Anthranilate (BioDeep_00000840471)
代谢物信息卡片
Anthranilate
化学式: C7H6NO2- (136.0399)
中文名称:
谱图信息:
最多检出来源 Viridiplantae(plant) 56.04%
分子结构信息
SMILES: C1=CC=C(C(=C1)C(=O)[O-])N
InChI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
描述信息
An aminobenzoate that is the conjugate base of anthranilic acid, obtained by deprotonation of the carboxy group.
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(13)
- superpathway of aromatic amino acid biosynthesis
- superpathway of chorismate metabolism
- superpathway of L-tryptophan biosynthesis
- aurachin A, B, C and D biosynthesis
- 2-heptyl-3-hydroxy-4(1H)-quinolone biosynthesis
- superpathway of quinolone and alkylquinolone biosynthesis
- L-tryptophan degradation I (via anthranilate)
- tryptophan degradation I (via anthranilate)
- superpathway of aromatic compound degradation via 2-hydroxypentadienoate
- superpathway of aromatic compound degradation via 3-oxoadipate
- fumiquinazoline D biosynthesis
- indole-3-acetate degradation
- 4'-methoxyviridicatin biosynthesis
PlantCyc(0)
代谢反应
19 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(16)
- 2-nitrobenzoate degradation II:
H+ + NAD(P)H + O2 + anthranilate ⟶ CO2 + NAD(P)+ + ammonium + catechol - anthranilate degradation I (aerobic):
H+ + NAD(P)H + O2 + anthranilate ⟶ CO2 + NAD(P)+ + ammonium + catechol - indole-3-acetate degradation:
H+ + NAD(P)H + O2 + anthranilate ⟶ CO2 + NAD(P)+ + ammonium + catechol - superpathway of aromatic compound degradation via 2-hydroxypentadienoate:
O2 + catechol ⟶ H+ + HMS - superpathway of aromatic compound degradation via 3-oxoadipate:
O2 + catechol ⟶ H+ + HMS - anthranilate degradation I (aerobic):
H+ + NAD(P)H + O2 + anthranilate ⟶ CO2 + NAD(P)+ + ammonia + catechol - anthranilate degradation I (aerobic):
H+ + NAD(P)H + O2 + anthranilate ⟶ CO2 + NAD(P)+ + ammonium + catechol - superpathway of aromatic compound degradation via 3-oxoadipate:
O2 + trp ⟶ N-formylkynurenine - tryptophan degradation I (via anthranilate):
H+ + O2 + trp ⟶ N-formylkynurenine - tryptophan degradation I (via anthranilate):
N-formylkynurenine + H2O ⟶ H+ + formate + kynurenine - 5-N-acetylardeemin biosynthesis:
DMAPP + ardeemin FQ ⟶ ardeemin + diphosphate - anthranilate degradation III (anaerobic):
ATP + anthranilate + coenzyme A ⟶ 2-aminobenzoyl-CoA + AMP + H+ + diphosphate - viridicatin biosynthesis:
(-)-cyclopenine ⟶ H+ + methyl isocyanate + viridicatin - 4'-methoxyviridicatin biosynthesis:
(-)-4'-methoxycyclopenine ⟶ 4'-methoxyviridicatin + H+ + methyl isocyanate - fumiquinazoline D biosynthesis:
ATP + ala + fumiquinazoline F-indoline-2',3'-diol ⟶ AMP + H+ + H2O + diphosphate + fumiquinazoline A - asperlicin E biosynthesis:
H+ + NAD(P)H + O2 + asperlicin C ⟶ H2O + NAD(P)+ + asperlicin E
Plant Reactome(0)
INOH(0)
PlantCyc(2)
- anthranilate degradation I (aerobic):
H+ + NAD(P)H + O2 + anthranilate ⟶ CO2 + NAD(P)+ + ammonium + catechol - anthranilate degradation I (aerobic):
H+ + NAD(P)H + O2 + anthranilate ⟶ CO2 + NAD(P)+ + ammonium + catechol
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Yu Chen, Yansong Fu, Yanwei Xia, Youzhi Miao, Jiahui Shao, Wei Xuan, Yunpeng Liu, Weibing Xun, Qiuyan Yan, Qirong Shen, Ruifu Zhang. Trichoderma-secreted anthranilic acid promotes lateral root development via auxin signaling and RBOHF-induced endodermal cell wall remodeling.
Cell reports.
2024 Apr; 43(4):114030. doi:
10.1016/j.celrep.2024.114030. [PMID: 38551966] - Johann Steiner, Henrik Dobrowolny, Paul C Guest, Hans-Gert Bernstein, Dietmar Fuchs, Julien Roeser, Paul Summergrad, Gregory Oxenkrug. Gender-specific elevation of plasma anthranilic acid in schizophrenia: Protection against glutamatergic hypofunction?.
Schizophrenia research.
2022 05; 243(?):483-485. doi:
10.1016/j.schres.2022.01.048. [PMID: 35151533] - Shihao Song, Xiuyun Sun, Quan Guo, Binbin Cui, Yu Zhu, Xia Li, Jianuan Zhou, Lian-Hui Zhang, Yinyue Deng. An anthranilic acid-responsive transcriptional regulator controls the physiology and pathogenicity of Ralstonia solanacearum.
PLoS pathogens.
2022 05; 18(5):e1010562. doi:
10.1371/journal.ppat.1010562. [PMID: 35617422] - Cheng-Wei Lu, Chen-Jung Lin, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin, Su-Jane Wang. An Anthranilate Derivative Inhibits Glutamate Release and Glutamate Excitotoxicity in Rats.
International journal of molecular sciences.
2022 Feb; 23(5):. doi:
10.3390/ijms23052641. [PMID: 35269784] - Takayuki Katoh, Hiroaki Suga. In Vitro Selection of Foldamer-Like Macrocyclic Peptides Containing 2-Aminobenzoic Acid and 3-Aminothiophene-2-Carboxylic Acid.
Journal of the American Chemical Society.
2022 02; 144(5):2069-2072. doi:
10.1021/jacs.1c12133. [PMID: 35099961] - Majid Mohammad Nezhad, Abolfazl Semnani, Nahid Tavakkoli, Mahboube Shirani. Selective and highly efficient removal of uranium from radioactive effluents by activated carbon functionalized with 2-aminobenzoic acid as a new sorbent.
Journal of environmental management.
2021 Dec; 299(?):113587. doi:
10.1016/j.jenvman.2021.113587. [PMID: 34479154] - Pei-Nan Chen, Meng-Jiao Hao, Hou-Jin Li, Jun Xu, Taifo Mahmud, Wen-Jian Lan. Biotransformations of anthranilic acid and phthalimide to potent antihyperlipidemic alkaloids by the marine-derived fungus Scedosporium apiospermum F41-1.
Bioorganic chemistry.
2021 11; 116(?):105375. doi:
10.1016/j.bioorg.2021.105375. [PMID: 34563999] - Radhika Chakraberty, Bela Reiz, Christopher W Cairo. Profiling of glycosphingolipids with SCDase digestion and HPLC-FLD-MS.
Analytical biochemistry.
2021 10; 631(?):114361. doi:
10.1016/j.ab.2021.114361. [PMID: 34478702] - Mélanie Bourgin, Lisa Derosa, Carolina Alves Costa Silva, Anne-Gaëlle Goubet, Agathe Dubuisson, François-Xavier Danlos, Claudia Grajeda-Iglesias, Luigi Cerbone, Arthur Geraud, Ariane Laparra, Fanny Aprahamian, Nitharsshini Nirmalathasan, Frank Madeo, Laurence Zitvogel, Guido Kroemer, Sylvère Durand. Circulating acetylated polyamines correlate with Covid-19 severity in cancer patients.
Aging.
2021 09; 13(17):20860-20885. doi:
10.18632/aging.203525. [PMID: 34517343] - J Steiner, H-G Bernstein, P C Guest, P Summergrad, G Oxenkrug. Plasma leptin correlates with anthranilic acid in schizophrenia but not in major depressive disorder.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2020 12; 41(?):167-168. doi:
10.1016/j.euroneuro.2020.08.001. [PMID: 32855025] - Amy G Aslamkhan, Qiuwei Xu, Amy Loughlin, Heather Vu, Stephen Pacchione, Bhavana Bhatt, Ivy Garfinkel, Tara Grady Styring, Lisa LaFranco-Scheuch, Kara Pearson, Spencer Reynolds, Nianyu Li, Heather Zhou, J Richard Miller, Nicolas Solban, Alan Bass, Warren E Glaab. Characterization of indoleamine-2,3-dioxygenase 1, tryptophan-2,3-dioxygenase, and Ido1/Tdo2 knockout mice.
Toxicology and applied pharmacology.
2020 11; 406(?):115216. doi:
10.1016/j.taap.2020.115216. [PMID: 32871117] - Magdalena Wysocka, Anita Romanowska, Natalia Gruba, Michalina Michalska, Artur Giełdoń, Adam Lesner. A Peptidomimetic Fluorescent Probe to Detect the Trypsin β2 Subunit of the Human 20S Proteasome.
International journal of molecular sciences.
2020 Mar; 21(7):. doi:
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Scientific reports.
2020 02; 10(1):1961. doi:
10.1038/s41598-020-58806-w. [PMID: 32029791] - Karen M Ryan, Kelly A Allers, Declan M McLoughlin, Andrew Harkin. Tryptophan metabolite concentrations in depressed patients before and after electroconvulsive therapy.
Brain, behavior, and immunity.
2020 01; 83(?):153-162. doi:
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Frontiers in immunology.
2020; 11(?):157. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Sep; 1126-1127(?):121736. doi:
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The New phytologist.
2019 08; 223(3):1420-1432. doi:
10.1111/nph.15877. [PMID: 31038751] - Cristina Román-Hidalgo, Germán López-Pérez, María Jesús Martín-Valero, Miguel Ángel Bello-López. Chitosan tailor-made membranes as biopolymeric support for electromembrane extraction.
Talanta.
2019 Jul; 199(?):290-295. doi:
10.1016/j.talanta.2019.02.079. [PMID: 30952260] - Martina Curto, Luana Lionetto, Francesco Fazio, Valentina Corigliano, Anna Comparelli, Stefano Ferracuti, Maurizio Simmaco, Ferdinando Nicoletti, Ross J Baldessarini. Serum xanthurenic acid levels: Reduced in subjects at ultra high risk for psychosis.
Schizophrenia research.
2019 06; 208(?):465-466. doi:
10.1016/j.schres.2019.02.020. [PMID: 30837204] - Thi Quynh Do, Bich Ngan Truong, Huong Doan Thi Mai, Thuy Linh Nguyen, Van Hung Nguyen, Hai Dang Nguyen, Tien Dat Nguyen, The Cuong Nguyen, Trieu Vung Luong, Loc Thang Giang, Van Minh Chau, Van Cuong Pham. New dianthramide and cinnamic ester glucosides from the roots of Aconitum carmichaelii.
Journal of Asian natural products research.
2019 Jun; 21(6):507-515. doi:
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Chemical communications (Cambridge, England).
2019 May; 55(37):5371-5374. doi:
10.1039/c9cc01831j. [PMID: 30994648] - Mengchan Liu, Yanxi Jia, Yunchang Xie, Chunyan Zhang, Junying Ma, Changli Sun, Jianhua Ju. Identification of the Actinomycin D Biosynthetic Pathway from Marine-Derived Streptomyces costaricanus SCSIO ZS0073.
Marine drugs.
2019 Apr; 17(4):. doi:
10.3390/md17040240. [PMID: 31018504] - Adnan Khan, Soo An Choi, Jinhyuk Na, Aryo Dimas Pamungkas, Keum Ji Jung, Sun Ha Jee, Youngja H Park. Noninvasive Serum Metabolomic Profiling Reveals Elevated Kynurenine Pathway's Metabolites in Humans with Prostate Cancer.
Journal of proteome research.
2019 04; 18(4):1532-1541. doi:
10.1021/acs.jproteome.8b00803. [PMID: 30628444] - Wouter J C de Bruijn, Sarah van Dinteren, Harry Gruppen, Jean-Paul Vincken. Mass spectrometric characterisation of avenanthramides and enhancing their production by germination of oat (Avena sativa).
Food chemistry.
2019 Mar; 277(?):682-690. doi:
10.1016/j.foodchem.2018.11.013. [PMID: 30502203] - Maurizio Pompili, Luana Lionetto, Martina Curto, Alberto Forte, Denise Erbuto, Franco Montebovi, Maria Elena Seretti, Isabella Berardelli, Gianluca Serafini, Marco Innamorati, Mario Amore, Ross J Baldessarini, Paolo Girardi, Maurizio Simmaco. Tryptophan and Kynurenine Metabolites: Are They Related to Depression?.
Neuropsychobiology.
2019; 77(1):23-28. doi:
10.1159/000491604. [PMID: 30110684] - Thales Kronenberger, Björn Windshügel, Carsten Wrenger, Kathia M Honorio, Vinicius G Maltarollo. On the relationship of anthranilic derivatives structure and the FXR (Farnesoid X receptor) agonist activity.
Journal of biomolecular structure & dynamics.
2018 Dec; 36(16):4378-4391. doi:
10.1080/07391102.2017.1417161. [PMID: 29237358] - Abdulla A-B Badawy. Hypothesis kynurenic and quinolinic acids: The main players of the kynurenine pathway and opponents in inflammatory disease.
Medical hypotheses.
2018 Sep; 118(?):129-138. doi:
10.1016/j.mehy.2018.06.021. [PMID: 30037600] - Mohanapriya Jayapal, Hema Jagadeesan, Manojkumar Shanmugam, Perinba Danisha J, Shobana Murugesan. Sequential anaerobic-aerobic treatment using plant microbe integrated system for degradation of azo dyes and their aromatic amines by-products.
Journal of hazardous materials.
2018 07; 354(?):231-243. doi:
10.1016/j.jhazmat.2018.04.050. [PMID: 29754041] - Jason Walsh, Jordan Haddock, Jeffrey B Blumberg, Diane L McKay, Xiaoyong Wei, Gregory Dolnikowski, C-Y Oliver Chen. Identification of methylated metabolites of oat avenanthramides in human plasma using UHPLC QToF-MS.
International journal of food sciences and nutrition.
2018 May; 69(3):377-383. doi:
10.1080/09637486.2017.1371116. [PMID: 28889763] - Román-Hidalgo Cristina, Martín-Valero María Jesús, Fernández-Torres Rut, Bello-López Miguel Ángel. Use of Polymer Inclusion Membranes (PIMs) as support for electromembrane extraction of non-steroidal anti-inflammatory drugs and highly polar acidic drugs.
Talanta.
2018 Mar; 179(?):601-607. doi:
10.1016/j.talanta.2017.11.066. [PMID: 29310282] - Tomasz W Kaminski, Krystyna Pawlak, Malgorzata Karbowska, Michal Mysliwiec, Waldemar Grzegorzewski, Jakub Kuna, Dariusz Pawlak. Association between uremic toxin-anthranilic acid and fibrinolytic system activity in predialysis patients at different stages of chronic kidney disease.
International urology and nephrology.
2018 Jan; 50(1):127-135. doi:
10.1007/s11255-017-1729-1. [PMID: 29058166] - Rémy B Teponno, Sara R Noumeur, Soleiman E Helaly, Stephan Hüttel, Daoud Harzallah, Marc Stadler. Furanones and Anthranilic Acid Derivatives from the Endophytic Fungus Dendrothyrium variisporum.
Molecules (Basel, Switzerland).
2017 Oct; 22(10):. doi:
10.3390/molecules22101674. [PMID: 28991218] - War War May Zin, Suradet Buttachon, Tida Dethoup, José A Pereira, Luís Gales, Ângela Inácio, Paulo M Costa, Michael Lee, Nazim Sekeroglu, Artur M S Silva, Madalena M M Pinto, Anake Kijjoa. Antibacterial and antibiofilm activities of the metabolites isolated from the culture of the mangrove-derived endophytic fungus Eurotium chevalieri KUFA 0006.
Phytochemistry.
2017 Sep; 141(?):86-97. doi:
10.1016/j.phytochem.2017.05.015. [PMID: 28586721] - Rasmus Dam Wollenberg, Wagma Saei, Klaus Ringsborg Westphal, Carina Sloth Klitgaard, Kåre Lehmann Nielsen, Erik Lysøe, Donald Max Gardiner, Reinhard Wimmer, Teis Esben Sondergaard, Jens Laurids Sørensen. Chrysogine Biosynthesis Is Mediated by a Two-Module Nonribosomal Peptide Synthetase.
Journal of natural products.
2017 07; 80(7):2131-2135. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Jun; 90(?):332-338. doi:
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Bioscience, biotechnology, and biochemistry.
2017 Mar; 81(3):431-440. doi:
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European journal of nutrition.
2017 Feb; 56(1):261-272. doi:
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Molecular plant-microbe interactions : MPMI.
2017 02; 30(2):113-126. doi:
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Ukrainian biochemical journal.
2017 Jan; 89(1):59-70. doi:
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Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2017; 137(2):215-220. doi:
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Nature communications.
2016 10; 7(?):13083. doi:
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Journal of natural medicines.
2016 Oct; 70(4):816-24. doi:
10.1007/s11418-016-1019-8. [PMID: 27351981] - René Fuertig, Angelo Ceci, Sandrine M Camus, Erwan Bezard, Andreas H Luippold, Bastian Hengerer. LC-MS/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain.
Bioanalysis.
2016 Sep; 8(18):1903-17. doi:
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The Journal of nutrition.
2016 09; 146(9):1801-6. doi:
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Neuroscience.
2016 08; 329(?):337-48. doi:
10.1016/j.neuroscience.2016.05.024. [PMID: 27210075] - Natalia Gruba, Magdalena Wysocka, Magdalena Brzezińska, Dawid Dębowski, Marcin Sieńczyk, Ewa Gorodkiewicz, Tomasz Guszcz, Cezary Czaplewski, Krzysztof Rolka, Adam Lesner. Bladder cancer detection using a peptide substrate of the 20S proteasome.
The FEBS journal.
2016 08; 283(15):2929-48. doi:
10.1111/febs.13786. [PMID: 27326540] - Saikat Biswas, Pramit Kumar Chowdhury. Correlated and Anticorrelated Domain Movement of Human Serum Albumin: A Peek into the Complexity of the Crowded Milieu.
The journal of physical chemistry. B.
2016 06; 120(22):4897-911. doi:
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International journal of molecular sciences.
2016 Apr; 17(4):536. doi:
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Heart (British Cardiac Society).
2016 Feb; 102(3):230-7. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
2015 Oct; 112(42):13033-8. doi:
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Psychiatria polska.
2015 May; 49(3):435-53. doi:
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The Journal of nutrition.
2015 Apr; 145(4):701-7. doi:
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Journal of pharmaceutical and biomedical analysis.
2015 Mar; 107(?):426-31. doi:
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Arteriosclerosis, thrombosis, and vascular biology.
2015 Feb; 35(2):455-62. doi:
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Bioorganic & medicinal chemistry.
2015 Feb; 23(3):499-514. doi:
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The journal of headache and pain.
2015; 17(?):27. doi:
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The journal of headache and pain.
2015; 17(?):47. doi:
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Applied biochemistry and biotechnology.
2014 Oct; 174(4):1535-1547. doi:
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Epilepsy & behavior : E&B.
2014 Aug; 37(?):133-8. doi:
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Natural product communications.
2014 Aug; 9(8):1159-62. doi:
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Analytical biochemistry.
2014 Jul; 457(?):31-7. doi:
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Fitoterapia.
2014 Mar; 93(?):62-6. doi:
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The Analyst.
2013 Sep; 138(18):5461-9. doi:
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The Journal of nutrition.
2013 Sep; 143(9):1509-19. doi:
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Applied microbiology and biotechnology.
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Bioorganic & medicinal chemistry.
2013 Aug; 21(16):4762-7. doi:
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Clinical and experimental immunology.
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The Journal of nutrition.
2013 Jun; 143(6):859-66. doi:
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2012 Jun; 898(?):121-9. doi:
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Chemical & pharmaceutical bulletin.
2012; 60(10):1290-300. doi:
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Methods in molecular biology (Clifton, N.J.).
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Mutation research.
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Chemical biology & drug design.
2011 Jun; 77(6):450-9. doi:
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Plant physiology.
2011 Mar; 155(3):1325-38. doi:
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Current microbiology.
2010 Oct; 61(4):285-90. doi:
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Plant physiology.
2010 Aug; 153(4):1795-807. doi:
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Journal of pediatric endocrinology & metabolism : JPEM.
2010 Mar; 23(3):277-82. doi:
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Advances in medical sciences.
2010; 55(2):204-11. doi:
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The American journal of the medical sciences.
2009 Oct; 338(4):293-300. doi:
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Electrophoresis.
2009 Aug; 30(15):2632-9. doi:
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Analytical biochemistry.
2008 Aug; 379(1):45-59. doi:
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Bioscience, biotechnology, and biochemistry.
2008 Jul; 72(7):1667-72. doi:
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The Plant journal : for cell and molecular biology.
2008 Feb; 53(3):541-53. doi:
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The Biochemical journal.
2008 Jan; 409(2):571-80. doi:
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Pharmaceutical research.
2007 Aug; 24(8):1457-72. doi:
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International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.
2007 Jul; 77(4):255-62. doi:
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Clinical chemistry.
2007 May; 53(5):947-54. doi:
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Bioorganic & medicinal chemistry letters.
2007 Apr; 17(8):2347-50. doi:
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Analytical chemistry.
2006 Dec; 78(24):8491-8. doi:
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Clinical and experimental pharmacology & physiology.
2006 Nov; 33(11):1078-87. doi:
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Advances in medical sciences.
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Biotechnology letters.
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The Plant journal : for cell and molecular biology.
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Journal of industrial microbiology & biotechnology.
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International urology and nephrology.
2005; 37(3):621-7. doi:
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Biotechnology and applied biochemistry.
2004 Feb; 39(Pt 1):123-8. doi:
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The Journal of biological chemistry.
2003 Feb; 278(8):6275-81. doi:
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Advances in experimental medicine and biology.
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