Antibiotic 1233A (BioDeep_00000840402)
代谢物信息卡片
化学式: C18H28O5 (324.1936638)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CCCCC1C(C(=O)O1)CO)CC(=CC(=CC(=O)O)C)C
InChI: InChI=1S/C18H28O5/c1-12(8-13(2)9-14(3)10-17(20)21)6-4-5-7-16-15(11-19)18(22)23-16/h9-10,12,15-16,19H,4-8,11H2,1-3H3,(H,20,21)/b13-9+,14-10+/t12-,15-,16-/m1/s1
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Pan Liao, Shiu-Cheung Lung, Wai Lung Chan, Menglong Hu, Geoffrey Kwai-Wai Kong, Thomas J Bach, Quan Hao, Clive Lo, Mee-Len Chye. Overexpression and Inhibition of 3-Hydroxy-3-Methylglutaryl-CoA Synthase Affect Central Metabolic Pathways in Tobacco.
Plant & cell physiology.
2021 Mar; 62(1):205-218. doi:
10.1093/pcp/pcaa154. [PMID: 33340324] - Florence Pojer, Jean-Luc Ferrer, Stéphane B Richard, Dinesh A Nagegowda, Mee-Len Chye, Thomas J Bach, Joseph P Noel. Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.
Proceedings of the National Academy of Sciences of the United States of America.
2006 Aug; 103(31):11491-6. doi:
10.1073/pnas.0604935103. [PMID: 16864776] - Dinesh A Nagegowda, Thomas J Bach, Mee-Len Chye. Brassica juncea 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase 1: expression and characterization of recombinant wild-type and mutant enzymes.
The Biochemical journal.
2004 Nov; 383(Pt. 3):517-27. doi:
10.1042/bj20040721. [PMID: 15233626] - H Hashizume, H Ito, T Morikawa, N Kanaya, H Nagashima, H Usui, H Tomoda, T Sunazuka, H Kumagai, S Omura. Synthesis and biological activity of new 3-hydroxy-3-methylglutaryl-CoA synthase inhibitors: 2-oxetanones with a side chain mimicking the extended structure of 1233A.
Chemical & pharmaceutical bulletin.
1994 Oct; 42(10):2097-107. doi:
10.1248/cpb.42.2097. [PMID: 7805135] - H Tomoda, S Omura. Lipid metabolism inhibitors of microbial origin.
The Kitasato archives of experimental medicine.
1993 Apr; 65 Suppl(?):1-12. doi:
". [PMID: 7967370] - H Kumagai, H Tomoda, S Omura. Method of search for microbial inhibitors of mevalonate biosynthesis using animal cells.
The Journal of antibiotics.
1990 Apr; 43(4):397-402. doi:
10.7164/antibiotics.43.397. [PMID: 1972152] - M Berlan. [Consequences of the administration of alpha or beta drenolytic agents on the mobilization of plasma free fatty acids as induced by noradrenaline and isoprenaline in the dog].
Comptes rendus des seances de la Societe de biologie et de ses filiales.
1976 Oct; 170(3):672-9. doi:
. [PMID: 10055]