Vatinoxan Hydrochloride (BioDeep_00000840137)
代谢物信息卡片
Vatinoxan Hydrochloride
化学式: C20H27ClN4O4S (454.1441452000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CS(=O)(=O)NCCN1C(=O)NCC12CCN3CCC4=C(C3C2)OC5=CC=CC=C45.Cl
InChI: /m0./s1
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kristi Kobluk, Bruno H Pypendop. Effects of dopamine, norepinephrine or phenylephrine on the prevention of hypotension in isoflurane-anesthetized cats administered vatinoxan or vatinoxan and dexmedetomidine.
Veterinary anaesthesia and analgesia.
2022 Jan; 49(1):54-64. doi:
10.1016/j.vaa.2021.11.001. [PMID: 34906421] - Magdy Adam, Jere Lindén, Marja Raekallio, Ahmed Abu-Shahba, Bettina Mannerström, Riitta Seppänen-Kaijansinkko, Anna Meller, Kati Salla. Concentrations of vatinoxan and xylazine in plasma, cerebrospinal fluid and brain tissue following intravenous administration in sheep.
Veterinary anaesthesia and analgesia.
2021 Nov; 48(6):900-905. doi:
10.1016/j.vaa.2021.08.003. [PMID: 34561183] - Stephan Neudeck, Lara Twele, Veronika Kopp, Sabine Kästner. Pharmacodynamics and plasma concentrations of dexmedetomidine with or without vatinoxan as a constant-rate infusion in horses anaesthetized with isoflurane-A pilot study.
Journal of veterinary pharmacology and therapeutics.
2021 Sep; 44(5):754-765. doi:
10.1111/jvp.12992. [PMID: 34159620] - Rachel C Hector, Marlis L Rezende, Khursheed R Mama, Eugene P Steffey, Marja R Raekallio, Outi M Vainio. Combined effects of dexmedetomidine and vatinoxan infusions on minimum alveolar concentration and cardiopulmonary function in sevoflurane-anesthetized dogs.
Veterinary anaesthesia and analgesia.
2021 May; 48(3):314-323. doi:
10.1016/j.vaa.2020.12.007. [PMID: 33678575] - J R Box, N P Karikoski, H E Tanskanen, M R Raekallio. The effects of an alpha-2-adrenoceptor agonist, antagonist, and their combination on the blood insulin, glucose, and glucagon concentrations in insulin sensitive and dysregulated horses.
Veterinary journal (London, England : 1997).
2021 Mar; 269(?):105610. doi:
10.1016/j.tvjl.2021.105610. [PMID: 33593492] - Juhana M Honkavaara, Marja R Raekallio, Pernilla M Syrja, Bruno H Pypendop, Heather K Knych, Ira J Kallio-Kujala, Outi M Vainio. Concentrations of medetomidine enantiomers and vatinoxan, an α2-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs.
Veterinary anaesthesia and analgesia.
2020 Jan; 47(1):47-52. doi:
10.1016/j.vaa.2019.07.004. [PMID: 31761600] - Bruno H Pypendop, Hanna Ahokoivu, Juhana Honkavaara. Pharmacokinetics of vatinoxan in male neutered cats anesthetized with isoflurane.
Veterinary anaesthesia and analgesia.
2020 Jan; 47(1):70-75. doi:
10.1016/j.vaa.2019.10.004. [PMID: 31806431] - Bruno H Pypendop, Hanna Ahokoivu, Juhana Honkavaara. Pharmacokinetics of dexmedetomidine during administration of vatinoxan in male neutered cats anesthetized with isoflurane.
Journal of veterinary pharmacology and therapeutics.
2020 Jan; 43(1):1-5. doi:
10.1111/jvp.12796. [PMID: 31318080] - Alison T Jaeger, Bruno H Pypendop, Hanna Ahokoivu, Juhana Honkavaara. Cardiopulmonary effects of dexmedetomidine, with and without vatinoxan, in isoflurane-anesthetized cats.
Veterinary anaesthesia and analgesia.
2019 Nov; 46(6):753-764. doi:
10.1016/j.vaa.2019.05.012. [PMID: 31416697] - Heta Turunen, Marja R Raekallio, Juhana M Honkavaara, Flavia Restitutti, Ira J Kallio-Kujala, Magdy Adam, Katri Nevanperä, Mika Scheinin, Sofia K Männikkö, Heidi J Hautajärvi, Paula Larenza Menzies, Outi M Vainio. Cardiovascular and sedation reversal effects of intramuscular administration of atipamezole in dogs treated with medetomidine hydrochloride with or without the peripheral α2-adrenoceptor antagonist vatinoxan hydrochloride.
American journal of veterinary research.
2019 Oct; 80(10):912-922. doi:
10.2460/ajvr.80.10.912. [PMID: 31556714] - H A Tapio, M R Raekallio, A K Mykkänen, D Al-Ramahi, M Scheinin, H J Hautajärvi, S Männikkö, O Vainio. Effects of vatinoxan on cardiorespiratory function, fecal output and plasma drug concentrations in horses anesthetized with isoflurane and infusion of medetomidine.
Veterinary journal (London, England : 1997).
2019 Sep; 251(?):105345. doi:
10.1016/j.tvjl.2019.105345. [PMID: 31492389] - H Tapio, M R Raekallio, A Mykkänen, S Männikkö, M Scheinin, R C Bennett, O Vainio. Effects of vatinoxan on cardiorespiratory function and gastrointestinal motility during constant-rate medetomidine infusion in standing horses.
Equine veterinary journal.
2019 Sep; 51(5):646-652. doi:
10.1111/evj.13085. [PMID: 30793362] - H Rossi, M Raekallio, M Määttä, H Tapio, M Hanifeh, J Junnila, M M Rajamäki, A Mykkänen. Effects of general anaesthesia in dorsal recumbency with and without vatinoxan on bronchoalveolar lavage cytology of healthy horses.
Veterinary journal (London, England : 1997).
2019 Sep; 251(?):105352. doi:
10.1016/j.tvjl.2019.105352. [PMID: 31492391] - Bruno H Pypendop, Hanna Ahokoivu, Juhana Honkavaara. Effects of dexmedetomidine, with or without vatinoxan (MK-467), on minimum alveolar concentration of isoflurane in cats.
Veterinary anaesthesia and analgesia.
2019 Jul; 46(4):443-451. doi:
10.1016/j.vaa.2019.02.004. [PMID: 30982711] - I J Kallio-Kujala, R C Bennett, M R Raekallio, E Yatkin, A Meierjohann, E Savontaus, M Scheinin, T Spillmann, O M Vainio. Effects of dexmedetomidine and MK-467 on plasma glucose, insulin and glucagon in a glibenclamide-induced canine hypoglycaemia model.
Veterinary journal (London, England : 1997).
2018 Dec; 242(?):33-38. doi:
10.1016/j.tvjl.2018.09.012. [PMID: 30503541] - Magdy Adam, Marja R Raekallio, Outi M Vainio. Sedative effect of intramuscular medetomidine with and without vatinoxan (MK-467), and its reversal with atipamezole in sheep.
Veterinary anaesthesia and analgesia.
2018 Nov; 45(6):788-793. doi:
10.1016/j.vaa.2018.06.009. [PMID: 30301665] - I J Kallio-Kujala, H A Turunen, M R Raekallio, J M Honkavaara, K M Salla, D Casoni, H J Hautajärvi, O M Vainio. Peripherally acting α-adrenoceptor antagonist MK-467 with intramuscular medetomidine and butorphanol in dogs: A prospective, randomised, clinical trial.
Veterinary journal (London, England : 1997).
2018 Oct; 240(?):22-26. doi:
10.1016/j.tvjl.2018.08.007. [PMID: 30268328] - Magdy Adam, Marja R Raekallio, Kati M Salla, Juhana M Honkavaara, Sofia Männikkö, Mika Scheinin, Marena Kajula, Sari H Mölsä, Outi M Vainio. Effects of the peripherally acting α2-adrenoceptor antagonist MK-467 on cardiopulmonary function in sheep sedated by intramuscular administration of medetomidine and ketamine and reversed by intramuscular administration of atipamezole.
American journal of veterinary research.
2018 Sep; 79(9):921-932. doi:
10.2460/ajvr.79.9.921. [PMID: 30153057] - Manuel Martin-Flores, Daniel M Sakai, Juhana Honkavaara, Luis Campoy, Diego A Portela, Robin D Gleed. Hemodynamic effects of MK-467 following intravenous administration to isoflurane-anesthetized cats concurrently receiving dexmedetomidine.
American journal of veterinary research.
2018 Jul; 79(7):711-717. doi:
10.2460/ajvr.79.7.711. [PMID: 29943632] - Ira J Kallio-Kujala, Marja R Raekallio, Juhana Honkavaara, Rachel C Bennett, Heta Turunen, Mika Scheinin, Heidi Hautajärvi, Outi Vainio. Peripheral α2-adrenoceptor antagonism affects the absorption of intramuscularly coadministered drugs.
Veterinary anaesthesia and analgesia.
2018 Jul; 45(4):405-413. doi:
10.1016/j.vaa.2018.01.008. [PMID: 29891212] - M Adam, M R Raekallio, T Keskitalo, J M Honkavaara, M Scheinin, M Kajula, S Mölsä, O M Vainio. The impact of MK-467 on plasma drug concentrations, sedation and cardiopulmonary changes in sheep treated with intramuscular medetomidine and atipamezole for reversal.
Journal of veterinary pharmacology and therapeutics.
2018 Jun; 41(3):447-456. doi:
10.1111/jvp.12486. [PMID: 29352473] - Heidi A Tapio, Marja R Raekallio, Anna Mykkänen, Khursheed Mama, Jóse L Mendez-Angulo, Heidi Hautajärvi, Outi M Vainio. Effects of MK-467 hydrochloride and hyoscine butylbromide on cardiorespiratory and gastrointestinal changes induced by detomidine hydrochloride in horses.
American journal of veterinary research.
2018 Apr; 79(4):376-387. doi:
10.2460/ajvr.79.4.376. [PMID: 29583040] - Kati M Salla, Cosmin I Tuns, Rachel C Bennett, Marja R Raekallio, Mika Scheinin, Erja Kuusela, Outi M Vainio. Cardiovascular effects of premedication with medetomidine alone and in combination with MK-467 or glycopyrrolate in dogs subsequently anesthetized with isoflurane.
American journal of veterinary research.
2017 Nov; 78(11):1245-1254. doi:
10.2460/ajvr.78.11.1245. [PMID: 29076369] - Rachel Bennett, Mari Palviainen, Marikki Peltoniemi, Lauri Vuorilehto, Mika Scheinin, Marja Raekallio, Outi Vainio. The role of active transport in the transcellular movement of the peripheral α2-adrenoceptor antagonist, MK-467: An in vitro pilot study.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
2017 Oct; 81(4):318-320. doi:
NULL. [PMID: 29081592] - Rachel C Bennett, Kati M Salla, Marja R Raekallio, Mika Scheinin, Outi M Vainio. Effects of the α2-adrenoceptor agonist medetomidine on the distribution and clearance of alfaxalone during coadministration by constant rate infusion in dogs.
American journal of veterinary research.
2017 Aug; 78(8):956-964. doi:
10.2460/ajvr.78.8.956. [PMID: 28738010] - Flavia Restitutti, M Johanna Kaartinen, Marja R Raekallio, Otto Wejberg, Emmi Mikkola, Jerome R E Del Castillo, Mika Scheinin, Outi M Vainio. Plasma concentration and cardiovascular effects of intramuscular medetomidine combined with three doses of the peripheral alpha2-antagonist MK-467 in dogs.
Veterinary anaesthesia and analgesia.
2017 May; 44(3):417-426. doi:
10.1016/j.vaa.2016.04.006. [PMID: 28552594] - Annemarie de Vries, Soile Ae Pakkanen, Marja R Raekallio, Abel Ekiri, Mika Scheinin, Polly M Taylor, Outi M Vainio. Clinical effects and pharmacokinetic variables of romifidine and the peripheral α2 -adrenoceptor antagonist MK-467 in horses.
Veterinary anaesthesia and analgesia.
2016 Nov; 43(6):599-610. doi:
10.1111/vaa.12354. [PMID: 26918855] - B H Pypendop, J Honkavaara, J E Ilkiw. Pharmacokinetics of dexmedetomidine, MK-467, and their combination following intravenous administration in male cats.
Journal of veterinary pharmacology and therapeutics.
2016 Oct; 39(5):460-8. doi:
10.1111/jvp.12302. [PMID: 26896345] - R C Bennett, K M Salla, M R Raekallio, L Hänninen, V M Rinne, M Scheinin, O M Vainio. Effects of MK-467 on the antinociceptive and sedative actions and pharmacokinetics of medetomidine in dogs.
Journal of veterinary pharmacology and therapeutics.
2016 Aug; 39(4):336-43. doi:
10.1111/jvp.12292. [PMID: 26763145] - R C Bennett, J Hokkanen, M R Raekallio, O M Vainio. The impact of medetomidine on the protein-binding characteristics of MK-467 in canine plasma.
Journal of veterinary pharmacology and therapeutics.
2016 Aug; 39(4):405-7. doi:
10.1111/jvp.12291. [PMID: 26763140] - Suvi T Ruohonen, Ville Ranta-Panula, Sanna Bastman, Paulina Chrusciel, Mika Scheinin, Tomi Streng. Potentiation of Glibenclamide Hypoglycaemia in Mice by MK-467, a Peripherally Acting Alpha2-Adrenoceptor Antagonist.
Basic & clinical pharmacology & toxicology.
2015 Dec; 117(6):392-8. doi:
10.1111/bcpt.12440. [PMID: 26132275] - Soile Ae Pakkanen, Marja R Raekallio, Anna K Mykkänen, Kati M Salla, Annemarie de Vries, Lauri Vuorilehto, Mika Scheinin, Outi M Vainio. Detomidine and the combination of detomidine and MK-467, a peripheral alpha-2 adrenoceptor antagonist, as premedication in horses anaesthetized with isoflurane.
Veterinary anaesthesia and analgesia.
2015 Sep; 42(5):527-36. doi:
10.1111/vaa.12238. [PMID: 25529045] - Johanna Kaartinen, Jérôme R E del Castillo, Kati Salla, Eric Troncy, Marja R Raekallio, Outi M Vainio. Haemodynamic interactions of medetomidine and the peripheral alpha-2 antagonist MK-467 during step infusions in isoflurane-anaesthetised dogs.
Veterinary journal (London, England : 1997).
2014 Nov; 202(2):353-60. doi:
10.1016/j.tvjl.2014.08.019. [PMID: 25201249] - Flavia Restitutti, Merja R Laitinen, Marja R Raekallio, Mari Vainionpää, Robert T O'Brien, Erja Kuusela, Outi M Vainio. Effect of MK-467 on organ blood flow parameters detected by contrast-enhanced ultrasound in dogs treated with dexmedetomidine.
Veterinary anaesthesia and analgesia.
2013 Nov; 40(6):e48-56. doi:
10.1111/vaa.12058. [PMID: 23802592] - Mari H Vainionpää, Marja R Raekallio, Soile A E Pakkanen, Ville Ranta-Panula, Valtteri M Rinne, Mika Scheinin, Outi M Vainio. Plasma drug concentrations and clinical effects of a peripheral alpha-2-adrenoceptor antagonist, MK-467, in horses sedated with detomidine.
Veterinary anaesthesia and analgesia.
2013 May; 40(3):257-64. doi:
10.1111/vaa.12012. [PMID: 23368795] - F Restitutti, M Raekallio, M Vainionpää, E Kuusela, O Vainio. Plasma glucose, insulin, free fatty acids, lactate and cortisol concentrations in dexmedetomidine-sedated dogs with or without MK-467: a peripheral α-2 adrenoceptor antagonist.
Veterinary journal (London, England : 1997).
2012 Aug; 193(2):481-5. doi:
10.1016/j.tvjl.2011.12.010. [PMID: 22277719] - Juhana Honkavaara, Flavia Restitutti, Marja Raekallio, Kati Salla, Erja Kuusela, Ville Ranta-Panula, Valtteri Rinne, Outi Vainio, Mika Scheinin. Influence of MK-467, a peripherally acting α2-adrenoceptor antagonist on the disposition of intravenous dexmedetomidine in dogs.
Drug metabolism and disposition: the biological fate of chemicals.
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British journal of clinical pharmacology.
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British journal of pharmacology.
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10.1111/j.1476-5381.1992.tb14353.x. [PMID: 1356562] - J B Warren, C T Dollery, D Sciberras, M R Goldberg. Assessment of MK-467, a peripheral alpha 2-adrenergic receptor antagonist, with intravenous clonidine.
Clinical pharmacology and therapeutics.
1991 Jul; 50(1):71-7. doi:
10.1038/clpt.1991.105. [PMID: 1677320] - K Szemeredi, R Stull, I J Kopin, D S Goldstein. Effects of a peripherally acting alpha 2-adrenoceptor antagonist (L-659,066) on hemodynamics and plasma levels of catechols in conscious rats.
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