(2R)-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one (BioDeep_00000840366)
代谢物信息卡片
(2R)-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
化学式: C15H12O5 (272.0684702)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC=C(C=C3)O
InChI: InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2/t13-/m1/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D004965 - Estrogen Antagonists
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sharat Sarmah, Archita Goswami, Vinay Kumar Belwal, Atanu Singha Roy. Mitigation of ribose and glyoxal induced glycation, AGEs formation and aggregation of human serum albumin by citrus fruit phytochemicals naringin and naringenin: An insight into their mechanism of action.
Food research international (Ottawa, Ont.).
2022 Jul; 157(?):111358. doi:
10.1016/j.foodres.2022.111358. [PMID: 35761621] - Sakshi Verma, Smriti Batoye, Rajinder Jindal. Protective efficacy of naringenin against cadmium-induced redox imbalance in Labeo rohita: an integrated biomarker approach.
Environmental science and pollution research international.
2022 Apr; 29(17):25591-25604. doi:
10.1007/s11356-021-17703-z. [PMID: 34846652] - Ru-Rong Gu, Xian-Hua Meng, Yin Zhang, Hai-Yan Xu, Li Zhan, Zhao-Bing Gao, Jun-Li Yang, Yue-Ming Zheng. (-)-Naringenin 4',7-dimethyl Ether Isolated from Nardostachys jatamansi Relieves Pain through Inhibition of Multiple Channels.
Molecules (Basel, Switzerland).
2022 Mar; 27(5):. doi:
10.3390/molecules27051735. [PMID: 35268839] - Nada Oršolić, Johann Nemrava, Željko Jeleč, Marina Kukolj, Dyana Odeh, Boris Jakopović, Maja Jazvinšćak Jembrek, Tomica Bagatin, Rajko Fureš, Dinko Bagatin. Antioxidative and Anti-Inflammatory Activities of Chrysin and Naringenin in a Drug-Induced Bone Loss Model in Rats.
International journal of molecular sciences.
2022 Mar; 23(5):. doi:
10.3390/ijms23052872. [PMID: 35270014] - Fatemeh Naeini, Zahra Namkhah, Helda Tutunchi, Seyed Mahdi Rezayat, Siavash Mansouri, Mehdi Yaseri, Mohammad Javad Hosseinzadeh-Attar. Effects of naringenin supplementation on cardiovascular risk factors in overweight/obese patients with nonalcoholic fatty liver disease: a pilot double-blind, placebo-controlled, randomized clinical trial.
European journal of gastroenterology & hepatology.
2022 03; 34(3):345-353. doi:
10.1097/meg.0000000000002323. [PMID: 34860705] - Naglaa M Ammar, Heba A Hassan, Heba M I Abdallah, Sherif M Afifi, Abdelbaset M Elgamal, Abdel Razik H Farrag, Abd El-Nasser G El-Gendy, Mohamed A Farag, Abdelsamed I Elshamy. Protective Effects of Naringenin from Citrus sinensis (var. Valencia) Peels against CCl4-Induced Hepatic and Renal Injuries in Rats Assessed by Metabolomics, Histological and Biochemical Analyses.
Nutrients.
2022 Feb; 14(4):. doi:
10.3390/nu14040841. [PMID: 35215494] - Yi Yang, Jiuying Liu, Weiwei Xu. Naringenin and morin reduces insulin resistance and endometrial hyperplasia in the rat model of polycystic ovarian syndrome through enhancement of inflammation and autophagic apoptosis.
Acta biochimica Polonica.
2022 Feb; 69(1):91-100. doi:
10.18388/abp.2020_5722. [PMID: 35143137] - Suresh S Dhanisha, Sudarsanan Drishya, Karyath P Gangaraj, Muliyar K Rajesh, Chandrasekharan Guruvayoorappan. Molecular Docking Studies of Naringenin and its Protective Efficacy against Methotrexate Induced Oxidative Tissue Injury.
Anti-cancer agents in medicinal chemistry.
2022; 22(1):169-180. doi:
10.2174/1871520621666210322102915. [PMID: 34225639] - Hui Liu, Hui Zhao, Jingjin Che, Weijie Yao. Naringenin Protects against Hypertension by Regulating Lipid Disorder and Oxidative Stress in a Rat Model.
Kidney & blood pressure research.
2022; 47(6):423-432. doi:
10.1159/000524172. [PMID: 35354142] - Osama M Ahmed, Adel A Ahmed, Hanaa I Fahim, Mohamed Y Zaky. Quercetin and naringenin abate diethylnitrosamine/acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats: the roles of oxidative stress, inflammation and cell apoptosis.
Drug and chemical toxicology.
2022 Jan; 45(1):262-273. doi:
10.1080/01480545.2019.1683187. [PMID: 31665932] - Shujun Xu, Bingxin Wu, Biying Zhong, Luoqi Lin, Yining Ding, Xiao Jin, Zhiwei Huang, Miaoyang Lin, Huanlin Wu, Danping Xu. Naringenin alleviates myocardial ischemia/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2) /System xc-/ glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis.
Bioengineered.
2021 12; 12(2):10924-10934. doi:
10.1080/21655979.2021.1995994. [PMID: 34699317] - Abdulkadir Şahin, Muhammed Sedat Sakat, Korhan Kılıç, Bülent Aktan, Serkan Yildirim, Fatih Mehmet Kandemir, Muhammed Bahaeddin Dortbudak, Sefa Kucukler. The protective effect of Naringenin against ovalbumin-induced allergic rhinitis in rats.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery.
2021 Dec; 278(12):4839-4846. doi:
10.1007/s00405-021-06769-7. [PMID: 33772317] - Fatemeh Naeini, Zahra Namkhah, Helda Tutunchi, Seyed Mahdi Rezayat, Siavash Mansouri, Seyed Ali Jazayeri-Tehrani, Mehdi Yaseri, Mohammad Javad Hosseinzadeh-Attar. Effects of naringenin supplementation in overweight/obese patients with non-alcoholic fatty liver disease: study protocol for a randomized double-blind clinical trial.
Trials.
2021 Nov; 22(1):801. doi:
10.1186/s13063-021-05784-7. [PMID: 34774104] - Rhubaniya Mahendran, Soo Kun Lim, Kien Chai Ong, Kek Heng Chua, Hwa Chia Chai. Natural-derived compounds and their mechanisms in potential autosomal dominant polycystic kidney disease (ADPKD) treatment.
Clinical and experimental nephrology.
2021 Nov; 25(11):1163-1172. doi:
10.1007/s10157-021-02111-x. [PMID: 34254206] - Hany Elsawy, Abdullah M Alzahrani, Manal Alfwuaires, Ashraf M Abdel-Moneim, Mahmoud Khalil. Nephroprotective effect of naringin in methotrexate induced renal toxicity in male rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Nov; 143(?):112180. doi:
10.1016/j.biopha.2021.112180. [PMID: 34536756] - A Madeswaran, S Brahmasundari, P G Midhuna. In silico molecular docking studies of certain commercially available flavonoids as effective antiviral agents against spike glycoprotein of SARS-CoV-2.
European review for medical and pharmacological sciences.
2021 Nov; 25(21):6741-6744. doi:
10.26355/eurrev_202111_27119. [PMID: 34787879] - Zahra Namkhah, Fatemeh Naeini, Seyed Mahdi Rezayat, Mehdi Yaseri, Siavash Mansouri, Mohammad Javad Hosseinzadeh-Attar. Does naringenin supplementation improve lipid profile, severity of hepatic steatosis and probability of liver fibrosis in overweight/obese patients with NAFLD? A randomised, double-blind, placebo-controlled, clinical trial.
International journal of clinical practice.
2021 Nov; 75(11):e14852. doi:
10.1111/ijcp.14852. [PMID: 34516703] - Bide Duan, Yuan Li, Hui Geng, Airong Ma, Xiuzhi Yang. Naringenin prevents pregnancy-induced hypertension via suppression of JAK/STAT3 signalling pathway in mice.
International journal of clinical practice.
2021 Oct; 75(10):e14509. doi:
10.1111/ijcp.14509. [PMID: 34117816] - A Hajizadeh, S M Abtahi Froushani, A A Tehrani, S Azizi, S R Bani Hashemi. Effects of Naringenin on Experimentally Induced Rheumatoid Arthritis in Wistar Rats.
Archives of Razi Institute.
2021 10; 76(4):903-912. doi:
10.22092/ari.2020.351612.1527. [PMID: 35096326] - Ravindra Babu Pingili, Sridhar Vemulapalli, Vijaya R Dirisala, Surya Sandeep Mullapudi, Yamini Gullapalli, Naveen Babu Kilaru. Effect of naringenin on the pharmacokinetics of metoprolol succinate in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2021 Aug; 51(8):926-932. doi:
10.1080/00498254.2021.1942311. [PMID: 34138683] - Xiaolan Xu, Lulu Shen, Qiuchi Xu, Xiaochen Bai, Zhonggui He, Tianhong Zhang, Qikun Jiang. Development and optimization of a high-throughput HPLC-MS/MS method for the simultaneous determination of naringenin and its valine carbamate prodrug in rat plasma.
Biomedical chromatography : BMC.
2021 Aug; 35(8):e5119. doi:
10.1002/bmc.5119. [PMID: 33749889] - Antonella D'Amore, Antonella Gradogna, Fioretta Palombi, Velia Minicozzi, Matteo Ceccarelli, Armando Carpaneto, Antonio Filippini. The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection.
Cells.
2021 05; 10(5):. doi:
10.3390/cells10051130. [PMID: 34067054] - Xiaolan Xu, Yiqin Lv, Kuanjin Tang, Bin Song, Qikun Jiang, Lingling Sun, Zhonggui He, Tianhong Zhang. The simultaneous determination of naringenin and its valine carbamate prodrug in rat plasma using supercritical fluid chromatography -tandem mass spectrometric method.
Journal of pharmaceutical and biomedical analysis.
2021 Feb; 195(?):113848. doi:
10.1016/j.jpba.2020.113848. [PMID: 33421667] - Emilio Di Maria, Paolo Martini, Massimo Gennarelli. Naringerin as candidate drug against SARS-CoV-2: The role for TPC2 genomic variants in COVID-19.
Pharmacological research.
2021 02; 164(?):105402. doi:
10.1016/j.phrs.2020.105402. [PMID: 33359911] - Rui Hu, Shu Liu, Gulinigaer Anwaier, Qinyu Wang, Wanli Shen, Qiang Shen, Rong Qi. Formulation and intestinal absorption of naringenin loaded nanostructured lipid carrier and its inhibitory effects on nonalcoholic fatty liver disease.
Nanomedicine : nanotechnology, biology, and medicine.
2021 02; 32(?):102310. doi:
10.1016/j.nano.2020.102310. [PMID: 33184021] - Yi Qiao Hua, Yi Zeng, Jin Xu, Xiao Le Xu. Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe-/-mice: role of SIRT1.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Jan; 81(?):153412. doi:
10.1016/j.phymed.2020.153412. [PMID: 33234364] - Yanfei Du, Jun Ma, Yu Fan, Xinyu Wang, Shuzhan Zheng, Jian Feng, Jiafu Li, Zhongcai Fan, Guang Li, Qiang Ye. Naringenin: A Promising Therapeutic Agent against Organ Fibrosis.
Oxidative medicine and cellular longevity.
2021; 2021(?):1210675. doi:
10.1155/2021/1210675. [PMID: 34804359] - Nicola Clementi, Carolina Scagnolari, Antonella D'Amore, Fioretta Palombi, Elena Criscuolo, Federica Frasca, Alessandra Pierangeli, Nicasio Mancini, Guido Antonelli, Massimo Clementi, Armando Carpaneto, Antonio Filippini. Naringenin is a powerful inhibitor of SARS-CoV-2 infection in vitro.
Pharmacological research.
2021 01; 163(?):105255. doi:
10.1016/j.phrs.2020.105255. [PMID: 33096221] - Theresa Saenger, Florian Hübner, Viktoria Lindemann, Kristina Ganswind, Hans-Ulrich Humpf. Urinary Biomarkers for Orange Juice Consumption.
Molecular nutrition & food research.
2021 01; 65(2):e2000781. doi:
10.1002/mnfr.202000781. [PMID: 33216459] - Yogesh A Kulkarni, Sachin V Suryavanshi. Combination of Naringenin and Lisinopril Ameliorates Nephropathy in Type-1 Diabetic Rats.
Endocrine, metabolic & immune disorders drug targets.
2021; 21(1):173-182. doi:
10.2174/1871530320666200516163919. [PMID: 32416710] - Jicang Wang, Huali Zhu, Shu Lin, Ke Wang, Hongwei Wang, Zongping Liu. Protective effect of naringenin against cadmium-induced testicular toxicity in male SD rats.
Journal of inorganic biochemistry.
2021 01; 214(?):111310. doi:
10.1016/j.jinorgbio.2020.111310. [PMID: 33221601] - Helda Tutunchi, Fatemeh Naeini, Alireza Ostadrahimi, Mohammad Javad Hosseinzadeh-Attar. Naringenin, a flavanone with antiviral and anti-inflammatory effects: A promising treatment strategy against COVID-19.
Phytotherapy research : PTR.
2020 Dec; 34(12):3137-3147. doi:
10.1002/ptr.6781. [PMID: 32613637] - Bo Wang, Jiquan Shen, Quan Zhou, Deru Meng, Youwu He, Feifei Chen, Shuanghu Wang, Weiping Ji. Effects of naringenin on the pharmacokinetics of tofacitinib in rats.
Pharmaceutical biology.
2020 Dec; 58(1):225-230. doi:
10.1080/13880209.2020.1738504. [PMID: 32202190] - Mio Nakashima, Misaki Hisada, Natsuko Goda, Takeshi Tenno, Ayaka Kotake, Yuko Inotsume, Ikuo Kameoka, Hidekazu Hiroaki. Opposing Effect of Naringenin and Quercetin on the Junctional Compartment of MDCK II Cells to Modulate the Tight Junction.
Nutrients.
2020 Oct; 12(11):. doi:
10.3390/nu12113285. [PMID: 33120983] - Tajdar Husain Khan, Majid Ahmad Ganaie, Khalid Mofleh Alharthy, Hassan Madkhali, Basit Latief Jan, Ishfaq Ahmad Sheikh. Naringenin prevents doxorubicin-induced toxicity in kidney tissues by regulating the oxidative and inflammatory insult in Wistar rats.
Archives of physiology and biochemistry.
2020 Oct; 126(4):300-307. doi:
10.1080/13813455.2018.1529799. [PMID: 30406686] - Jesús Alfredo Araujo-León, Rolffy Ortiz-Andrade, Rivelino Armando Vera-Sánchez, Julio Enrique Oney-Montalvo, Tania Isolina Coral-Martínez, Zulema Cantillo-Ciau. Development and Optimization of a High Sensitivity LC-MS/MS Method for the Determination of Hesperidin and Naringenin in Rat Plasma: Pharmacokinetic Approach.
Molecules (Basel, Switzerland).
2020 Sep; 25(18):. doi:
10.3390/molecules25184241. [PMID: 32947773] - Mohd Shahnawaz Khan, Faizan Abul Qais, Md Tabish Rehman, Mohd Hasan Ismail, Majed S Alokail, Nojood Altwaijry, Nouf Omar Alafaleq, Mohamed F AlAjmi, Nusaibah Salem, Rawiah Alqhatani. Mechanistic inhibition of non-enzymatic glycation and aldose reductase activity by naringenin: Binding, enzyme kinetics and molecular docking analysis.
International journal of biological macromolecules.
2020 Sep; 159(?):87-97. doi:
10.1016/j.ijbiomac.2020.04.226. [PMID: 32437808] - Edith P Mato Mofo, M Faadiel Essop, Peter M O Owira. Citrus fruit-derived flavonoid naringenin and the expression of hepatic organic cation transporter 1 protein in diabetic rats treated with metformin.
Basic & clinical pharmacology & toxicology.
2020 Sep; 127(3):211-220. doi:
10.1111/bcpt.13407. [PMID: 32180335] - Ademola Adetokunbo Oyagbemi, Temidayo Olutayo Omobowale, Olumuyiwa Abiola Adejumobi, Abiodun Mary Owolabi, Blessing Seun Ogunpolu, Olufunke Olubunmi Falayi, Fasilat Oluwakemi Hassan, Iyanuoluwa Omolola Ogunmiluyi, Ebunoluwa Racheal Asenuga, Olufunke Eunice Ola-Davies, Kehinde Olugboyega Soetan, Adebowale Benard Saba, Adeolu Alex Adedapo, Sanah Malomile Nkadimeng, Lyndy Joy McGaw, Oluwafemi Omoniyi Oguntibeju, Momoh Audu Yakubu. Antihypertensive power of Naringenin is mediated via attenuation of mineralocorticoid receptor (MCR)/ angiotensin converting enzyme (ACE)/ kidney injury molecule (Kim-1) signaling pathway.
European journal of pharmacology.
2020 Aug; 880(?):173142. doi:
10.1016/j.ejphar.2020.173142. [PMID: 32422184] - Seema Zargar, Salman Alamery, Ahmed H Bakheit, Tanveer A Wani. Poziotinib and bovine serum albumin binding characterization and influence of quercetin, rutin, naringenin and sinapic acid on their binding interaction.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Jul; 235(?):118335. doi:
10.1016/j.saa.2020.118335. [PMID: 32278151] - Iasim Tahiri, Yaiza Garro-Aguilar, Valerie Cayssials, David Achaintre, Francesca Romana Mancini, Yahya Mahamat-Saleh, Marie-Christine Boutron-Ruault, Tilman Kühn, Verena Katzke, Heiner Boeing, Antonia Trichopoulou, Anna Karakatsani, Elisavet Valanou, Domenico Palli, Sabina Sieri, Maria Santucci de Magistris, Rosario Tumino, Alessandra Macciotta, Inge Huybrechts, Antonio Agudo, Augustin Scalbert, Raul Zamora-Ros. Urinary flavanone concentrations as biomarkers of dietary flavanone intakes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
The British journal of nutrition.
2020 03; 123(6):691-698. doi:
10.1017/s0007114519003131. [PMID: 31791423] - Amal A El Daibani, Yuecheng Xi, Lijun Luo, Xue Mei, Chunyang Zhou, Shin Yasuda, Ming-Cheh Liu. Sulfation of hesperetin, naringenin and apigenin by the human cytosolic sulfotransferases: a comprehensive analysis.
Natural product research.
2020 Mar; 34(6):797-803. doi:
10.1080/14786419.2018.1503264. [PMID: 30398375] - Ahmed Mokhtar Abu El-Saad, Wessam Mohamad Abdel-Wahab. Naringenin Attenuates Toxicity and Oxidative Stress Induced by Lambda-cyhalothrin in Liver of Male Rats.
Pakistan journal of biological sciences : PJBS.
2020 Mar; 23(4):510-517. doi:
10.3923/pjbs.2020.510.517. [PMID: 32363836] - Sofiene Ben Kaab, Laurence Lins, Marwa Hanafi, Iness Bettaieb Rebey, Magali Deleu, Marie-Laure Fauconnier, Riadh Ksouri, M Haissam Jijakli, Caroline De Clerck. Cynara cardunculus Crude Extract as a Powerful Natural Herbicide and Insight into the Mode of Action of Its Bioactive Molecules.
Biomolecules.
2020 01; 10(2):. doi:
10.3390/biom10020209. [PMID: 32023949] - Amayrani Abrego-Peredo, Héctor Romero-Ramírez, Enrique Espinosa, Gabriela López-Herrera, Fabio García-García, Mónica Flores-Muñoz, Claudia Sandoval-Montes, Juan Carlos Rodríguez-Alba. Naringenin mitigates autoimmune features in lupus-prone mice by modulation of T-cell subsets and cytokines profile.
PloS one.
2020; 15(5):e0233138. doi:
10.1371/journal.pone.0233138. [PMID: 32421738] - Lara Testai, Eugenia Piragine, Ilaria Piano, Lorenzo Flori, Eleonora Da Pozzo, Vincenzo Miragliotta, Andrea Pirone, Valentina Citi, Lorenzo Di Cesare Mannelli, Simone Brogi, Sara Carpi, Alma Martelli, Paola Nieri, Claudia Martini, Carla Ghelardini, Claudia Gargini, Vincenzo Calderone. The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1.
Oxidative medicine and cellular longevity.
2020; 2020(?):4650207. doi:
10.1155/2020/4650207. [PMID: 32047577] - Jianli Liu, Zhijun Yang, Ye Cheng, Qiong Wu, Yin He, Qijiu Li, Xiangyu Cao. Eriodictyol and naringenin inhibit the formation of AGEs: An in vitro and molecular interaction study.
Journal of molecular recognition : JMR.
2020 01; 33(1):e2814. doi:
10.1002/jmr.2814. [PMID: 31637788] - Ricardo Wesley Alberca, Franciane Mouradian Emidio Teixeira, Danielle Rosa Beserra, Emily Araujo de Oliveira, Milena Mary de Souza Andrade, Anna Julia Pietrobon, Maria Notomi Sato. Perspective: The Potential Effects of Naringenin in COVID-19.
Frontiers in immunology.
2020; 11(?):570919. doi:
10.3389/fimmu.2020.570919. [PMID: 33101291] - Candida J Rebello, Robbie A Beyl, Juan J L Lertora, Frank L Greenway, Eric Ravussin, David M Ribnicky, Alexander Poulev, Brandon J Kennedy, Hector F Castro, Shawn R Campagna, Ann A Coulter, Leanne M Redman. Safety and pharmacokinetics of naringenin: A randomized, controlled, single-ascending-dose clinical trial.
Diabetes, obesity & metabolism.
2020 01; 22(1):91-98. doi:
10.1111/dom.13868. [PMID: 31468636] - Zuhal Uckun, Sevda Guzel, Necmiye Canacankatan, Cem Yalaza, Deniz Kibar, Banu Coskun Yilmaz. Potential protective effects of naringenin against vancomycin-induced nephrotoxicity via reduction on apoptotic and oxidative stress markers in rats.
Drug and chemical toxicology.
2020 Jan; 43(1):104-111. doi:
10.1080/01480545.2018.1512612. [PMID: 30257567] - Bin-Chun Li, Tian Zhang, Yan-Qin Li, Guo-Bin Ding. Target Discovery of Novel α-L-Rhamnosidases from Human Fecal Metagenome and Application for Biotransformation of Natural Flavonoid Glycosides.
Applied biochemistry and biotechnology.
2019 Dec; 189(4):1245-1261. doi:
10.1007/s12010-019-03063-5. [PMID: 31236895] - Xiaoting Xu, Tingwen Lei, Wenchao Li, Hailong Ou. Enhanced cellular cholesterol efflux by naringenin is mediated through inhibiting endoplasmic reticulum stress - ATF6 activity in macrophages.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2019 10; 1864(10):1472-1482. doi:
10.1016/j.bbalip.2019.06.005. [PMID: 31176760] - Rui Shi, Jia-Wen Xu, Zi-Ting Xiao, Ruo-Fei Chen, Yi-Lin Zhang, Jia-Bi Lin, Ke-Ling Cheng, Gu-Yi Wei, Pei-Bo Li, Wen-Liang Zhou, Wei-Wei Su. Naringin and Naringenin Relax Rat Tracheal Smooth by Regulating BKCa Activation.
Journal of medicinal food.
2019 Sep; 22(9):963-970. doi:
10.1089/jmf.2018.4364. [PMID: 31259654] - Lin Mu, Guoxin Hu, Jian Liu, Yan Chen, Wenjuan Cui, Lujun Qiao. Protective Effects of Naringenin in a Rat Model of Sepsis-Triggered Acute Kidney Injury via Activation of Antioxidant Enzymes and Reduction in Urinary Angiotensinogen.
Medical science monitor : international medical journal of experimental and clinical research.
2019 Aug; 25(?):5986-5991. doi:
10.12659/msm.916400. [PMID: 31401645] - Shumei Ding, Hongmei Qiu, Jiajun Huang, Rongchun Chen, Jie Zhang, Bo Huang, Xunliang Zou, Oumei Cheng, Qingsong Jiang. Activation of 20-HETE/PPARs involved in reno-therapeutic effect of naringenin on diabetic nephropathy.
Chemico-biological interactions.
2019 Jul; 307(?):116-124. doi:
10.1016/j.cbi.2019.05.004. [PMID: 31063766] - Amy C Burke, Brian G Sutherland, Dawn E Telford, Marisa R Morrow, Cynthia G Sawyez, Jane Y Edwards, Murray W Huff. Naringenin enhances the regression of atherosclerosis induced by a chow diet in Ldlr-/- mice.
Atherosclerosis.
2019 07; 286(?):60-70. doi:
10.1016/j.atherosclerosis.2019.05.009. [PMID: 31102954] - Mathabo Ruth Lutu, Sanelisiwe Nzuza, Pascale Edith Mofo Mato, Khmera Govender, Londiwe Mphumelelo Gumede, Sinenhlanhla Innocentia Kumalo, Nontokozo Nomfundo Mlambo, Ranjendraparsad Hurchund, Peter Mark Oroma Owira. DNA polymerase-γ hypothesis in nucleoside reverse transcriptase-induced mitochondrial toxicity revisited: A potentially protective role for citrus fruit-derived naringenin?.
European journal of pharmacology.
2019 Jun; 852(?):159-166. doi:
10.1016/j.ejphar.2019.03.017. [PMID: 30876974] - Xi Huang, Jianjun Xu, Juan He, Shaoqi Shi, Hongbin Yan, Jian Wang, Ping Ren. Pharmacokinetic study of the prokinetic ABCs liquiritigenin, naringenin and hesperitin following the oral administration of Si-Ni-San decoction to functional dyspepsia patients.
Xenobiotica; the fate of foreign compounds in biological systems.
2019 Jun; 49(6):708-717. doi:
10.1080/00498254.2018.1493756. [PMID: 30286676] - Kiran George, Nisha Susan Thomas, Raman Malathi. Modulatory Effect of Selected Dietary Phytochemicals on Delayed Rectifier K+ Current in Human Prostate Cancer Cells.
The Journal of membrane biology.
2019 06; 252(2-3):195-206. doi:
10.1007/s00232-019-00070-9. [PMID: 31165179] - Jia Liu, Hanqing Liu, Qingqi Zeng. The effect of naringenin on the pharmacokinetics of ibrutinib in rat: A drug-drug interaction study.
Biomedical chromatography : BMC.
2019 May; 33(5):e4507. doi:
10.1002/bmc.4507. [PMID: 30754071] - Amy C Burke, Dawn E Telford, Jane Y Edwards, Brian G Sutherland, Cynthia G Sawyez, Murray W Huff. Naringenin Supplementation to a Chow Diet Enhances Energy Expenditure and Fatty Acid Oxidation, and Reduces Adiposity in Lean, Pair-Fed Ldlr-/- Mice.
Molecular nutrition & food research.
2019 03; 63(6):e1800833. doi:
10.1002/mnfr.201800833. [PMID: 30578663] - Yanli Hong, Yanyun Yin, Yong Tan, Ke Hong, Huifang Zhou. The Flavanone, Naringenin, Modifies Antioxidant and Steroidogenic Enzyme Activity in a Rat Model of Letrozole-Induced Polycystic Ovary Syndrome.
Medical science monitor : international medical journal of experimental and clinical research.
2019 Jan; 25(?):395-401. doi:
10.12659/msm.912341. [PMID: 30636259] - Osama M Ahmed, Hanaa I Fahim, Heba Y Ahmed, Hessah Mohammed Al-Muzafar, Rasha R Ahmed, Kamal Adel Amin, El-Shaymaa El-Nahass, Walaa H Abdelazeem. The Preventive Effects and the Mechanisms of Action of Navel Orange Peel Hydroethanolic Extract, Naringin, and Naringenin in N-Acetyl-p-aminophenol-Induced Liver Injury in Wistar Rats.
Oxidative medicine and cellular longevity.
2019; 2019(?):2745352. doi:
10.1155/2019/2745352. [PMID: 31049130] - Amr A Fouad, Marwa M M Refaie, Manal I Abdelghany. Naringenin palliates cisplatin and doxorubicin gonadal toxicity in male rats.
Toxicology mechanisms and methods.
2019 Jan; 29(1):67-73. doi:
10.1080/15376516.2018.1512180. [PMID: 30106323] - Zhizhi Wang, Shanshan Wang, Jianqiao Zhao, Changan Yu, Yi Hu, Yimin Tu, Zufang Yang, Jingang Zheng, Yong Wang, Yanxiang Gao. Naringenin Ameliorates Renovascular Hypertensive Renal Damage by Normalizing the Balance of Renin-Angiotensin System Components in Rats.
International journal of medical sciences.
2019; 16(5):644-653. doi:
10.7150/ijms.31075. [PMID: 31217731] - Pauline Maciel August, Rafael Moura Maurmann, André Brum Saccomori, Mariana Crestani Scortegagna, Eduardo Borges Flores, Caroline Peres Klein, Bernardo Gindri Dos Santos, Vinicius Stone, Bárbara Mariño Dal Magro, Leo Cristhian, Carolina Nunes Santo, Régis Hözer, Cristiane Matté. Effect of maternal antioxidant supplementation and/or exercise practice during pregnancy on postnatal overnutrition induced by litter size reduction: Brain redox homeostasis at weaning.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2018 Dec; 71(?):146-155. doi:
10.1016/j.ijdevneu.2018.09.003. [PMID: 30232036] - Gurpreet Kaur, Kalpana Chauhan, Sukhbir Kaur. Immunotherapeutic potential of Codonopsis clematidea and naringenin against visceral leishmaniasis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Dec; 108(?):1048-1061. doi:
10.1016/j.biopha.2018.09.104. [PMID: 30372805] - Misturah Yetunde Adana, Edidiong Nnamso Akang, Edwin Coleridge Stephen Naidu, Peter Imo Aniekan, Koffi Kouame, Ugochukwu Offor, Oluwatosin Olalekan Ogedengbe, Onyemaechi Okpara Azu. Testicular microanatomical and hormonal alterations following use of antiretroviral therapy in Sprague Dawley rats: Role of Naringenin.
Andrologia.
2018 Nov; 50(9):e13137. doi:
10.1111/and.13137. [PMID: 30168163] - Chao Zhang, Wenfeng Zeng, Yi Yao, Bin Xu, Xiuli Wei, Luoyang Wang, Xiaozhe Yin, Apurba Kumar Barman, Fayun Zhang, Chunling Zhang, Qibin Song, Wei Liang. Naringenin Ameliorates Radiation-Induced Lung Injury by Lowering IL-1β Level.
The Journal of pharmacology and experimental therapeutics.
2018 08; 366(2):341-348. doi:
10.1124/jpet.118.248807. [PMID: 29866791] - Xuan Zeng, Weiwei Su, Hong Liu, Yuying Zheng, Taobin Chen, Weijian Zhang, Zenghao Yan, Yang Bai, Hongliang Yao. Simultaneous determination of rosuvastatin, naringin and naringenin in rat plasma by RRLC-MS/MS and its application to a pharmacokinetic drug interaction study.
Journal of chromatographic science.
2018 Aug; 56(7):611-618. doi:
10.1093/chromsci/bmy034. [PMID: 29701749] - Xuan Zeng, Weiwei Su, Yuying Zheng, Hong Liu, Panlin Li, Weijian Zhang, Yuting Liang, Yang Bai, Wei Peng, Hongliang Yao. UFLC-Q-TOF-MS/MS-Based Screening and Identification of Flavonoids and Derived Metabolites in Human Urine after Oral Administration of Exocarpium Citri Grandis Extract.
Molecules (Basel, Switzerland).
2018 Apr; 23(4):. doi:
10.3390/molecules23040895. [PMID: 29649170] - Vasanti M Suvarna, Preeti C Sangave. HPLC Estimation, Ex vivo Everted Sac Permeability and In Vivo Pharmacokinetic Studies of Darunavir.
Journal of chromatographic science.
2018 Apr; 56(4):307-316. doi:
10.1093/chromsci/bmx113. [PMID: 29342239] - Sugumar Mani, Sathiya Sekar, Rajamani Barathidasan, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Murugan Sevanan, Saravana Babu Chidambaram, Musthafa Mohamed Essa, Gilles J Guillemin, Meena Kishore Sakharkar. Naringenin Decreases α-Synuclein Expression and Neuroinflammation in MPTP-Induced Parkinson's Disease Model in Mice.
Neurotoxicity research.
2018 04; 33(3):656-670. doi:
10.1007/s12640-018-9869-3. [PMID: 29427283] - Mayank Kumar Singh, Deep Pooja, Halley Gora Ravuri, Anusha Gunukula, Hitesh Kulhari, Ramakrishna Sistla. Fabrication of surfactant-stabilized nanosuspension of naringenin to surpass its poor physiochemical properties and low oral bioavailability.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Feb; 40(?):48-54. doi:
10.1016/j.phymed.2017.12.021. [PMID: 29496174] - Jianqiao Yin, Yichao Liang, Dalu Wang, Zhaopeng Yan, Hongzhuan Yin, Di Wu, Qi Su. Naringenin induces laxative effects by upregulating the expression levels of c-Kit and SCF, as well as those of aquaporin 3 in mice with loperamide-induced constipation.
International journal of molecular medicine.
2018 Feb; 41(2):649-658. doi:
10.3892/ijmm.2017.3301. [PMID: 29207043] - Ashok K Singh, Vinit Raj, Amit K Keshari, Amit Rai, Pranesh Kumar, Atul Rawat, Biswanath Maity, Dinesh Kumar, Anand Prakash, Arnab De, Amalesh Samanta, Bolay Bhattacharya, Sudipta Saha. Isolated mangiferin and naringenin exert antidiabetic effect via PPARγ/GLUT4 dual agonistic action with strong metabolic regulation.
Chemico-biological interactions.
2018 Jan; 280(?):33-44. doi:
10.1016/j.cbi.2017.12.007. [PMID: 29223569] - Junpeng Wang, Xinli Niu, Chunfang Wu, Dayong Wu. Naringenin Modifies the Development of Lineage-Specific Effector CD4+ T Cells.
Frontiers in immunology.
2018; 9(?):2267. doi:
10.3389/fimmu.2018.02267. [PMID: 30327657] - Yong Li, Yiyuan Pan, Lin Gao, Jingzhu Zhang, Xiaochun Xie, Zhihui Tong, Baiqiang Li, Gang Li, Guotao Lu, Weiqin Li. Naringenin Protects against Acute Pancreatitis in Two Experimental Models in Mice by NLRP3 and Nrf2/HO-1 Pathways.
Mediators of inflammation.
2018; 2018(?):3232491. doi:
10.1155/2018/3232491. [PMID: 29849486] - Poonam Parashar, Chandra Bhushan Tripathi, Malti Arya, Jovita Kanoujia, Mahendra Singh, Abhishek Yadav, Amit Kumar, Anupam Guleria, Shubhini A Saraf. Biotinylated naringenin intensified anticancer effect of gefitinib in urethane-induced lung cancer in rats: favourable modulation of apoptotic regulators and serum metabolomics.
Artificial cells, nanomedicine, and biotechnology.
2018; 46(sup3):S598-S610. doi:
10.1080/21691401.2018.1505738. [PMID: 30322263] - Evgenios Stylos, Maria V Chatziathanasiadou, Antonis Tsiailanis, Tahsin F Kellici, Maria Tsoumani, Androniki D Kostagianni, Maria Deligianni, Alexandros D Tselepis, Andreas G Tzakos. Tailoring naringenin conjugates with amplified and triple antiplatelet activity profile: Rational design, synthesis, human plasma stability and in vitro evaluation.
Biochimica et biophysica acta. General subjects.
2017 Nov; 1861(11 Pt A):2609-2618. doi:
10.1016/j.bbagen.2017.08.018. [PMID: 28844979] - Osama M Ahmed, Mohamed A Hassan, Sanaa M Abdel-Twab, Manal N Abdel Azeem. Navel orange peel hydroethanolic extract, naringin and naringenin have anti-diabetic potentials in type 2 diabetic rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Oct; 94(?):197-205. doi:
10.1016/j.biopha.2017.07.094. [PMID: 28759757] - Xuan Zeng, Weiwei Su, Yang Bai, Taobin Chen, Zenghao Yan, Jiawei Wang, Minmin Su, Yuying Zheng, Wei Peng, Hongliang Yao. Urinary metabolite profiling of flavonoids in Chinese volunteers after consumption of orange juice by UFLC-Q-TOF-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Sep; 1061-1062(?):79-88. doi:
10.1016/j.jchromb.2017.07.015. [PMID: 28711784] - Gema Pereira-Caro, Thelma Polyviou, Iziar A Ludwig, Ana-Maria Nastase, José Manuel Moreno-Rojas, Ada L Garcia, Dalia Malkova, Alan Crozier. Bioavailability of orange juice (poly)phenols: the impact of short-term cessation of training by male endurance athletes.
The American journal of clinical nutrition.
2017 Sep; 106(3):791-800. doi:
10.3945/ajcn.116.149898. [PMID: 28747329] - Zafer Sahin, Ahmet Ozkaya, Gokhan Cuce, Mirac Uckun, Ertan Yologlu. Investigation of the effect of naringenin on oxidative stress-related alterations in testis of hydrogen peroxide-administered rats.
Journal of biochemical and molecular toxicology.
2017 Sep; 31(9):. doi:
10.1002/jbt.21928. [PMID: 28467669] - Junqin Liang, Yilinuer Halipu, Fengxia Hu, Buwajieer Yakeya, Wenjing Chen, Huan Zhang, Xiaojing Kang. Naringenin protects keratinocytes from oxidative stress injury via inhibition of the NOD2-mediated NF-κB pathway in pemphigus vulgaris.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Aug; 92(?):796-801. doi:
10.1016/j.biopha.2017.05.112. [PMID: 28591691] - Emily J Johnson, Christina S Won, Kathleen Köck, Mary F Paine. Prioritizing pharmacokinetic drug interaction precipitants in natural products: application to OATP inhibitors in grapefruit juice.
Biopharmaceutics & drug disposition.
2017 Apr; 38(3):251-259. doi:
10.1002/bdd.2061. [PMID: 28032362] - Pius Fasinu, Yahya E Choonara, Pradeep Kumar, Lisa C du Toit, Divya Bijukumar, Riaz A Khan, Viness Pillay. Enhancement of the Oral Bioavailability of Felodipine Employing 8-Arm-Poly(Ethylene Glycol): In Vivo, In Vitro and In Silico Evaluation.
AAPS PharmSciTech.
2017 Apr; 18(3):617-628. doi:
10.1208/s12249-016-0545-8. [PMID: 27173987] - Abdulaziz S Al-Roujayee. Naringenin improves the healing process of thermally-induced skin damage in rats.
The Journal of international medical research.
2017 Apr; 45(2):570-582. doi:
10.1177/0300060517692483. [PMID: 28415935] - Yu-Mei Zhang, Hong-Yu Ren, Xian-Lin Zhao, Juan Li, Jun-Yi Li, Fu-Sheng Wu, Hang Su, Wen-Fu Tang. Pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction in the liver of rats with severe acute pancreatitis.
World journal of gastroenterology.
2017 Feb; 23(8):1367-1374. doi:
10.3748/wjg.v23.i8.1367. [PMID: 28293083] - Nora A Bawazeer, Hani Choudary, Mazin A Zamzami, Wesam H Abdulaal, Mustafa Zeyadi, Ashwag ALbukhari, Bruce Middleton, Said S Moselhy. POSSIBLE REGULATION OF LDL-RECEPTOR BY NARINGENIN IN HEPG2 HEPATOMA CELL LINE.
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2017; 14(1):278-287. doi:
10.21010/ajtcam.v14i1.30. [PMID: 28480406] - Agustín Pérez-Fonseca, Yazmin Alcala-Canto, Abdelfattah Z M Salem, Aldo B Alberti-Navarro. Anticoccidial efficacy of naringenin and a grapefruit peel extract in growing lambs naturally-infected with Eimeria spp.
Veterinary parasitology.
2016 Dec; 232(?):58-65. doi:
10.1016/j.vetpar.2016.11.009. [PMID: 27890083] - Arumugam Ramakrishnan, Natesan Vijayakumar, Mani Renuka. Naringin regulates glutamate-nitric oxide cGMP pathway in ammonium chloride induced neurotoxicity.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Dec; 84(?):1717-1726. doi:
10.1016/j.biopha.2016.10.080. [PMID: 27836465] - Julian K Aschoff, Ken M Riedl, Jessica L Cooperstone, Josef Högel, Anja Bosy-Westphal, Steven J Schwartz, Reinhold Carle, Ralf M Schweiggert. Urinary excretion of Citrus flavanones and their major catabolites after consumption of fresh oranges and pasteurized orange juice: A randomized cross-over study.
Molecular nutrition & food research.
2016 12; 60(12):2602-2610. doi:
10.1002/mnfr.201600315. [PMID: 27488098] - Katarzyna Brodowska, Isabel Correia, Eugenio Garribba, Fernanda Marques, Elżbieta Klewicka, Elżbieta Łodyga-Chruscińska, João Costa Pessoa, Aliaksandr Dzeikala, Longin Chrusciński. Coordination ability and biological activity of a naringenin thiosemicarbazone.
Journal of inorganic biochemistry.
2016 12; 165(?):36-48. doi:
10.1016/j.jinorgbio.2016.09.014. [PMID: 27764708] - Chao Wang, Rui-Qin Fan, Yan-Xiang Zhang, Hao Nie, Kan Li. Naringenin protects against isoniazid- and rifampicin-induced apoptosis in hepatic injury.
World journal of gastroenterology.
2016 Nov; 22(44):9775-9783. doi:
10.3748/wjg.v22.i44.9775. [PMID: 27956801] - R Pradeep Kumar, Annie Abraham. PVP- coated naringenin nanoparticles for biomedical applications - In vivo toxicological evaluations.
Chemico-biological interactions.
2016 Sep; 257(?):110-8. doi:
10.1016/j.cbi.2016.07.012. [PMID: 27417253] - Naiara Orrego-Lagarón, Miriam Martínez-Huélamo, Paola Quifer-Rada, Rosa M Lamuela-Raventos, Elvira Escribano-Ferrer. Absorption and disposition of naringenin and quercetin after simultaneous administration via intestinal perfusion in mice.
Food & function.
2016 Sep; 7(9):3880-9. doi:
10.1039/c6fo00633g. [PMID: 27515345] - Souvik Roy, Faiqa Ahmed, Sritama Banerjee, Urmi Saha. Naringenin ameliorates streptozotocin-induced diabetic rat renal impairment by downregulation of TGF-β1 and IL-1 via modulation of oxidative stress correlates with decreased apoptotic events.
Pharmaceutical biology.
2016 Sep; 54(9):1616-27. doi:
10.3109/13880209.2015.1110599. [PMID: 26928632] - Boran Ni, Sali Cao, Lijun Feng, Xingbin Yin, Wenping Wang, Xin Zhang, Jian Ni. Simultaneous Analysis of Quercetin and Naringenin in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry: Application to a Pharmacokinetic Study After Oral Administration.
Journal of chromatographic science.
2016 Sep; 54(8):1359-64. doi:
10.1093/chromsci/bmw079. [PMID: 27199443]