3,5-cyclic AMP(1-) (BioDeep_00000840369)
代谢物信息卡片
3,5-cyclic AMP(1-)
化学式: C10H11N5O6P- (328.0446936)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 28.57%
分子结构信息
SMILES: C1C2C(C(C(O2)N3C=NC4=C(N=CN=C43)N)O)OP(=O)(O1)[O-]
InChI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1
描述信息
An organophosphate oxoanion that is the conjugate base of 3,5-cyclic AMP arising from deprotonation of the free phosphate OH group; major species at pH 7.3.
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
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同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:58165
- PubChem: 7059571
- MeSH: Cyclic AMP
- CAS: 62906-31-4
- MetaboLights: MTBLC58165
分类词条
相关代谢途径
Reactome(26)
- Metabolism
- Sensory Perception
- Disease
- Transport of small molecules
- Aquaporin-mediated transport
- Signaling Pathways
- Immune System
- Signaling by Receptor Tyrosine Kinases
- Infectious disease
- Adaptive Immune System
- Leishmania infection
- Bacterial Infection Pathways
- Parasitic Infection Pathways
- Glycolysis
- Carbohydrate metabolism
- Glucose metabolism
- Integration of energy metabolism
- Neuronal System
- Transmission across Chemical Synapses
- Signaling by GPCR
- GPCR downstream signalling
- G alpha (i) signalling events
- Olfactory Signaling Pathway
- Opioid Signalling
- DARPP-32 events
- Intracellular signaling by second messengers
BioCyc(7)
- superpathway of anaerobic energy metabolism (invertebrates)
- superpathway of purines degradation in plants
- superpathway of microbial D-galacturonate and D-glucuronate degradation
- gluconeogenesis I
- glycolysis II (from fructose 6-phosphate)
- hexitol fermentation to lactate, formate, ethanol and acetate
- anaerobic energy metabolism (invertebrates, cytosol)
PlantCyc(6)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Chunhua Gao, Zhe Wang, Xiaojing Liu, Rongzhen Sun, Shengyao Ma, Zongchen Ma, Qi Wang, Guoqiang Li, Han-Ting Zhang. The Construction and Application of a New Screening Method for Phosphodiesterase Inhibitors.
Biosensors.
2024 May; 14(5):. doi:
10.3390/bios14050252. [PMID: 38785726] - Guido Domingo, Milena Marsoni, Eleonora Davide, Stefania Fortunato, Maria Concetta de Pinto, Marcella Bracale, Gianluca Molla, Chris Gehring, Candida Vannini. The cAMP-dependent phosphorylation footprint in response to heat stress.
Plant cell reports.
2024 May; 43(6):137. doi:
10.1007/s00299-024-03213-y. [PMID: 38713285] - Laura Yunuen Hernández-Sánchez, María Eva González-Trujano, Diego A Moreno, David Martínez-Vargas, Heike Vibrans, Alberto Hernandez-Leon, Alejandro Dorazco-González, Francisco Pellicer, Marcos Soto-Hernández. Antinociceptive effects of Raphanus sativus sprouts involve the opioid and 5-HT1A serotonin receptors, cAMP/cGMP pathways, and the central activity of sulforaphane.
Food & function.
2024 May; 15(9):4773-4784. doi:
10.1039/d3fo05229j. [PMID: 38469873] - Alexander J Dear, Gonzalo A Garcia, Georg Meisl, Galen A Collins, Tuomas P J Knowles, Alfred L Goldberg. Maximum entropy determination of mammalian proteome dynamics.
Proceedings of the National Academy of Sciences of the United States of America.
2024 Apr; 121(18):e2313107121. doi:
10.1073/pnas.2313107121. [PMID: 38652742] - Chiaki Yamamoto, Fumio Takahashi, Noriyuki Suetsugu, Kazumasa Yamada, Shinya Yoshikawa, Takayuki Kohchi, Masahiro Kasahara. The cAMP signaling module regulates sperm motility in the liverwort Marchantia polymorpha.
Proceedings of the National Academy of Sciences of the United States of America.
2024 Apr; 121(16):e2322211121. doi:
10.1073/pnas.2322211121. [PMID: 38593080] - Milan Sencanski, Sanja Glisic, Valentina Kubale, Marko Cotman, Janez Mavri, Milka Vrecl. Computational Modeling and Characterization of Peptides Derived from Nanobody Complementary-Determining Region 2 (CDR2) Targeting Active-State Conformation of the β2-Adrenergic Receptor (β2AR).
Biomolecules.
2024 Mar; 14(4):. doi:
10.3390/biom14040423. [PMID: 38672440] - Yidong Cai, Jinggang Dong, Jianqiang Huang, Jiaojiao He, Yonghua Hu, Zhihai Sui, Ping Tang. The cyclic AMP (cAMP) phosphodiesterase CpdA required for growth, biofilm formation, motility and pathogenicity of Edwardsiella piscicida.
Microbial pathogenesis.
2024 Mar; 188(?):106545. doi:
10.1016/j.micpath.2024.106545. [PMID: 38244636] - Xuemeng Zhao, Wen Li, Xiliu Li, Zhenhua Jia, Shuishan Song, Qian Zhao. The Effect of Bacterial AHL on the Cyclic Adenosine Monophosphate Content in Plants According to High-Performance Liquid Chromatography.
Molecules (Basel, Switzerland).
2024 Feb; 29(5):. doi:
10.3390/molecules29051074. [PMID: 38474586] - Zihan Li, Chengshan Zhu, Cong Yin, Heyu Li, Yimei Liu, Juan Li. Multi-omics reveals the testosterone promotion effect mechanism of Cordyceps Sobolifera on leydig cells.
Journal of ethnopharmacology.
2024 Feb; ?(?):117817. doi:
10.1016/j.jep.2024.117817. [PMID: 38316217] - Xueli Cao, Yu Xiao, Erin Huiting, Xujun Cao, Dong Li, Jie Ren, Iana Fedorova, Hao Wang, Linlin Guan, Yu Wang, Lingyin Li, Joseph Bondy-Denomy, Yue Feng. Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides.
Molecular cell.
2024 Jan; 84(2):375-385.e7. doi:
10.1016/j.molcel.2023.11.026. [PMID: 38103556] - Hongying Zhang, Yongliang Liu, Jieya Liu, Jinzhu Chen, Jiao Wang, Hui Hua, Yangfu Jiang. cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment.
Journal of hematology & oncology.
2024 Jan; 17(1):5. doi:
10.1186/s13045-024-01524-x. [PMID: 38233872] - Caitlyn Henry, Mackenzie Wilcox, Angela L Asirvatham. Forskolin-mediated cAMP activation upregulates TNF-α expression despite NF-κB downregulation in LPS-treated Schwann cells.
PloS one.
2024; 19(4):e0302223. doi:
10.1371/journal.pone.0302223. [PMID: 38625986] - Ilona Turek, Chris Gehring. Peptide-Mediated Cyclic Nucleotide Signaling in Plants: Identification and Characterization of Interactor Proteins with Nucleotide Cyclase Activity.
Methods in molecular biology (Clifton, N.J.).
2024; 2731(?):179-204. doi:
10.1007/978-1-0716-3511-7_14. [PMID: 38019435] - Yon-Suk Kim, Eun-Bin Lee, Ye-Ji Yu, Ga-Won Kim, Woo-Jung Kim, Dong-Kug Choi. Ethyl Acetate Fraction from a Catalpa ovata G. Don Extract Inhibits ɑ-MSH-Induced Melanogenesis through the cAMP/CREB Pathway.
International journal of molecular sciences.
2023 Dec; 25(1):. doi:
10.3390/ijms25010151. [PMID: 38203322] - Huang Xi, Xia Youguang, Han Kai, Q I Weiwei, Linghu Qing, Zhang Qing, Xue Jingbo. Hetong decoction relieves loperamide-induced constipation in rats by regulating expression of aquaporins.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2023 Oct; 43(6):1160-1167. doi:
10.19852/j.cnki.jtcm.2023.06.008. [PMID: 37946478] - Robin Klein, Jannis Brehm, Juliane Wissig, Ralf Heermann, Gottfried Unden. A signaling complex of adenylate cyclase CyaC of Sinorhizobium meliloti with cAMP and the transcriptional regulators Clr and CycR.
BMC microbiology.
2023 08; 23(1):236. doi:
10.1186/s12866-023-02989-5. [PMID: 37633907] - Zhihui Sun, Yan Tie, Xinyi Tong, Mingchang Cheng, Yushan Wu, Pingxiang Xu, Ming Xue, Liping Xu, Xuelin Zhou. Multi-omics approaches revealed the therapeutic mechanisms of Suo-Quan-Wan for treating overactive bladder in spontaneously hypertensive rats.
Journal of ethnopharmacology.
2023 Aug; 318(Pt B):117066. doi:
10.1016/j.jep.2023.117066. [PMID: 37604331] - Guido Domingo, Milena Marsoni, Luca Chiodaroli, Stefania Fortunato, Marcella Bracale, Maria Concetta De Pinto, Chris Gehring, Candida Vannini. Quantitative phosphoproteomics reveals novel roles of cAMP in plants.
Proteomics.
2023 Aug; 23(15):e2300165. doi:
10.1002/pmic.202300165. [PMID: 37264754] - Citlaly Gutiérrez-Rodelo, Shirlley Elizabeth Martínez-Tolibia, Guadalupe Elide Morales-Figueroa, Josué Arturo Velázquez-Moyado, J Alberto Olivares-Reyes, Andrés Navarrete-Castro. Modulating cyclic nucleotides pathways by bioactive compounds in combatting anxiety and depression disorders.
Molecular biology reports.
2023 Jul; ?(?):. doi:
10.1007/s11033-023-08650-8. [PMID: 37486442] - Linlin Qi, Jiří Friml. Tale of cAMP as a second messenger in auxin signaling and beyond.
The New phytologist.
2023 Jul; ?(?):. doi:
10.1111/nph.19123. [PMID: 37434303] - Brygida Świeżawska-Boniecka, Adriana Szmidt-Jaworska. Phytohormones and cyclic nucleotides - Long-awaited couples?.
Journal of plant physiology.
2023 07; 286(?):154005. doi:
10.1016/j.jplph.2023.154005. [PMID: 37186984] - Sasanka Ramanadham, John Turk, Sushant Bhatnagar. Noncanonical Regulation of cAMP-Dependent Insulin Secretion and Its Implications in Type 2 Diabetes.
Comprehensive Physiology.
2023 06; 13(3):5023-5049. doi:
10.1002/cphy.c220031. [PMID: 37358504] - Maura Greiser, Mariusz Karbowski, Aaron David Kaplan, Andrew Kyle Coleman, Nicolas Verhoeven, Carmen A Mannella, W Jonathan Lederer, Liron Boyman. Calcium and bicarbonate signaling pathways have pivotal, resonating roles in matching ATP production to demand.
eLife.
2023 Jun; 12(?):. doi:
10.7554/elife.84204. [PMID: 37272417] - Havva Afshari, Shokoofe Noori, Afshin Zarghi. A novel combination of metformin and resveratrol alleviates hepatic steatosis by activating autophagy through the cAMP/AMPK/SIRT1 signaling pathway.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 May; ?(?):. doi:
10.1007/s00210-023-02520-7. [PMID: 37209153] - Jakob Andersson, David Kleinheinz, Ulrich Ramach, Nikolaus Kiesenhofer, Alex Ashenden, Markus Valtiner, Stephen Holt, Ingo Koeper, Philipp A M Schmidpeter, Wolfgang Knoll. Native Function of the Bacterial Ion Channel SthK in a Sparsely Tethered Lipid Bilayer Membrane Architecture.
The journal of physical chemistry. B.
2023 04; 127(16):3641-3650. doi:
10.1021/acs.jpcb.2c07252. [PMID: 37072125] - Yangyun Wang, Chaoliang Shi, Wandong Yu, Wei Jiao, Guowei Shi. Efficacy of Yougui pill combined with Buzhong Yiqi decoction in alleviating the sexual dysfunction in female rats through modulation of the gut microbiota.
Pharmaceutical biology.
2022 Dec; 60(1):46-55. doi:
10.1080/13880209.2021.2010774. [PMID: 34904911] - Deng Zang, Chao Niu, Xueying Lu, Haji Akber Aisa. A Novel Furocoumarin Derivative, 5-((diethylamino)me-13 thyl)-3-phenyl-7H-furo [3,2-g] chromen-7-one Upregulates Melanin Synthesis via the Activation of cAMP/PKA and MAPKs Signal Pathway: In Vitro and In Vivo Study.
International journal of molecular sciences.
2022 Nov; 23(22):. doi:
10.3390/ijms232214190. [PMID: 36430668] - Linlin Qi, Mateusz Kwiatkowski, Huihuang Chen, Lukas Hoermayer, Scott Sinclair, Minxia Zou, Charo I Del Genio, Martin F Kubeš, Richard Napier, Krzysztof Jaworski, Jiří Friml. Adenylate cyclase activity of TIR1/AFB auxin receptors in plants.
Nature.
2022 11; 611(7934):133-138. doi:
10.1038/s41586-022-05369-7. [PMID: 36289340] - Yuwei Liu, Shen Shen, Zhimin Hao, Qing Wang, Yumei Zhang, Yulan Zhao, Yameng Tong, Fanli Zeng, Jingao Dong. Protein kinase A participates in hyphal and appressorial development by targeting Efg1-mediated transcription of a Rab GTPase in Setosphaeria turcica.
Molecular plant pathology.
2022 11; 23(11):1608-1619. doi:
10.1111/mpp.13253. [PMID: 35929228] - Naoki Matsumoto, Nalin Singh, Kin Sing Lee, Bogdan Barnych, Christophe Morisseau, Bruce D Hammock. The epoxy fatty acid pathway enhances cAMP in mammalian cells through multiple mechanisms.
Prostaglandins & other lipid mediators.
2022 10; 162(?):106662. doi:
10.1016/j.prostaglandins.2022.106662. [PMID: 35779854] - Yue DU, Zhi-Wang Wang, Jian-Hong Xi, Ji-Yang Li, Ke-Ke Liang, Ke-Ting Huang, Hui-Ying Luo. [Effects of Angelicae Sinensis Radix on cAMP/Epac signaling pathway in the treatment of chronically infected cough mice with Yin deficiency syndrome].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2022 Sep; 38(5):475-479. doi:
10.12047/j.cjap.6296.2022.089. [PMID: 37088755] - Mingqian Li, Fei Li, Jiabin Chen, He Su, Guanping Chen, Jili Cao, Jiacheng Li, Liyao Dong, Zhihong Yu, Yifan Wang, Chun Zhou, Yongqiang Zhu, Qin Wei, Qun Li, Kequn Chai. Mechanistic insights on cytotoxicity of KOLR, Cinnamomum pauciflorum Nees leaf derived active ingredient, by targeting signaling complexes of phosphodiesterase 3B and rap guanine nucleotide exchange factor 3.
Phytotherapy research : PTR.
2022 Sep; 36(9):3540-3554. doi:
10.1002/ptr.7521. [PMID: 35703011] - Adilson Guilherme, Leslie A Rowland, Hui Wang, Michael P Czech. The adipocyte supersystem of insulin and cAMP signaling.
Trends in cell biology.
2022 Aug; ?(?):. doi:
10.1016/j.tcb.2022.07.009. [PMID: 35989245] - Kota Kakeshita, Tsutomu Koike, Teruhiko Imamura, Hayato Fujioka, Hidenori Yamazaki, Koichiro Kinugawa. Altered arginine vasopressin-cyclic AMP-aquaporin 2 pathway in patients with chronic kidney disease.
Clinical and experimental nephrology.
2022 Aug; 26(8):788-796. doi:
10.1007/s10157-022-02220-1. [PMID: 35503490] - Jingjing Cao, Rendong Zheng, Xiaoyan Chang, Yuanyuan Zhao, Dongjian Zhang, Meng Gao, Zhiqi Yin, Cuihua Jiang, Jian Zhang. Cyclocarya paliurus triterpenoids suppress hepatic gluconeogenesis via AMPK-mediated cAMP/PKA/CREB pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jul; 102(?):154175. doi:
10.1016/j.phymed.2022.154175. [PMID: 35609386] - Xudong Cao, Peng Wang, Haoxing Yuan, Haoran Zhang, Yan He, Kequan Fu, Qian Fang, Hongli Liu, Limin Su, Long Yin, Pei Xu, Yuyang Xie, Xiaochun Xiong, Junqi Wang, Xu Zhu, Dong Guo. Benzodiazepine Derivatives as Potent Vasopressin V2 Receptor Antagonists for the Treatment of Autosomal Dominant Kidney Disease.
Journal of medicinal chemistry.
2022 Jul; 65(13):9295-9311. doi:
10.1021/acs.jmedchem.2c00567. [PMID: 35579344] - Qi Lai, Yanhua Ma, Jin Bai, Min Zhuang, Shaofei Pei, Ni He, Junlin Yin, Baomin Fan, Zhaoxiang Bian, Guangzhi Zeng, Chengyuan Lin. Mechanisms for Bile Acids CDCA- and DCA-Stimulated Hepatic Spexin Expression.
Cells.
2022 07; 11(14):. doi:
10.3390/cells11142159. [PMID: 35883602] - María M Adeva-Andany, Carlos Fernández-Fernández, Natalia Carneiro-Freire, Elvira Castro-Quintela, Matilde Vila-Altesor, Manuel González-Lucán. Cardiovascular Protection Associated With Cilostazol, Colchicine, and Target of Rapamycin Inhibitors.
Journal of cardiovascular pharmacology.
2022 07; 80(1):31-43. doi:
10.1097/fjc.0000000000001276. [PMID: 35384911] - Guilherme Ruiz Leonardi, Caroline Honaiser Lescano, Jose Luiz Costa, Bruna Mazetto, Fernanda Andrade Orsi, Fabiola Zakia Monica. Adenosine diphosphate-induced aggregation is enhanced in platelets obtained from patients with thrombotic primary antiphospholipid syndrome (t-PAPS): Role of P2Y12 -cAMP signaling pathway.
Journal of thrombosis and haemostasis : JTH.
2022 07; 20(7):1699-1711. doi:
10.1111/jth.15724. [PMID: 35395698] - Zixuan Wang, Xinyuan Wei, Caili Ji, Wenhua Yu, Chuanwang Song, Caizhi Wang. PGE2 inhibits neutrophil phagocytosis through the EP2R-cAMP-PTEN pathway.
Immunity, inflammation and disease.
2022 07; 10(7):e662. doi:
10.1002/iid3.662. [PMID: 35759236] - Dongli Yu, Wen Song, Eddie Yong Jun Tan, Li Liu, Yu Cao, Jan Jirschitzka, Ertong Li, Elke Logemann, Chenrui Xu, Shijia Huang, Aolin Jia, Xiaoyu Chang, Zhifu Han, Bin Wu, Paul Schulze-Lefert, Jijie Chai. TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death.
Cell.
2022 06; 185(13):2370-2386.e18. doi:
10.1016/j.cell.2022.04.032. [PMID: 35597242] - Sofia Brito, Jin-Myoung Baek, Byungsun Cha, Hyojin Heo, Su-Hyun Lee, Lei Lei, So Young Jung, So Min Lee, Sang Hun Lee, Byeong-Mun Kwak, Sehyun Chae, Mi-Gi Lee, Bum-Ho Bin. Nicotinamide mononucleotide reduces melanin production in aged melanocytes by inhibiting cAMP/Wnt signaling.
Journal of dermatological science.
2022 Jun; 106(3):159-169. doi:
10.1016/j.jdermsci.2022.05.002. [PMID: 35610161] - Baijin Chang, Yanru Liu, Jingting Hu, Zhishu Tang, Zhidong Qiu, Zhongxing Song, Ailing Jia, Yuru Zhang. Bupleurum chinense DC improves CUMS-induced depressive symptoms in rats through upregulation of the cAMP/PKA/CREB signalling pathway.
Journal of ethnopharmacology.
2022 May; 289(?):115034. doi:
10.1016/j.jep.2022.115034. [PMID: 35092825] - Robert L Rodgers. Glucagon, cyclic AMP, and hepatic glucose mobilization: A half-century of uncertainty.
Physiological reports.
2022 05; 10(9):e15263. doi:
10.14814/phy2.15263. [PMID: 35569125] - Maria F Fernandes, Michelle V Tomczewski, Robin E Duncan. Glucagon-like Peptide-1 Secretion Is Inhibited by Lysophosphatidic Acid.
International journal of molecular sciences.
2022 Apr; 23(8):. doi:
10.3390/ijms23084163. [PMID: 35456981] - Zeyun Mi, Yandong Song, Jiuchen Wang, Zhiheng Liu, Xinyi Cao, Lin Dang, Yumei Lu, Yongzhan Sun, Hui Xiong, Lirong Zhang, Yupeng Chen. cAMP-Induced Nuclear Condensation of CRTC2 Promotes Transcription Elongation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease.
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
2022 04; 9(10):e2104578. doi:
10.1002/advs.202104578. [PMID: 35037420] - Emiliana Echeverría, Sonia Ripoll, Lucas Fabián, Carina Shayo, Federico Monczor, Natalia C Fernández. Novel inhibitors of phosphorylation independent activity of GRK2 modulate cAMP signaling.
Pharmacology research & perspectives.
2022 04; 10(2):e00913. doi:
10.1002/prp2.913. [PMID: 35184416] - Monika Chodasiewicz, Olga Kerber, Michal Gorka, Juan C Moreno, Israel Maruri-Lopez, Romina I Minen, Arun Sampathkumar, Andrew D L Nelson, Aleksandra Skirycz. 2',3'-cAMP treatment mimics the stress molecular response in Arabidopsis thaliana.
Plant physiology.
2022 03; 188(4):1966-1978. doi:
10.1093/plphys/kiac013. [PMID: 35043968] - Chiara Piantoni, Manuel Paina, David Molla, Sheng Liu, Giorgia Bertoli, Hongmei Jiang, Yanyan Wang, Yi Wang, Yi Wang, Dario DiFrancesco, Andrea Barbuti, Annalisa Bucchi, Mirko Baruscotti. Chinese natural compound decreases pacemaking of rabbit cardiac sinoatrial cells by targeting second messenger regulation of f-channels.
eLife.
2022 03; 11(?):. doi:
10.7554/elife.75119. [PMID: 35315774] - Elizabeth H Theng, Lee S Weinstein, Michael T Collins. Calvarial hyperostosis in primary hyperparathyroidism and other settings of increased cAMP signalling.
Lancet (London, England).
2022 03; 399(10328):956. doi:
10.1016/s0140-6736(22)00149-0. [PMID: 35248187] - Wen-Xia Yang, Yu Liu, Shu-Min Zhang, Hua-Fen Wang, Yi-Fei Liu, Jia-Lu Liu, Xiao-Hui Li, Meng-Ru Zeng, Yu-Zhang Han, Fu-You Liu, Lin Sun, Li Xiao. Epac activation ameliorates tubulointerstitial inflammation in diabetic nephropathy.
Acta pharmacologica Sinica.
2022 Mar; 43(3):659-671. doi:
10.1038/s41401-021-00689-2. [PMID: 34103688] - Rebecca LaCroix, Benjamin Lin, Tae-Yun Kang, Andre Levchenko. Complex effects of kinase localization revealed by compartment-specific regulation of protein kinase A activity.
eLife.
2022 02; 11(?):. doi:
10.7554/elife.66869. [PMID: 35199643] - William J Moss, Caitlyn E Patterson, Alexander K Jochmans, Kevin M Brown. Functional Analysis of the Expanded Phosphodiesterase Gene Family in Toxoplasma gondii Tachyzoites.
mSphere.
2022 02; 7(1):e0079321. doi:
10.1128/msphere.00793-21. [PMID: 35107337] - Min Yan, Yan Wang, Ritesh Balaso Watharkar, Yunfeng Pu, Cuiyun Wu, Minjuan Lin, Dengyang Lu, Mingzhe Liu, Jingkai Bao, Yilei Xia. Physicochemical and antioxidant activity of fruit harvested from eight jujube (Ziziphus jujuba Mill.) cultivars at different development stages.
Scientific reports.
2022 02; 12(1):2272. doi:
10.1038/s41598-022-06313-5. [PMID: 35145206] - Yaqing Zhang, Yonghua Li, Qilong Wang, Dongyu Zheng, Xue Feng, Wei Zhao, Linlin Cai, Qingqing Zhang, Haitao Xu, Hailong Fu. Attenuation of hepatic ischemia‑reperfusion injury by adipose stem cell‑derived exosome treatment via ERK1/2 and GSK‑3β signaling pathways.
International journal of molecular medicine.
2022 02; 49(2):. doi:
10.3892/ijmm.2021.5068. [PMID: 34878156] - Mitsugi Ookawara, Yasunori Nio. Phosphodiesterase 4 inhibitors in diabetic nephropathy.
Cellular signalling.
2022 02; 90(?):110185. doi:
10.1016/j.cellsig.2021.110185. [PMID: 34785349] - Atsuya Urita, Yohei Ishibashi, Ryotaro Kawaguchi, Yukimi Yanase, Motohiro Tani. Crosstalk between protein kinase A and the HOG pathway under impaired biosynthesis of complex sphingolipids in budding yeast.
The FEBS journal.
2022 02; 289(3):766-786. doi:
10.1111/febs.16188. [PMID: 34492172] - Shin-Sook Yoon, Hyuk-Woo Kwon, Jung-Hae Shin, Man Hee Rhee, Chang-Eun Park, Dong-Ha Lee. Anti-Thrombotic Effects of Artesunate through Regulation of cAMP and PI3K/MAPK Pathway on Human Platelets.
International journal of molecular sciences.
2022 Jan; 23(3):. doi:
10.3390/ijms23031586. [PMID: 35163507] - Hee Jung Kim, Dong Uk Im, Gia Cac Chau, Neeraj Kumar Mishra, In Su Kim, Sung Hee Um. Novel anti-adipogenic effect of CF3-allylated indole in 3T3-L1 cells.
Chemico-biological interactions.
2022 Jan; 352(?):109782. doi:
10.1016/j.cbi.2021.109782. [PMID: 34932954] - Andrew Lutas, Kayla Fernando, Stephen X Zhang, Abhijeet Sambangi, Mark L Andermann. History-dependent dopamine release increases cAMP levels in most basal amygdala glutamatergic neurons to control learning.
Cell reports.
2022 01; 38(4):110297. doi:
10.1016/j.celrep.2022.110297. [PMID: 35081349] - Muhammad Aslam, Yury Ladilov. Emerging Role of cAMP/AMPK Signaling.
Cells.
2022 01; 11(2):. doi:
10.3390/cells11020308. [PMID: 35053423] - Sandrine Baltzer, Timur Bulatov, Christopher Schmied, Andreas Krämer, Benedict-Tilman Berger, Andreas Oder, Ryan Walker-Gray, Christin Kuschke, Kerstin Zühlke, Jenny Eichhorst, Martin Lehmann, Stefan Knapp, John Weston, Jens Peter von Kries, Roderich D Süssmuth, Enno Klussmann. Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells.
International journal of molecular sciences.
2022 Jan; 23(2):. doi:
10.3390/ijms23020763. [PMID: 35054947] - Teng Ma, Weisheng Lu, Yongkang Wang, Peng Qian, Hong Tian, Xiangdong Gao, Wenbing Yao. An oral GLP-1 and GIP dual receptor agonist improves metabolic disorders in high fat-fed mice.
European journal of pharmacology.
2022 Jan; 914(?):174635. doi:
10.1016/j.ejphar.2021.174635. [PMID: 34800466] - Shijun Yan, Jason M Conley, Austin M Reilly, Natalie D Stull, Surabhi D Abhyankar, Aaron C Ericsson, Tatsuyoshi Kono, Andrei I Molosh, Chandrashekhar A Kubal, Carmella Evans-Molina, Hongxia Ren. Intestinal Gpr17 deficiency improves glucose metabolism by promoting GLP-1 secretion.
Cell reports.
2022 01; 38(1):110179. doi:
10.1016/j.celrep.2021.110179. [PMID: 34986353] - Yash R Mehta, Spencer A Lewis, Kirby T Leo, Lihe Chen, Euijung Park, Viswanathan Raghuram, Chung-Lin Chou, Chin-Rang Yang, Hiroaki Kikuchi, Syed Khundmiri, Brian G Poll, Mark A Knepper. 'ADPKD-omics': determinants of cyclic AMP levels in renal epithelial cells.
Kidney international.
2022 01; 101(1):47-62. doi:
10.1016/j.kint.2021.10.014. [PMID: 34757121] - Leandro Bueno Bergantin. Neuroinflammation, Diabetes and COVID-19: Perspectives Coming from Ca2+/cAMP Signalling.
Current drug research reviews.
2022; 14(1):6-10. doi:
10.2174/2589977514666211231141401. [PMID: 34970961] - Xu Feng, Ye Xiao, Qi Guo, Hui Peng, Hai-Yan Zhou, Jian-Ping Wang, Zhu-Ying Xia. Parathyroid hormone alleviates non-alcoholic liver steatosis via activating the hepatic cAMP/PKA/CREB pathway.
Frontiers in endocrinology.
2022; 13(?):899731. doi:
10.3389/fendo.2022.899731. [PMID: 36060945] - Thomas C Rich, Wenkuan Xin, Silas J Leavesley, C Michael Francis, Mark Taylor. Ion Channel-Based Reporters for cAMP Detection.
Methods in molecular biology (Clifton, N.J.).
2022; 2483(?):265-279. doi:
10.1007/978-1-0716-2245-2_17. [PMID: 35286682] - Ilkay Erdogan Orhan, Abdur Rauf, Muhammad Saleem, Anees Ahmed Khalil. Natural Molecules as Talented Inhibitors of Nucleotide Pyrophosphatases/ Phosphodiesterases (PDEs).
Current topics in medicinal chemistry.
2022; 22(3):209-228. doi:
10.2174/1568026621666210909164118. [PMID: 34503407] - Leandro B Bergantin. A Timeline of Ca2+/cAMP Signalling: From Basic Research to Potential Therapeutics for Dementia.
Current Alzheimer research.
2022; 19(3):179-187. doi:
10.2174/1567205019666220415125447. [PMID: 35430979] - Teng Fu, Hyun-Hoo Park, Kyoung Su Kim. Role of the cAMP signaling pathway in the dissemination and development on pepper fruit anthracnose disease caused by Colletotrichum scovillei.
Frontiers in cellular and infection microbiology.
2022; 12(?):1003195. doi:
10.3389/fcimb.2022.1003195. [PMID: 36262188] - Yoshihisa Yamada, Hiroyuki Fujiki, Hiroshi Mizuguchi, Yukinobu Takeshita, Katsuji Hattori, Koji Ohmoto, Miki Aihara, Keisuke Nagano, Yoshimasa Isakari, Miho Yamamoto, Yoshitaka Yamamura. [Tolvaptan, a vasopressin V2 receptor antagonist, is the world's first approved drug for treatment of autosomal dominant polycystic kidney disease (ADPKD)].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2022; 157(4):254-260. doi:
10.1254/fpj.22006. [PMID: 35781456] - Oleg Dyachok, Yunjian Xu, Olof Idevall-Hagren, Anders Tengholm. Fluorescent Translocation Reporters for Sub-plasma Membrane cAMP Imaging.
Methods in molecular biology (Clifton, N.J.).
2022; 2483(?):319-338. doi:
10.1007/978-1-0716-2245-2_20. [PMID: 35286685] - Leandro Bueno Bergantin. The Interactions among Hypertension, Cancer, and COVID-19: Perspective with Regard to Ca2+/cAMP Signalling.
Current cancer drug targets.
2022; 22(5):351-360. doi:
10.2174/1568009622666220215143805. [PMID: 35168520] - Nobuko Kuroishi, Sayaka Nagata, Emiko Akashi, Shinya Ashizuka, Johji Kato, Motoo Yamasaki, Kazuo Kitamura. Development of a novel human adrenomedullin derivative: human serum albumin-conjugated adrenomedullin.
Journal of biochemistry.
2021 Dec; 170(4):445-451. doi:
10.1093/jb/mvab057. [PMID: 33964134] - Haruka Sasaki, Yi Zhang, Charles W Emala, Kentaro Mizuta. Melatonin MT2 receptor is expressed and potentiates contraction in human airway smooth muscle.
American journal of physiology. Lung cellular and molecular physiology.
2021 12; 321(6):L991-L1005. doi:
10.1152/ajplung.00273.2021. [PMID: 34612067] - Shabbir Ahmed, Yonggyun Kim. PGE2 mediates hemocyte-spreading behavior by activating aquaporin via cAMP and rearranging actin cytoskeleton via Ca2.
Developmental and comparative immunology.
2021 12; 125(?):104230. doi:
10.1016/j.dci.2021.104230. [PMID: 34388674] - Tiphaine Belleville-Rolland, Alexandre Leuci, Alexandre Mansour, Benoit Decouture, Fanny Martin, Sonia Poirault-Chassac, Margot Rouaud, Hippolyte Guerineau, Blandine Dizier, Dominique Pidard, Pascale Gaussem, Christilla Bachelot-Loza. Role of Membrane Lipid Rafts in MRP4 (ABCC4) Dependent Regulation of the cAMP Pathway in Blood Platelets.
Thrombosis and haemostasis.
2021 12; 121(12):1628-1636. doi:
10.1055/a-1481-2663. [PMID: 33851387] - Zhan-Guo Gao, R Rama Suresh, Kenneth A Jacobson. Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists.
Purinergic signalling.
2021 12; 17(4):737-746. doi:
10.1007/s11302-021-09823-5. [PMID: 34713378] - Youchao Qi, Linkai Shi, Guozhen Duan, Yonggui Ma, Peifeng Li. Taurochenodeoxycholic Acid Increases cAMP Content via Specially Interacting with Bile Acid Receptor TGR5.
Molecules (Basel, Switzerland).
2021 Nov; 26(23):. doi:
10.3390/molecules26237066. [PMID: 34885648] - Ahmad Qasem, Abed Elrahman Naser, Saleh A Naser. Enteropathogenic infections modulate intestinal serotonin transporter (SERT) function by activating Toll-like receptor 2 (TLR-2) in Crohn's disease.
Scientific reports.
2021 11; 11(1):22624. doi:
10.1038/s41598-021-02050-3. [PMID: 34799637] - Liangfeng Huang, Kai Xiao, Junjun Zhang, Pengfei Zhang, Wengtan He, Yuyan Tang, Weihan Yang, Xingchen Huang, Runfeng Liu, Xianwei Liang, Xingting Liu, Qiang Fu, Yangqing Lu, Ming Zhang. Comparative transcriptome analysis reveals potential testosterone function-related regulatory genes/pathways of Leydig cells in immature and mature buffalo (Bubalus bubalis) testes.
Gene.
2021 Nov; 802(?):145870. doi:
10.1016/j.gene.2021.145870. [PMID: 34363886] - Vishal R Patel, Arturo M Salinas, Darong Qi, Shipra Gupta, David J Sidote, Marcel P Goldschen-Ohm. Single-molecule imaging with cell-derived nanovesicles reveals early binding dynamics at a cyclic nucleotide-gated ion channel.
Nature communications.
2021 11; 12(1):6459. doi:
10.1038/s41467-021-26816-5. [PMID: 34753946] - Jianzeng Liu, Rui Jiang, Jingyuan Zhou, Xiaohao Xu, Zhuo Sun, Jing Li, Xuenan Chen, Zhenzhuo Li, Xiuci Yan, Daqing Zhao, Zemiao Zheng, Liwei Sun. Salicylic acid in ginseng root alleviates skin hyperpigmentation disorders by inhibiting melanogenesis and melanosome transport.
European journal of pharmacology.
2021 Nov; 910(?):174458. doi:
10.1016/j.ejphar.2021.174458. [PMID: 34480884] - Emma T B Olesen, Robert A Fenton. Aquaporin 2 regulation: implications for water balance and polycystic kidney diseases.
Nature reviews. Nephrology.
2021 11; 17(11):765-781. doi:
10.1038/s41581-021-00447-x. [PMID: 34211154] - Shamil N Galimov, Julia Y Gromenko, Kirill V Bulygin, Kamil Sh Galimov, Elmira F Galimova, Mikhail Y Sinelnikov. The level of secondary messengers and the redox state of NAD+/NADH are associated with sperm quality in infertility.
Journal of reproductive immunology.
2021 11; 148(?):103383. doi:
10.1016/j.jri.2021.103383. [PMID: 34534880] - Laura Wilson, Alice E Pollard, Lucy Penfold, Phillip J Muckett, Chad Whilding, Mohammad Bohlooly-Y, Patricia Wilson, David Carling. Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype.
Clinical science (London, England : 1979).
2021 10; 135(20):2393-2408. doi:
10.1042/cs20210821. [PMID: 34622923] - Kiran L Sharma, Shuo Jia, Tasnim H Beacon, Ifeoluwa Adewumi, Camila López, Pingzhao Hu, Wayne Xu, James R Davie. Mitogen-induced transcriptional programming in human fibroblasts.
Gene.
2021 Oct; 800(?):145842. doi:
10.1016/j.gene.2021.145842. [PMID: 34274479] - Shang Yang, Oana M Constantin, Divya Sachidanandan, Hannes Hofmann, Tobias C Kunz, Vera Kozjak-Pavlovic, Thomas G Oertner, Georg Nagel, Robert J Kittel, Christine E Gee, Shiqiang Gao. PACmn for improved optogenetic control of intracellular cAMP.
BMC biology.
2021 10; 19(1):227. doi:
10.1186/s12915-021-01151-9. [PMID: 34663304] - Kaili Chang, Ruqun Xue, Minglai Zhao, Yuqing Zhao, Weien Yu, Zhonghua Zhao, Xueguang Liu. EP300/CBP is crucial for cAMP-PKA pathway to alleviate podocyte dedifferentiation via targeting Notch3 signaling.
Experimental cell research.
2021 10; 407(2):112825. doi:
10.1016/j.yexcr.2021.112825. [PMID: 34506759] - Alex D White, Karina A Peña, Lisa J Clark, Christian Santa Maria, Shi Liu, Frédéric G Jean-Alphonse, Ji Young Lee, Saifei Lei, Zhiqiang Cheng, Chia-Ling Tu, Fei Fang, Nicholas Szeto, Thomas J Gardella, Kunhong Xiao, Samuel H Gellman, Ivet Bahar, Ieva Sutkeviciute, Wenhan Chang, Jean-Pierre Vilardaga. Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation.
Science signaling.
2021 Oct; 14(703):eabc5944. doi:
10.1126/scisignal.abc5944. [PMID: 34609896] - Kanako Miyano, Yuki Yoshida, Shigeto Hirayama, Hideki Takahashi, Haruka Ono, Yoshiyuki Meguro, Sei Manabe, Akane Komatsu, Miki Nonaka, Takaaki Mizuguchi, Hideaki Fujii, Yoshikazu Higami, Minoru Narita, Yasuhito Uezono. Oxytocin Is a Positive Allosteric Modulator of κ-Opioid Receptors but Not δ-Opioid Receptors in the G Protein Signaling Pathway.
Cells.
2021 10; 10(10):. doi:
10.3390/cells10102651. [PMID: 34685631] - Munkhzaya Byambaragchaa, Hoon-Ki Seong, Seung-Hee Choi, Dae-Jung Kim, Myung-Hwa Kang, Kwan-Sik Min. Constitutively Activating Mutants of Equine LH/CGR Constitutively Induce Signal Transduction and Inactivating Mutations Impair Biological Activity and Cell-Surface Receptor Loss In Vitro.
International journal of molecular sciences.
2021 Oct; 22(19):. doi:
10.3390/ijms221910723. [PMID: 34639064] - Giorgia Schena, Monica Carmosino, Samantha Chiurlia, Laura Onuchic, Mauro Mastropasqua, Eugenio Maiorano, Francesco P Schena, Michael J Caplan. β3 adrenergic receptor as potential therapeutic target in ADPKD.
Physiological reports.
2021 10; 9(20):e15058. doi:
10.14814/phy2.15058. [PMID: 34676684] - Annarita Di Mise, Xiaofang Wang, Hong Ye, Lorenzo Pellegrini, Vicente E Torres, Giovanna Valenti. Pre-clinical evaluation of dual targeting of the GPCRs CaSR and V2R as therapeutic strategy for autosomal dominant polycystic kidney disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 10; 35(10):e21874. doi:
10.1096/fj.202100774r. [PMID: 34486176] - Thomas C Rich, Silas J Leavesley, Angela P Brandon, Cilina A Evans, S Vamsee Raju, Brant M Wagener. Phosphodiesterase 4 mediates interleukin-8-induced heterologous desensitization of the β2 -adrenergic receptor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 10; 35(10):e21946. doi:
10.1096/fj.202002712rr. [PMID: 34555226] - Komal Thapa, Thakur Gurjeet Singh, Amarjot Kaur. Cyclic nucleotide phosphodiesterase inhibition as a potential therapeutic target in renal ischemia reperfusion injury.
Life sciences.
2021 Oct; 282(?):119843. doi:
10.1016/j.lfs.2021.119843. [PMID: 34298037] - Momoka Yamaguchi, Naoki Dohi, Akira Ooka, Shin-Ya Saito, Tomohisa Ishikawa. Caffeine-induced inversion of prostaglandin E2 effects on hepatic stellate cell activation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Oct; 142(?):111989. doi:
10.1016/j.biopha.2021.111989. [PMID: 34388524] - Guoping Chen, Hong Wang, Wenjing Zhang, Jiaqiang Zhou. Dapagliflozin Reduces Urinary Albumin Excretion by Downregulating the Expression of cAMP, MAPK, and cGMP-PKG Signaling Pathways Associated Genes.
Genetic testing and molecular biomarkers.
2021 Oct; 25(10):627-637. doi:
10.1089/gtmb.2021.0086. [PMID: 34672772]