Iomazenil (123I) (BioDeep_00000840271)

   


代谢物信息卡片


Iomazenil (123I)

化学式: C15H14IN3O3 (411.00798840000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC=C3I)C
InChI: InChI=1S/C15H14IN3O3/c1-3-22-15(21)13-11-7-18(2)14(20)12-9(16)5-4-6-10(12)19(11)8-17-13/h4-6,8H,3,7H2,1-2H3/i16-4

描述信息

C1446 - Radiopharmaceutical Compound > C2124 - Radioconjugate

同义名列表

1 个代谢物同义名

Iomazenil (123I)



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Muttaquina Hossain, Baitun Nahar, Md Ahshanul Haque, Dinesh Mondal, Mustafa Mahfuz, Nurun Nahar Naila, Md Amran Gazi, Md Mehedi Hasan, Nur Muhammad Shahedul Haque, Rashidul Haque, Michael B Arndt, Judd L Walson, Tahmeed Ahmed. Serum Adipokines, Growth Factors, and Cytokines Are Independently Associated with Stunting in Bangladeshi Children. Nutrients. 2019 Aug; 11(8):. doi: 10.3390/nu11081827. [PMID: 31394828]
  • Asuka Mizutani, Masato Kobayashi, Ken-Ichi Fujita, Kotaro Takahashi, Tsuzumi Hokama, Hiroaki Takasu, Kodai Nishi, Ryuichi Nishii, Naoto Shikano, Kazuki Fukuchi, Keiichi Kawai. 123I-iomazenil whole-body imaging to detect hepatic carboxylesterase drug-metabolizing enzyme activity. Nuclear medicine communications. 2018 Sep; 39(9):825-833. doi: 10.1097/mnm.0000000000000875. [PMID: 29877992]
  • John R Atack, Wai-Si Eng, Ray E Gibson, Christine Ryan, Barbara Francis, Bindi Sohal, Gerard R Dawson, Richard J Hargreaves, H Donald Burns. The plasma-occupancy relationship of the novel GABAA receptor benzodiazepine site ligand, alpha5IA, is similar in rats and primates. British journal of pharmacology. 2009 Jul; 157(5):796-803. doi: 10.1111/j.1476-5381.2009.00216.x. [PMID: 19422390]
  • Deepak Cyril D'Souza, Roberto B Gil, Edward Zuzarte, Lisa M MacDougall, Lia Donahue, John S Ebersole, Nashaat N Boutros, Tom Cooper, John Seibyl, John H Krystal. gamma-Aminobutyric acid-serotonin interactions in healthy men: implications for network models of psychosis and dissociation. Biological psychiatry. 2006 Jan; 59(2):128-37. doi: 10.1016/j.biopsych.2005.06.020. [PMID: 16140281]
  • Nobuyoshi Fukumitsu, Shigeyuki Ogi, Mayuki Uchiyama, Yutaka Mori. Benzodiazepine effect of (125)I-iomazenil-benzodiazepine receptor binding and serum corticosterone level in a rat model. Nuclear medicine and biology. 2005 Jan; 32(1):95-100. doi: 10.1016/j.nucmedbio.2004.06.008. [PMID: 15691666]
  • Nobuyoshi Fukumitsu, Shigeyuki Ogi, Mayuki Uchiyama, Yutaka Mori. 125I-iomazenil - benzodiazepine receptor binding and serum corticosterone level during psychological stress in a rat model. Nuclear medicine and biology. 2004 Feb; 31(2):283-9. doi: 10.1016/j.nucmedbio.2003.06.002. [PMID: 15013495]
  • Anne Lingford-Hughes, Susan P Hume, Adrian Feeney, Ella Hirani, Safiye Osman, Vincent J Cunningham, Victor W Pike, David J Brooks, David J Nutt. Imaging the GABA-benzodiazepine receptor subtype containing the alpha5-subunit in vivo with [11C]Ro15 4513 positron emission tomography. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2002 Jul; 22(7):878-89. doi: 10.1097/00004647-200207000-00013. [PMID: 12142573]
  • L H Pinborg, C Videbaek, S G Hasselbalch, S A Sørensen, A Wagner, O B Paulson, G M Knudsen. Benzodiazepine receptor quantification in Huntington's disease with [(123)I]omazenil and SPECT. Journal of neurology, neurosurgery, and psychiatry. 2001 May; 70(5):657-61. doi: 10.1136/jnnp.70.5.657. [PMID: 11309461]
  • J D Bremner, R B Innis, S M Southwick, L Staib, S Zoghbi, D S Charney. Decreased benzodiazepine receptor binding in prefrontal cortex in combat-related posttraumatic stress disorder. The American journal of psychiatry. 2000 Jul; 157(7):1120-6. doi: 10.1176/appi.ajp.157.7.1120. [PMID: 10873921]
  • J D Bremner, R B Innis, T White, M Fujita, D Silbersweig, A W Goddard, L Staib, E Stern, A Cappiello, S Woods, R Baldwin, D S Charney. SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder. Biological psychiatry. 2000 Jan; 47(2):96-106. doi: 10.1016/s0006-3223(99)00188-2. [PMID: 10664825]
  • J D Bremner, A Horti, L H Staib, Y Zea-Ponce, R Soufer, D S Charney, R Baldwin. Kinetic modeling of benzodiazepine receptor binding with PET and high specific activity [(11)C]Iomazenil in healthy human subjects. Synapse (New York, N.Y.). 2000 Jan; 35(1):68-77. doi: 10.1002/(sici)1098-2396(200001)35:1<68::aid-syn9>3.0.co;2-h. [PMID: 10579810]
  • N P Verhoeff, O A Petroff, F Hyder, S S Zoghbi, M Fujita, N Rajeevan, D L Rothman, J P Seibyl, R H Mattson, R B Innis. Effects of vigabatrin on the GABAergic system as determined by [123I]iomazenil SPECT and GABA MRS. Epilepsia. 1999 Oct; 40(10):1433-8. doi: 10.1111/j.1528-1157.1999.tb02016.x. [PMID: 10528940]
  • C Videbaek, P Ott, O B Paulson, G M Knudsen. Blood-brain barrier transport and protein binding of flumazenil and iomazenil in the rat: implications for neuroreceptor studies. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 1999 Sep; 19(9):948-55. doi: 10.1097/00004647-199909000-00002. [PMID: 10478646]
  • J D Bremner, R Baldwin, A Horti, L H Staib, C K Ng, P Z Tan, Y Zea-Ponce, S Zoghbi, J P Seibyl, R Soufer, D S Charney, R B Innis. Quantitation of benzodiazepine receptor binding with PET [11C]iomazenil and SPECT [123I]iomazenil: preliminary results of a direct comparison in healthy human subjects. Psychiatry research. 1999 Aug; 91(2):79-91. doi: 10.1016/s0925-4927(99)00015-3. [PMID: 10515463]
  • F Kapczinski, J Quevedo, H V Curran, S Fleminger, B Toone, A Cluckie, M Lader. Brain uptake of iomazenil in cirrhotic patients: a single photon emission tomography study. Journal of psychopharmacology (Oxford, England). 1999; 13(3):219-25. doi: 10.1177/026988119901300302. [PMID: 10512075]
  • K Ito, T Momose, H Kotaki, Y Kojima, K Yamamoto, M Katashima, Y Sawada, Y Sasaki, T Iga. Pharmacokinetic analysis of benzodiazepine receptor binding of [123I]iomazenil in human brain. Pharmaceutical research. 1997 Aug; 14(8):999-1003. doi: 10.1023/a:1012188909100. [PMID: 9279879]
  • C Burger, A Buck. Tracer kinetic modelling of receptor data with mathematical metabolite correction. European journal of nuclear medicine. 1996 May; 23(5):539-45. doi: 10.1007/bf00833389. [PMID: 8698059]
  • G Westera, A Buck, C Burger, K L Leenders, G K von Schulthess, A P Schubiger. Carbon-11 and iodine-123 labelled iomazenil: a direct PET-SPET compari son. European journal of nuclear medicine. 1996 Jan; 23(1):5-12. doi: 10.1007/bf01736983. [PMID: 8586102]
  • H Yoshimura, A Yanai, H Matsumoto, K Ida, M Kurami, Y Yonekura, K Torizuka. [Pharmacokinetics of 123I-iomazenil, a benzodiazepine receptor seeker]. Kaku igaku. The Japanese journal of nuclear medicine. 1995 Sep; 32(9):1037-43. doi: NULL. [PMID: 8523840]
  • C Videbaek, J V Andersen, L Dalgaard, C Foged, O B Paulson, A N Lassen. Neuroreceptor quantification in vivo by the steady state principle and [123I]iomazenil in rats. European journal of pharmacology. 1995 Aug; 281(2):117-22. doi: 10.1016/0014-2999(95)00205-y. [PMID: 7589198]
  • Y Onishi, Y Yonekura, T Mukai, S Nishizawa, F Tanaka, H Okazawa, K Ishizu, T Fujita, H Shibasaki, J Konishi. Simple quantification of benzodiazepine receptor binding and ligand transport using iodine-123-iomazenil and two SPECT scans. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1995 Jul; 36(7):1201-10. doi: NULL. [PMID: 7790945]
  • A Abi-Dargham, M Gandelman, S S Zoghbi, M Laruelle, R M Baldwin, P Randall, Y Zea-Ponce, D S Charney, P B Hoffer, R B Innis. Reproducibility of SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1995 Feb; 36(2):167-75. doi: NULL. [PMID: 7830108]
  • M Laruelle, A Abi-Dargham, M S al-Tikriti, R M Baldwin, Y Zea-Ponce, S S Zoghbi, D S Charney, P B Hoffer, R B Innis. SPECT quantification of [123I]iomazenil binding to benzodiazepine receptors in nonhuman primates: II. Equilibrium analysis of constant infusion experiments and correlation with in vitro parameters. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 1994 May; 14(3):453-65. doi: 10.1038/jcbfm.1994.56. [PMID: 8163587]
  • A Abi-Dargham, M Laruelle, J Seibyl, Z Rattner, R M Baldwin, S S Zoghbi, Y Zea-Ponce, J D Bremner, T M Hyde, D S Charney. SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil: kinetic and equilibrium paradigms. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1994 Feb; 35(2):228-38. doi: NULL. [PMID: 8294990]
  • C Videbaek, L Friberg, S Holm, S Wammen, C Foged, J V Andersen, L Dalgaard, N A Lassen. Benzodiazepine receptor equilibrium constants for flumazenil and midazolam determined in humans with the single photon emission computer tomography tracer [123I]iomazenil. European journal of pharmacology. 1993 Nov; 249(1):43-51. doi: 10.1016/0014-2999(93)90660-a. [PMID: 8282018]
  • N P Verhoeff, E Busemann Sokole, D Hengst, J B Stubbs, E A van Royen. Dosimetry of iodine-123 iomazenil in humans. European journal of nuclear medicine. 1993 Jul; 20(7):580-4. doi: 10.1007/bf00176551. [PMID: 8370378]
  • S S Zoghbi, R M Baldwin, J P Seibyl, M S al-Tikriti, Y Zea-Ponce, M Laruelle, E H Sybirska, S W Woods, A W Goddard, R T Malison. Pharmacokinetics of the SPECT benzodiazepine receptor radioligand [123I]iomazenil in human and non-human primates. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. 1992 Nov; 19(8):881-8. doi: 10.1016/0883-2897(92)90174-w. [PMID: 1330992]
  • R B Innis, M S al-Tikriti, S S Zoghbi, R M Baldwin, E H Sybirska, M A Laruelle, R T Malison, J P Seibyl, R C Zimmermann, E W Johnson. SPECT imaging of the benzodiazepine receptor: feasibility of in vivo potency measurements from stepwise displacement curves. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1991 Sep; 32(9):1754-61. doi: NULL. [PMID: 1652627]
  • E W Johnson, S W Woods, S Zoghbi, B J McBride, R M Baldwin, R B Innis. Receptor binding characterization of the benzodiazepine radioligand 125I-Ro16-0154: potential probe for SPECT brain imaging. Life sciences. 1990; 47(17):1535-46. doi: 10.1016/0024-3205(90)90182-q. [PMID: 2174487]
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