid peroxidation in human leukemia U937 cells. Molecular and cellular biochemistry. 2002 Mar; 232(1-2):103-11. doi: 10.1023/a:1014834315936. [PMID: 12030366]
  • Jun Hiratake, Makoto Inoue, Kanzo Sakata. gamma-Glutamyltranspeptidase and gamma-glutamyl peptide ligases: fluorophosphonate and phosphonodifluoromethyl ketone analogs as probes of tetrahedral transition state and gamma-glutamyl-phosphate intermediate. Methods in enzymology. 2002; 354(?):272-95. doi: 10.1016/s0076-6879(02)54023-4. [PMID: 12418234]
  • Danyelle M Townsend, Marie H Hanigan. Inhibition of gamma-glutamyl transpeptidase or cysteine S-conjugate beta-lyase activity blocks the nephrotoxicity of cisplatin in mice. The Journal of pharmacology and experimental therapeutics. 2002 Jan; 300(1):142-8. doi: 10.1124/jpet.300.1.142. [PMID: 11752109]
  • Elena Obrador, Julian Carretero, Angel Ortega, Ignacio Medina, Vicente Rodilla, José A Pellicer, José M Estrela. gamma-Glutamyl transpeptidase overexpression increases metastatic growth of B16 melanoma cells in the mouse liver. Hepatology (Baltimore, Md.). 2002 Jan; 35(1):74-81. doi: 10.1053/jhep.2002.30277. [PMID: 11786961]
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  • Vernon T Cannon, Delon W Barfuss, Rudolfs K Zalups. Molecular homology and the luminal transport of Hg2+ in the renal proximal tubule. Journal of the American Society of Nephrology : JASN. 2000 Mar; 11(3):394-402. doi: 10.1681/asn.v113394. [PMID: 10703663]
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  • J C Cutrín, B Zingaro, S Camandola, A Boveris, A Pompella, G Poli. Contribution of gamma glutamyl transpeptidase to oxidative damage of ischemic rat kidney. Kidney international. 2000 Feb; 57(2):526-33. doi: 10.1046/j.1523-1755.2000.00871.x. [PMID: 10652029]
  • R Kannan, R Chakrabarti, D Tang, K J Kim, N Kaplowitz. GSH transport in human cerebrovascular endothelial cells and human astrocytes: evidence for luminal localization of Na+-dependent GSH transport in HCEC. Brain research. 2000 Jan; 852(2):374-82. doi: 10.1016/s0006-8993(99)02184-8. [PMID: 10678765]
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  • J L VanSteenhouse, J S Prescott, S A Barker. Identification of the 1-cyano-3,4-epithiobutane-derived urinary mercapturic acid N-acetyl-S-(4-cyano-2-thio-1-butyl)-cysteine in male Fischer 344 rats. Journal of applied toxicology : JAT. 2000 Jan; 20(1):1-10. doi: 10.1002/(sici)1099-1263(200001/02)20:1<1::aid-jat599>3.0.co;2-4. [PMID: 10641011]
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  • S Dominici, M Valentini, E Maellaro, B Del Bello, A Paolicchi, E Lorenzini, R Tongiani, M Comporti, A Pompella. Redox modulation of cell surface protein thiols in U937 lymphoma cells: the role of gamma-glutamyl transpeptidase-dependent H2O2 production and S-thiolation. Free radical biology & medicine. 1999 Sep; 27(5-6):623-35. doi: 10.1016/s0891-5849(99)00111-2. [PMID: 10490284]
  • S Gunnarsdottir, A A Elfarra. Glutathione-dependent metabolism of cis-3-(9H-purin-6-ylthio)acrylic acid to yield the chemotherapeutic drug 6-mercaptopurine: evidence for two distinct mechanisms in rats. The Journal of pharmacology and experimental therapeutics. 1999 Sep; 290(3):950-7. doi: NULL. [PMID: 10454464]
  • H Song, C A Lang, T S Chen. The role of glutathione in p-aminophenol-induced nephrotoxicity in the mouse. Drug and chemical toxicology. 1999 Aug; 22(3):529-44. doi: 10.3109/01480549909042530. [PMID: 10445162]
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  • J L VanSteenhouse, J S Prescott, D H Swenson. Protection from 1-cyano-3,4-epithiobutane nephrotoxicity by aminooxyacetic acid and effect on xenobiotic-metabolizing enzymes in male Fischer 344 rats. Journal of applied toxicology : JAT. 1999 Jul; 19(4):237-49. doi: 10.1002/(sici)1099-1263(199907/08)19:4<237::aid-jat569>3.0.co;2-7. [PMID: 10439337]
  • M Kashiba, E Kasahara, K C Chien, M Inoue. Fates and vascular action of S-nitrosoglutathione and related compounds in the circulation. Archives of biochemistry and biophysics. 1999 Mar; 363(2):213-8. doi: 10.1006/abbi.1998.1055. [PMID: 10068442]
  • R K Zalups, D W Barfuss, L H Lash. Disposition of inorganic mercury following biliary obstruction and chemically induced glutathione depletion: dispositional changes one hour after the intravenous administration of mercuric chloride. Toxicology and applied pharmacology. 1999 Jan; 154(2):135-44. doi: 10.1006/taap.1998.8562. [PMID: 9925797]
  • B del Bello, A Paolicchi, M Comporti, A Pompella, E Maellaro. Hydrogen peroxide produced during gamma-glutamyl transpeptidase activity is involved in prevention of apoptosis and maintainance of proliferation in U937 cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1999 Jan; 13(1):69-79. doi: 10.1096/fasebj.13.1.69. [PMID: 9872931]
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