Tebipenem pivoxil hydrobromide (BioDeep_00000840289)
代谢物信息卡片
Tebipenem pivoxil hydrobromide
化学式: C22H32BrN3O6S2 (577.0915792000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C2C(C(=O)N2C(=C1SC3CN(C3)C4=NCCS4)C(=O)OCOC(=O)C(C)(C)C)C(C)O.Br
InChI: /m1./s1
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C2140 - Adjuvant > C183118 - Beta-lactamase Inhibitor
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Keith A Rodvold, Mark H Gotfried, Vipul Gupta, Amanda Ek, Praveen Srivastava, Angela Talley, Jon Bruss. Plasma and Intrapulmonary Concentrations of Tebipenem following Oral Administration of Tebipenem Pivoxil Hydrobromide to Healthy Adult Subjects.
Antimicrobial agents and chemotherapy.
2022 Jul; 66(7):e0059022. doi:
10.1128/aac.00590-22. [PMID: 35762796] - Vipul K Gupta, Gina Patel, Leanne Gasink, Floni Bajraktari, Yang Lei, Akash Jain, Praveen Srivastava, Angela K Talley. Bioequivalence of two oral formulations of tebipenem pivoxil hydrobromide in healthy subjects.
Clinical and translational science.
2022 Jul; 15(7):1654-1663. doi:
10.1111/cts.13280. [PMID: 35411579] - Gina Patel, Keith A Rodvold, Vipul K Gupta, Jon Bruss, Leanne Gasink, Floni Bajraktari, Yang Lei, Akash Jain, Praveen Srivastava, Angela K Talley. Pharmacokinetics of Oral Tebipenem Pivoxil Hydrobromide in Subjects with Various Degrees of Renal Impairment.
Antimicrobial agents and chemotherapy.
2022 05; 66(5):e0240721. doi:
10.1128/aac.02407-21. [PMID: 35420493] - Vipul K Gupta, Gary Maier, Paul Eckburg, Lisa Morelli, Yang Lei, Akash Jain, Erika Manyak, David Melnick. Randomized, Double-Blind, Placebo- and Positive-Controlled Crossover Study of the Effects of Tebipenem Pivoxil Hydrobromide on QT/QTc Intervals in Healthy Subjects.
Antimicrobial agents and chemotherapy.
2021 06; 65(7):e0014521. doi:
10.1128/aac.00145-21. [PMID: 33875429] - Paul B Eckburg, Akash Jain, Susannah Walpole, Grayson Moore, Luke Utley, Erika Manyak, Aaron Dane, David Melnick. Safety, Pharmacokinetics, and Food Effect of Tebipenem Pivoxil Hydrobromide after Single and Multiple Ascending Oral Doses in Healthy Adult Subjects.
Antimicrobial agents and chemotherapy.
2019 09; 63(9):. doi:
10.1128/aac.00618-19. [PMID: 31262768] - Laura McEntee, Adam Johnson, Nicola Farrington, Jennifer Unsworth, Aaron Dane, Akash Jain, Nicole Cotroneo, Ian Critchley, David Melnick, Thomas Parr, Paul G Ambrose, Shampa Das, William Hope. Pharmacodynamics of Tebipenem: New Options for Oral Treatment of Multidrug-Resistant Gram-Negative Infections.
Antimicrobial agents and chemotherapy.
2019 08; 63(8):. doi:
10.1128/aac.00603-19. [PMID: 31109982] - Siqi Xue, Zhiying Qin, Guanghui Ren, Zhongjie Yang, Yang Lu, Yongjie Zhang, Ning Li, Xijing Chen, Di Zhao. A validated UPLC-MS/MS method for determination of tebipenem in human plasma and its application to a pharmacokinetic study in healthy volunteers.
Journal of pharmaceutical and biomedical analysis.
2019 Jun; 170(?):30-39. doi:
10.1016/j.jpba.2019.03.010. [PMID: 30903927] - Hiroshi Sakata. Clinical evaluation of 3-day tebipenem pivoxil therapy in children with community-acquired pneumonia.
The Japanese journal of antibiotics.
2016 Sep; 69(3):125-130. doi:
NULL. [PMID: 30226948] - Visanu Thamlikitkul, Narisorn Lorchirachoonkul, Surapee Tiengrim. In vitro and in vivo activity of tebipenem against ESBL-producing E. coli.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2014 Dec; 97(12):1259-68. doi:
NULL. [PMID: 25764632] - Rinya Sugita. Good transfer of tebipenem into middle ear effusion conduces to the favorable clinical outcomes of tebipenem pivoxil in pediatric patients with acute otitis media.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2013 Jun; 19(3):465-71. doi:
10.1007/s10156-012-0513-5. [PMID: 23393013] - Hiroshi Sakata. [Clinical efficacy of tebipenem pivoxil treatment in children with pneumonia, who had no relief despite having administered oral beta-lactam antibiotics].
The Japanese journal of antibiotics.
2011 Jun; 64(3):171-7. doi:
NULL. [PMID: 21861308] - Koji Kijima, Jun Morita, Katsuyoshi Suzuki, Makoto Aoki, Kazuhiko Kato, Hiroyuki Hayashi, Shigeki Shibasaki, Tohru Kurosawa. [Pharmacokinetics of tebipenem pivoxil, a novel oral carbapenem antibiotic, in experimental animals].
The Japanese journal of antibiotics.
2009 Jun; 62(3):214-40. doi:
NULL. [PMID: 19882982] - Shunkichi Baba, Hiroshi Kasahara, Jun Morita, Kazumasa Aizawa, Keisuke Sunakawa. [Tissue and aural discharge distribution of tebipenem pivoxil].
The Japanese journal of antibiotics.
2009 Apr; 62(2):127-35. doi:
NULL. [PMID: 19673354] - Koji Kijima, Nobuo Sato, Tomokazu Koresawa, Jun Morita, Hiroyuki Hayashi, Shigeki Shibasaki, Tohru Kurosawa, Kyoichi Totsuka. [Pharmacokinetics analysis of tebipenem pivoxil in a phase II clinical trial in otolaryngological infections].
The Japanese journal of antibiotics.
2009 Apr; 62(2):143-54. doi:
NULL. [PMID: 19673356] - Shunkichi Baba, Noboru Yamanaka, Kenji Suzuki, Mitsuru Furukawa, Nobuhiko Furuya, Kimiko Ubukata, Kyoichi Totsuka. [Clinical efficacy, safety and PK-PD analysis of tebipenem pivoxil in a phase II clinical trial in otolaryngological infections].
The Japanese journal of antibiotics.
2009 Apr; 62(2):155-77. doi:
NULL. [PMID: 19673357] - Nobuo Sato, Koji Kijima, Tomokazu Koresawa, Nayu Mitomi, Jun Morita, Hisashi Suzuki, Hiroyuki Hayashi, Shigeki Shibasaki, Tohru Kurosawa, Kyoichi Totsuka. Population pharmacokinetics of tebipenem pivoxil (ME1211), a novel oral carbapenem antibiotic, in pediatric patients with otolaryngological infection or pneumonia.
Drug metabolism and pharmacokinetics.
2008; 23(6):434-46. doi:
10.2133/dmpk.23.434. [PMID: 19122338] - George G Zhanel, Ryan Wiebe, Leanne Dilay, Kristjan Thomson, Ethan Rubinstein, Daryl J Hoban, Ayman M Noreddin, James A Karlowsky. Comparative review of the carbapenems.
Drugs.
2007; 67(7):1027-52. doi:
10.2165/00003495-200767070-00006. [PMID: 17488146]