Chlorin (BioDeep_00000840565)
代谢物信息卡片
Chlorin
化学式: C20H16N4 (312.1374896)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC2=NC1=CC3=CC=C(N3)C=C4C=CC(=N4)C=C5C=CC(=C2)N5
InChI: InChI=1S/C20H16N4/c1-2-14-10-16-5-6-18(23-16)12-20-8-7-19(24-20)11-17-4-3-15(22-17)9-13(1)21-14/h1-6,9-12,22-23H,7-8H2
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Olga P Krivosheeva, Maxim A Doctor, Ekaterina A Larkina, Alexander S Vedenkin, Tatiana A Nikolskaya. Effect of substituents in chlorin e6 derivatives on the loading efficiency of the photosensitizer into the liposome membrane and their biological activity.
Photodiagnosis and photodynamic therapy.
2023 Jun; 42(?):103328. doi:
10.1016/j.pdpdt.2023.103328. [PMID: 36775229] - Andrey V Kustov, Philipp K Morshnev, Natal'ya V Kukushkina, Nataliya L Smirnova, Dmitry B Berezin, Dmitry R Karimov, Olga V Shukhto, Tatyana V Kustova, Dmitry V Belykh, Marina V Mal'shakova, Vladimir P Zorin, Tatyana E Zorina. Solvation, Cancer Cell Photoinactivation and the Interaction of Chlorin Photosensitizers with a Potential Passive Carrier Non-Ionic Surfactant Tween 80.
International journal of molecular sciences.
2022 May; 23(10):. doi:
10.3390/ijms23105294. [PMID: 35628108] - Natalia Sh Lebedeva, Yury A Gubarev, Galina M Mamardashvili, Svetlana V Zaitceva, Sergey A Zdanovich, Alena S Malyasova, Julia V Romanenko, Mikhail O Koifman, Oskar I Koifman. Theoretical and experimental study of interaction of macroheterocyclic compounds with ORF3a of SARS-CoV-2.
Scientific reports.
2021 09; 11(1):19481. doi:
10.1038/s41598-021-99072-8. [PMID: 34593970] - Qing Zhang, Lian Wu, Shaozheng Liu, Qingjie Chen, Lingpeng Zeng, Xuezhong Chen, Qing Zhang. Moderating hypoxia and promoting immunogenic photodynamic therapy by HER-2 nanobody conjugate nanoparticles for ovarian cancer treatment.
Nanotechnology.
2021 Jul; 32(42):. doi:
10.1088/1361-6528/ac07d1. [PMID: 34319255] - Xing-Jie Zhang, Ming-Hui Liu, Yu-Sha Luo, Gui-Yan Han, Zhi-Qiang Ma, Fei Huang, Yuan Wang, Zhen-Yuan Miao, Wan-Nian Zhang, Chun-Quan Sheng, Jian-Zhong Yao. Novel dual-mode antitumor chlorin-based derivatives as potent photosensitizers and histone deacetylase inhibitors for photodynamic therapy and chemotherapy.
European journal of medicinal chemistry.
2021 May; 217(?):113363. doi:
10.1016/j.ejmech.2021.113363. [PMID: 33744687] - Natalya Sh Lebedeva, Yury A Gubarev, Mikhail O Koifman, Oskar I Koifman. The Application of Porphyrins and Their Analogues for Inactivation of Viruses.
Molecules (Basel, Switzerland).
2020 Sep; 25(19):. doi:
10.3390/molecules25194368. [PMID: 32977525] - Pengju Cai, Wenjiang Yang, Zhesheng He, Huiju Jia, Huangwei Wang, Wencong Zhao, Liang Gao, Zhiyong Zhang, Fuping Gao, Xueyun Gao. A chlorin-lipid nanovesicle nucleus drug for amplified therapeutic effects of lung cancer by internal radiotherapy combined with the Cerenkov radiation-induced photodynamic therapy.
Biomaterials science.
2020 Sep; 8(17):4841-4851. doi:
10.1039/d0bm00778a. [PMID: 32776056] - Bhakti Petigara Harp, Peter F Scholl, Patrick J Gray, Pierluigi Delmonte. Quantitation of copper chlorophylls in green table olives by ultra-high-performance liquid chromatography with inductively coupled plasma isotope dilution mass spectrometry.
Journal of chromatography. A.
2020 Jun; 1620(?):461008. doi:
10.1016/j.chroma.2020.461008. [PMID: 32252985] - Mihaela N Mocanu, Fei Yan. Ultrasound-assisted interaction between chlorin-e6 and human serum albumin: pH dependence, singlet oxygen production, and formulation effect.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2018 Feb; 190(?):208-214. doi:
10.1016/j.saa.2017.09.017. [PMID: 28926772] - Arthur B Volovetsky, Vladimir S Sukhov, Irina V Balalaeva, Varvara V Dudenkova, Natalia Yu Shilyagina, Аlexey V Feofanov, Anastasija V Efremenko, Mikhail A Grin, Andrey F Mironov, Igor B Sivaev, Vladimir I Bregadze, Anna V Maslennikova. Pharmacokinetics of Chlorin e₆-Cobalt Bis(Dicarbollide) Conjugate in Balb/c Mice with Engrafted Carcinoma.
International journal of molecular sciences.
2017 Nov; 18(12):. doi:
10.3390/ijms18122556. [PMID: 29182594] - Patrícia M R Pereira, Sandrina Silva, Mafalda Bispo, Mónica Zuzarte, Célia Gomes, Henrique Girão, José A S Cavaleiro, Carlos A F Ribeiro, João P C Tomé, Rosa Fernandes. Mitochondria-Targeted Photodynamic Therapy with a Galactodendritic Chlorin to Enhance Cell Death in Resistant Bladder Cancer Cells.
Bioconjugate chemistry.
2016 Nov; 27(11):2762-2769. doi:
10.1021/acs.bioconjchem.6b00519. [PMID: 27750007] - Kenneth K Ng, Misa Takada, Kara Harmatys, Juan Chen, Gang Zheng. Chlorosome-Inspired Synthesis of Templated Metallochlorin-Lipid Nanoassemblies for Biomedical Applications.
ACS nano.
2016 04; 10(4):4092-101. doi:
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The journal of physical chemistry. B.
2015 Aug; 119(32):10231-43. doi:
10.1021/acs.jpcb.5b04841. [PMID: 26230425] - Martina Vermathen, Mattia Marzorati, Peter Bigler. Self-assembling properties of porphyrinic photosensitizers and their effect on membrane interactions probed by NMR spectroscopy.
The journal of physical chemistry. B.
2013 Jun; 117(23):6990-7001. doi:
10.1021/jp403331n. [PMID: 23687989] - Lijuan Wang, Jun Zhang, Jiahong Wang, Wangxiao He, Hongen Huang. Effects of high-intensity training and resumed training on macroelement and microelement of elite basketball athletes.
Biological trace element research.
2012 Nov; 149(2):148-54. doi:
10.1007/s12011-012-9420-y. [PMID: 22528783] - Huan-You Lin, Hsi-Lin Chiu, Yu-Hsuang Lan, Chih-Ying Tzeng, Tzong-Huei Lee, Ching-Kuo Lee, Yi-Yuan Shao, Chiy-Rong Chen, Chi-I Chang, Yueh-Hsiung Kuo. Ficuschlorins A - D, lactone Chlorins from the leaves of ficus microcarpa.
Chemistry & biodiversity.
2011 Sep; 8(9):1701-8. doi:
10.1002/cbdv.201000175. [PMID: 21922658] - Huan-You Lin, Hsi-Lin Chiu, Te-Ling Lu, Chih-Ying Tzeng, Tzong-Huei Lee, Ching-Kuo Lee, Yi-Yuan Shao, Chiy-Rong Chen, Chi-I Chang, Yueh-Hsiung Kuo. Ficusmicrochlorin A-C, two new methoxy lactone chlorins and an anhydride chlorin from the leaves of Ficus microcarpa.
Chemical & pharmaceutical bulletin.
2011; 59(1):113-6. doi:
10.1248/cpb.59.113. [PMID: 21212558] - Noémie Thomas, Marlène Pernot, Régis Vanderesse, Philippe Becuwe, Ezatul Kamarulzaman, David Da Silva, Aurélie François, Céline Frochot, François Guillemin, Muriel Barberi-Heyob. Photodynamic therapy targeting neuropilin-1: Interest of pseudopeptides with improved stability properties.
Biochemical pharmacology.
2010 Jul; 80(2):226-35. doi:
10.1016/j.bcp.2010.03.036. [PMID: 20380812] - Shimshon Ben Dror, Irena Bronshtein, Hana Weitman, Kevin M Smith, William G O'Neal, Peter A Jacobi, Benjamin Ehrenberg. The binding of analogs of porphyrins and chlorins with elongated side chains to albumin.
European biophysics journal : EBJ.
2009 Sep; 38(7):847-55. doi:
10.1007/s00249-009-0444-y. [PMID: 19330323] - Noémie Thomas, Denise Bechet, Philippe Becuwe, Loraine Tirand, Régis Vanderesse, Céline Frochot, François Guillemin, Muriel Barberi-Heyob. Peptide-conjugated chlorin-type photosensitizer binds neuropilin-1 in vitro and in vivo.
Journal of photochemistry and photobiology. B, Biology.
2009 Aug; 96(2):101-8. doi:
10.1016/j.jphotobiol.2009.04.008. [PMID: 19464192] - Cheng-Liang Peng, Ping-Shan Lai, Feng-Huei Lin, Steven Yueh-Hsiu Wu, Ming-Jium Shieh. Dual chemotherapy and photodynamic therapy in an HT-29 human colon cancer xenograft model using SN-38-loaded chlorin-core star block copolymer micelles.
Biomaterials.
2009 Jul; 30(21):3614-25. doi:
10.1016/j.biomaterials.2009.03.048. [PMID: 19395020] - Julien Gravier, Beata Korchowiec, Raphaël Schneider, Ewa Rogalska. Interaction of amphiphilic chlorin-based photosensitizers with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine monolayers.
Chemistry and physics of lipids.
2009 Apr; 158(2):102-9. doi:
10.1016/j.chemphyslip.2009.01.004. [PMID: 19428354] - Shimshon Ben Dror, Irena Bronshtein, Yuval Garini, William G O'Neal, Peter A Jacobi, Benjamin Ehrenberg. The localization and photosensitization of modified chlorin photosensitizers in artificial membranes.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.
2009 Mar; 8(3):354-61. doi:
10.1039/b814970d. [PMID: 19255676] - Noémie Thomas, Loraine Tirand, Etienne Chatelut, François Plénat, Céline Frochot, Marc Dodeller, François Guillemin, Muriel Barberi-Heyob. Tissue distribution and pharmacokinetics of an ATWLPPR-conjugated chlorin-type photosensitizer targeting neuropilin-1 in glioma-bearing nude mice.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.
2008 Apr; 7(4):433-41. doi:
10.1039/b718259g. [PMID: 18385885] - S Al-Omari. Photophysical properties and localization of chlorins substituted with methoxy groups, hydroxyl groups and alkyl chains in liposome-like cellular membrane.
Biomedical materials (Bristol, England).
2007 Jun; 2(2):107-15. doi:
10.1088/1748-6041/2/2/008. [PMID: 18458443] - Loraine Tirand, Noémie Thomas, Marc Dodeller, Dominique Dumas, Céline Frochot, Benoît Maunit, François Guillemin, Muriel Barberi-Heyob. Metabolic profile of a peptide-conjugated chlorin-type photosensitizer targeting neuropilin-1: an in vivo and in vitro study.
Drug metabolism and disposition: the biological fate of chemicals.
2007 May; 35(5):806-13. doi:
10.1124/dmd.106.013763. [PMID: 17283031] - Padmaja P Mishra, Sunita Patel, Anindya Datta. Effect of increased hydrophobicity on the binding of two model amphiphilic chlorin drugs for photodynamic therapy with blood plasma and its components.
The journal of physical chemistry. B.
2006 Oct; 110(42):21238-44. doi:
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Emergency medicine journal : EMJ.
2006 Jun; 23(6):421-4. doi:
10.1136/emj.2003.011775. [PMID: 16714497] - Florentina Cañada-Cañada, Antonia Bautista-Sánchez, Myriam Taverna, Patrice Prognon, Philippe Maillard, David S Grierson, Athena Kasselouri. Simple sensitive and simultaneous high-performance liquid chromatography method of glucoconjugated and non-glucoconjugated porphyrins and chlorins using near infra-red fluorescence detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Jul; 821(2):166-72. doi:
10.1016/j.jchromb.2005.04.024. [PMID: 15939678] - Florentina Cañada-Cañada, Athena Kasselouri, Patrice Prognon, Philippe Maillard, David S Grierson, Stephanie Descroix, Myriam Taverna. Enhanced detection of seven glucoconjugated and hydroxylated porphyrins and chlorins by nonaqueous capillary electrophoresis combined with stacking.
Journal of chromatography. A.
2005 Mar; 1068(1):123-30. doi:
10.1016/j.chroma.2004.10.104. [PMID: 15844550] - Stefano Santabarbara, Ilya Kuprov, Wendy V Fairclough, Saul Purton, Peter J Hore, Peter Heathcote, Mike C W Evans. Bidirectional electron transfer in photosystem I: determination of two distances between P700+ and A1- in spin-correlated radical pairs.
Biochemistry.
2005 Feb; 44(6):2119-28. doi:
10.1021/bi048445d. [PMID: 15697238] - J P Strachan, D F O'Shea, T Balasubramanian, J S Lindsey. Rational synthesis of meso-substituted chlorin building blocks.
The Journal of organic chemistry.
2000 May; 65(10):3160-72. doi:
10.1021/jo991942t. [PMID: 10814212] - D Lapotko, T Romanovskaya, G Kutchinsky, V Zharov. Photothermal studies of modulating effect of photoactivated chlorin on interaction of blood cells with bacteria.
Cytometry.
1999 Dec; 37(4):320-6. doi:
10.1002/(sici)1097-0320(19991201)37:4<320::aid-cyto10>3.0.co;2-u. [PMID: 10547618] - T V Akhlynina, D A Jans, A A Rosenkranz, N V Statsyuk, I Y Balashova, G Toth, I Pavo, A B Rubin, A S Sobolev. Nuclear targeting of chlorin e6 enhances its photosensitizing activity.
The Journal of biological chemistry.
1997 Aug; 272(33):20328-31. doi:
10.1074/jbc.272.33.20328. [PMID: 9252335] - M Grandadam, D Ingrand, J M Huraux, B Aveline, O Delgado, C Vever-Bizet, D Brault. Photodynamic inactivation of cell-free HIV strains by a red-absorbing chlorin-type photosensitizer.
Journal of photochemistry and photobiology. B, Biology.
1995 Dec; 31(3):171-7. doi:
10.1016/1011-1344(95)07201-2. [PMID: 8583284] - B A Goff, U Hermanto, J Rumbaugh, J Blake, M Bamberg, T Hasan. Photoimmunotherapy and biodistribution with an OC125-chlorin immunoconjugate in an in vivo murine ovarian cancer model.
British journal of cancer.
1994 Sep; 70(3):474-80. doi:
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Biofizika.
1989 Jul; 34(4):598-601. doi:
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Molekuliarnaia biologiia.
1988 Jul; 22(4):968-75. doi:
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Biofizika.
1988 May; 33(3):471-4. doi:
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Clinical chemistry.
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